| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aurélien Tourteau, Natascha Leleu-Chavain, Mathilde Body-Malapel, Virginie Andrzejak, Amélie Barczyk, Madjid Djouina, Benoit Rigo, Pierre Desreumaux, Philippe Chavatte, Régis Mille. Switching cannabinoid response from CB(2) agonists to FAAH inhibitors. Bioorganic & medicinal chemistry letters. vol 24. issue 5. 2014-10-28. PMID:24508127. |
switching cannabinoid response from cb(2) agonists to faah inhibitors. |
2014-10-28 |
2023-08-12 |
mouse |
| Aurélien Tourteau, Natascha Leleu-Chavain, Mathilde Body-Malapel, Virginie Andrzejak, Amélie Barczyk, Madjid Djouina, Benoit Rigo, Pierre Desreumaux, Philippe Chavatte, Régis Mille. Switching cannabinoid response from CB(2) agonists to FAAH inhibitors. Bioorganic & medicinal chemistry letters. vol 24. issue 5. 2014-10-28. PMID:24508127. |
the pharmacological results led to identify structure-activity relationships enabling to switch cannabinoid response from cb2 agonists to faah inhibitors. |
2014-10-28 |
2023-08-12 |
mouse |
| Peggy Schneider, Christin Hannusch, Christian Schmahl, Martin Bohus, Rainer Spanagel, Miriam Schneide. Adolescent peer-rejection persistently alters pain perception and CB1 receptor expression in female rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 24. issue 2. 2014-10-21. PMID:23669059. |
both groups also differed in their endocrine stress-response, and expression levels of the cannabinoid cb1 receptor were increased in the thalamus, whereas faah levels were decreased in the amygdala. |
2014-10-21 |
2023-08-12 |
rat |
| Barbara Bosier, Giulio G Muccioli, Didier M Lamber. The FAAH inhibitor URB597 efficiently reduces tyrosine hydroxylase expression through CB₁- and FAAH-independent mechanisms. British journal of pharmacology. vol 169. issue 4. 2014-10-08. PMID:22970888. |
anandamide and 2-arachidonoylglycerol are neuromodulatory lipids interacting with cannabinoid receptors, whose availability is regulated by the balance between 'on demand' generation and enzymatic degradation [by fatty acid amide hydrolase (faah)/monoacylglycerol lipase]. |
2014-10-08 |
2023-08-12 |
Not clear |
| Roger G Pertwe. Elevating endocannabinoid levels: pharmacological strategies and potential therapeutic applications. The Proceedings of the Nutrition Society. vol 73. issue 1. 2014-09-24. PMID:24135210. |
for inhibition of endocannabinoid metabolism, research has focused particularly on two highly investigated endocannabinoids, anandamide and 2-arachidonoyl glycerol, and hence on inhibitors of the main anandamide-metabolising enzyme, fatty acid amide hydrolase (faah), and of the main 2-arachidonoyl glycerol-metabolising enzyme, monoacylglycerol (mag) lipase. |
2014-09-24 |
2023-08-12 |
Not clear |
| D A de Luis, O Izaola, R Aller, B de La Fuente, D Pachec. Effects of C358A polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) on weight loss, adipocytokines levels, and insulin resistance after a high polyunsaturated fat diet in obese patients. Journal of endocrinological investigation. vol 36. issue 11. 2014-09-23. PMID:24445122. |
effects of c358a polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (faah) on weight loss, adipocytokines levels, and insulin resistance after a high polyunsaturated fat diet in obese patients. |
2014-09-23 |
2023-08-12 |
Not clear |
| Ahmet Ulugö. The endocannabinoid system as a potential therapeutic target for pain modulation. Balkan medical journal. vol 31. issue 2. 2014-09-10. PMID:25207181. |
cannabinoid therapy re-gained attention only after the discovery of endocannabinoids and fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), the enzymes playing a role in endocannabinoid metabolism. |
2014-09-10 |
2023-08-13 |
Not clear |
| Kieran Rea, Weredeselam M Olango, Bright N Okine, Manish K Madasu, Iseult C McGuire, Kathleen Coyle, Brendan Harhen, Michelle Roche, David P Fin. Impaired endocannabinoid signalling in the rostral ventromedial medulla underpins genotype-dependent hyper-responsivity to noxious stimuli. Pain. vol 155. issue 1. 2014-09-02. PMID:24076311. |
