| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrea Navarria, Alessandra Tamburella, Fabio A Iannotti, Vincenzo Micale, Giovanni Camillieri, Lucia Gozzo, Roberta Verde, Roberta Imperatore, Gian Marco Leggio, Filippo Drago, Vincenzo Di Marz. The dual blocker of FAAH/TRPV1 N-arachidonoylserotonin reverses the behavioral despair induced by stress in rats and modulates the HPA-axis. Pharmacological research. vol 87. 2015-04-13. PMID:24861565. |
n-arachidonoylserotonin (aa-5-ht), a dual blocker at fatty acid amide hydrolase (faah, the enzyme responsible for the inactivation of the endocannabinoid anandamide) and transient receptor potential vanilloid type-1 channel (trpv1), produces anxiolytic-like effects in mice. |
2015-04-13 |
2023-08-13 |
mouse |
| Luara A Batista, Pedro H Gobira, Thercia G Viana, Daniele C Aguiar, Fabricio A Moreir. Inhibition of endocannabinoid neuronal uptake and hydrolysis as strategies for developing anxiolytic drugs. Behavioural pharmacology. vol 25. issue 5-6. 2015-03-31. PMID:25083569. |
the endocannabinoid system comprises the cb1 and cb2 receptors (the targets of the cannabis sativa compound delta-9-tetrahydrocannabinol), the endogenous ligands (endocannabinoids) arachidonoyl ethanolamide (anandamide) and 2-arachidonoyl glycerol, their synthesizing machinery and membrane transport system, and the hydrolyzing enzymes fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), respectively. |
2015-03-31 |
2023-08-13 |
Not clear |
| Luara A Batista, Pedro H Gobira, Thercia G Viana, Daniele C Aguiar, Fabricio A Moreir. Inhibition of endocannabinoid neuronal uptake and hydrolysis as strategies for developing anxiolytic drugs. Behavioural pharmacology. vol 25. issue 5-6. 2015-03-31. PMID:25083569. |
understanding the pharmacological properties of faah and magl inhibitors may contribute toward the development of new anxiolytic interventions based on the endocannabinoid system. |
2015-03-31 |
2023-08-13 |
Not clear |
| Justin W Hicks, Jun Parkes, Junchao Tong, Sylvain Houle, Neil Vasdev, Alan A Wilso. Radiosynthesis and ex vivo evaluation of [(11)C-carbonyl]carbamate- and urea-based monoacylglycerol lipase inhibitors. Nuclear medicine and biology. vol 41. issue 8. 2015-03-12. PMID:24969632. |
monoacylglycerol lipase (magl) and fatty acid amide hydrolase (faah) are the two primary enzymes that regulate the tone of endocannabinoid signaling. |
2015-03-12 |
2023-08-13 |
mouse |
| Simon Nicolussi, Andrea Chicca, Mark Rau, Sabine Rihs, Michael Soeberdt, Christoph Abels, Jürg Gertsc. Correlating FAAH and anandamide cellular uptake inhibition using N-alkylcarbamate inhibitors: from ultrapotent to hyperpotent. Biochemical pharmacology. vol 92. issue 4. 2015-03-09. PMID:25283614. |
besides the suggested role of a putative endocannabinoid membrane transporter mediating the cellular uptake of the endocannabinoid anandamide (aea), this process is intrinsically coupled to aea degradation by the fatty acid amide hydrolase (faah). |
2015-03-09 |
2023-08-13 |
Not clear |
| Simon Nicolussi, Andrea Chicca, Mark Rau, Sabine Rihs, Michael Soeberdt, Christoph Abels, Jürg Gertsc. Correlating FAAH and anandamide cellular uptake inhibition using N-alkylcarbamate inhibitors: from ultrapotent to hyperpotent. Biochemical pharmacology. vol 92. issue 4. 2015-03-09. PMID:25283614. |
while being inactive at cannabinoid receptors and monoacylglycerol lipase, these n-alkylcarbamates showed potent to ultrapotent picomolar faah inhibition in u937 cells. |
2015-03-09 |
2023-08-13 |
Not clear |
| R J Bluett, J C Gamble-George, D J Hermanson, N D Hartley, L J Marnett, S Pate. Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation. Translational psychiatry. vol 4. 2015-03-06. PMID:25004388. |
