Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Lu Wang, Joji Yui, Qifan Wang, Yiding Zhang, Wakana Mori, Yoko Shimoda, Masayuki Fujinaga, Katsushi Kumata, Tomoteru Yamasaki, Akiko Hatori, Benjamin H Rotstein, Thomas Lee Collier, Chongzhao Ran, Neil Vasdev, Ming-Rong Zhang, Steven H Lian. Synthesis and Preliminary PET Imaging Studies of a FAAH Radiotracer ([¹¹C]MPPO) Based on α-Ketoheterocyclic Scaffold. ACS chemical neuroscience. vol 7. issue 1. 2016-10-13. PMID:26505525. |
fatty acid amide hydrolase (faah) is one of the principle enzymes for metabolizing endogenous cannabinoid neurotransmitters such as anandamide, and thus regulates endocannabinoid (ecb) signaling. |
2016-10-13 |
2023-08-13 |
Not clear |
Lu Wang, Joji Yui, Qifan Wang, Yiding Zhang, Wakana Mori, Yoko Shimoda, Masayuki Fujinaga, Katsushi Kumata, Tomoteru Yamasaki, Akiko Hatori, Benjamin H Rotstein, Thomas Lee Collier, Chongzhao Ran, Neil Vasdev, Ming-Rong Zhang, Steven H Lian. Synthesis and Preliminary PET Imaging Studies of a FAAH Radiotracer ([¹¹C]MPPO) Based on α-Ketoheterocyclic Scaffold. ACS chemical neuroscience. vol 7. issue 1. 2016-10-13. PMID:26505525. |
quantification of faah in the living brain by positron emission tomography (pet) would help our understanding of the endocannabinoid system in these conditions. |
2016-10-13 |
2023-08-13 |
Not clear |
Kristiina Cajanus, Emil J Holmström, Maija Wessman, Verneri Anttila, Mari A Kaunisto, Eija Kals. Effect of endocannabinoid degradation on pain: role of FAAH polymorphisms in experimental and postoperative pain in women treated for breast cancer. Pain. vol 157. issue 2. 2016-10-13. PMID:26808012. |
effect of endocannabinoid degradation on pain: role of faah polymorphisms in experimental and postoperative pain in women treated for breast cancer. |
2016-10-13 |
2023-08-13 |
Not clear |
Kristiina Cajanus, Emil J Holmström, Maija Wessman, Verneri Anttila, Mari A Kaunisto, Eija Kals. Effect of endocannabinoid degradation on pain: role of FAAH polymorphisms in experimental and postoperative pain in women treated for breast cancer. Pain. vol 157. issue 2. 2016-10-13. PMID:26808012. |
fatty acid amide hydrolase (faah) metabolizes the endocannabinoid anandamide, which has an important role in nociception. |
2016-10-13 |
2023-08-13 |
Not clear |
Imre Farkas, Csaba Vastagh, Erzsébet Farkas, Flóra Bálint, Katalin Skrapits, Erik Hrabovszky, Csaba Fekete, Zsolt Liposit. Glucagon-Like Peptide-1 Excites Firing and Increases GABAergic Miniature Postsynaptic Currents (mPSCs) in Gonadotropin-Releasing Hormone (GnRH) Neurons of the Male Mice via Activation of Nitric Oxide (NO) and Suppression of Endocannabinoid Signaling Pathways. Frontiers in cellular neuroscience. vol 10. 2016-09-27. PMID:27672360. |
intracellular application of the transient receptor potential vanilloid 1 (trpv1)-antagonist 2e-n-(2, 3-dihydro-1,4-benzodioxin-6-yl)-3-[4-(1, 1-dimethylethyl)phenyl]-2-propenamide (amg9810; 10 μm) or the fatty acid amide hydrolase (faah)-inhibitor pf3845 (5 μm) impeded the glp-1-triggered endocannabinoid pathway indicating an anandamide-trpv1-sensitive control of 2-arachidonoylglycerol (2-ag) production. |
2016-09-27 |
2023-08-13 |
mouse |
Sari Yrjölä, Teija Parkkari, Dina Navia-Paldanius, Tuomo Laitinen, Agnieszka A Kaczor, Tarja Kokkola, Frank Adusei-Mensah, Juha R Savinainen, Jarmo T Laitinen, Antti Poso, Amy Alexander, June Penman, Lisa Stott, Marie Anskat, Andrew J Irving, Tapio J Nevalaine. Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists. European journal of medicinal chemistry. vol 107. 2016-09-20. PMID:26575458. |
the designed compounds were not active when tested against various endocannabinoid targets (cb1r, cb2r, faah, mgl, abhd6 and abhd12), indicating compounds' selectivity for the gpr55. |
2016-09-20 |
2023-08-13 |
Not clear |
