| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrey Postnov, Mark E Schmidt, Darrel J Pemberton, Jan de Hoon, Anne van Hecken, Maarten van den Boer, Peter Zannikos, Peter van der Ark, James A Palmer, Stef Rassnick, Sofie Celen, Guy Bormans, Koen van Laer. Fatty Acid Amide Hydrolase Inhibition by JNJ-42165279: A Multiple-Ascending Dose and a Positron Emission Tomography Study in Healthy Volunteers. Clinical and translational science. vol 11. issue 4. 2019-07-15. PMID:29575526. |
inhibition of fatty acid amide hydrolase (faah) potentiates endocannabinoid activity and is hypothesized to have therapeutic potential for mood and anxiety disorders and pain. |
2019-07-15 |
2023-08-13 |
human |
| Noelia Aparicio, M Teresa Grande, Samuel Ruiz de Martín Esteban, Alicia López, Gonzalo Ruiz-Pérez, Mario Amores, Carmen Vázquez, Ana M Martínez-Relimpio, M Ruth Pazos, Benjamin F Cravatt, Rosa M Tolón, Julián Romer. Role of interleukin 1-beta in the inflammatory response in a fatty acid amide hydrolase-knockout mouse model of Alzheimer's disease. Biochemical pharmacology. vol 157. 2019-07-08. PMID:30195729. |
based on previously reported data, in which we described a paradoxical effect of the genetic deletion of the fatty acid amide hydrolase, we here aimed to expand our knowledge on the role of the endocannabinoid system in the context of alzheimer's disease. |
2019-07-08 |
2023-08-13 |
mouse |
| Han-Jun Kim, Eun-Ji Choi, Hyo Sung Kim, Chan-Woong Choi, Sik-Won Choi, Sun-Lim Kim, Woo-Duck Seo, Sun Hee D. Germinated soy germ extract ameliorates obesity through beige fat activation. Food & function. vol 10. issue 2. 2019-07-01. PMID:30681105. |
furthermore, gene and protein expression levels of endocannabinoid system-related factors such as nape-pld, faah, dagl-α, and cb2 were altered along with browning and beige fat activation by gsge. |
2019-07-01 |
2023-08-13 |
mouse |
| Thangesweran Ayakannu, Anthony H Taylor, Timothy H Marczylo, Justin C Konj. New Insights of Uterine Leiomyoma Pathogenesis: Endocannabinoid System. Medical science monitor basic research. vol 25. 2019-07-01. PMID:30842391. |
components studied included cannabinoid receptors 1 (cb1) and 2 (cb2); the g protein-coupled receptor gpr55; transient potential vanilloid receptor 1 (trpv1) and the endocannabinoid modulating enzymes n-acylphosphatidylethanolamine-specific phospholipase d (nape-pld) and fatty acid amide hydrolase (faah), and their n-acylethanolamine (nae) ligands: n-arachidonylethanolamine (aea), n-oleoylethanolamine (oea), and n-palmityolethanaolamine (pea). |
2019-07-01 |
2023-08-13 |
Not clear |
| Thangesweran Ayakannu, Anthony H Taylor, Timothy H Marczylo, Justin C Konj. New Insights of Uterine Leiomyoma Pathogenesis: Endocannabinoid System. Medical science monitor basic research. vol 25. 2019-07-01. PMID:30842391. |
significant correlations between reduced faah, cb1, and gpr55 expression and pea in fibroids indicate that the loss of these endocannabinoid system components are biomarkers of leiomyomata. |
2019-07-01 |
2023-08-13 |
Not clear |
| Anne Gärtner, Denise Dörfel, Kersten Diers, Stephanie H Witt, Alexander Strobel, Burkhard Brock. Impact of FAAH genetic variation on fronto-amygdala function during emotional processing. European archives of psychiatry and clinical neuroscience. vol 269. issue 2. 2019-06-20. PMID:30291441. |
recent translational studies identified a common endocannabinoid polymorphism, faah c385a, in the gene for the fatty acid amide hydrolase (faah). |
2019-06-20 |
2023-08-13 |
Not clear |
