| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luciano R Vilela, Daniel C Medeiros, Gustavo H S Rezende, Antônio Carlos P de Oliveira, Marcio F D Moraes, Fabrício A Moreir. Effects of cannabinoids and endocannabinoid hydrolysis inhibition on pentylenetetrazole-induced seizure and electroencephalographic activity in rats. Epilepsy research. vol 104. issue 3. 2013-11-14. PMID:23352737. |
the animals received injections of win-55,212-2 (0.3-3 mg/kg, non-selective) or acea (1-4 mg/kg, cb1-selective), two synthetic cannabinoids, or urb-597 (0.3-3 mg/kg), an anandamide-hydrolysis inhibitor (faah enzyme inhibitor), followed by ptz. |
2013-11-14 |
2023-08-12 |
rat |
| Filippo Molica, Fabienne Burger, Aurélien Thomas, Christian Staub, Anne Tailleux, Bart Staels, Graziano Pelli, Andreas Zimmer, Benjamin Cravatt, Christian M Matter, Pal Pacher, Sabine Steffen. Endogenous cannabinoid receptor CB1 activation promotes vascular smooth-muscle cell proliferation and neointima formation. Journal of lipid research. vol 54. issue 5. 2013-11-04. PMID:23479425. |
here, we studied a potential activation of the endocannabinoid system and the effect of fa amide hydrolase (faah) deficiency, the major enzyme responsible for endocannabinoid anandamide degradation, in arterial injury. |
2013-11-04 |
2023-08-12 |
mouse |
| María Jesús Luque-Rojas, Pablo Galeano, Juan Suárez, Pedro Araos, Luis J Santín, Fernando Rodríguez de Fonseca, Eduardo Blanco Calv. Hyperactivity induced by the dopamine D2/D3 receptor agonist quinpirole is attenuated by inhibitors of endocannabinoid degradation in mice. The international journal of neuropsychopharmacology. vol 16. issue 3. 2013-10-31. PMID:22647577. |
we analysed the effects of inhibition of the two main endocannabinoid degradation enzymes: fatty acid amide hydrolase (faah), using inhibitor urb597 (1 mg/kg); monoacylglycerol lipase (magl), using inhibitor urb602 (10 mg/kg). |
2013-10-31 |
2023-08-12 |
mouse |
| Panayiotis Filis, Peter C Kind, Norah Spear. Implantation failure in mice with a disruption in Phospholipase C beta 1 gene: lack of embryonic attachment, aberrant steroid hormone signalling and defective endocannabinoid metabolism. Molecular human reproduction. vol 19. issue 5. 2013-10-30. PMID:23295235. |
ko implantation sites expressed markedly less fatty acid amide hydrolase and monoacylglycerol lipase, indicating that endocannabinoid metabolism was also affected. |
2013-10-30 |
2023-08-12 |
mouse |
| Tiziana Bisogno, Mauro Maccarron. Latest advances in the discovery of fatty acid amide hydrolase inhibitors. Expert opinion on drug discovery. vol 8. issue 5. 2013-10-25. PMID:23488865. |
fatty acid amide hydrolase (faah) is the major catabolic enzyme of the endocannabinoid n-arachidonoylethanolamine (anandamide) that, with different degrees of efficiency, also hydrolyzes other endogenous fatty acid ethanolamides. |
2013-10-25 |
2023-08-12 |
Not clear |
| Jianqin Zhuang, De-Ping Yang, Spyros P Nikas, Jianhong Zhao, Jianxin Guo, Alexandros Makriyanni. The interaction of fatty acid amide hydrolase (FAAH) inhibitors with an anandamide carrier protein using (19)F-NMR. The AAPS journal. vol 15. issue 2. 2013-10-22. PMID:23344792. |
the data suggest that interactions of faah inhibitors with albumin may provide added advantages for their ability to modulate endocannabinoid levels for a range of applications including analgesia, antiemesis, and neuroprotection. |
2013-10-22 |
2023-08-12 |
Not clear |
| Katarzyna Starowicz, Wioletta Makuch, Michal Korostynski, Natalia Malek, Michal Slezak, Magdalena Zychowska, Stefania Petrosino, Luciano De Petrocellis, Luigia Cristino, Barbara Przewlocka, Vincenzo Di Marz. Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism. PloS one. vol 8. issue 4. 2013-10-22. PMID:23573230. |
