All Relations between fatty acid amide hydrolase and cannabinoids

Publication Sentence Publish Date Extraction Date Species
Marc P Baggelaar, Pascal J P Chameau, Vasudev Kantae, Jessica Hummel, Ku-Lung Hsu, Freek Janssen, Tom van der Wel, Marjolein Soethoudt, Hui Deng, Hans den Dulk, Marco Allarà, Bogdan I Florea, Vincenzo Di Marzo, Wytse J Wadman, Chris G Kruse, Herman S Overkleeft, Thomas Hankemeier, Taco R Werkman, Benjamin F Cravatt, Mario van der Stel. Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons. Journal of the American Chemical Society. vol 137. issue 27. 2016-05-23. PMID:26083464. lei105 did not affect other enzymes involved in endocannabinoid metabolism including abhydrolase domain-containing protein 6, abhydrolase domain-containing protein 12, monoacylglycerol lipase, and fatty acid amide hydrolase and did not display affinity for the cannabinoid cb1 receptor. 2016-05-23 2023-08-13 mouse
Erin M Rock, Cheryl L Limebeer, Jordan M Ward, Arianne Cohen, Katherine Grove, Micah J Niphakis, Benjamin F Cravatt, Linda A Parke. Interference with acute nausea and anticipatory nausea in rats by fatty acid amide hydrolase (FAAH) inhibition through a PPARα and CB1 receptor mechanism, respectively: a double dissociation. Psychopharmacology. vol 232. issue 20. 2016-05-13. PMID:26297326. fatty acid amide hydrolase (faah) inhibition elevates anandamide (aea), which acts on cannabinoid (cb1 and cb2) receptors, as well as n-palmitoylethanolamide (pea) and n-oleoylethanolamine (oea), which act on peroxisome proliferator-activated receptor alpha (pparα). 2016-05-13 2023-08-13 rat
Giulio Poli, Niccolò Giuntini, Adriano Martinelli, Tiziano Tuccinard. Application of a FLAP-consensus docking mixed strategy for the identification of new fatty acid amide hydrolase inhibitors. Journal of chemical information and modeling. vol 55. issue 3. 2016-05-10. PMID:25746133. fatty acid amide hydrolase (faah) is the principal responsible for the termination of anandamide signaling, a major actor of the endocannabinoid system. 2016-05-10 2023-08-13 Not clear
Giulio Poli, Niccolò Giuntini, Adriano Martinelli, Tiziano Tuccinard. Application of a FLAP-consensus docking mixed strategy for the identification of new fatty acid amide hydrolase inhibitors. Journal of chemical information and modeling. vol 55. issue 3. 2016-05-10. PMID:25746133. the indirect stimulation of endocannabinoid responses achieved through faah inhibition can represent a valid pharmacological strategy for the treatment of neurodegenerative and neuroinflammatory diseases such as multiple sclerosis, alzheimer's, huntington's, and parkinson's diseases, as well as rheumatoid arthritis, gastrointestinal inflammatory states, anxiety, and other pathologies. 2016-05-10 2023-08-13 Not clear
Chihiro Nozaki, Astrid Markert, Andreas Zimme. Inhibition of FAAH reduces nitroglycerin-induced migraine-like pain and trigeminal neuronal hyperactivity in mice. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 8. 2016-05-06. PMID:25910421. we have therefore investigated mice with a genetic deletion of the two main cannabinoid receptors cb1 and cb2, or the main endocannabinoid degrading enzymes, faah and monoacylglycerol lipase (magl), which degrades 2-arachidonoylglycerol (2-ag), in a nitroglycerine-induced animal model of migraine. 2016-05-06 2023-08-13 mouse
Zuzana Justinova, Leigh V Panlilio, Guillermo Moreno-Sanz, Godfrey H Redhi, Alessia Auber, Maria E Secci, Paola Mascia, Tiziano Bandiera, Andrea Armirotti, Rosalia Bertorelli, Svetlana I Chefer, Chanel Barnes, Sevil Yasar, Daniele Piomelli, Steven R Goldber. Effects of Fatty Acid Amide Hydrolase (FAAH) Inhibitors in Non-Human Primate Models of Nicotine Reward and Relapse. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 9. 2016-04-26. PMID:25754762. both faah inhibitors: (1) blocked faah activity in brain and liver, increasing levels of endogenous ligands for cannabinoid and α-type peroxisome proliferator-activated (ppar-α) receptors; (2) shifted nicotine self-administration dose-response functions in a manner consistent with reduced nicotine reward; (3) blocked reinstatement of nicotine seeking induced by reexposure to either nicotine priming or nicotine-associated cues; and (4) had no effect on cocaine or food self-administration. 2016-04-26 2023-08-13 rat
