All Relations between fatty acid amide hydrolase and cannabinoids

Publication Sentence Publish Date Extraction Date Species
Michael A Wortley, John J Adcock, Eric D Dubuis, Sarah A Maher, Sara J Bonvini, Isabelle Delescluse, Ross Kinloch, Gordon McMurray, Christelle Perros-Huguet, Marianthi Papakosta, Mark A Birrell, Maria G Belvis. Targeting fatty acid amide hydrolase as a therapeutic strategy for antitussive therapy. The European respiratory journal. vol 50. issue 3. 2018-05-30. PMID:28931663. cannabinoids inhibit vagal sensory nerve activation and the cough reflex, so it was hypothesised that faah inhibition would produce antitussive activity 2018-05-30 2023-08-13 Not clear
Tanya S King-Himmelreich, Christine V Möser, Miriam C Wolters, Julia Schmetzer, Yannik Schreiber, Nerea Ferreirós, Otto Q Russe, Gerd Geisslinger, Ellen Niederberge. AMPK contributes to aerobic exercise-induced antinociception downstream of endocannabinoids. Neuropharmacology. vol 124. 2018-05-09. PMID:28479394. levels of the endocannabinoid anandamide (aea) were increased after physical activity in both wild type and ampkα2 knockout mice, in association with decreased expression of the aea-hydrolyzing enzyme faah and an increased level of the cannabinoid receptor 1 (cb1). 2018-05-09 2023-08-13 mouse
Camilla P Dias-Rocha, Mariana M Almeida, Erika M Santana, Julia C B Costa, Juliana G Franco, Carmen C Pazos-Moura, Isis H Trevenzol. Maternal high-fat diet induces sex-specific endocannabinoid system changes in newborn rats and programs adiposity, energy expenditure and food preference in adulthood. The Journal of nutritional biochemistry. vol 51. 2018-05-09. PMID:29102876. the ecs consists mainly of endogenous ligands, cannabinoid receptors (cb1 and cb2), and the enzymes fatty acid anandamide hydrolase (faah) and monoacylglycerol lipase (magl). 2018-05-09 2023-08-13 rat
Megan L Uhelski, Kalpna Gupta, Donald A Simon. Sensitization of C-fiber nociceptors in mice with sickle cell disease is decreased by local inhibition of anandamide hydrolysis. Pain. vol 158. issue 9. 2018-05-02. PMID:28570479. since there is growing evidence that increasing local levels of endocannabinoids can decrease hyperalgesia, we examined the effects of urb597, a fatty acid amide hydrolase (faah) inhibitor, which blocks the hydrolysis of the endogenous cannabinoid anandamide, on hyperalgesia and sensitization of cutaneous nociceptors in a humanized mouse model of scd. 2018-05-02 2023-08-13 mouse
Eric Murillo-Rodriguez, Jose Carlos Pastrana-Trejo, Mireille Salas-Crisóstomo, Miriel de-la-Cru. The Endocannabinoid System Modulating Levels of Consciousness, Emotions and Likely Dream Contents. CNS & neurological disorders drug targets. vol 16. issue 4. 2018-04-16. PMID:28240187. among the modulatory properties of the endocannabinoid system, current data indicate that the sleep-wake cycle is under the influence of endocannabinoids since the blocking of the cb1 cannabinoid receptor or the pharmacological inhibition of faah activity promotes wakefulness, whereas the obstruction of amt function enhances sleep. 2018-04-16 2023-08-13 mouse
Alexander I Helfand, Christopher M Olsen, Cecilia J Hillar. Cannabinoid Receptor 1 and Fatty Acid Amide Hydrolase Contribute to Operant Sensation Seeking in Mice. International journal of molecular sciences. vol 18. issue 8. 2018-04-16. PMID:28749428. the purpose of the studies in this report was to begin to explore the role of endocannabinoid signaling in oss utilizing cannabinoid receptor 1 (cb1r) and fatty acid amide hydrolase (faah) knock out mice. 2018-04-16 2023-08-13 mouse