among those tested, the 200 µg/rat dose of urb597 was the only one that elevated the levels of the faah non-endocannabinoid and anti-inflammatory substrates, oleoylethanolamide (oea) and palmitoylethanolamide (pea), and of the endocannabinoid faah substrate, 2-arachidonoylglycerol, and fully inhibited thermal and tactile nociception, although in a manner blocked almost uniquely by trpv1 antagonism. |
2013-10-22 |
2023-08-12 |
rat |
| Sören V Siegmund, Alexandra Wojtalla, Monika Schlosser, Andreas Zimmer, Manfred V Singe. Fatty acid amide hydrolase but not monoacyl glycerol lipase controls cell death induced by the endocannabinoid 2-arachidonoyl glycerol in hepatic cell populations. Biochemical and biophysical research communications. vol 437. issue 1. 2013-10-01. PMID:23806692. |
fatty acid amide hydrolase but not monoacyl glycerol lipase controls cell death induced by the endocannabinoid 2-arachidonoyl glycerol in hepatic cell populations. |
2013-10-01 |
2023-08-12 |
mouse |
| Leigh V Panlilio, Zuzana Justinova, Steven R Goldber. Inhibition of FAAH and activation of PPAR: new approaches to the treatment of cognitive dysfunction and drug addiction. Pharmacology & therapeutics. vol 138. issue 1. 2013-08-26. PMID:23333350. |
inhibitors of fatty acid amide hydrolase (faah) prevent the breakdown of endogenous ligands for cannabinoid receptors and peroxisome proliferator-activated receptors (ppar), prolonging and enhancing the effects of these ligands when they are naturally released. |
2013-08-26 |
2023-08-12 |
Not clear |
| Leigh V Panlilio, Zuzana Justinova, Steven R Goldber. Inhibition of FAAH and activation of PPAR: new approaches to the treatment of cognitive dysfunction and drug addiction. Pharmacology & therapeutics. vol 138. issue 1. 2013-08-26. PMID:23333350. |
these studies show that faah inhibitors can produce potentially therapeutic effects, some through cannabinoid receptors and some through ppar. |
2013-08-26 |
2023-08-12 |
Not clear |
| Laura E Wise, Kelly A Long, Rehab A Abdullah, Jonathan Z Long, Benjamin F Cravatt, Aron H Lichtma. Dual fatty acid amide hydrolase and monoacylglycerol lipase blockade produces THC-like Morris water maze deficits in mice. ACS chemical neuroscience. vol 3. issue 5. 2013-08-20. PMID:22860205. |
n-arachidonoylethanolamine (anandamide; aea) and 2-arachidonoylglycerol (2-ag) are endogenous cannabinoids that are predominantly metabolized by the respective enzymes fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl). |
2013-08-20 |
2023-08-12 |
mouse |
| Tatsuya Tai, Kazuhito Tsuboi, Toru Uyama, Kim Masuda, Benjamin F Cravatt, Hitoshi Houchi, Natsuo Ued. Endogenous molecules stimulating N-acylethanolamine-hydrolyzing acid amidase (NAAA). ACS chemical neuroscience. vol 3. issue 5. 2013-08-20. PMID:22860206. |
fatty acid amide hydrolase (faah) plays the central role in the degradation of bioactive n-acylethanolamines such as the endocannabinoid arachidonoylethanolamide (anandamide) in brain and peripheral tissues. |
2013-08-20 |
2023-08-12 |
mouse |
| Joost Wiskerke, Cristina Irimia, Benjamin F Cravatt, Taco J De Vries, Anton N M Schoffelmeer, Tommy Pattij, Loren H Parson. Characterization of the effects of reuptake and hydrolysis inhibition on interstitial endocannabinoid levels in the brain: an in vivo microdialysis study. ACS chemical neuroscience. vol 3. issue 5. 2013-08-20. PMID:22860210. |
compounds targeting the putative endocannabinoid transporter and hydrolytic enzymes (faah and magl) were compared. |
2013-08-20 |
2023-08-12 |
mouse |
| Micah J Niphakis, Douglas S Johnson, T Eric Ballard, Cory Stiff, Benjamin F Cravat. O-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase inhibitors. ACS chemical neuroscience. vol 3. issue 5. 2013-08-20. PMID:22860211. |