Parisa Hasanein, Masumeh Ghafari-Vahe. Fatty acid amide hydrolase inhibitor URB597 prevented tolerance and cognitive deficits induced by chronic morphine administration in rats. Behavioural pharmacology. vol 27. issue 1. 2016-09-19. PMID:26274041. |
inhibitors of the endocannabinoid metabolic enzyme fatty acid amide hydrolase exert therapeutic effects, but might also be associated with some of the adverse effects of cannabis. |
2016-09-19 |
2023-08-13 |
rat |
Shintaro Ogawa, Hiroshi Kunug. Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase: New Targets for Future Antidepressants. Current neuropharmacology. vol 13. issue 6. 2016-09-09. PMID:26630956. |
recently, endocannabinoid hydrolytic enzymes such as fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl) have become new therapeutic targets in the treatment of mdd. |
2016-09-09 |
2023-08-13 |
Not clear |
Dylan G Gee, Robert N Fetcho, Deqiang Jing, Anfei Li, Charles E Glatt, Andrew T Drysdale, Alexandra O Cohen, Danielle V Dellarco, Rui R Yang, Anders M Dale, Terry L Jernigan, Francis S Lee, B J Case. Individual differences in frontolimbic circuitry and anxiety emerge with adolescent changes in endocannabinoid signaling across species. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 16. 2016-09-02. PMID:27001846. |
we tested whether genetic alterations in endocannabinoid signaling related to a common polymorphism in fatty acid amide hydrolase (faah), which alters endocannabinoid anandamide (aea) levels, would impact the development of frontolimbic circuitry implicated in anxiety disorders. |
2016-09-02 |
2023-08-13 |
mouse |
Xiaofei Sun, Wenbo Deng, Yingju Li, Shuang Tang, Emma Leishman, Heather B Bradshaw, Sudhansu K De. Sustained Endocannabinoid Signaling Compromises Decidual Function and Promotes Inflammation-induced Preterm Birth. The Journal of biological chemistry. vol 291. issue 15. 2016-08-29. PMID:26900150. |
we show here that mice devoid of fatty acid amide hydrolase (faah) with elevated levels ofn-arachidonyl ethanolamide (anandamide), a major endocannabinoid lipid mediator, were more susceptible to ptb upon lipopolysaccharide (lps) challenge. |
2016-08-29 |
2023-08-13 |
mouse |
Luca Carnevali, Federica Vacondio, Stefano Rossi, Sergio Callegari, Emilio Macchi, Gilberto Spadoni, Annalida Bedini, Silvia Rivara, Marco Mor, Andrea Sgoif. Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 11. 2016-08-26. PMID:26391492. |
here, we examined cardiac activity in a rodent model of social stress-induced depression and investigated whether pharmacological inhibition of the enzyme fatty acid amide hydrolase (faah), which terminates signaling of the endocannabinoid anandamide, exerts antidepressant-like and cardioprotective effects. |
2016-08-26 |
2023-08-13 |
human |
Matthew J Pava, Alexandros Makriyannis, David M Lovinge. Endocannabinoid Signaling Regulates Sleep Stability. PloS one. vol 11. issue 3. 2016-08-12. PMID:27031992. |
increasing endocannabinoid tone with a selective inhibitor of monoacyglycerol lipase (jzl184) or fatty acid amide hydrolase (am3506) produced a transient increase in non-rapid eye movement (nrem) sleep due to an augmentation of the length of nrem bouts (nrem stability). |
2016-08-12 |
2023-08-13 |
mouse |
Jayendra Z Patel, John van Bruchem, Tuomo Laitinen, Agnieszka A Kaczor, Dina Navia-Paldanius, Teija Parkkari, Juha R Savinainen, Jarmo T Laitinen, Tapio J Nevalaine. Revisiting 1,3,4-Oxadiazol-2-ones: Utilization in the Development of ABHD6 Inhibitors. Bioorganic & medicinal chemistry. vol 23. issue 19. 2016-07-20. PMID:26344596. |
this compound at 10 μm concentration did not inhibit any other endocannabinoid hydrolases, such as faah, magl and abhd12, or bind to the cannabinoid receptors (cb₁ and cb₂). |
2016-07-20 |
2023-08-13 |
mouse |
Brian D Kangas, Michael Z Leonard, Vidyanand G Shukla, Shakiru O Alapafuja, Spyros P Nikas, Alexandros Makriyannis, Jack Bergma. Comparisons of Δ9-Tetrahydrocannabinol and Anandamide on a Battery of Cognition-Related Behavior in Nonhuman Primates. The Journal of pharmacology and experimental therapeutics. vol 357. issue 1. 2016-07-19. PMID:26826191. |
