| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sumit S Rathod, Yogeeta O Agrawa. Phytocannabinoids as Potential Multitargeting Neuroprotectants in Alzheimer's Disease. Current drug research reviews. 2023-05-03. PMID:37132109. |
the present article also discusses the implications of cannabinoid receptors (cb1 and cb2) as well as cannabinoid enzymes (faah and magl) modulators in ad. |
2023-05-03 |
2023-08-14 |
Not clear |
| Sumit S Rathod, Yogeeta O Agrawa. Phytocannabinoids as Potential Multitargeting Neuroprotectants in Alzheimer's Disease. Current drug research reviews. 2023-05-03. PMID:37132109. |
furthermore, naturally occurring cannabinoid metabolic enzymes (faah and magl) inhibit the nlrp3 inflammasome complex, which may offer significant neuroprotection. |
2023-05-03 |
2023-08-14 |
Not clear |
| Georgia Balsevich, Gavin N Petrie, Daniel E Heinz, Arashdeep Singh, Robert J Aukema, Avery C Hunker, Haley A Vecchiarelli, Hiulan Yau, Martin Sticht, Roger J Thompson, Francis S Lee, Larry S Zweifel, Prasanth K Chelikani, Nils C Gassen, Matthew N Hil. A genetic variant of fatty acid amide hydrolase (FAAH) exacerbates hormone-mediated orexigenic feeding in mice. eLife. vol 12. 2023-04-11. PMID:37039453. |
fatty acid amide hydrolase (faah) degrades the endocannabinoid anandamide. |
2023-04-11 |
2023-08-14 |
mouse |
| Adriana Della Pietra, Georgii Krivoshein, Konstantin Ivanov, Raisa Giniatullina, Henna-Kaisa Jyrkkänen, Ville Leinonen, Marko Lehtonen, Arn M J M van den Maagdenberg, Juha Savinainen, Rashid Giniatulli. Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain. The journal of headache and pain. vol 24. issue 1. 2023-04-10. PMID:37038131. |
engaging the endocannabinoid system through inhibition of monoacylglycerol lipase (magl) and fatty acid amide hydrolase (faah), degrading endocannabinoids (endocbs) 2-arachidonoylglycerol (2-ag) and anandamide (aea), was proposed as a promising approach to ameliorate migraine pain. |
2023-04-10 |
2023-08-14 |
human |
| Yannick Fotio, Alex Mabou Tagne, Kwang-Mook Jung, Daniele Piomell. Fatty acid amide hydrolase inhibition alleviates anxiety-like symptoms in a rat model used to study post-traumatic stress disorder. Psychopharmacology. 2023-04-05. PMID:37017699. |
preclinical and clinical evidence shows that inhibitors of the enzyme fatty acid amide hydrolase (faah), which deactivates the endocannabinoid anandamide, exhibit anxiolytic-like properties in animal models. |
2023-04-05 |
2023-08-14 |
rat |
| Leila Hosseinzadeh Anvar, Asghar Alejafar, Seyyed Ebrahim Moosavi, Saeid Charsouei, Narges Zeynalzadeh, Leila Mehdizadeh Fanid, Babak Emamalizadeh, Zahra Hassanpour Aydinlou, Helaleh Vaezi, Adel Kashefi, Carlos Tomaz, Masoud Nikanfar, Ali Ahmadalipou. The study of rs324420 (C385A) polymorphism of the FAAH gene of the endocannabinoid system in patients with epilepsy and ADHD. Epilepsy research. vol 192. 2023-04-05. PMID:37018974. |
the study of rs324420 (c385a) polymorphism of the faah gene of the endocannabinoid system in patients with epilepsy and adhd. |
2023-04-05 |
2023-08-14 |
human |
| b' Bruno M Fonseca, Niloy Bhowmick, Sara Cunha, Jo\\xc3\\xa3o Maia, Georgina Correia-da-Silva, Nat\\xc3\\xa9rcia Teixeira, Susana I S\\xc3\\xa. Long-Term Tamoxifen Effects in the Cyclic Interaction of the Endocannabinoid and Endocrine System in the Rat Central Nervous System. Biomedicines. vol 11. issue 3. 2023-03-29. PMID:36979699.' |
within the female reproductive tract, estrogen increases the expression of the cannabinoid receptors cb1 and cb2, and modifies the levels of anandamide (aea), the major endocannabinoid, by altering the expression of both aea synthesis (nape-pld) and catabolic enzymes (faah). |
2023-03-29 |
2023-08-14 |
rat |
| Simone Battaglia, Chiara Di Fazio, Carmelo M Vicario, Alessio Avenant. Neuropharmacological Modulation of N-methyl-D-aspartate, Noradrenaline and Endocannabinoid Receptors in Fear Extinction Learning: Synaptic Transmission and Plasticity. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36983000. |
we show that the administration of n-methyl-d-aspartate (nmda) agonists and modulation of the endocannabinoid system by fatty acid amide hydrolase (faah) inhibition can boost extinction learning through the stabilization and regulation of the receptor concentration. |