pharmacological blockade of the cannabinoid1 (cb1) receptor potentiates the hyperalgesia in wky rats, whereas inhibition of the endocannabinoid catabolising enzyme, fatty acid amide hydrolase, attenuates the hyperalgesia. |
2014-09-02 |
2023-08-12 |
human |
| Joel E Schlosburg, Steven G Kinsey, Bogna Ignatowska-Jankowska, Divya Ramesh, Rehab A Abdullah, Qing Tao, Lamont Booker, Jonathan Z Long, Dana E Selley, Benjamin F Cravatt, Aron H Lichtma. Prolonged monoacylglycerol lipase blockade causes equivalent cannabinoid receptor type 1 receptor-mediated adaptations in fatty acid amide hydrolase wild-type and knockout mice. The Journal of pharmacology and experimental therapeutics. vol 350. issue 2. 2014-08-26. PMID:24849924. |
complementary genetic and pharmacological approaches to inhibit monoacylglycerol lipase (magl) and fatty acid amide hydrolase (faah), the primary hydrolytic enzymes of the respective endogenous cannabinoids 2-arachidonoylglycerol (2-ag) and n-arachidonoylethanolamine, enable the exploration of potential therapeutic applications and physiologic roles of these enzymes. |
2014-08-26 |
2023-08-13 |
mouse |
| Joel E Schlosburg, Steven G Kinsey, Bogna Ignatowska-Jankowska, Divya Ramesh, Rehab A Abdullah, Qing Tao, Lamont Booker, Jonathan Z Long, Dana E Selley, Benjamin F Cravatt, Aron H Lichtma. Prolonged monoacylglycerol lipase blockade causes equivalent cannabinoid receptor type 1 receptor-mediated adaptations in fatty acid amide hydrolase wild-type and knockout mice. The Journal of pharmacology and experimental therapeutics. vol 350. issue 2. 2014-08-26. PMID:24849924. |
while cannabinoid receptor type 1 (cb1) function is maintained following chronic faah inactivation, prolonged excessive elevation of brain 2-ag levels, via magl inhibition, elicits both behavioral and molecular signs of cannabinoid tolerance and dependence. |
2014-08-26 |
2023-08-13 |
mouse |
| Jemma C Cable, Garry D Tan, Stephen P H Alexander, Saoirse E O'Sulliva. The effects of obesity, diabetes and metabolic syndrome on the hydrolytic enzymes of the endocannabinoid system in animal and human adipocytes. Lipids in health and disease. vol 13. 2014-08-25. PMID:24593280. |
we have shown that fatty acid amide hydrolase (faah, an endocannabinoid hydrolysing enzyme) in subcutaneous adipose tissue positively correlates with bmi in healthy volunteers. |
2014-08-25 |
2023-08-12 |
human |
| Kwannok Leung, Matthew W Elmes, Sherrye T Glaser, Dale G Deutsch, Martin Kaczoch. Role of FAAH-like anandamide transporter in anandamide inactivation. PloS one. vol 8. issue 11. 2014-08-18. PMID:24223930. |
anandamide (aea) is an endocannabinoid that is inactivated by cellular uptake followed by intracellular hydrolysis by fatty acid amide hydrolase (faah). |
2014-08-18 |
2023-08-12 |
Not clear |
| Mariateresa Cipriano, Emmelie Björklund, Alan A Wilson, Cenzo Congiu, Valentina Onnis, Christopher J Fowle. Inhibition of fatty acid amide hydrolase and cyclooxygenase by the N-(3-methylpyridin-2-yl)amide derivatives of flurbiprofen and naproxen. European journal of pharmacology. vol 720. issue 1-3. 2014-08-15. PMID:24120370. |
inhibitors of the metabolism of the endogenous cannabinoid ligand anandamide by fatty acid amide hydrolase (faah) reduce the gastric damage produced by non-steroidal anti-inflammatory agents and synergise with them in experimental pain models. |
2014-08-15 |
2023-08-12 |
rat |
| Patricia Rivera, Sergio Arrabal, Manuel Cifuentes, Jesús M Grondona, Margarita Pérez-Martín, Leticia Rubio, Antonio Vargas, Antonia Serrano, Francisco J Pavón, Juan Suárez, Fernando Rodríguez de Fonsec. Localization of the cannabinoid CB1 receptor and the 2-AG synthesizing (DAGLα) and degrading (MAGL, FAAH) enzymes in cells expressing the Ca(2+)-binding proteins calbindin, calretinin, and parvalbumin in the adult rat hippocampus. Frontiers in neuroanatomy. vol 8. 2014-07-14. PMID:25018703. |
