| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephen Pawsey, Mike Wood, Helen Browne, Kirsteen Donaldson, Mark Christie, Steven Warringto. Safety, Tolerability and Pharmacokinetics of FAAH Inhibitor V158866: A Double-Blind, Randomised, Placebo-Controlled Phase I Study in Healthy Volunteers. Drugs in R&D. vol 16. issue 2. 2017-05-01. PMID:26987975. |
the inhibition of fatty acid amide hydrolase 1 (faah) has been proposed as a novel mechanism for treating pain syndromes by increasing the levels of endogenous cannabinoids (ecs). |
2017-05-01 |
2023-08-13 |
human |
| A Abolghasemi, E Dirandeh, Z Ansari Pirsaraei, B Shohre. Dietary conjugated linoleic acid supplementation alters the expression of genes involved in the endocannabinoid system in the bovine endometrium and increases plasma progesterone concentrations. Theriogenology. vol 86. issue 6. 2017-04-17. PMID:27262886. |
the abundance of mrna encoding endocannabinoid receptor (cnr2), n-acyl phosphatidylethanolamine phospholipase d (napepld), fatty acid amide hydrolase (faah), n-acylethanolamine acid amidase (naaa), and monoglyceride lipase (mgll) was measured by real-time pcr. |
2017-04-17 |
2023-08-13 |
cattle |
| Rita Scarpelli, Oscar Sasso, Daniele Piomell. A Double Whammy: Targeting Both Fatty Acid Amide Hydrolase (FAAH) and Cyclooxygenase (COX) To Treat Pain and Inflammation. ChemMedChem. vol 11. issue 12. 2017-03-27. PMID:26486424. |
the endogenous levels of anandamide, an endocannabinoid mediator with analgesic and tissue-protective functions, are regulated by fatty acid amide hydrolase (faah). |
2017-03-27 |
2023-08-13 |
Not clear |
| Giorgia Macedonio, Azzurra Stefanucci, Cristina Maccallini, Sako Mirzaie, Ettore Novellino, Adriano Mollic. Hemopressin Peptides as Modulators of the Endocannabinoid System and their Potential Applications as Therapeutic Tools. Protein and peptide letters. vol 23. issue 12. 2017-03-27. PMID:27748182. |
these hydrolases, such as fatty acid amide hydrolase (faah) and monoacylglyceride lipase (magl), are possible therapeutic targets for the development of new drugs as indirect cannabinoid agonists. |
2017-03-27 |
2023-08-13 |
rat |
| Marisol Maya-López, Hipolito A Ruiz-Contreras, María de Jesús Negrete-Ruíz, Julián Elías Martínez-Sánchez, Juan Benítez-Valenzuela, Ana Laura Colín-González, Juana Villeda-Hernández, Laura Sánchez-Chapul, Carmen Parra-Cid, Edgar Rangel-López, Abel Santamarí. URB597 reduces biochemical, behavioral and morphological alterations in two neurotoxic models in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 88. 2017-03-13. PMID:28157650. |
urb597 is a compound largely linked to the inhibition of fatty acid amide hydrolase (faah), an enzyme responsible for the metabolic degradation of the endocannabinoid anandamide (aea). |
2017-03-13 |
2023-08-13 |
rat |
| Ludovica Monti, Azzurra Stefanucci, Stefano Pieretti, Francesca Marzoli, Lorenzo Fidanza, Adriano Mollica, Sako Mirzaie, Simone Carradori, Luciano De Petrocellis, Aniello Schiano Moriello, Sándor Benyhe, Ferenc Zádor, Edina Szűcs, Ferenc Ötvös, Anna I Erdei, Reza Samavati, Szabolcs Dvorácskó, Csaba Tömböly, Ettore Novellin. Evaluation of the analgesic effect of 4-anilidopiperidine scaffold containing ureas and carbamates. Journal of enzyme inhibition and medicinal chemistry. vol 31. issue 6. 2017-03-06. PMID:27063555. |
fatty acid amide hydrolase inhibition was evaluated, together with binding assays of cannabinoid receptors. |
2017-03-06 |
2023-08-13 |
Not clear |