2023-03-29 |
2023-08-14 |
Not clear |
| Barbara Emons, Larissa Arning, Vera-Estelle Makulla, Maria-Theresia Suchy, Dimitrios Tsikas, Thomas Lücke, Jörg T Epplen, Georg Juckel, Patrik Rose. Endocannabinergic modulation of central serotonergic activity in healthy human volunteers. Annals of general psychiatry. vol 22. issue 1. 2023-03-18. PMID:36932421. |
since the cannabinoid (cb) 1 receptor is activated by endogenous ligands such as aea and 2ag, whose concentration are controlled by the fatty acid amide hydrolase (faah) and monoacylglycerol lipase, respectively, we investigated the effects on serotonergic utilization. |
2023-03-18 |
2023-08-14 |
human |
| Barbara Emons, Larissa Arning, Vera-Estelle Makulla, Maria-Theresia Suchy, Dimitrios Tsikas, Thomas Lücke, Jörg T Epplen, Georg Juckel, Patrik Rose. Endocannabinergic modulation of central serotonergic activity in healthy human volunteers. Annals of general psychiatry. vol 22. issue 1. 2023-03-18. PMID:36932421. |
in this study, we investigated the impact of the rs1049353 single-nucleotide polymorphism (snp) of the cannabinoid receptor 1 (cnr1) gene, which codes the endocannabinoid cb1 receptor, and the rs324420 snp of the faah gene on the serotonergic and endocannabinoid system in 59 healthy volunteers. |
2023-03-18 |
2023-08-14 |
human |
| Arijana Demaili, Anna Portugalov, Michal Dudai, Mouna Maroun, Irit Akirav, Katharina Braun, Jörg Boc. Epigenetic (re)programming of gene expression changes of CB1R and FAAH in the medial prefrontal cortex in response to early life and adolescence stress exposure. Frontiers in cellular neuroscience. vol 17. 2023-03-13. PMID:36909279. |
thus, the present study addressed the hypotheses that els and adolescent stress differentially affect the expression of regulatory elements of the endocannabinoid system, cannabinoid receptor 1 (cb1r) and fatty acid amide hydrolase (faah) in the medial prefrontal cortex (mpfc) of adult female rats. |
2023-03-13 |
2023-08-14 |
rat |
| Jinhwan Lim, Hye-Lim Lee, Julie Nguyen, Joyce Shin, Samantha Getze, Caitlin Quach, Erica Squire, Kwang-Mook Jung, Stephen V Mahler, Ken Mackie, Daniele Piomelli, Ulrike Ludere. Adolescent exposure to low-dose Δ9-tetrahydrocannabinol (THC) depletes the ovarian reserve in female mice. Toxicological sciences : an official journal of the Society of Toxicology. 2023-03-13. PMID:36912754. |
enzymes involved in the formation (n-acylphosphatidylethanolamine phospholipase d) or deactivation (fatty acid amide hydrolase) of the endocannabinoid anandamide were expressed in granulosa cells of ovarian follicles and interstitial cells. |
2023-03-13 |
2023-08-14 |
mouse |
| Laura M Best, Christian S Hendershot, Jennifer F Buckman, Samantha Jagasar, Matthew D McPhee, Neel Muzumdar, Rachel F Tyndale, Sylvain Houle, Renee Logan, Marcos Sanches, Stephen J Kish, Bernard Le Foll, Isabelle Boilea. Association Between Fatty Acid Amide Hydrolase and Alcohol Response Phenotypes: A Positron Emission Tomography Imaging Study With [ Biological psychiatry. 2023-03-03. PMID:36868890. |
association between fatty acid amide hydrolase and alcohol response phenotypes: a positron emission tomography imaging study with [ reductions in fatty acid amide hydrolase (faah), the catabolic enzyme for the endocannabinoid anandamide, may play a role in drinking behavior and risk for alcohol use disorder. |
2023-03-03 |
2023-08-14 |
Not clear |
| Marialuisa de Ceglia, Maria Vittoria Micioni Di Bonaventura, Adele Romano, Marzia Friuli, Emanuela Micioni Di Bonaventura, Ana L Gavito, Luca Botticelli, Silvana Gaetani, Fernando Rodríguez de Fonseca, Carlo Cifan. Anxiety associated with palatable food withdrawal is reversed by the selective FAAH inhibitor PF-3845: A regional analysis of the contribution of endocannabinoid signaling machinery. The International journal of eating disorders. 2023-02-25. PMID:36840536. |
anxiety associated with palatable food withdrawal is reversed by the selective faah inhibitor pf-3845: a regional analysis of the contribution of endocannabinoid signaling machinery. |
2023-02-25 |
2023-08-14 |
Not clear |
