All Relations between fatty acid amide hydrolase and cannabinoids

Publication Sentence Publish Date Extraction Date Species
Douglas J Hermes, Changqing Xu, Justin L Poklis, Micah J Niphakis, Benjamin F Cravatt, Ken Mackie, Aron H Lichtman, Bogna M Ignatowska-Jankowska, Sylvia Fittin. Neuroprotective effects of fatty acid amide hydrolase catabolic enzyme inhibition in a HIV-1 Tat model of neuroAIDS. Neuropharmacology. vol 141. 2019-02-13. PMID:30114402. a major endocannabinoid, anandamide (n-arachidonoylethanolamine, aea), is metabolized by fatty acid amide hydrolase (faah). 2019-02-13 2023-08-13 Not clear
Douglas J Hermes, Changqing Xu, Justin L Poklis, Micah J Niphakis, Benjamin F Cravatt, Ken Mackie, Aron H Lichtman, Bogna M Ignatowska-Jankowska, Sylvia Fittin. Neuroprotective effects of fatty acid amide hydrolase catabolic enzyme inhibition in a HIV-1 Tat model of neuroAIDS. Neuropharmacology. vol 141. 2019-02-13. PMID:30114402. here we demonstrate using a murine prefrontal cortex primary culture model that the inhibition of faah, using pf3845, attenuates tat-mediated increases in intracellular calcium, neuronal death, and dendritic degeneration via cannabinoid receptors (cb 2019-02-13 2023-08-13 Not clear
Brittany N Szafran, Jung Hwa Lee, Abdolsamad Borazjani, Peter Morrison, Grace Zimmerman, Kelly L Andrzejewski, Matthew K Ross, Barbara L F Kapla. Characterization of Endocannabinoid-Metabolizing Enzymes in Human Peripheral Blood Mononuclear Cells under Inflammatory Conditions. Molecules (Basel, Switzerland). vol 23. issue 12. 2019-02-11. PMID:30513753. increased plasma levels of the pro-inflammatory cytokine interleukin-6 (il-6) and decreased fatty acid amide hydrolase (faah) activity in peripheral lymphocytes from individuals diagnosed with huntington's disease (hd) suggests that a similar negative feedback system between inflammation and the endocannabinoid system operates in humans. 2019-02-11 2023-08-13 mouse
E Dirandeh, J Ghaffar. Effects of feeding a source of omega-3 fatty acid during the early postpartum period on the endocannabinoid system in the bovine endometrium. Theriogenology. vol 121. 2018-12-31. PMID:30145543. on day 15 of synchronized estrous cycle (d0 = ovulation) uterine endometrial biopsies were collected to evaluate the expression of genes related to ecs (endocannabinoid receptor (cnr2), n-acyl phosphatidylethanolamine phospholipase d (napepld), fatty acid amide hydrolase (faah), n-acylethanolamine acid amidase (naaa), monoglyceride lipase (mgll)) and pgf2α. 2018-12-31 2023-08-13 cattle
Gaurav Bedse, Rebecca J Bluett, Toni A Patrick, Nicole K Romness, Andrew D Gaulden, Philip J Kingsley, Niels Plath, Lawrence J Marnett, Sachin Pate. Therapeutic endocannabinoid augmentation for mood and anxiety disorders: comparative profiling of FAAH, MAGL and dual inhibitors. Translational psychiatry. vol 8. issue 1. 2018-12-11. PMID:29695817. therapeutic endocannabinoid augmentation for mood and anxiety disorders: comparative profiling of faah, magl and dual inhibitors. 2018-12-11 2023-08-13 Not clear
John Hamilton, Matthew Marion, Antonio Figueiredo, Brendan H Clavin, Dale Deutsch, Martin Kaczocha, Samir Haj-Dahmane, Panayotis K Thano. Fatty acid binding protein deletion prevents stress-induced preference for cocaine and dampens stress-induced corticosterone levels. Synapse (New York, N.Y.). vol 72. issue 6. 2018-11-19. PMID:29457656. recently, fatty acid binding proteins (fabps) have been proposed as intracellular transporters of the endocannabinoid anandamide (aea) as well as other bioactive lipids to their catabolic enzyme, fatty acid amide hydrolase (faah). 2018-11-19 2023-08-13 mouse