Panayotis K Thanos, Brendan H Clavin, John Hamilton, Joseph R O'Rourke, Thomas Maher, Christopher Koumas, Erick Miao, Jessenia Lankop, Aya Elhage, Samir Haj-Dahmane, Dale Deutsch, Martin Kaczoch. Examination of the Addictive and Behavioral Properties of Fatty Acid-Binding Protein Inhibitor SBFI26. Frontiers in psychiatry. vol 7. 2016-04-19. PMID:27092087. recent research on the natural lipid ligands of cannabinoid receptors, also known as endocannabinoids, has shed light on the mechanisms of intracellular transport of the endocannabinoid anandamide by fatty acid-binding proteins (fabps) and subsequent catabolism by fatty acid amide hydrolase. 2016-04-19 2023-08-13 mouse
Sara R Nass, Jonathan Z Long, Joel E Schlosburg, Benjamin F Cravatt, Aron H Lichtman, Steven G Kinse. Endocannabinoid Catabolic Enzymes Play Differential Roles in Thermal Homeostasis in Response to Environmental or Immune Challenge. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 10. issue 2. 2016-04-01. PMID:25715681. inhibiting endocannabinoid catabolic enzymes, monoacylglycerol lipase (magl) or fatty acid amide hydrolase (faah), elevates levels of 2-ag or anandamide in vivo, respectively. 2016-04-01 2023-08-13 mouse
Y S Sakin, A Dogrul, F Ilkaya, M Seyrek, U H Ulas, M Gulsen, S Bagc. The effect of FAAH, MAGL, and Dual FAAH/MAGL inhibition on inflammatory and colorectal distension-induced visceral pain models in Rodents. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 27. issue 7. 2016-03-23. PMID:25869205. recent studies showed that the pharmacological inhibition of endocannabinoid degrading enzymes such as fatty acid amide hydrolase (faah) and monoacyl glycerol lipase (magl) elicit promising analgesic effects in a variety of nociceptive models without serious side effects. 2016-03-23 2023-08-13 Not clear
Daniela Schille. Behavioral genetics: of mice, men, and internal bliss. Current biology : CB. vol 25. issue 11. 2016-03-21. PMID:26035787. a mutation in the faah gene that enhances endocannabinoid signaling has been difficult to decipher, as it exists only in humans. 2016-03-21 2023-08-13 mouse
Farinaz Nasirinezhad, Stanislava Jergova, James P Pearson, Jacqueline Sage. Attenuation of persistent pain-related behavior by fatty acid amide hydrolase (FAAH) inhibitors in a rat model of HIV sensory neuropathy. Neuropharmacology. vol 95. 2016-03-08. PMID:25486617. to assess the contribution of cannabinoid receptors in these antinociceptive effects, cb1 antagonist am251 or cb2 antagonist sr144528 were tested in conjunction with faah inhibitors. 2016-03-08 2023-08-13 rat
Carmen Vázquez, Rosa María Tolón, María Ruth Pazos, Marta Moreno, Erin C Koester, Benjamin F Cravatt, Cecilia J Hillard, Julián Romer. Endocannabinoids regulate the activity of astrocytic hemichannels and the microglial response against an injury: In vivo studies. Neurobiology of disease. vol 79. 2016-03-02. PMID:25917763. furthermore, the genetic inactivation of the aea-degrading enzyme, fatty acid amide hydrolase (faah), also increased hc activity and enhanced the microglial response against an acute injury to the brain parenchyma, effects that were mediated by cannabinoid cb1 receptors. 2016-03-02 2023-08-13 mouse
Giulia Palermo, Inga Bauer, Pablo Campomanes, Andrea Cavalli, Andrea Armirotti, Stefania Girotto, Ursula Rothlisberger, Marco De Viv. Keys to Lipid Selection in Fatty Acid Amide Hydrolase Catalysis: Structural Flexibility, Gating Residues and Multiple Binding Pockets. PLoS computational biology. vol 11. issue 6. 2016-02-23. PMID:26111155. the fatty acid amide hydrolase (faah) regulates the endocannabinoid system cleaving primarily the lipid messenger anandamide. 2016-02-23 2023-08-13 Not clear
