All Relations between fatty acid amide hydrolase and cannabinoids

Publication Sentence Publish Date Extraction Date Species
Guillermo Moreno-Sanz, Andrea Duranti, Laurin Melzig, Claudio Fiorelli, Gian Filippo Ruda, Giampiero Colombano, Paola Mestichelli, Silvano Sanchini, Andrea Tontini, Marco Mor, Tiziano Bandiera, Rita Scarpelli, Giorgio Tarzia, Daniele Piomell. Synthesis and structure-activity relationship studies of O-biphenyl-3-yl carbamates as peripherally restricted fatty acid amide hydrolase inhibitors. Journal of medicinal chemistry. vol 56. issue 14. 2014-03-10. PMID:23822179. despite its inability to enter the central nervous system (cns), 3 exerts profound antinociceptive effects in mice and rats, which result from the inhibition of faah in peripheral tissues and the consequent enhancement of anandamide signaling at cb1 cannabinoid receptors localized on sensory nerve endings. 2014-03-10 2023-08-12 mouse
Himiko Suzuki, Yuki Ito, Yuki Noro, Mamoru Koketsu, Michihiro Kamijima, Motohiro Tomizaw. Organophosphate agents induce plasma hypertriglyceridemia in mouse via single or dual inhibition of the endocannabinoid hydrolyzing enzyme(s). Toxicology letters. vol 225. issue 1. 2014-03-06. PMID:24361246. diverse serine hydrolases including endocannabinoid metabolizing enzymes fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl) have been suggested as secondary targets for organophosphate (op) agents to exert adverse toxic effects such as lipid homeostasis disruption. 2014-03-06 2023-08-12 mouse
Himiko Suzuki, Yuki Ito, Yuki Noro, Mamoru Koketsu, Michihiro Kamijima, Motohiro Tomizaw. Organophosphate agents induce plasma hypertriglyceridemia in mouse via single or dual inhibition of the endocannabinoid hydrolyzing enzyme(s). Toxicology letters. vol 225. issue 1. 2014-03-06. PMID:24361246. the present findings suggest that op agents induce plasma hypertriglyceridemia in mouse through single or dual inhibition of faah or/and magl, apparently leading to overstimulation of cannabinoid signal regulating energy metabolism. 2014-03-06 2023-08-12 mouse
David A Barrière, Christophe Mallet, Anders Blomgren, Charlotte Simonsen, Laurence Daulhac, Frédéric Libert, Eric Chapuy, Monique Etienne, Edward D Högestätt, Peter M Zygmunt, Alain Eschalie. Fatty acid amide hydrolase-dependent generation of antinociceptive drug metabolites acting on TRPV1 in the brain. PloS one. vol 8. issue 8. 2014-03-03. PMID:23940628. in the rat, pharmacological inhibition of faah, trpv1, cannabinoid cb1 receptors and spinal 5-ht3 or 5-ht1a receptors, and chemical deletion of bulbospinal serotonergic pathways prevented the antinociceptive action of 4-aminophenol. 2014-03-03 2023-08-12 mouse
Justin W Hicks, Jun Parkes, Oleg Sadovski, Junchao Tong, Sylvain Houle, Neil Vasdev, Alan A Wilso. Synthesis and preclinical evaluation of [11C-carbonyl]PF-04457845 for neuroimaging of fatty acid amide hydrolase. Nuclear medicine and biology. vol 40. issue 6. 2014-02-25. PMID:23731552. fatty acid amide hydrolase (faah) has a significant role in regulating endocannabinoid signaling in the central nervous system. 2014-02-25 2023-08-12 Not clear
Joanna E Slusar, Elizabeth A Cairns, Anna-Maria Szczesniak, Heather B Bradshaw, Adriana Di Polo, Melanie E M Kell. The fatty acid amide hydrolase inhibitor, URB597, promotes retinal ganglion cell neuroprotection in a rat model of optic nerve axotomy. Neuropharmacology. vol 72. 2014-02-11. PMID:23643752. the endocannabinoid, n-arachidonoylethanolamine (aea), is degraded by the enzyme fatty acid amide hydrolase (faah). 2014-02-11 2023-08-12 rat