acute pharmacological inhibition of the anandamide-degrading enzyme, fatty acid amide hydrolase (faah), reverses the stress-induced anxiety state in a cannabinoid receptor-dependent manner. |
2015-03-06 |
2023-08-13 |
mouse |
| Andrea Chicca, Diego Caprioglio, Alberto Minassi, Vanessa Petrucci, Giovanni Appendino, Orazio Taglialatela-Scafati, Jürg Gertsc. Functionalization of β-caryophyllene generates novel polypharmacology in the endocannabinoid system. ACS chemical biology. vol 9. issue 7. 2015-02-26. PMID:24831513. |
while most changes on this element were detrimental for activity, ring-opening cross metathesis of 1 with ethyl acrylate followed by amide functionalization generated a series of new monocyclic amides (11a, 11b, 11c) that not only retained the cb2 receptor functional agonism of 1 but also reversibly inhibited fatty acid amide hydrolase (faah), the major endocannabinoid degrading enzyme, without affecting monoacylglycerol lipase (magl) and α,β hydrolases 6 and 12. |
2015-02-26 |
2023-08-13 |
Not clear |
| Latha Velayudhan, Erik Van Diepen, Mangesh Marudkar, Oliver Hands, Srinivas Suribhatla, Richard Prettyman, Jonathan Murray, Sarah Baillon, Sagnik Bhattacharyy. Therapeutic potential of cannabinoids in neurodegenerative disorders: a selective review. Current pharmaceutical design. vol 20. issue 13. 2015-02-20. PMID:23829360. |
elements of the ecs, such as fatty acid amide hydrolase or the cannabinoid receptors are now considered as promising pharmacological targets for some diseases. |
2015-02-20 |
2023-08-12 |
Not clear |
| Isabelle Boileau, Peter M Bloomfield, Pablo Rusjan, Romina Mizrahi, Asfandyar Mufti, Irina Vitcu, Stephen J Kish, Sylvain Houle, Alan A Wilson, Junchao Ton. Whole-body radiation dosimetry of 11C-carbonyl-URB694: a PET tracer for fatty acid amide hydrolase. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 55. issue 12. 2015-01-30. PMID:25413137. |
(11)c-carbonyl-urb694 ((11)c-curb) is a novel (11)c-labeled suicide irreversible radiotracer for pet developed as a surrogate measure of activity of the endocannabinoid metabolizing enzyme fatty acid amide hydrolase. |
2015-01-30 |
2023-08-13 |
Not clear |
| Agata M Wasik, Lina Nygren, Stefan Almestrand, Fang Zong, Jenny Flygare, Stefanie Baumgartner Wennerholm, Leonie Saft, Patrik Andersson, Eva Kimby, Björn E Wahlin, Birger Christensson, Birgitta Sande. Perturbations of the endocannabinoid system in mantle cell lymphoma: correlations to clinical and pathological features. Oncoscience. vol 1. issue 8. 2015-01-16. PMID:25594062. |
107 tumor tissues were analyzed for the mrna levels of cannabinoid receptors 1 and 2 (cnr1 and cnr2) and the two main enzymes regulating the endocannabinoid anandamide levels in tissue: napepld and faah (participating in synthesis and degradation, respectively). |
2015-01-16 |
2023-08-13 |
Not clear |
| Simon Nicolussi, Juan Manuel Viveros-Paredes, María Salomé Gachet, Mark Rau, Mario Eduardo Flores-Soto, Martina Blunder, Jürg Gertsc. Guineensine is a novel inhibitor of endocannabinoid uptake showing cannabimimetic behavioral effects in BALB/c mice. Pharmacological research. vol 80. 2015-01-06. PMID:24412246. |
noteworthy, guineensine did not inhibit endocannabinoid degrading enzymes fatty acid amide hydrolase (faah) or monoacylglycerol lipase (magl) nor interact with cannabinoid receptors or fatty acid binding protein 5 (fabp5), a major cytoplasmic aea carrier. |
2015-01-06 |
2023-08-12 |
mouse |
| Simon Nicolussi, Juan Manuel Viveros-Paredes, María Salomé Gachet, Mark Rau, Mario Eduardo Flores-Soto, Martina Blunder, Jürg Gertsc. Guineensine is a novel inhibitor of endocannabinoid uptake showing cannabimimetic behavioral effects in BALB/c mice. Pharmacological research. vol 80. 2015-01-06. PMID:24412246. |
guineensine is a novel plant natural product which specifically inhibits endocannabinoid uptake in different cell lines independent of faah. |