drugs studied included the cannabinoid agonist Δ(9)-thc, fatty acid amide hydrolase (faah) inhibitor cyclohexylcarbamic acid 3-carbamoylbiphenyl-3-yl ester (urb597), and endocannabinoid anandamide and its stable synthetic analog methanandamide [(r)-(+)-arachidonyl-1'-hydroxy-2'-propylamide]. |
2016-07-19 |
2023-08-13 |
human |
Cyro José de Moraes Martins, Virginia Genelhu, Marcia Mattos Gonçalves Pimentel, Bruno Miguel Jorge Celoria, Rogerio Fabris Mangia, Teresa Aveta, Cristoforo Silvestri, Vincenzo Di Marzo, Emilio Antonio Francischett. Circulating Endocannabinoids and the Polymorphism 385C>A in Fatty Acid Amide Hydrolase (FAAH) Gene May Identify the Obesity Phenotype Related to Cardiometabolic Risk: A Study Conducted in a Brazilian Population of Complex Interethnic Admixture. PloS one. vol 10. issue 11. 2016-06-27. PMID:26561012. |
we investigated a multiethnic brazilian population to study the relationships among the polymorphism 385c>a in an endocannabinoid degrading enzyme gene (faah), endocannabinoid levels and markers of cardiometabolic risk. |
2016-06-27 |
2023-08-13 |
Not clear |
Marjan Nikan, Seyed Mohammad Nabavi, Azadeh Manay. Ligands for cannabinoid receptors, promising anticancer agents. Life sciences. vol 146. 2016-06-13. PMID:26764235. |
therefore, modulation of endocannabinoid system by inhibition of fatty acid amide hydrolase (faah), the enzyme, which metabolized endocannabinoids, or application of multiple cannabinoid or cannabis-derived compounds, may be appropriate for the treatment of several cancer subtypes. |
2016-06-13 |
2023-08-13 |
Not clear |
K R Patil, S N Goyal, C Sharma, C R Patil, S Ojh. Phytocannabinoids for Cancer Therapeutics: Recent Updates and Future Prospects. Current medicinal chemistry. vol 22. issue 30. 2016-06-07. PMID:26179998. |
the ecs includes two g-protein-coupled receptors; the cannabinoid receptors-1 and -2 (cb1 and cb2) for marijuana's psychoactive principle Δ(9)-tetrahydrocannabinol (Δ(9)-thc), their endogenous small lipid ligands; namely anandamide (aea) and 2-arachidonoylglycerol (2-ag), also known as endocannabinoids and the enzymes for endocannabinoid biosynthesis and degradation such as fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl). |
2016-06-07 |
2023-08-13 |
Not clear |
Alessio Lodola, Riccardo Castelli, Marco Mor, Silvia Rivar. Fatty acid amide hydrolase inhibitors: a patent review (2009-2014). Expert opinion on therapeutic patents. vol 25. issue 11. 2016-06-01. PMID:26413912. |
fatty acid amide hydrolase (faah) is a key enzyme responsible for the degradation of the endocannabinoid anandamide. |
2016-06-01 |
2023-08-13 |
Not clear |
Eva M Marco, Cinzia Rapino, Antonio Caprioli, Franco Borsini, Giovanni Laviola, Mauro Maccarron. Potential Therapeutic Value of a Novel FAAH Inhibitor for the Treatment of Anxiety. PloS one. vol 10. issue 9. 2016-05-31. PMID:26360704. |
in the management of anxiety disorders, drug development strategies have left apart the direct activation of type-1 cannabinoid receptors to indirectly enhance ecb signalling through the inhibition of ecb deactivation, that is, the inhibition of the fatty acid amide hydrolase (faah) enzyme. |
2016-05-31 |
2023-08-13 |
mouse |
Sandra Gouveia-Figueira, Jessica Karlsson, Alessandro Deplano, Sanaz Hashemian, Mona Svensson, Marcus Fredriksson Sundbom, Cenzo Congiu, Valentina Onnis, Christopher J Fowle. Characterisation of (R)-2-(2-Fluorobiphenyl-4-yl)-N-(3-Methylpyridin-2-yl)Propanamide as a Dual Fatty Acid Amide Hydrolase: Cyclooxygenase Inhibitor. PloS one. vol 10. issue 9. 2016-05-30. PMID:26406890. |
increased endocannabinoid tonus by dual-action fatty acid amide hydrolase (faah) and substrate selective cyclooxygenase (cox-2) inhibitors is a promising approach for pain-relief. |
2016-05-30 |
2023-08-13 |
Not clear |