| Benoit Forget, Mihail Guranda, Islam Gamaleddin, Steven R Goldberg, Bernard Le Fol. Attenuation of cue-induced reinstatement of nicotine seeking by URB597 through cannabinoid CB1 receptor in rats. Psychopharmacology. vol 233. issue 10. 2017-02-22. PMID:26864774. |
the endocannabinoid system is composed of endocannabinoids (such as anandamide), their target receptors (cb1 and cb2 receptors, cb1rs and cb2rs), the enzymes that degrade them (fatty-acid-amide-hydrolase (faah) for anandamide), and an endocannabinoid transporter. |
2017-02-22 |
2023-08-13 |
rat |
| Ozgur Yesilyurt, Mutlu Cayirli, Yusuf Serdar Sakin, Melik Seyrek, Ahmet Akar, Ahmet Dogru. Systemic and spinal administration of FAAH, MAGL inhibitors and dual FAAH/MAGL inhibitors produce antipruritic effect in mice. Archives of dermatological research. vol 308. issue 5. 2017-02-17. PMID:27126057. |
the increase of endocannabinoid tonus by inhibiting fatty acid amide hydrolase (faah) or monoacylglycerol lipase (magl) represents a promising therapeutic approach in a variety of disease to overcome serious central side effects of exocannabinoids. |
2017-02-17 |
2023-08-13 |
mouse |
| Sean D Kodani, Haley B Overby, Christophe Morisseau, Jiangang Chen, Ling Zhao, Bruce D Hammoc. Parabens inhibit fatty acid amide hydrolase: A potential role in paraben-enhanced 3T3-L1 adipocyte differentiation. Toxicology letters. vol 262. 2017-02-06. PMID:27659731. |
we hypothesized these biological effects could be due to interference with the endocannabinoid system and identified fatty acid amide hydrolase (faah) as the direct molecular target of parabens. |
2017-02-06 |
2023-08-13 |
Not clear |
| Marta Baranowska-Kuczko, Hanna Kozłowska, Monika Kloza, Olga Karpińska, Marek Toczek, Ewa Harasim, Irena Kasacka, Barbara Malinowsk. Protective role of cannabinoid CB1 receptors and vascular effects of chronic administration of FAAH inhibitor URB597 in DOCA-salt hypertensive rats. Life sciences. vol 151. 2017-02-02. PMID:26969765. |
protective role of cannabinoid cb1 receptors and vascular effects of chronic administration of faah inhibitor urb597 in doca-salt hypertensive rats. |
2017-02-02 |
2023-08-13 |
rat |
| Klára Gyires, Zoltán S Zádor. Role of Cannabinoids in Gastrointestinal Mucosal Defense and Inflammation. Current neuropharmacology. vol 14. issue 8. 2017-01-17. PMID:26935536. |
similarly, indirect activation of cannabinoid receptors through elevation of endocannabinoid levels by globally acting or peripherally restricted inhibitors of their metabolizing enzymes (faah, magl) or by inhibitors of their cellular uptake reduces the gastric mucosal lesions induced by nsaids in a cb1 receptor-dependent fashion. |
2017-01-17 |
2023-08-13 |
Not clear |
| Claudius Füllhase, Andrea Schreiber, Armin Giese, Michael Schmidt, Francesco Montorsi, Christian Gratzke, Giovanni La Croce, Fabio Castiglione, Christian Stief, Petter Hedlun. Spinal neuronal cannabinoid receptors mediate urodynamic effects of systemic fatty acid amide hydrolase (FAAH) inhibition in rats. Neurourology and urodynamics. vol 35. issue 4. 2017-01-09. PMID:25788026. |
spinal neuronal cannabinoid receptors mediate urodynamic effects of systemic fatty acid amide hydrolase (faah) inhibition in rats. |
2017-01-09 |
2023-08-13 |
rat |
| Claudius Füllhase, Andrea Schreiber, Armin Giese, Michael Schmidt, Francesco Montorsi, Christian Gratzke, Giovanni La Croce, Fabio Castiglione, Christian Stief, Petter Hedlun. Spinal neuronal cannabinoid receptors mediate urodynamic effects of systemic fatty acid amide hydrolase (FAAH) inhibition in rats. Neurourology and urodynamics. vol 35. issue 4. 2017-01-09. PMID:25788026. |