Michał Biernacki, Ewa Ambrożewicz, Agnieszka Gęgotek, Marek Toczek, Katarzyna Bielawska, Elżbieta Skrzydlewsk. Redox system and phospholipid metabolism in the kidney of hypertensive rats after FAAH inhibitor URB597 administration. Redox biology. vol 15. 2018-10-12. PMID:29197803. the administration of faah inhibitor resulted in increased level of endocannabinoids in kidney of both groups of hypertensive rats led to enhanced expression of the cannabinoid receptors type 1 and 2 in shr as well as vanilloid receptor 1 receptors in doca-salt rats. 2018-10-12 2023-08-13 rat
Vimlesh Kumar, Arumugam Kumaresan, Pradeep Nag, Puneeth Kumar, Tirtha Kumar Datta, Rubina Kumari Baithalu, Tushar Kumar Mohant. Transcriptional abundance of type-1 endocannabinoid receptor (CB1) and fatty acid amide hydrolase (FAAH) in bull spermatozoa: Relationship with field fertility. Theriogenology. vol 114. 2018-10-08. PMID:29660628. transcriptional abundance of type-1 endocannabinoid receptor (cb1) and fatty acid amide hydrolase (faah) in bull spermatozoa: relationship with field fertility. 2018-10-08 2023-08-13 cattle
Vimlesh Kumar, Arumugam Kumaresan, Pradeep Nag, Puneeth Kumar, Tirtha Kumar Datta, Rubina Kumari Baithalu, Tushar Kumar Mohant. Transcriptional abundance of type-1 endocannabinoid receptor (CB1) and fatty acid amide hydrolase (FAAH) in bull spermatozoa: Relationship with field fertility. Theriogenology. vol 114. 2018-10-08. PMID:29660628. in the present study, we report the differences in the expression level of components of ecs [type-1 endocannabinoid receptor (cb1) and fatty acid amide hydrolase (faah)] in spermatozoa from bulls with different field fertility ratings. 2018-10-08 2023-08-13 cattle
R Bonsale, R Seyed Sharifi, E Dirandeh, N Hedayat, A Mojtahedin, M Ghorbanalinia, A Abolghasem. Endocannabinoids as endometrial inflammatory markers in lactating Holstein cows. Reproduction in domestic animals = Zuchthygiene. vol 53. issue 3. 2018-10-01. PMID:29542183. blood samples were collected at 26 and 30 days relative to calving to determine plasma tumour necrosis factor (tnf) and lipopolysaccharide-binding protein (lbp) concentrations; moreover, uterine biopsy was carried out on day 26 post-partum to measure mrna abundance of tnf, interleukin-1b (il1b), interleukin-6 (il-6), c-x-c motif chemokine ligand 8 (cxcl8), endocannabinoid receptor (cnr2), n-acyl phosphatidylethanolamine phospholipase d (napepld), fatty acid amide hydrolase (faah), n-acylethanolamine acid amidase (naaa) and monoglyceride lipase (mgll) by real-time pcr. 2018-10-01 2023-08-13 cattle
R Bonsale, R Seyed Sharifi, E Dirandeh, N Hedayat, A Mojtahedin, M Ghorbanalinia, A Abolghasem. Endocannabinoids as endometrial inflammatory markers in lactating Holstein cows. Reproduction in domestic animals = Zuchthygiene. vol 53. issue 3. 2018-10-01. PMID:29542183. in conclusion, relative mrna expression of tnf, il1b and cxcl8 and plasma concentration of lbp increased during inflammatory condition along with decreased endocannabinoids hydrolyzing enzyme (naaa and faah), increased enzymes that synthesize endocannabinoids (napepld) and relative gene expression of the endocannabinoid receptor; together, these contribute to increased endocannabinoids levels during inflammation. 2018-10-01 2023-08-13 cattle
S Ückert, G la Croce, A Bettiga, K Albrecht, R Buono, F Benigni, M A Kuczyk, P Hedlun. Expression and distribution of key proteins of the endocannabinoid system in the human seminal vesicles. Andrologia. vol 50. issue 2. 2018-09-18. PMID:28786134. as information is scarce on the expression of the ecs in human male reproductive tissues, this study aimed to investigate by means of molecular biology (rt-pcr) and immunohistochemistry/immunofluorescence the expression and distribution of cb1 and cb2, gpr55 (an orphan g protein-coupled receptor that recognises cannabinoid ligands) and faah (isoforms 1 and 2) in the human seminal vesicles (sv). 2018-09-18 2023-08-13 human
