| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jenny L Wiley, Timothy W Lefever, Nikita S Pulley, Julie A Marusich, Benjamin F Cravatt, Aron H Lichtma. Just add water: cannabinoid discrimination in a water T-maze with FAAH(-/-) and FAAH(+/+) mice. Behavioural pharmacology. vol 27. issue 5. 2017-11-08. PMID:27385208. |
just add water: cannabinoid discrimination in a water t-maze with faah(-/-) and faah(+/+) mice. |
2017-11-08 |
2023-08-13 |
mouse |
| Josée Guindo. A novel inhibitor of endocannabinoid catabolic enzymes sheds light on behind the scene interplay between chronic pain, analgesic tolerance, and heroin dependence. Neuropharmacology. vol 114. 2017-10-26. PMID:27890603. |
wilkerson and colleagues, in this issue, examine sa-57, an inhibitor of two different endocannabinoid catabolic enzymes faah and magl, demonstrating its analgesic effectiveness and morphine-sparing properties in a chronic pain model, as well as its ability to reduce heroin seeking behavior in a self-administration paradigm in mice. |
2017-10-26 |
2023-08-13 |
mouse |
| Whitney E Melroy-Greif, Kirk C Wilhelmsen, Cindy L Ehler. Genetic variation in FAAH is associated with cannabis use disorders in a young adult sample of Mexican Americans. Drug and alcohol dependence. vol 166. 2017-10-23. PMID:27394933. |
five genes known to play a role in the endocannabinoid system and cuds were examined in a community sample of young adult mexican americans (mas): cnr1, mgll, faah, dagla, and daglb. |
2017-10-23 |
2023-08-13 |
Not clear |
| Lu Wang, Wakana Mori, Ran Cheng, Joji Yui, Akiko Hatori, Longle Ma, Yiding Zhang, Benjamin H Rotstein, Masayuki Fujinaga, Yoko Shimoda, Tomoteru Yamasaki, Lin Xie, Yuji Nagai, Takafumi Minamimoto, Makoto Higuchi, Neil Vasdev, Ming-Rong Zhang, Steven H Lian. Synthesis and Preclinical Evaluation of Sulfonamido-based [(11)C-Carbonyl]-Carbamates and Ureas for Imaging Monoacylglycerol Lipase. Theranostics. vol 6. issue 8. 2017-10-16. PMID:27279908. |
the most potent compounds were a novel magl inhibitor, n-((1-(1h-1,2,4-triazole-1-carbonyl)piperidin-4-yl) methyl)-4-chlorobenzenesulfonamide (tzpu; ic50 = 35.9 nm), and the known inhibitor 1,1,1,3,3,3-hexafluoropropan-2-yl 4-(((4-chlorophenyl)sulfonamido) methyl)piperidine-1-carboxylate (sar127303; ic50 = 39.3 nm), which were also shown to be selective for magl over fatty acid amide hydrolase (faah), and cannabinoid receptors (cb1 & cb2). |
2017-10-16 |
2023-08-13 |
rat |
| Angel Escamilla-Ramírez, Esperanza García, Guadalupe Palencia-Hernández, Ana Laura Colín-González, Sonia Galván-Arzate, Isaac Túnez, Julio Sotelo, Abel Santamarí. URB597 and the Cannabinoid WIN55,212-2 Reduce Behavioral and Neurochemical Deficits Induced by MPTP in Mice: Possible Role of Redox Modulation and NMDA Receptors. Neurotoxicity research. vol 31. issue 4. 2017-10-02. PMID:28092019. |
while synthetic cannabinoid receptor (cbr) agonists such as win55,212-2 act directly on cbr, agents like urb597, a fatty acid amide hydrolase (faah) inhibitor, induce a more "physiological" activation of cbr by increasing the endogenous levels of the endocannabinoid anandamide (aea). |
2017-10-02 |
2023-08-13 |
mouse |
| Alessandro Deplano, Carmine Marco Morgillo, Monica Demurtas, Emmelie Björklund, Mariateresa Cipriano, Mona Svensson, Sanaz Hashemian, Giovanni Smaldone, Emilia Pedone, F Javier Luque, Maria G Cabiddu, Ettore Novellino, Christopher J Fowler, Bruno Catalanotti, Valentina Onni. Novel propanamides as fatty acid amide hydrolase inhibitors. European journal of medicinal chemistry. vol 136. 2017-09-26. PMID:28535469. |
fatty acid amide hydrolase (faah) has a key role in the control of the cannabinoid signaling, through the hydrolysis of the endocannabinoids anandamide and in some tissues 2-arachidonoylglycerol. |
2017-09-26 |
2023-08-13 |
mouse |
