All Relations between fatty acid amide hydrolase and cannabinoids

Publication Sentence Publish Date Extraction Date Species
Hongfeng Den. Recent advances in the discovery and evaluation of fatty acid amide hydrolase inhibitors. Expert opinion on drug discovery. vol 5. issue 10. 2012-10-02. PMID:22823990. the identification of fatty acid amide hydrolase (faah), a key enzyme responsible for the degradation of endocannabinoids, has brought in tremendous opportunities in that inhibition of faah leads to local elevation of endocannabinoids under certain stimuli, thus, avoiding the side effects from global activation of cannabinoid receptors by exogenous cannabimimetic compounds. 2012-10-02 2023-08-12 Not clear
Jamie J Hopps, William R Dunn, Michael D Randal. Enhanced vasorelaxant effects of the endocannabinoid-like mediator, oleamide, in hypertension. European journal of pharmacology. vol 684. issue 1-3. 2012-09-10. PMID:22465182. the augmented responses to oleamide in shr arteries were unaffected by either inhibition of nitric oxide synthase (300 μm l-name) or fatty acid amide hydrolase (1 μm urb597) and independent of cannabinoid cb(1) receptors or the endothelium. 2012-09-10 2023-08-12 rat
Ryan K Butler, Gemma K Ford, Michelle Hogan, Michelle Roche, Karen M Doyle, John P Kelly, David A Kendall, Victoria Chapman, David P Fin. Fear-induced suppression of nociceptive behaviour and activation of Akt signalling in the rat periaqueductal grey: role of fatty acid amide hydrolase. Journal of psychopharmacology (Oxford, England). vol 26. issue 1. 2012-08-21. PMID:21926424. we investigated the effects of the fatty acid amide hydrolase (faah) inhibitor urb597, which inhibits the catabolism of the endocannabinoid anandamide and related n-acylethanolamines, on expression of fca and fear and pain related behaviour per se in rats. 2012-08-21 2023-08-12 rat
Oscar Sasso, Rosalia Bertorelli, Tiziano Bandiera, Rita Scarpelli, Giampiero Colombano, Andrea Armirotti, Guillermo Moreno-Sanz, Angelo Reggiani, Daniele Piomell. Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions. Pharmacological research. vol 65. issue 5. 2012-08-09. PMID:22420940. fatty-acid amide hydrolase (faah) catalyzes the intracellular hydrolysis of the endocannabinoid anandamide and other bioactive lipid amides. 2012-08-09 2023-08-12 mouse
Gemma K Ford, Siobhan Kieran, Kenneth Dolan, Brendan Harhen, David P Fin. A role for the ventral hippocampal endocannabinoid system in fear-conditioned analgesia and fear responding in the presence of nociceptive tone in rats. Pain. vol 152. issue 11. 2012-07-31. PMID:21864979. these data suggest an important role for the endocannabinoid system in the vhip in fca, whereby levels of 2-arachidonoylglycerol and the faah substrates palmitoylethanolamide and anandamide are increased in rats expressing fca, and pharmacological inhibition of faah in the vhip enhances this form of endogenous analgesia via a cb(1) receptor-dependent mechanism. 2012-07-31 2023-08-12 rat
Maria Scherma, Zuzana Justinová, Claudio Zanettini, Leigh V Panlilio, Paola Mascia, Paola Fadda, Walter Fratta, Alexandros Makriyannis, Subramanian K Vadivel, Islam Gamaleddin, Bernard Le Foll, Steven R Goldber. The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine-induced dopamine elevations in the nucleus accumbens shell in rats. British journal of pharmacology. vol 165. issue 8. 2012-07-27. PMID:21557729. fatty acid amide hydrolase inhibitors block the degradation (and thereby magnify and prolong the actions) of the endocannabinoid anandamide (aea), and also the non-cannabinoid fatty acid ethanolamides oleoylethanolamide (oea) and palmitoylethanolamide (pea). 2012-07-27 2023-08-12 rat