Ran Wang, Abdolsamad Borazjani, Anberitha T Matthews, Lee C Mangum, Mariola J Edelmann, Matthew K Ros. Identification of palmitoyl protein thioesterase 1 in human THP1 monocytes and macrophages and characterization of unique biochemical activities for this enzyme. Biochemistry. vol 52. issue 43. 2014-02-11. PMID:24083319. however, magl and other endocannabinoid hydrolases, faah, abhd6, and abhd12, did not have a role because of limited expression or no expression. 2014-02-11 2023-08-12 mouse
Ozge Gunduz-Cinar, Matthew N Hill, Bruce S McEwen, Andrew Holme. Amygdala FAAH and anandamide: mediating protection and recovery from stress. Trends in pharmacological sciences. vol 34. issue 11. 2014-01-27. PMID:24325918. additionally, inhibition of faah facilitates long-term fear extinction and rescues deficient fear extinction in rodent models by enhancing aea-cb1 (cannabinoid type 1) receptor signaling and synaptic plasticity in the bla. 2014-01-27 2023-08-12 Not clear
Jie Liu, Resat Cinar, Keming Xiong, Grzegorz Godlewski, Tony Jourdan, Yuhong Lin, James M Ntambi, George Kuno. Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous inhibitors of fatty acid amide hydrolase. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 47. 2014-01-22. PMID:24191036. the hfd-induced increase in the hepatic levels of the endocannabinoid anandamide [i.e., arachidonoylethanolamide (aea)] has been attributed to reduced activity of the aea-degrading enzyme fatty acid amide hydrolase (faah). 2014-01-22 2023-08-12 mouse
Divya Ramesh, Thomas F Gamage, Tim Vanuytsel, Robert A Owens, Rehab A Abdullah, Micah J Niphakis, Terez Shea-Donohue, Benjamin F Cravatt, Aron H Lichtma. Dual inhibition of endocannabinoid catabolic enzymes produces enhanced antiwithdrawal effects in morphine-dependent mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 6. 2014-01-21. PMID:23303065. inhibition of the endocannabinoid catabolic enzymes, monoacylglycerol lipase (magl) or fatty acid amide hydrolase (faah) attenuates naloxone-precipitated opioid withdrawal signs in mice via activation of cb1 receptors. 2014-01-21 2023-08-12 mouse
Oleg Sadovski, Justin W Hicks, Jun Parkes, Roger Raymond, José Nobrega, Sylvain Houle, Mariateresa Cipriano, Christopher J Fowler, Neil Vasdev, Alan A Wilso. Development and characterization of a promising fluorine-18 labelled radiopharmaceutical for in vivo imaging of fatty acid amide hydrolase. Bioorganic & medicinal chemistry. vol 21. issue 14. 2014-01-21. PMID:23712084. fatty acid amide hydrolase (faah), the enzyme responsible for terminating signaling by the endocannabinoid anandamide, plays an important role in the endocannabinoid system, and faah inhibitors are attractive drugs for pain, addiction, and neurological disorders. 2014-01-21 2023-08-12 human
V K Grolmusz, B Stenczer, T Fekete, G Szendei, A Patócs, K Rácz, P Reisman. Lack of association between C385A functional polymorphism of the fatty acid amide hydrolase gene and polycystic ovary syndrome. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 121. issue 6. 2014-01-17. PMID:23616186. fatty acid amide hydrolase is responsible for degradating anandamide, a key messenger of the endocannabinoid system. 2014-01-17 2023-08-12 human
N Benson, E Metelkin, O Demin, G L Li, D Nichols, P H van der Graa. A systems pharmacology perspective on the clinical development of Fatty Acid amide hydrolase inhibitors for pain. CPT: pharmacometrics & systems pharmacology. vol 3. 2014-01-16. PMID:24429592. the level of the endocannabinoid anandamide is controlled by fatty acid amide hydrolase (faah). 2014-01-16 2023-08-12 Not clear
Alline C Campos, Zaira Ortega, Javier Palazuelos, Manoela V Fogaça, Daniele C Aguiar, Javier Díaz-Alonso, Silvia Ortega-Gutiérrez, Henar Vázquez-Villa, Fabricio A Moreira, Manuel Guzmán, Ismael Galve-Roperh, Francisco S Guimarãe. The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system. The international journal of neuropsychopharmacology. vol 16. issue 6. 2014-01-15. PMID:23298518. moreover, antagonists of these two receptors or endocannabinoid depletion by fatty acid amide hydrolase overexpression prevented cbd-induced cell proliferation. 2014-01-15 2023-08-12 mouse