Gen Zheng, Shuangsong Hong, John M Hayes, John W Wile. Chronic stress and peripheral pain: Evidence for distinct, region-specific changes in visceral and somatosensory pain regulatory pathways. Experimental neurology. vol 273. 2016-02-18. PMID:26408049. we found that chronic stress induced reciprocal changes in the endocannabinoid 2-ag (increased) and endocannabinoid degradation enzymes cox-2 and faah (decreased), associated with down-regulation of cb1 and up-regulation of trpv1 receptors in l6-s2 drg but not l4-l5 drg neurons. 2016-02-18 2023-08-13 rat
Isabelle Boileau, Pablo M Rusjan, Belinda Williams, Esmaeil Mansouri, Romina Mizrahi, Vincenzo De Luca, Douglas S Johnson, Alan A Wilson, Sylvain Houle, Stephen J Kish, Junchao Ton. Blocking of fatty acid amide hydrolase activity with PF-04457845 in human brain: a positron emission tomography study with the novel radioligand [(11)C]CURB. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 11. 2016-02-16. PMID:26082009. positron emission tomography with [(11)c]curb was recently developed to quantify fatty acid amide hydrolase (faah), the enzyme responsible for hydrolyzing the endocannabinoid anandamide. 2016-02-16 2023-08-13 human
Iva Dincheva, Andrew T Drysdale, Catherine A Hartley, David C Johnson, Deqiang Jing, Elizabeth C King, Stephen Ra, J Megan Gray, Ruirong Yang, Ann Marie DeGruccio, Chienchun Huang, Benjamin F Cravatt, Charles E Glatt, Matthew N Hill, B J Casey, Francis S Le. FAAH genetic variation enhances fronto-amygdala function in mouse and human. Nature communications. vol 6. 2016-02-08. PMID:25731744. we developed a knock-in mouse that biologically recapitulates a common human mutation in the gene for fatty acid amide hydrolase (faah) (c385a; rs324420), the primary catabolic enzyme for the endocannabinoid anandamide. 2016-02-08 2023-08-13 mouse
N Hlavacova, M Chmelova, V Danevova, A Csanova, D Jezov. Inhibition of fatty-acid amide hydrolyse (FAAH) exerts cognitive improvements in male but not female rats. Endocrine regulations. vol 49. issue 3. 2016-02-01. PMID:26238495. given the fact that sexual dimorphism exists in the different components of the endocannabinoid system, the aim of this study was to test the hypothesis that cognition enhancing effect of the acute inhibition of faah by urb597 is gender dependent. 2016-02-01 2023-08-13 rat
Natalia Malek, Monika Mrugala, Wioletta Makuch, Natalia Kolosowska, Barbara Przewlocka, Marcin Binkowski, Martyna Czaja, Enrico Morera, Vincenzo Di Marzo, Katarzyna Starowic. A multi-target approach for pain treatment: dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis. Pain. vol 156. issue 5. 2016-01-26. PMID:25719612. we first investigated the mia-induced model of oa by (1) characterizing the pain phenotype and degenerative changes within the joint using x-ray microtomography and (2) evaluating nerve injury and inflammation marker (atf-3 and il-6) expression in the lumbar dorsal root ganglia of osteoarthritic rats and differences in gene and protein expression of the cannabinoid cb1 receptors faah and trpv1. 2016-01-26 2023-08-13 human
D Matthew Walentiny, Robert E Vann, Jenny L Wile. Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice. Neuropharmacology. vol 93. 2016-01-01. PMID:25698527. pharmacological inhibition of monoacylglycerol lipase (magl), the primary catabolic enzyme for the endocannabinoid 2-arachidonoylglycerol (2-ag), with jzl184 resulted in full substitution for thc in faah knockout mice and nearly full substitution in wildtypes. 2016-01-01 2023-08-13 mouse
D Matthew Walentiny, Robert E Vann, Jenny L Wile. Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice. Neuropharmacology. vol 93. 2016-01-01. PMID:25698527. quantification of brain endocannabinoid levels revealed expected elevations in anandamide in faah knockout mice compared to wildtypes and equipotent dose-dependent elevations in 2-ag following jzl184 administration. 2016-01-01 2023-08-13 mouse