Georgia Balsevich, Martin Sticht, Nicole P Bowles, Arashdeep Singh, Tiffany T Y Lee, Zhiying Li, Prasanth K Chelikani, Francis S Lee, Stephanie L Borgland, Cecilia J Hillard, Bruce S McEwen, Matthew N Hil. Role for fatty acid amide hydrolase (FAAH) in the leptin-mediated effects on feeding and energy balance. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 29. 2018-09-11. PMID:29967158. therefore, we explored the interaction between leptin and endocannabinoid signaling with a focus on fatty acid amide hydrolase (faah), the primary degradative enzyme for the endocannabinoid 2018-09-11 2023-08-13 Not clear
Sanaz Hashemian, Mireille Alhouayek, Christopher J Fowle. TLR4 receptor expression and function in F11 dorsal root ganglion × neuroblastoma hybrid cells. Innate immunity. vol 23. issue 8. 2018-07-23. PMID:28958207. f11 cells expressed the endocannabinoid metabolizing enzymes fatty acid amide hydrolase and n-acylethanolamine acid amidase (both murine), which were functionally active. 2018-07-23 2023-08-13 mouse
Divya Ramesh, Amy D'Agata, Angela R Starkweather, Erin E Youn. Contribution of Endocannabinoid Gene Expression and Genotype on Low Back Pain Susceptibility and Chronicity. The Clinical journal of pain. vol 34. issue 1. 2018-07-17. PMID:28481838. therefore, this study sought to examine cannabinoid type 1 (cnr1), type 2 (cnr2) receptors, fatty acid amide hydrolase (faah), and the vanilloid receptor (transient receptor potential cation channel subfamily v member 1 [trpv1]) gene expression profiles among individuals with acute and chronic low back pain (clbp) at their baseline visit. 2018-07-17 2023-08-13 human
A Wasilewski, A Misicka, M Sacharczuk, J Fichn. Modulation of the endocannabinoid system by the fatty acid amide hydrolase, monoacylglycerol and diacylglycerol lipase inhibitors as an attractive target for secretory diarrhoea therapy. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 68. issue 4. 2018-07-02. PMID:29151076. modulation of the endocannabinoid system by the fatty acid amide hydrolase, monoacylglycerol and diacylglycerol lipase inhibitors as an attractive target for secretory diarrhoea therapy. 2018-07-02 2023-08-13 mouse
Karen L G Farizatto, Sara A McEwan, Vinogran Naidoo, Spyros P Nikas, Vidyanand G Shukla, Michael F Almeida, Aaron Byrd, Heather Romine, David A Karanian, Alexandros Makriyannis, Ben A Bah. Inhibitor of Endocannabinoid Deactivation Protects Against In Vitro and In Vivo Neurotoxic Effects of Paraoxon. Journal of molecular neuroscience : MN. vol 63. issue 1. 2018-06-27. PMID:28803438. next, the pxn toxicity was tested for protective effects by the fatty acid amide hydrolase (faah) inhibitor am5206, a compound linked to enhanced repair signaling through the endocannabinoid pathway. 2018-06-27 2023-08-13 rat
Marek Toczek, Barbara Malinowsk. Enhanced endocannabinoid tone as a potential target of pharmacotherapy. Life sciences. vol 204. 2018-06-12. PMID:29729263. to date, the most investigated compounds are inhibitors of fatty acid amide hydrolase (faah), an enzyme that degrades the endocannabinoid anandamide. 2018-06-12 2023-08-13 human
Marek Toczek, Barbara Malinowsk. Enhanced endocannabinoid tone as a potential target of pharmacotherapy. Life sciences. vol 204. 2018-06-12. PMID:29729263. however, application of faah inhibitors (and consequently other endocannabinoid degradation inhibitors) in medicine became questionable due to a lack of therapeutic efficacy in clinical trials and serious adverse effects evoked by one specific compound. 2018-06-12 2023-08-13 human
Ann Kristin Frøyset, Essa Ahsan Khan, Kari Espolin Fladmar. Quantitative proteomics analysis of zebrafish exposed to sub-lethal dosages of β-methyl-amino-L-alanine (BMAA). Scientific reports. vol 6. 2018-06-01. PMID:27404450. we also found that bmaa influenced the endocannabinoid system by up-regulation of fatty acid amide hydrolase (faah) and that faah inhibitor urb597 reduced the bmaa effect on heart rate and gsk3 expression. 2018-06-01 2023-08-13 zebrafish