the two major endocannabinoid transmitters, anandamide (aea) and 2-arachidonoylglycerol (2-ag), are degraded by distinct enzymes in the nervous system, fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), respectively. |
2013-08-20 |
2023-08-12 |
Not clear |
| Micah J Niphakis, Douglas S Johnson, T Eric Ballard, Cory Stiff, Benjamin F Cravat. O-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase inhibitors. ACS chemical neuroscience. vol 3. issue 5. 2013-08-20. PMID:22860211. |
faah and magl inhibitors cause elevations in brain aea and 2-ag levels, respectively, and reduce pain, anxiety, and depression in rodents without causing the full spectrum of psychotropic behavioral effects observed with direct cannabinoid receptor-1 (cb1) agonists. |
2013-08-20 |
2023-08-12 |
Not clear |
| Micah J Niphakis, Douglas S Johnson, T Eric Ballard, Cory Stiff, Benjamin F Cravat. O-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase inhibitors. ACS chemical neuroscience. vol 3. issue 5. 2013-08-20. PMID:22860211. |
these findings have inspired the development of several classes of endocannabinoid hydrolase inhibitors, most of which have been optimized to show specificity for either faah or magl or, in certain cases, equipotent activity for both enzymes. |
2013-08-20 |
2023-08-12 |
Not clear |
| Eric Murillo-Rodríguez, Marcela Palomero-Rivero, Diana Millán-Aldaco, Vincenzo Di Marz. The administration of endocannabinoid uptake inhibitors OMDM-2 or VDM-11 promotes sleep and decreases extracellular levels of dopamine in rats. Physiology & behavior. vol 109. 2013-08-12. PMID:23238438. |
the family of the endocannabinoid system comprises endogenous lipids (such as anandamide [ana]), receptors (cb(1)/cb(2) cannabinoid receptors), metabolic enzymes (fatty acid amide hydrolase [faah]) and a putative membrane transporter (anandamide membrane transporter [amt]). |
2013-08-12 |
2023-08-12 |
rat |
| Israel Matos, Allisson Freire Bento, Rodrigo Marcon, Rafaela Franco Claudino, João B Calixt. Preventive and therapeutic oral administration of the pentacyclic triterpene α,β-amyrin ameliorates dextran sulfate sodium-induced colitis in mice: the relevance of cannabinoid system. Molecular immunology. vol 54. issue 3-4. 2013-08-12. PMID:23454360. |
besides, our data demonstrated that mrna expression for both the endocannabinoid hydrolase monoglyceride lipase 1 (mgl1) and fatty acid amide hydrolase (faah) were significantly reduced in the colon of α,β-amyrin-treated mice. |
2013-08-12 |
2023-08-12 |
mouse |
| Claudius Füllhase, Andrea Russo, Fabio Castiglione, Fabio Benigni, Lysanne Campeau, Francesco Montorsi, Christian Gratzke, Arianna Bettiga, Christian Stief, Karl-Erik Andersson, Petter Hedlun. Spinal cord FAAH in normal micturition control and bladder overactivity in awake rats. The Journal of urology. vol 189. issue 6. 2013-07-17. PMID:23219540. |
we assessed whether spinal inhibition of the cannabinoid degrading enzyme faah would have urodynamic effects in normal rats and rats with bladder overactivity induced by partial urethral obstruction or prostaglandin e2. |
2013-07-17 |
2023-08-12 |
rat |
| Claudius Füllhase, Andrea Russo, Fabio Castiglione, Fabio Benigni, Lysanne Campeau, Francesco Montorsi, Christian Gratzke, Arianna Bettiga, Christian Stief, Karl-Erik Andersson, Petter Hedlun. Spinal cord FAAH in normal micturition control and bladder overactivity in awake rats. The Journal of urology. vol 189. issue 6. 2013-07-17. PMID:23219540. |
we also determined the expression of faah, and the cannabinoid receptors cb1 and cb2 in the sacral spinal cord. |
2013-07-17 |
2023-08-12 |
rat |