localization of the cannabinoid cb1 receptor and the 2-ag synthesizing (daglα) and degrading (magl, faah) enzymes in cells expressing the ca(2+)-binding proteins calbindin, calretinin, and parvalbumin in the adult rat hippocampus. |
2014-07-14 |
2023-08-13 |
rat |
| Miquel Bioque, Borja García-Bueno, Karina S Macdowell, Ana Meseguer, Pilar A Saiz, Mara Parellada, Ana Gonzalez-Pinto, Roberto Rodriguez-Jimenez, Antonio Lobo, Juan C Leza, Miguel Bernard. Peripheral endocannabinoid system dysregulation in first-episode psychosis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 13. 2014-07-01. PMID:23822951. |
protein expression of cannabinoid receptor 2 (cb2), the protein levels of the main endocannabinoid synthesizing enzymes n-acyl phosphatidylethanolamine phospholipase (nape) and diacylglycerol lipase (dagl), and of degradation enzymes fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl) were determined by western blot analysis in peripheral blood mononuclear cells (pbmcs). |
2014-07-01 |
2023-08-12 |
human |
| E L Nurmi, S L Spilman, F Whelan, L L Scahill, M G Aman, C J McDougle, L E Arnold, B Handen, C Johnson, D G Sukhodolsky, D J Posey, L Lecavalier, K A Stigler, L Ritz, E Tierney, B Vitiello, J T McCracke. Moderation of antipsychotic-induced weight gain by energy balance gene variants in the RUPP autism network risperidone studies. Translational psychiatry. vol 3. 2014-06-05. PMID:23799528. |
we found no evidence for association with a reported functional variant in the endocannabinoid metabolic enzyme, fatty acid amide hydrolase, whereas body mass index-associated single-nucleotide polymorphisms in fto and mc4r showed only trend associations. |
2014-06-05 |
2023-08-12 |
Not clear |
| O Gunduz-Cinar, K P MacPherson, R Cinar, J Gamble-George, K Sugden, B Williams, G Godlewski, T S Ramikie, A X Gorka, S O Alapafuja, S P Nikas, A Makriyannis, R Poulton, S Patel, A R Hariri, A Caspi, T E Moffitt, G Kunos, A Holme. Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity. Molecular psychiatry. vol 18. issue 7. 2014-05-02. PMID:22688188. |
the endocannabinoid anandamide is degraded by the catabolic enzyme fatty acid amide hydrolase (faah). |
2014-05-02 |
2023-08-12 |
mouse |
| Haifa Almukadi, Hui Wu, Mark Böhlke, Charles J Kelley, Timothy J Maher, Alejandro Pino-Figuero. The macamide N-3-methoxybenzyl-linoleamide is a time-dependent fatty acid amide hydrolase (FAAH) inhibitor. Molecular neurobiology. vol 48. issue 2. 2014-04-21. PMID:23853040. |
previous studies have also demonstrated the activity of the pentane extract and its macamides, the most representative lipophilic constituents of maca, in the endocannabinoid system as fatty acid amide hydrolase (faah) inhibitors. |
2014-04-21 |
2023-08-12 |
Not clear |
| Haifa Almukadi, Hui Wu, Mark Böhlke, Charles J Kelley, Timothy J Maher, Alejandro Pino-Figuero. The macamide N-3-methoxybenzyl-linoleamide is a time-dependent fatty acid amide hydrolase (FAAH) inhibitor. Molecular neurobiology. vol 48. issue 2. 2014-04-21. PMID:23853040. |
one of the most active macamides, n-3-methoxybenzyl-linoleamide, was studied to determine its mechanism of interaction with faah and whether it has inhibitory activity on mono-acyl glycerol lipase (magl), the second enzyme responsible for endocannabinoid degradation. |
2014-04-21 |
2023-08-12 |
Not clear |
| Sabatino Maione, Barbara Costa, Fabiana Piscitelli, Enrico Morera, Maria De Chiaro, Francesca Comelli, Serena Boccella, Francesca Guida, Roberta Verde, Giorgio Ortar, Vincenzo Di Marz. Piperazinyl carbamate fatty acid amide hydrolase inhibitors and transient receptor potential channel modulators as "dual-target" analgesics. Pharmacological research. vol 76. 2014-04-16. PMID:23911581. |
we showed previously that inhibiting fatty acid amide hydrolase (faah), an endocannabinoid degrading enzyme, and transient receptor potential vanilloid type-1 (trpv1) channels with the same molecule, the naturally occurring n-arachidonoyl-serotonin (aa-5-ht), produces more efficacious anti-nociceptive and anti-hyperalgesic actions than the targeting of faah or trpv1 alone. |
2014-04-16 |
2023-08-12 |
mouse |