| Alessandro Deplano, Carmine Marco Morgillo, Monica Demurtas, Emmelie Björklund, Mariateresa Cipriano, Mona Svensson, Sanaz Hashemian, Giovanni Smaldone, Emilia Pedone, F Javier Luque, Maria G Cabiddu, Ettore Novellino, Christopher J Fowler, Bruno Catalanotti, Valentina Onni. Novel propanamides as fatty acid amide hydrolase inhibitors. European journal of medicinal chemistry. vol 136. 2017-09-26. PMID:28535469. |
faah inhibition represents a promising strategy to activate the cannabinoid system, since it does not result in the psychotropic and peripheral side effects characterizing the agonists of the cannabinoid receptors. |
2017-09-26 |
2023-08-13 |
mouse |
| Carmen Rodríguez-Cueto, Mariluz Hernández-Gálvez, Cecilia J Hillard, Patricia Maciel, Sara Valdeolivas, José A Ramos, María Gómez-Ruiz, Javier Fernández-Rui. Altered striatal endocannabinoid signaling in a transgenic mouse model of spinocerebellar ataxia type-3. PloS one. vol 12. issue 4. 2017-09-07. PMID:28448548. |
we also measured the endocannabinoid lipids in the striatum and despite a marked increase in the faah enzyme in this area, no overall changes in these lipids were found. |
2017-09-07 |
2023-08-13 |
mouse |
| Liubov Shubina, Rubin Aliev, Valentina Kitchigin. Endocannabinoid-dependent protection against kainic acid-induced long-term alteration of brain oscillations in guinea pigs. Brain research. vol 1661. 2017-08-16. PMID:28192082. |
to clarify whether the activation of endocannabinoid (ecb) system can influence toxic ka action, am404, an ecb reuptake inhibitor, and urb597, an inhibitor of fatty acid amide hydrolase, were applied. |
2017-08-16 |
2023-08-13 |
Not clear |
| Isabelle Boileau, Esmaeil Mansouri, Belinda Williams, Bernard Le Foll, Pablo Rusjan, Romina Mizrahi, Rachel F Tyndale, Marilyn A Huestis, Doris E Payer, Alan A Wilson, Sylvain Houle, Stephen J Kish, Junchao Ton. Fatty Acid Amide Hydrolase Binding in Brain of Cannabis Users: Imaging With the Novel Radiotracer [ Biological psychiatry. vol 80. issue 9. 2017-08-09. PMID:27345297. |
fatty acid amide hydrolase binding in brain of cannabis users: imaging with the novel radiotracer [ one of the major mechanisms for terminating the actions of the endocannabinoid anandamide is hydrolysis by fatty acid amide hydrolase (faah), and inhibitors of the enzyme were suggested as potential treatment for human cannabis dependence. |
2017-08-09 |
2023-08-13 |
human |
| Vidya Chidambaran, Valentina Pilipenko, Kristie Spruance, Raja Venkatasubramanian, Jing Niu, Tsuyoshi Fukuda, Tomoyuki Mizuno, Kejian Zhang, Kenneth Kaufman, Alexander A Vinks, Lisa J Martin, Senthilkumar Sadhasiva. Fatty acid amide hydrolase-morphine interaction influences ventilatory response to hypercapnia and postoperative opioid outcomes in children. Pharmacogenomics. vol 18. issue 2. 2017-08-03. PMID:27977335. |
fatty acid amide hydrolase (faah) degrades anandamide, an endogenous cannabinoid. |
2017-08-03 |
2023-08-13 |
Not clear |
| Stefan Zahov, David Garzinsky, Walburga Hanekamp, Matthias Leh. 1-Heteroarylpropan-2-ones as inhibitors of fatty acid amide hydrolase: Studies on structure-activity relationships and metabolic stability. Bioorganic & medicinal chemistry. vol 25. issue 3. 2017-08-03. PMID:27989417. |
the serine hydrolase fatty acid amide hydrolase (faah) catalyzes the degradation of the endocannabinoid anandamide, which possesses analgesic and anti-inflammatory effects. |
2017-08-03 |
2023-08-13 |
Not clear |
| Stephen O Pember, Galo L Mejia, Theodore J Price, Robert J Pasteri. Piperidinyl thiazole isoxazolines: A new series of highly potent, slowly reversible FAAH inhibitors with analgesic properties. Bioorganic & medicinal chemistry letters. vol 26. issue 12. 2017-07-20. PMID:27130358. |
fatty acid amide hydrolase (faah) is a membrane anchored serine hydrolase that has a principle role in the metabolism of the endogenous cannabinoid anandamide. |
2017-07-20 |
2023-08-13 |
human |