N P Bowles, M N Hill, S M Bhagat, I N Karatsoreos, C J Hillard, B S McEwe. Chronic, noninvasive glucocorticoid administration suppresses limbic endocannabinoid signaling in mice. Neuroscience. vol 204. 2012-07-23. PMID:21939741. more precisely, we explored the effects of a 4-week exposure to cort dissolved in the drinking water of mice (100 μg/ml) and measured cannabinoid cb(1) receptor binding, endocannabinoid content, activity of the endocannabinoid degrading enzyme fatty acid amide hydrolase (faah), and mrna expression of both the cb(1) receptor and faah in both the hippocampus and amygdala. 2012-07-23 2023-08-12 mouse
C J Hillard, K M Weinlander, K L Stuh. Contributions of endocannabinoid signaling to psychiatric disorders in humans: genetic and biochemical evidence. Neuroscience. vol 204. 2012-07-23. PMID:22123166. genetic polymorphisms in the human genes for two important proteins of the endocannabinoid signaling system, the cb1 cannabinoid receptor (cb1r) and fatty acid amide hydrolase (faah), have been explored in the context of normal and pathological conditions. 2012-07-23 2023-08-12 human
C J Hillard, K M Weinlander, K L Stuh. Contributions of endocannabinoid signaling to psychiatric disorders in humans: genetic and biochemical evidence. Neuroscience. vol 204. 2012-07-23. PMID:22123166. in the case of the gene for faah, the mechanistic relationships among the common genetic polymorphism, the expression of the faah protein, and its likely impact on endocannabinoid signaling are understood. 2012-07-23 2023-08-12 human
Michael Camilleri, David A Katzk. Irritable bowel syndrome: methods, mechanisms, and pathophysiology. Genetic epidemiology and pharmacogenetics in irritable bowel syndrome. American journal of physiology. Gastrointestinal and liver physiology. vol 302. issue 10. 2012-07-20. PMID:22403795. the second objective is to review pharmacogenetics in ibs, with the focus on cytochrome p-450 metabolism of drugs used in ibs, modulation of motor and sensory responses to serotonergic agents based on the 5-hydroxytryptamine (5-ht) transporter-linked polymorphic region (5-httlpr) and 5-ht(3) genetic variants, responses to a nonselective cannabinoid agonist (dronabinol) based on cannabinoid receptor (cnr1) and fatty acid amide hydrolase (faah) variation, and responses to a bile acid (sodium chenodeoxycholate) and bile acid binding (colesevelam) based on klothoβ (klb) and fibroblast growth factor receptor 4 (fgfr4) variation. 2012-07-20 2023-08-12 Not clear
Udeni Yapa, Jeffery J Prusakiewicz, Ann D Wrightstone, Lori J Christine, Joe Palandra, Elizabeth Groeber, Arthur J Wittwe. High-performance liquid chromatography-tandem mass spectrometry assay of fatty acid amide hydrolase (FAAH) in blood: FAAH inhibition as clinical biomarker. Analytical biochemistry. vol 421. issue 2. 2012-06-19. PMID:22107886. fatty acid amide hydrolase (faah) is one of the main enzymes responsible for the degradation of the endocannabinoid anandamide (n-arachidonoylethanolamine, aea). 2012-06-19 2023-08-12 human
Christin Rakers, Alexander A Zoerner, Stefan Engeli, Sandor Batkai, Jens Jordan, Dimitrios Tsika. Stable isotope liquid chromatography-tandem mass spectrometry assay for fatty acid amide hydrolase activity. Analytical biochemistry. vol 421. issue 2. 2012-06-19. PMID:22146559. fatty acid amide hydrolase (faah) is the main enzyme responsible for the hydrolysis of the endocannabinoid anandamide (arachidonoyl ethanolamide, aea) to arachidonic acid (aa) and ethanolamine (ea). 2012-06-19 2023-08-12 human
Bernard P Roques, Marie-Claude Fournié-Zaluski, Michel Wur. Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain. Nature reviews. Drug discovery. vol 11. issue 4. 2012-06-05. PMID:22460123. stemming from the same pharmacological concept, fatty acid amide hydrolase (faah) inhibitors have also been found to have analgesic effects in pain models by preventing the breakdown of endogenous cannabinoids. 2012-06-05 2023-08-12 Not clear