Pedro H Gobira, Isabel V Lima, Luara A Batista, Antônio C de Oliveira, Leonardo B Resstel, Carsten T Wotjak, Daniele C Aguiar, Fabricio A Moreir. N-arachidonoyl-serotonin, a dual FAAH and TRPV1 blocker, inhibits the retrieval of contextual fear memory: Role of the cannabinoid CB1 receptor in the dorsal hippocampus. Journal of psychopharmacology (Oxford, England). vol 31. issue 6. 2018-03-22. PMID:28583049. n-arachidonoyl-serotonin, a dual faah and trpv1 blocker, inhibits the retrieval of contextual fear memory: role of the cannabinoid cb1 receptor in the dorsal hippocampus. 2018-03-22 2023-08-13 Not clear
Tingting Duan, Ning Gu, Ying Wang, Feng Wang, Jie Zhu, Yiru Fang, Yuan Shen, Jing Han, Xia Zhan. Fatty acid amide hydrolase inhibitors produce rapid anti-anxiety responses through amygdala long-term depression in male rodents. Journal of psychiatry & neuroscience : JPN. vol 42. issue 4. 2018-03-09. PMID:28234213. inhibition of the fatty acid amide hydrolase (faah), the endocannabinoid 2018-03-09 2023-08-13 Not clear
Attila Köfalvi, Cristina Lemos, Ana M Martín-Moreno, Bárbara S Pinheiro, Luis García-García, Miguel A Pozo, Ângela Valério-Fernandes, Rui O Beleza, Paula Agostinho, Ricardo J Rodrigues, Susana J Pasquaré, Rodrigo A Cunha, María L de Ceballo. Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease. Neuropharmacology. vol 110. issue Pt A. 2018-02-22. PMID:26976670. among the endocannabinoid metabolizing enzymes, the selective inhibition of cox-2, rather than that of faah, magl or α,βdh6/12, also stimulates the uptake of glucose in hippocampal slices of middle-aged mice, an effect that was again prevented by am630. 2018-02-22 2023-08-13 mouse
Marta Celorrio, Diana Fernández-Suárez, Estefanía Rojo-Bustamante, Víctor Echeverry-Alzate, María J Ramírez, Cecilia J Hillard, José A López-Moreno, Rafael Maldonado, Julen Oyarzábal, Rafael Franco, María S Aymeric. Fatty acid amide hydrolase inhibition for the symptomatic relief of Parkinson's disease. Brain, behavior, and immunity. vol 57. 2018-01-11. PMID:27318096. together, these results demonstrate an effect of fatty acid amide hydrolase inhibition on the motor symptoms of parkinson's disease in two distinct experimental models that is mediated by cannabinoid receptors. 2018-01-11 2023-08-13 mouse
Andrea Pirone, Carlo Cantile, Vincenzo Miragliotta, Carla Lenzi, Elisabetta Giannessi, Bruno Cozz. Immunohistochemical distribution of the cannabinoid receptor 1 and fatty acid amide hydrolase in the dog claustrum. Journal of chemical neuroanatomy. vol 74. 2018-01-10. PMID:26907575. cannabinoid receptor 1 (cb1r) and fatty acid amide hydrolase (faah) are part of the endocannabinoid system (ecb) which exerts a neuromodulatory activity on different brain functions and plays a key role in neurogenesis. 2018-01-10 2023-08-13 dog
Na Cui, Yang Yang, Yueming Xu, Jie Zhang, Lei Jiang, Guimin Ha. Decreased expression of fatty acid amide hydrolase in women with polycystic ovary syndrome. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. vol 33. issue 5. 2018-01-04. PMID:28132572. the expression of cannabinoid receptors (cb1) and fatty acid amide hydrolase (faah) in the endometrium were immunohistochemically stained and compared between women with pcos and the control group. 2018-01-04 2023-08-13 Not clear
Douglas R Smith, Christine M Stanley, Theodore Foss, Richard G Boles, Kevin McKerna. Rare genetic variants in the endocannabinoid system genes CNR1 and DAGLA are associated with neurological phenotypes in humans. PloS one. vol 12. issue 11. 2017-12-26. PMID:29145497. rare genetic variants in the core endocannabinoid system genes cnr1, cnr2, dagla, mgll and faah were identified in molecular testing data from 6,032 patients with a broad spectrum of neurological disorders. 2017-12-26 2023-08-13 mouse