2015-01-06 |
2023-08-12 |
mouse |
| Yingjie Jiang, Yuqiang Nie, Yuyuan Li, Long Zhan. Association of cannabinoid type 1 receptor and fatty acid amide hydrolase genetic polymorphisms in Chinese patients with irritable bowel syndrome. Journal of gastroenterology and hepatology. vol 29. issue 6. 2014-12-30. PMID:24444427. |
association of cannabinoid type 1 receptor and fatty acid amide hydrolase genetic polymorphisms in chinese patients with irritable bowel syndrome. |
2014-12-30 |
2023-08-12 |
Not clear |
| Yingjie Jiang, Yuqiang Nie, Yuyuan Li, Long Zhan. Association of cannabinoid type 1 receptor and fatty acid amide hydrolase genetic polymorphisms in Chinese patients with irritable bowel syndrome. Journal of gastroenterology and hepatology. vol 29. issue 6. 2014-12-30. PMID:24444427. |
here, we investigated whether genetic variants of the cannabinoid type 1 receptor (cnr1) and fatty acid amide hydrolase (faah) are associated with the pathogenesis of ibs. |
2014-12-30 |
2023-08-12 |
Not clear |
| Andrew J Kwilasz, Rehab A Abdullah, Justin L Poklis, Aron H Lichtman, Sidney S Negu. Effects of the fatty acid amide hydrolase inhibitor URB597 on pain-stimulated and pain-depressed behavior in rats. Behavioural pharmacology. vol 25. issue 2. 2014-12-09. PMID:24583930. |
fatty acid amide hydrolase (faah) inhibitors increase physiological levels of the endocannabinoid anandamide, which may confer improved efficacy and safety relative to direct cbr agonists. |
2014-12-09 |
2023-08-12 |
rat |
| Martin Kaczocha, Mario J Rebecchi, Brian P Ralph, Yu-Han Gary Teng, William T Berger, William Galbavy, Matthew W Elmes, Sherrye T Glaser, Liqun Wang, Robert C Rizzo, Dale G Deutsch, Iwao Ojim. Inhibition of fatty acid binding proteins elevates brain anandamide levels and produces analgesia. PloS one. vol 9. issue 4. 2014-12-03. PMID:24705380. |
the endocannabinoid anandamide (aea) is an antinociceptive lipid that is inactivated through cellular uptake and subsequent catabolism by fatty acid amide hydrolase (faah). |
2014-12-03 |
2023-08-13 |
mouse |
| Y Nasser, M Bashashati, C N Andrew. Toward modulation of the endocannabinoid system for treatment of gastrointestinal disease: FAAHster but not "higher". Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 26. issue 4. 2014-11-26. PMID:24641009. |
inhibition of fatty acid amide hydrolase (faah), an important enzyme for the degradation of anandamide and other endogenous cannabinoids, is a promising target to achieve this goal. |
2014-11-26 |
2023-08-12 |
mouse |
| Yuki Ito, Motohiro Tomizawa, Himiko Suzuki, Ai Okamura, Katsumi Ohtani, Mari Nunome, Yuki Noro, Dong Wang, Tamie Nakajima, Michihiro Kamijim. Fenitrothion action at the endocannabinoid system leading to spermatotoxicity in Wistar rats. Toxicology and applied pharmacology. vol 279. issue 3. 2014-11-17. PMID:24998969. |
fnt oxon (bioactive metabolite of fnt) preferentially inhibited the fatty acid amide hydrolase (faah), an endocannabinoid anandamide (aea) hydrolase, in the rat cellular membrane preparation from the testis in vitro. |
2014-11-17 |
2023-08-13 |
rat |
| Yuki Ito, Motohiro Tomizawa, Himiko Suzuki, Ai Okamura, Katsumi Ohtani, Mari Nunome, Yuki Noro, Dong Wang, Tamie Nakajima, Michihiro Kamijim. Fenitrothion action at the endocannabinoid system leading to spermatotoxicity in Wistar rats. Toxicology and applied pharmacology. vol 279. issue 3. 2014-11-17. PMID:24998969. |
accordingly, the present study proposes that the fnt-elicited spermatotoxicity appears to be related to inhibition of faah leading to overstimulation of the endocannabinoid signaling system, which plays crucial roles in spermatogenesis and sperm motility acquirement. |
2014-11-17 |
2023-08-13 |
rat |