| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thomas F Gamage, Bogna M Ignatowska-Jankowska, Pretal P Muldoon, Benjamin F Cravatt, M Imad Damaj, Aron H Lichtma. Differential effects of endocannabinoid catabolic inhibitors on morphine withdrawal in mice. Drug and alcohol dependence. vol 146. 2015-12-18. PMID:25479915. |
inhibition of endocannabinoid catabolic enzymes fatty acid amide hydrolase (faah) and/or monoacylglycerol lipase (magl) reduces somatic morphine withdrawal signs, but its effects on aversive aspects of withdrawal are unknown. |
2015-12-18 |
2023-08-13 |
mouse |
| Andreas Zimme. Genetic Manipulation of the Endocannabinoid System. Handbook of experimental pharmacology. vol 231. 2015-12-16. PMID:26408160. |
the first gene deletions of the cannabinoid cb(1) receptor were described in the late 1990s, soon followed by cb(2) and faah mutations in early 2000. |
2015-12-16 |
2023-08-13 |
mouse |
| Timothy M Shoup, Ali A Bonab, Alan A Wilson, Neil Vasde. Synthesis and preclinical evaluation of [¹⁸F]FCHC for neuroimaging of fatty acid amide hydrolase. Molecular imaging and biology. vol 17. issue 2. 2015-12-08. PMID:25273322. |
fatty acid amide hydrolase (faah), a catabolic enzyme which regulates lipid transmitters in the endocannabinoid system, is an avidly sought therapeutic and positron emission tomography (pet) imaging target for studies involving addiction and neurological disorders. |
2015-12-08 |
2023-08-13 |
rat |
| Megan L Uhelski, Iryna A Khasabova, Donald A Simon. Inhibition of anandamide hydrolysis attenuates nociceptor sensitization in a murine model of chemotherapy-induced peripheral neuropathy. Journal of neurophysiology. vol 113. issue 5. 2015-12-01. PMID:25505113. |
in this study we determined whether inhibition of fatty acid amide hydrolase (faah), which slows the breakdown of the endocannabinoid anandamide (aea), reduced sensitization of nociceptors produced by chemotherapy. |
2015-12-01 |
2023-08-13 |
mouse |
| Liubov Shubina, Rubin Aliev, Valentina Kitchigin. Attenuation of kainic acid-induced status epilepticus by inhibition of endocannabinoid transport and degradation in guinea pigs. Epilepsy research. vol 111. 2015-12-01. PMID:25769371. |
for this purpose, the inhibitors of endocannabinoid transport, am404, and enzymatic (fatty acid amide hydrolase) degradation, urb597, were applied. |
2015-12-01 |
2023-08-13 |
Not clear |
| Zun-Yi Wang, Peiqing Wang, Cecilia J Hillard, Dale E Bjorlin. Attenuation of cystitis and pain sensation in mice lacking fatty acid amide hydrolase. Journal of molecular neuroscience : MN. vol 55. issue 4. 2015-11-27. PMID:25374388. |
these data indicate that endogenous substrates of faah, including the cannabinoid aea, play an inhibitory role in bladder inflammation and subsequent changes in pain perception. |
2015-11-27 |
2023-08-13 |
mouse |
| Ekaitz Agirregoitia, Inés Ibarra-Lecue, Lide Totorikaguena, Rosario Mendoza, Antonia Expósito, Roberto Matorras, Leyre Urigüen, Naiara Agirregoiti. Dynamics of expression and localization of the cannabinoid system in granulosa cells during oocyte nuclear maturation. Fertility and sterility. vol 104. issue 3. 2015-11-23. PMID:26144572. |
to describe the expression of cannabinoid receptors cb1 and cb2 and cannabinoid-degrading enzymes fatty acid amide hydrolase (faah) and monoglyceride lipase (mgll) in human granulosa cells and to investigate their differential distribution with respect to cb1 at various stages during the nuclear maturation of the oocyte. |
2015-11-23 |
2023-08-13 |
human |
| Gergely Fügedi, Miklós Molnár, János Rigó, Júlia Schönléber, Ilona Kovalszky, Attila Molvare. Increased placental expression of cannabinoid receptor 1 in preeclampsia: an observational study. BMC pregnancy and childbirth. vol 14. 2015-11-16. PMID:25444073. |