| Marialuisa de Ceglia, Maria Vittoria Micioni Di Bonaventura, Adele Romano, Marzia Friuli, Emanuela Micioni Di Bonaventura, Ana L Gavito, Luca Botticelli, Silvana Gaetani, Fernando Rodríguez de Fonseca, Carlo Cifan. Anxiety associated with palatable food withdrawal is reversed by the selective FAAH inhibitor PF-3845: A regional analysis of the contribution of endocannabinoid signaling machinery. The International journal of eating disorders. 2023-02-25. PMID:36840536. |
currently, no pharmacological treatment is effective for obesity-related anxiety, so we investigated the endocannabinoid system (ecs), and specifically the fatty acid amide hydrolase (faah), as an interesting emerging target in this context because of its key role in the regulation of both energy homeostasis and emotional behavior. |
2023-02-25 |
2023-08-14 |
Not clear |
| Rosiane Aparecida Miranda, Vanessa Silva Tavares Rodrigues, Thamara Cherem Peixoto, Alex C Manhães, Egberto Gaspar de Moura, Patricia Cristina Lisbo. Nicotine exposure during breastfeeding alters the expression of endocannabinoid system biomarkers in female but not in male offspring at adulthood. Journal of developmental origins of health and disease. 2023-02-23. PMID:36815400. |
we evaluated protein expression of n-acylphosphatidylethanolamide-phospholipase d (nape-pld), fatty acid amide hydrolase (faah), diacylglycerol lipase (dagl), monoacylglycerol lipase (magl) and cannabinoid receptors (cb1 and/or cb2) in lateral hypothalamus, paraventricular nucleus of the hypothalamus, liver, visceral adipose tissue (vat), adrenal and thyroid. |
2023-02-23 |
2023-08-14 |
rat |
| Ashraf Duzan, Desiree Reinken, Timothy L McGomery, Nicholas M Ferencz, Jacob M Plummer, Mufeed M Bast. Endocannabinoids are potential inhibitors of glioblastoma multiforme proliferation. Journal of integrative medicine. 2023-02-22. PMID:36805391. |
cannabinoids promote atypical protein kinase c, deactivate fatty acid amide hydrolase enzymes, and activate transient receptor potential vanilloid 1 (trpv1) and trpv2 to induce pro-apoptotic signaling pathways without increasing endogenous cannabinoids. |
2023-02-22 |
2023-08-14 |
human |
| Lakhan S Khara, Declan W Al. The endocannabinoid system's involvement in motor development relies on cannabinoid receptors, TRP channels, and Sonic Hedgehog signaling. Physiological reports. vol 11. issue 1. 2023-01-13. PMID:36636759. |
to investigate the involvement of canonical and non-canonical cannabinoid receptors, trp channels, and the shh pathway in the development of sensorimotor function in zebrafish, we treated developing animals with pharmacological inhibitors of the cb1r, cb2r, trpa1/trpv1/trpm8, and a smoothened (smo) agonist, along with inhibitors of the ecs catabolic enzymes fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl) during the first ~24 h of zebrafish embryogenesis. |
2023-01-13 |
2023-08-14 |
zebrafish |
| Meenakshi Ahluwalia, Hannah Mcmichael, Manish Kumar, Mario P Espinosa, Asamoah Bosomtwi, Yujiao Lu, Hesam Khodadadi, Abbas Jarrahi, Mohammad B Khan, David C Hess, Scott Y Rahimi, John R Vender, Fernando L Vale, Molly Braun, Babak Baban, Krishnan M Dhandapani, Kumar Vaibha. Altered endocannabinoid metabolism compromises the brain-CSF barrier and exacerbates chronic deficits after traumatic brain injury in mice. Experimental neurology. 2023-01-10. PMID:36627040. |
reductions in endocannabinoid (2-ag and aea) levels in plasma were supported by higher expression of their respective metabolizing enzymes, monoacylglycerol lipase (magl), fatty acid amide hydrolase (faah), and cyclooxygenase 2 (cox-2) in the post-tbi mouse brain. |
2023-01-10 |
2023-08-14 |
mouse |
| Carmine Marco Morgillo, Antonio Lupia, Alessandro Deplano, Luciano Pirone, Bianca Fiorillo, Emilia Pedone, F Javier Luque, Valentina Onnis, Federica Moraca, Bruno Catalanott. Molecular Basis for Non-Covalent, Non-Competitive FAAH Inhibition. International journal of molecular sciences. vol 23. issue 24. 2022-12-23. PMID:36555144. |
fatty acid amide hydrolase (faah) plays a key role in the control of cannabinoid signaling and it represents a promising therapeutic strategy for the treatment of a wide range of diseases, including neuropathic pain and chronic inflammation. |
2022-12-23 |
2023-08-14 |
Not clear |