to test if urodynamic effects from systemic fatty acid amide hydrolase (faah) inhibition involve sacral spinal cannabinoid type 1 (cb1) or type 2 (cb2) receptors. |
2017-01-09 |
2023-08-13 |
rat |
| Julien Matricon, Alexandre Seillier, Andrea Giuffrid. Distinct neuronal activation patterns are associated with PCP-induced social withdrawal and its reversal by the endocannabinoid-enhancing drug URB597. Neuroscience research. vol 110. 2017-01-03. PMID:27091613. |
the fatty acid amide hydrolase inhibitor, urb597, an endocannabinoid enhancing drug, reverses social withdrawal in the sub-chronic pcp rat model of schizophrenia, but reduces social interaction (si) in controls. |
2017-01-03 |
2023-08-13 |
rat |
| Lawrence M Carey, Richard A Slivicki, Emma Leishman, Ben Cornett, Ken Mackie, Heather Bradshaw, Andrea G Hohman. A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase. Molecular pain. vol 12. 2016-12-26. PMID:27178246. |
fatty-acid amide hydrolase (faah) is the major enzyme responsible for degradation of anandamide, an endocannabinoid. |
2016-12-26 |
2023-08-13 |
mouse |
| Lawrence M Carey, Richard A Slivicki, Emma Leishman, Ben Cornett, Ken Mackie, Heather Bradshaw, Andrea G Hohman. A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase. Molecular pain. vol 12. 2016-12-26. PMID:27178246. |
pharmacological inhibition or genetic deletion of faah (faah ko) produces antinociception in preclinical pain models that is largely attributed to anandamide-induced activation of cannabinoid receptors. |
2016-12-26 |
2023-08-13 |
mouse |
| Anne Kerbrat, Jean-Christophe Ferré, Pierre Fillatre, Thomas Ronzière, Stéphane Vannier, Béatrice Carsin-Nicol, Sylvain Lavoué, Marc Vérin, Jean-Yves Gauvrit, Yves Le Tulzo, Gilles Eda. Acute Neurologic Disorder from an Inhibitor of Fatty Acid Amide Hydrolase. The New England journal of medicine. vol 375. issue 18. 2016-12-13. PMID:27806235. |
a decrease in fatty acid amide hydrolase (faah) activity increases the levels of endogenous analogues of cannabinoids, or endocannabinoids. |
2016-12-13 |
2023-08-13 |
human |
| F Markus Leweke, Juliane K Mueller, Bettina Lange, Cathrin Rohlede. Therapeutic Potential of Cannabinoids in Psychosis. Biological psychiatry. vol 79. issue 7. 2016-10-28. PMID:26852073. |
second, the modulation of endocannabinoid levels by use of the phytocannabinoid cannabidiol and selective fatty acid amide hydrolase inhibitors has been proposed, and the antipsychotic properties of cannabidiol are currently being investigated in humans. |
2016-10-28 |
2023-08-13 |
Not clear |
| Marco Migliore, Damien Habrant, Oscar Sasso, Clara Albani, Sine Mandrup Bertozzi, Andrea Armirotti, Daniele Piomelli, Rita Scarpell. Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies. European journal of medicinal chemistry. vol 109. 2016-10-21. PMID:26774927. |
this favorable interaction is attributed to the accumulation of protective faah substrates, such as the endocannabinoid anandamide, and suggests that agents simultaneously targeting cox and faah might provide an innovative strategy to combat pain and inflammation with reduced side effects. |
2016-10-21 |
2023-08-13 |
Not clear |
| Nicholas S Adamson Barnes, Vanessa A Mitchell, Nicholas P Kazantzis, Christopher W Vaugha. Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine neuropathic pain model. British journal of pharmacology. vol 173. issue 1. 2016-10-13. PMID:26398331. |
conversely, selective fatty acid amide hydrolase (faah) inhibitors that enhance the endocannabinoid system have a better therapeutic window, but lesser efficacy. |
2016-10-13 |
2023-08-13 |
Not clear |