in the present study, we aimed to analyze cannabinoid receptor 1 (cb1), cb2 and fatty acid amid hydrolase (faah) expressions and localization in normal and preeclamptic placenta, in order to determine whether placental endocannabinoid expression pattern differs between normal pregnancy and preeclampsia. |
2015-11-16 |
2023-08-13 |
Not clear |
| Igor Ivanov, Philipp Borchert, Burkhard Hin. A simple method for simultaneous determination of N-arachidonoylethanolamine, N-oleoylethanolamine, N-palmitoylethanolamine and 2-arachidonoylglycerol in human cells. Analytical and bioanalytical chemistry. vol 407. issue 6. 2015-11-16. PMID:25519724. |
accordingly, inhibition of fatty acid amide hydrolase (faah), a degrading enzyme of the endocannabinoids n-arachidonoylethanolamine (anandamide; aea) and 2-arachidonoylglycerol (2-ag) as well as of the endocannabinoid-like substances n-oleoylethanolamine (oea) and n-palmitoylethanolamine (pea), can cause augmented endogenous cannabinoid tone. |
2015-11-16 |
2023-08-13 |
human |
| Nurcan Calimli Tosun, Ozgur Gunduz, Ahmet Ulugo. Attenuation of serotonin-induced itch responses by inhibition of endocannabinoid degradative enzymes, fatty acid amide hydrolase and monoacylglycerol lipase. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 3. 2015-11-10. PMID:24915981. |
attenuation of serotonin-induced itch responses by inhibition of endocannabinoid degradative enzymes, fatty acid amide hydrolase and monoacylglycerol lipase. |
2015-11-10 |
2023-08-13 |
mouse |
| Nurcan Calimli Tosun, Ozgur Gunduz, Ahmet Ulugo. Attenuation of serotonin-induced itch responses by inhibition of endocannabinoid degradative enzymes, fatty acid amide hydrolase and monoacylglycerol lipase. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 3. 2015-11-10. PMID:24915981. |
we propose that augmenting the endocannabinoid tonus by inhibition of degradative enzymes, faah and magl, but not cellular uptake, may be a novel target for the development of antipruritic agents. |
2015-11-10 |
2023-08-13 |
mouse |
| F Ativie, O Albayram, K Bach, B Pradier, A Zimmer, A Bilkei-Gorz. Enhanced microglial activity in FAAH(-/-) animals. Life sciences. vol 138. 2015-11-09. PMID:25534441. |
enhanced levels of the endocannabinoid n-arachidonoyl ethanolamine (aea, also referred to as anandamide) as well as non-cannabinoid lipids like palmitoylethanolamine (pea) due to genetic deletion or pharmacologic blockade of its degrading enzyme fatty acid amide hydrolase (faah) reduced neuroinflammatory changes in models of neurodegeneration. |
2015-11-09 |
2023-08-13 |
Not clear |
| Nino Tabatadze, Guangzhe Huang, Renee M May, Anant Jain, Catherine S Woolle. Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 32. 2015-11-05. PMID:26269634. |
independently of e2, a fatty acid amide hydrolase inhibitor, which blocks breakdown of anandamide, suppressed >50% of inhibitory synapses in females with no effect in males, indicating tonic endocannabinoid release in females that is absent in males. |
2015-11-05 |
2023-08-13 |
rat |
| Gaurav Bedse, Roberto Colangeli, Angelo M Lavecchia, Adele Romano, Fabio Altieri, Carlo Cifani, Tommaso Cassano, Silvana Gaetan. Role of the basolateral amygdala in mediating the effects of the fatty acid amide hydrolase inhibitor URB597 on HPA axis response to stress. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 24. issue 9. 2015-11-02. PMID:25106694. |
these results suggest that the bla is a key structure involved in the anti-stress effects of urb597, and support the evidence that enhancement of endogenous cannabinoid signaling by inhibiting faah represents a potential therapeutic strategy for the management of stress-related disorders. |