| Roberto Colangeli, Massimo Pierucci, Arcangelo Benigno, Giuseppe Campiani, Stefania Butini, Giuseppe Di Giovann. The FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity. Scientific reports. vol 7. issue 1. 2019-06-13. PMID:28894217. |
we found that both the fatty acid amide hydrolase (faah) inhibitor urb597 and the synthetic cannabinoid agonist win55,212-2 displayed am251-sensitive anti-seizure effects. |
2019-06-13 |
2023-08-13 |
rat |
| J M Viveros-Paredes, R E Gonzalez-Castañeda, A Escalante-Castañeda, A R Tejeda-Martínez, F Castañeda-Achutiguí, M E Flores-Sot. Effect of inhibition of fatty acid amide hydrolase on MPTP-induced dopaminergic neuronal damage. Neurologia (Barcelona, Spain). vol 34. issue 3. 2019-06-10. PMID:28104279. |
the endocannabinoid system is known to modulate the nigrostriatal pathway through endogenous ligands such as anandamide (aea), which is hydrolysed by fatty acid amide hydrolase (faah). |
2019-06-10 |
2023-08-13 |
Not clear |
| Marguerite M Patel, David A Nielsen, Thomas R Kosten, Richard De La Garza, Thomas F Newton, Christopher D Verric. FAAH variant Pro129Thr modulates subjective effects produced by cocaine administration. The American journal on addictions. vol 27. issue 7. 2019-06-10. PMID:30126012. |
the endogenous cannabinoid anandamide (aea), an agonist at type-1 cannabinoid (cb1) receptors, is metabolized by fatty acid amide hydrolase (faah). |
2019-06-10 |
2023-08-13 |
human |
| Marguerite M Patel, David A Nielsen, Thomas R Kosten, Richard De La Garza, Thomas F Newton, Christopher D Verric. FAAH variant Pro129Thr modulates subjective effects produced by cocaine administration. The American journal on addictions. vol 27. issue 7. 2019-06-10. PMID:30126012. |
the common variant rs324420 c->a within the faah gene on chromosome 1 codes for a missense substitution (pro129thr), resulting in decreased faah activity and increased endocannabinoid potentiation. |
2019-06-10 |
2023-08-13 |
human |
| Xiaofei Sun, Alexandra Tavenier, Wenbo Deng, Emma Leishman, Heather B Bradshaw, Sudhansu K De. Metformin attenuates susceptibility to inflammation-induced preterm birth in mice with higher endocannabinoid levels. Biology of reproduction. vol 98. issue 2. 2019-06-04. PMID:29228105. |
fatty acid amide hydrolase mutant females (faah-/-) with higher endocannabinoid levels are also more susceptible to preterm birth upon lipopolysaccharide (lps) challenge due to enhanced decidual senescence; this is associated with mitogen-activated protein kinase p38 activation. |
2019-06-04 |
2023-08-13 |
mouse |
| Sharon Fidelman, Tomer Mizrachi Zer-Aviv, Rachel Lange, Cecilia J Hillard, Irit Akira. Chronic treatment with URB597 ameliorates post-stress symptoms in a rat model of PTSD. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 28. issue 5. 2019-04-08. PMID:29519609. |
chronic cannabinoid treatment with urb597 can ameliorate ptsd-like symptoms suggesting faah inhibitors as a potentially effective therapeutic strategy for the treatment of disorders associated with inefficient fear coping. |
2019-04-08 |
2023-08-13 |
rat |
| Jacqueline-Marie N Ferland, Madison R Carr, Angela M Lee, Myrthe E Hoogeland, Catharine A Winstanley, Tommy Patti. Examination of the effects of cannabinoid ligands on decision making in a rat gambling task. Pharmacology, biochemistry, and behavior. vol 170. 2019-03-22. PMID:29787777. |
animals were also treated acutely with the fatty acid amide hydrolase (faah) inhibitor urb597 to selectively upregulate the endocannabinoid anandamide. |
2019-03-22 |
2023-08-13 |
human |
| Helen de Morais, Yane Costa Chaves, Ana Paula Farias Waltrick, Carlos Henrique Alves Jesus, Karina Genaro, José Alexandre Crippa, Joice Maria da Cunha, Janaína Menezes Zanovel. Sub-chronic treatment with cannabidiol but not with URB597 induced a mild antidepressant-like effect in diabetic rats. Neuroscience letters. vol 682. 2019-03-11. PMID:29885450. |