Daniela Wenzel, Michaela Matthey, Laura Bindila, Raissa Lerner, Beat Lutz, Andreas Zimmer, Bernd K Fleischman. Endocannabinoid anandamide mediates hypoxic pulmonary vasoconstriction. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 46. 2014-01-08. PMID:24167249. herein, we show that the endocannabinoid anandamide (aea) is a key mediator of hypoxic pulmonary vasoconstriction (hpv) via fatty acid amide hydrolase (faah)-dependent metabolites. 2014-01-08 2023-08-12 mouse
Heikki Käsnänen, Anna Minkkilä, Susanna Taupila, Jayendra Z Patel, Teija Parkkari, Maija Lahtela-Kakkonen, Susanna M Saario, Tapio Nevalainen, Antti Pos. 1,3,4-Oxadiazol-2-ones as fatty-acid amide hydrolase and monoacylglycerol lipase inhibitors: Synthesis, in vitro evaluation and insight into potency and selectivity determinants by molecular modelling. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 49. issue 3. 2014-01-07. PMID:23557840. inhibition of the key hydrolytic enzymes of the endocannabinoid system, fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), has been proposed as potential mode of action for various therapeutic applications. 2014-01-07 2023-08-12 Not clear
Christopher J Fowler, Andreas Josefsson, Lina Thors, Sui Chu Chung, Peter Hammarsten, Pernilla Wikström, Anders Berg. Tumour epithelial expression levels of endocannabinoid markers modulate the value of endoglin-positive vascular density as a prognostic marker in prostate cancer. Biochimica et biophysica acta. vol 1831. issue 10. 2013-12-03. PMID:23262399. fatty acid amide hydrolase (faah) is responsible for the hydrolysis of the endogenous cannabinoid (cb) receptor ligand anandamide. 2013-12-03 2023-08-12 Not clear
Christopher J Fowler, Andreas Josefsson, Lina Thors, Sui Chu Chung, Peter Hammarsten, Pernilla Wikström, Anders Berg. Tumour epithelial expression levels of endocannabinoid markers modulate the value of endoglin-positive vascular density as a prognostic marker in prostate cancer. Biochimica et biophysica acta. vol 1831. issue 10. 2013-12-03. PMID:23262399. scores for the angiogenesis markers endoglin and von willebrand factor (vwf), the endocannabinoid markers fatty acid amide hydrolase (faah) and cannabinoid cb1 receptors and the cell proliferation marker ki-67 were available in the database. 2013-12-03 2023-08-12 Not clear
Angela Holtfrerich, Walburga Hanekamp, Matthias Leh. (4-Phenoxyphenyl)tetrazolecarboxamides and related compounds as dual inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). European journal of medicinal chemistry. vol 63. 2013-11-27. PMID:23455058. inhibitors of the enzymes fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), the principle enzymes involved in the degradation of endogenous cannabinoids like anandamide and 2-arachidonoylglycerol, have potential utility in the treatment of several disorders including pain, inflammation and anxiety. 2013-11-27 2023-08-12 rat
Daniel de Luis, Rocio Aller, Olatz Izaola, Rosa Conde, Beatriz de la Fuente, Manuel Gonzalez Sagrad. Genetic variation in the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and their influence on weight loss and insulin resistance under a high monounsaturated fat hypocaloric diet. Journal of diabetes and its complications. vol 27. issue 3. 2013-11-25. PMID:23333123. genetic variation in the endocannabinoid degrading enzyme fatty acid amide hydrolase (faah) and their influence on weight loss and insulin resistance under a high monounsaturated fat hypocaloric diet. 2013-11-25 2023-08-12 Not clear