| Jenny L Wilkerson, Sudeshna Ghosh, Mohammed Mustafa, Rehab A Abdullah, Micah J Niphakis, Roberto Cabrera, Rafael L Maldonado, Benjamin F Cravatt, Aron H Lichtma. The endocannabinoid hydrolysis inhibitor SA-57: Intrinsic antinociceptive effects, augmented morphine-induced antinociception, and attenuated heroin seeking behavior in mice. Neuropharmacology. vol 114. 2017-07-11. PMID:27890602. |
inhibitors of the primary endocannabinoid catabolic enzymes fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl) show opioid-sparing effects in preclinical models of pain. |
2017-07-11 |
2023-08-13 |
mouse |
| Agnieszka Zakrzeska, Tomasz Grędziński, Wioleta Kisiel, Ewa Chabielsk. Cannabinoids and haemostasis. Postepy higieny i medycyny doswiadczalnej (Online). vol 70. issue 0. 2017-07-10. PMID:27383573. |
the range of biological functions of endo- and plant cannabinoids, expanded to include the process of hemostasis, may constitute a condition for their recognition as a new factor responsible for thromboembolism in smokers of marijuana, in pathological disorders with increased levels of endocannabinoids and in individuals with polymorphisms of faah c385a and a385a. |
2017-07-10 |
2023-08-13 |
Not clear |
| Serena Montanari, Laura Scalvini, Manuela Bartolini, Federica Belluti, Silvia Gobbi, Vincenza Andrisano, Alessia Ligresti, Vincenzo Di Marzo, Silvia Rivara, Marco Mor, Alessandra Bisi, Angela Ramp. Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents. Journal of medicinal chemistry. vol 59. issue 13. 2017-05-29. PMID:27309570. |
in particular, indirectly enhancing endocannabinoid signaling to therapeutic levels through faah inhibition might be beneficial for neurodegenerative disorders such as alzheimer's disease, effectively preventing or slowing the progression of the disease. |
2017-05-29 |
2023-08-13 |
Not clear |
| Michał Biernacki, Wojciech Łuczaj, Agnieszka Gęgotek, Marek Toczek, Katarzyna Bielawska, Elżbieta Skrzydlewsk. Crosstalk between liver antioxidant and the endocannabinoid systems after chronic administration of the FAAH inhibitor, URB597, to hypertensive rats. Toxicology and applied pharmacology. vol 301. 2017-05-26. PMID:27086176. |
crosstalk between liver antioxidant and the endocannabinoid systems after chronic administration of the faah inhibitor, urb597, to hypertensive rats. |
2017-05-26 |
2023-08-13 |
rat |
| Michał Biernacki, Wojciech Łuczaj, Agnieszka Gęgotek, Marek Toczek, Katarzyna Bielawska, Elżbieta Skrzydlewsk. Crosstalk between liver antioxidant and the endocannabinoid systems after chronic administration of the FAAH inhibitor, URB597, to hypertensive rats. Toxicology and applied pharmacology. vol 301. 2017-05-26. PMID:27086176. |
the aim of this study was to evaluate the effects of chronic administration of the fatty acid amide hydrolase (faah) inhibitor [3-(3-carbamoylphenyl)phenyl]n-cyclohexylcarbamate (urb597) on the endocannabinoid system and on the redox balance in the livers of doca-salt hypertensive rats. |
2017-05-26 |
2023-08-13 |
rat |
| Vyvyca J Walker, Alisha P Griffin, Dagan K Hammar, Paul F Hollenber. Metabolism of Anandamide by Human Cytochrome P450 2J2 in the Reconstituted System and Human Intestinal Microsomes. The Journal of pharmacology and experimental therapeutics. vol 357. issue 3. 2017-05-23. PMID:27000802. |
faah hydrolyzes and, as a consequence, inactivates anandamide (aea), a prominent endocannabinoid. |
2017-05-23 |
2023-08-13 |
human |
| Irene M Wohlman, Gabriella M Composto, Diane E Heck, Ned D Heindel, C Jeffrey Lacey, Christophe D Guillon, Robert P Casillas, Claire R Croutch, Donald R Gerecke, Debra L Laskin, Laurie B Joseph, Jeffrey D Laski. Mustard vesicants alter expression of the endocannabinoid system in mouse skin. Toxicology and applied pharmacology. vol 303. 2017-05-23. PMID:27125198. |
taken together, these data indicate that the endocannabinoid system is important in regulating skin homeostasis and that inhibitors of faah may be useful as medical countermeasures against vesicants. |
2017-05-23 |
2023-08-13 |
mouse |