Iram P Rodriguez-Sanchez, Josee Guindon, Marco Ruiz, M Elizabeth Tejero, Gene Hubbard, Laura E Martinez-de-Villarreal, Hugo A Barrera-Saldaña, Edward J Dick, Anthony G Comuzzie, Natalia E Schlabritz-Loutsevitc. The endocannabinoid system in the baboon (Papio spp.) as a complex framework for developmental pharmacology. Neurotoxicology and teratology. vol 58. 2017-12-22. PMID:27327781. consumption of exogenous cannabinoids interferes with the endogenous cannabinoid (or "endocannabinoid" (ecb)) system (ecs), which comprises n-arachidonylethanolamide (anandamide, aea), 2-arachidonoyl glycerol (2-ag), endocannabinoid receptors (cannabinoid receptors 1 and 2 (cb1r and cb2r), encoded by cnr1 and cnr2, respectively), and synthesizing/degrading enzymes (faah, fatty-acid amide hydrolase; magl, monoacylglycerol lipase; dagl-α, diacylglycerol lipase-alpha). 2017-12-22 2023-08-13 Not clear
Emma Leishman, Ben Cornett, Karl Spork, Alex Straiker, Ken Mackie, Heather B Bradsha. Broad impact of deleting endogenous cannabinoid hydrolyzing enzymes and the CB1 cannabinoid receptor on the endogenous cannabinoid-related lipidome in eight regions of the mouse brain. Pharmacological research. vol 110. 2017-12-21. PMID:27109320. the enzymes fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl) hydrolyze endogenous cannabinoids (ecbs), n-arachidonoyl ethanolamine (aea) and 2-arachidonoyl glycerol (2-ag), respectively. 2017-12-21 2023-08-13 mouse
Wei Li, Cong-Li Zhang, Zheng-Guo Qi. Differential expression of endocannabinoid system-related genes in the dorsal hippocampus following expression and reinstatement of morphine conditioned place preference in mice. Neuroscience letters. vol 643. 2017-12-19. PMID:28192193. we found that expression of morphine cpp was associated with significant increases in mrna expression for the primary clearance routes for anandamide (aea) and 2-ag (fatty acid amide hydrolase [faah] and monoacylglycerol lipase [magl], respectively), but with reductions in cannabinoid 1 receptors (cb1r) and cb2r in dorsal hippocampus following the expression of cpp. 2017-12-19 2023-08-13 mouse
Ying Wang, Xia Zhan. FAAH inhibition produces antidepressant-like efforts of mice to acute stress via synaptic long-term depression. Behavioural brain research. vol 324. 2017-12-13. PMID:28193523. recent studies have shown that inhibition of fatty acid amide hydrolase (faah), the major degradative enzyme of the endocannabinoid n-arachidonoylethanolamine (aea), produced antidepressant behavioral responses, but its underlying mechanism is not clear. 2017-12-13 2023-08-13 mouse
Russell L Carr, Nathan H Armstrong, Alenda T Buchanan, Jeffrey B Eells, Afzaal N Mohammed, Matthew K Ross, Carole A Nai. Decreased anxiety in juvenile rats following exposure to low levels of chlorpyrifos during development. Neurotoxicology. vol 59. 2017-11-22. PMID:26642910. exposure to chlorpyrifos (cpf) during the late preweanling period in rats inhibits the endocannabinoid metabolizing enzymes fatty acid hydrolase (faah) and monoacylglycerol lipase (magl), resulting in accumulation of their respective substrates anandamide (aea) and 2-arachidonylglycerol (2-ag). 2017-11-22 2023-08-13 rat
Elif Bilgic, Elif Guzel, Sevil Kose, Makbule Cisel Aydin, Eda Karaismailoglu, Irem Akar, Alp Usubutun, Petek Korkusu. Endocannabinoids modulate apoptosis in endometriosis and adenomyosis. Acta histochemica. vol 119. issue 5. 2017-11-16. PMID:28549792. endocannabinoid receptors cb1 and cb2, their synthesizing and catabolizing enzymes (faah, nape-pld, dagl, magl) and the apoptotic indexes were immunohistochemically assessed in endometriotic and adenomyotic tissues. 2017-11-16 2023-08-13 Not clear
Jenny L Wiley, Timothy W Lefever, Nikita S Pulley, Julie A Marusich, Benjamin F Cravatt, Aron H Lichtma. Just add water: cannabinoid discrimination in a water T-maze with FAAH(-/-) and FAAH(+/+) mice. Behavioural pharmacology. vol 27. issue 5. 2017-11-08. PMID:27385208. just add water: cannabinoid discrimination in a water t-maze with faah(-/-) and faah(+/+) mice. 2017-11-08 2023-08-13 mouse