2015-11-02 |
2023-08-13 |
Not clear |
| P P Muldoon, J Chen, J L Harenza, R A Abdullah, L J Sim-Selley, B F Cravatt, M F Miles, X Chen, A H Lichtman, M I Dama. Inhibition of monoacylglycerol lipase reduces nicotine withdrawal. British journal of pharmacology. vol 172. issue 3. 2015-11-02. PMID:25258021. |
while blockade of fatty acid amide hydrolase, the primary catabolic enzyme of the endocannabinoid arachidonoylethanolamine (anandamide), exacerbates withdrawal responses in nicotine-dependent mice, the role of monoacylglycerol lipase (magl), the main hydrolytic enzyme of a second endocannabinoid 2-arachidonylglycerol (2-ag), in nicotine withdrawal remains unexplored. |
2015-11-02 |
2023-08-13 |
mouse |
| Fernanda Crunfli, Fabiana C Vilela, Alexandre Giusti-Paiv. Cannabinoid CB1 receptors mediate the effects of dipyrone. Clinical and experimental pharmacology & physiology. vol 42. issue 3. 2015-10-27. PMID:25430877. |
we hypothesize that the mechanism of action of dipyrone may involve inhibition of cyclo-oxygenase and fatty acid amide hydrolase, which together provide additional arachidonic acid as substrate for endocannabinoid synthesis or other related molecules. |
2015-10-27 |
2023-08-13 |
Not clear |
| Patricia Rivera, Eduardo Blanco, Laura Bindila, Francisco Alen, Antonio Vargas, Leticia Rubio, Francisco J Pavón, Antonia Serrano, Beat Lutz, Fernando Rodríguez de Fonseca, Juan Suáre. Pharmacological activation of CB2 receptors counteracts the deleterious effect of ethanol on cell proliferation in the main neurogenic zones of the adult rat brain. Frontiers in cellular neuroscience. vol 9. 2015-10-20. PMID:26483633. |
we evaluated the protective effects of the selective cb1 receptor agonist acea, the selective cb2 receptor agonist jwh133 and the fatty-acid amide-hydrolase (faah) inhibitor urb597, which enhances endocannabinoid receptor activity, on npc proliferation in rats with forced consumption of ethanol (10%) or sucrose liquid diets for 2 weeks. |
2015-10-20 |
2023-08-13 |
rat |
| Isabelle Boileau, Rachel F Tyndale, Belinda Williams, Esmaeil Mansouri, Duncan J Westwood, Bernard Le Foll, Pablo M Rusjan, Romina Mizrahi, Vincenzo De Luca, Qian Zhou, Alan A Wilson, Sylvain Houle, Stephen J Kish, Junchao Ton. The fatty acid amide hydrolase C385A variant affects brain binding of the positron emission tomography tracer [11C]CURB. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 8. 2015-10-15. PMID:26036940. |
the common functional single-nucleotide polymorphism (rs324420, c385a) of the endocannabinoid inactivating enzyme fatty acid amide hydrolase (faah) has been associated with anxiety disorder relevant phenotype and risk for addictions. |
2015-10-15 |
2023-08-13 |
human |
| Jani Korhonen, Anne Kuusisto, John van Bruchem, Jayendra Z Patel, Tuomo Laitinen, Dina Navia-Paldanius, Jarmo T Laitinen, Juha R Savinainen, Teija Parkkari, Tapio J Nevalaine. Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). Bioorganic & medicinal chemistry. vol 22. issue 23. 2015-10-05. PMID:25282655. |
the key hydrolytic enzymes of the endocannabinoid system, fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), are potential targets for various therapeutic applications. |
2015-10-05 |
2023-08-13 |
Not clear |
| Giulia Palermo, Ursula Rothlisberger, Andrea Cavalli, Marco De Viv. Computational insights into function and inhibition of fatty acid amide hydrolase. European journal of medicinal chemistry. vol 91. 2015-09-30. PMID:25240419. |
faah is a critical enzyme of the endocannabinoid system, being mainly responsible for regulating the level of its main cannabinoid substrate anandamide. |
2015-09-30 |
2023-08-13 |
Not clear |