also, to better understand the functionality of the endocannabinoid system in diabetic animals we also evaluated the effect of urb597, a fatty acid amide hydrolase inhibitor. |
2019-03-11 |
2023-08-13 |
rat |
| Michał Biernacki, Barbara Malinowska, Magdalena Timoszuk, Martek Toczek, Anna Jastrząb, Patryk Remiszewski, Elżbieta Skrzydlewsk. Hypertension and chronic inhibition of endocannabinoid degradation modify the endocannabinoid system and redox balance in rat heart and plasma. Prostaglandins & other lipid mediators. vol 138. 2019-02-25. PMID:30201316. |
inhibitors of fatty acid amide hydrolase (faah), the key enzyme responsible for degradation of the endocannabinoid anandamide, are postulated to possess anti-hypertensive potential. |
2019-02-25 |
2023-08-13 |
rat |
| Michał Biernacki, Barbara Malinowska, Magdalena Timoszuk, Martek Toczek, Anna Jastrząb, Patryk Remiszewski, Elżbieta Skrzydlewsk. Hypertension and chronic inhibition of endocannabinoid degradation modify the endocannabinoid system and redox balance in rat heart and plasma. Prostaglandins & other lipid mediators. vol 138. 2019-02-25. PMID:30201316. |
here, we compared the effects of hypertension and chronic faah inhibition by urb597 on the endocannabinoid system and redox balance in spontaneously hypertensive rats (shr) and hypertensive deoxycorticosterone acetate (doca)-salt rats. |
2019-02-25 |
2023-08-13 |
rat |
| Min Jee Kim, Motomasa Tanioka, Sun Woo Um, Seong-Karp Hong, Bae Hwan Le. Analgesic effects of FAAH inhibitor in the insular cortex of nerve-injured rats. Molecular pain. vol 14. 2019-02-20. PMID:30380982. |
endogenous cannabinoids (endocannabinoids), which have been shown to attenuate pain, are simultaneously degraded by fatty acid amide hydrolase (faah) that halts the mechanisms of action. |
2019-02-20 |
2023-08-13 |
rat |
| Min Jee Kim, Motomasa Tanioka, Sun Woo Um, Seong-Karp Hong, Bae Hwan Le. Analgesic effects of FAAH inhibitor in the insular cortex of nerve-injured rats. Molecular pain. vol 14. 2019-02-20. PMID:30380982. |
our results suggest that microinjection of faah inhibitor into the insular cortex causes analgesic effects by decreasing neural excitability and increasing signals related to the endogenous cannabinoid pathway in the insular cortex. |
2019-02-20 |
2023-08-13 |
rat |
| Jenny L Wilkerson, Zachary A Curry, Pamela D Kinlow, Brittany L Mason, Ku-Lung Hsu, Mario van der Stelt, Benjamin F Cravatt, Aron H Lichtma. Evaluation of different drug classes on transient sciatic nerve injury-depressed marble burying in mice. Pain. vol 159. issue 6. 2019-02-19. PMID:29528965. |
in addition, we tested drugs targeting distinct components of the endocannabinoid system, including agonists at cannabinoid receptors type 1 (cb1) and type 2 (cb2), as well as inhibitors of the endocannabinoid-regulating enzymes fatty acid amide hydrolase and monoacylglycerol lipase. |
2019-02-19 |
2023-08-13 |
mouse |
| Kushal Gandhi, Cun Li, Nadezhda German, Cezary Skobowiat, Maira Carrillo, Raja Reddy Kallem, Eneko Larumbe, Stacy Martinez, Marcel Chuecos, Gary Ventolini, Peter Nathanielsz, Natalia Schlabritz-Loutsevitc. Effect of maternal high-fat diet on key components of the placental and hepatic endocannabinoid system. American journal of physiology. Endocrinology and metabolism. vol 314. issue 4. 2019-02-18. PMID:29138223. |
mrna and protein expression of endocannabinoid receptors (cb1r and cb2r), faah, dagl, magl, and cox-2 were determined. |
2019-02-18 |
2023-08-13 |
Not clear |