Marion Feledziak, Didier M Lambert, Jacqueline Marchand-Brynaert, Giulio G Mucciol. Inhibitors of the endocannabinoid-degrading enzymes, or how to increase endocannabinoid's activity by preventing their hydrolysis. Recent patents on CNS drug discovery. vol 7. issue 1. 2012-06-04. PMID:22280341. to date four enzymes - fatty acid amide hydrolase (faah), n-acylethanolamine-hydrolyzing acid amidase (naaa), monoacylglycerol lipase (magl), α/β-hydrolase domain 6 (abhd6) - were shown to control endocannabinoid levels in tissues or in intact cells. 2012-06-04 2023-08-12 Not clear
Inés Díaz-Laviad. The endocannabinoid system in prostate cancer. Nature reviews. Urology. vol 8. issue 10. 2012-05-31. PMID:21912423. normal prostate tissue expresses several constituents of the endocannabinoid system including the cb(1) receptor, receptors belonging to the transient receptor potential family and fatty acid amide hydrolase, a hydrolyzing enzyme, all of which have been localized in the glandular epithelia. 2012-05-31 2023-08-12 Not clear
Valentina Pomatto, Francesco Palermo, Gilberto Mosconi, Erika Cottone, Paolo Cocci, Massimo Nabissi, Luca Borgio, Alberta M Polzonetti-Magni, Maria Fosca Franzon. Xenoestrogens elicit a modulation of endocannabinoid system and estrogen receptors in 4NP treated goldfish, Carassius auratus. General and comparative endocrinology. vol 174. issue 1. 2012-04-25. PMID:21855545. first of all the estrogenic effects induced by 4np were demonstrated by a dose-dependent increase of plasma levels and gene expression of the biomarker vitellogenin, then changes in cannabinoid receptors and anandamide degradative enzyme, the fatty acid amide hydrolase (faah), were analysed by means of real time pcr. 2012-04-25 2023-08-12 zebrafish
Anna L Bowman, Alexandros Makriyanni. Approximating protein flexibility through dynamic pharmacophore models: application to fatty acid amide hydrolase (FAAH). Journal of chemical information and modeling. vol 51. issue 12. 2012-04-17. PMID:22098169. the approach was applied to fatty acid amide hydrolase (faah), a key deactivating enzyme in the endocannabinoid system. 2012-04-17 2023-08-12 Not clear
Andrea Cippitelli, Giuseppe Astarita, Andrea Duranti, Giovanni Caprioli, Massimo Ubaldi, Serena Stopponi, Marsida Kallupi, Gianni Sagratini, Fernando Rodrìguez de Fonseca, Daniele Piomelli, Roberto Ciccociopp. Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition. PloS one. vol 6. issue 11. 2012-04-09. PMID:22140525. endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of faah inhibition. 2012-04-09 2023-08-12 rat
Siamak Shahidi, Parisa Hasanei. Behavioral effects of fatty acid amide hydrolase inhibition on morphine withdrawal symptoms. Brain research bulletin. vol 86. issue 1-2. 2012-04-04. PMID:21763761. the present study examined whether augmentation of the endocannabinoid system by inhibition of fatty acid amide hydrolase could suppress the morphine withdrawal syndrome in morphine-addicted rats. 2012-04-04 2023-08-12 rat
Shuqi Xie, Abdolsamad Borazjani, M Jason Hatfield, Carol C Edwards, Philip M Potter, Matthew K Ros. Inactivation of lipid glyceryl ester metabolism in human THP1 monocytes/macrophages by activated organophosphorus insecticides: role of carboxylesterases 1 and 2. Chemical research in toxicology. vol 23. issue 12. 2012-03-20. PMID:21049984. collectively, the results suggest that in addition to magl and fatty-acid amide hydrolase (faah), which have both been documented to terminate endocannabinoid signaling, ces may also have a role. 2012-03-20 2023-08-12 human