| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Divya Ramesh, Gracious R Ross, Joel E Schlosburg, Robert A Owens, Rehab A Abdullah, Steven G Kinsey, Jonathan Z Long, Daniel K Nomura, Laura J Sim-Selley, Benjamin F Cravatt, Hamid I Akbarali, Aron H Lichtma. Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated opioid withdrawal symptoms in mice. The Journal of pharmacology and experimental therapeutics. vol 339. issue 1. 2011-11-22. PMID:21719468. |
the endogenous cannabinoids, n-arachidonoylethanolamine (anandamide; aea) and 2-arachidonylglycerol (2-ag), activate both cannabinoid receptors but are rapidly metabolized by fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), respectively. |
2011-11-22 |
2023-08-12 |
mouse |
| Jemma C Cable, Garry D Tan, Stephen P H Alexander, Saoirse E O'Sulliva. The activity of the endocannabinoid metabolising enzyme fatty acid amide hydrolase in subcutaneous adipocytes correlates with BMI in metabolically healthy humans. Lipids in health and disease. vol 10. 2011-11-22. PMID:21813022. |
the activity of the endocannabinoid metabolising enzyme fatty acid amide hydrolase in subcutaneous adipocytes correlates with bmi in metabolically healthy humans. |
2011-11-22 |
2023-08-12 |
human |
| Claudio Zanettini, Leigh V Panlilio, Mano Alicki, Steven R Goldberg, József Haller, Sevil Yasa. Effects of endocannabinoid system modulation on cognitive and emotional behavior. Frontiers in behavioral neuroscience. vol 5. 2011-11-10. PMID:21949506. |
in addition, studies are reviewed that involved genetic disruption of cannabinoid receptors or genetic or pharmacological manipulation of the endocannabinoid-degrading enzyme, fatty acid amide hydrolase (faah). |
2011-11-10 |
2023-08-12 |
Not clear |
| William R Marrs, Eric A Horne, Silvia Ortega-Gutierrez, Jose Antonio Cisneros, Cong Xu, Yi Hsing Lin, Giulio G Muccioli, Maria L Lopez-Rodriguez, Nephi Stell. Dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons. The Journal of biological chemistry. vol 286. issue 33. 2011-10-19. PMID:21665953. |
dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons. |
2011-10-19 |
2023-08-12 |
Not clear |
| Sudhir N Umathe, Shyamshree S S Manna, Nishant S Jai. Involvement of endocannabinoids in antidepressant and anti-compulsive effect of fluoxetine in mice. Behavioural brain research. vol 223. issue 1. 2011-10-18. PMID:21549765. |
the results revealed that intracerebroventricular injections of endocannabinoid analogues, anandamide, a cb(1) agonist (aea: 1-20 μg/mouse); am404, an anandamide transport inhibitor (0.1-10 μg/mouse); and urb597, a fatty acid amide hydrolase inhibitor (0.05-10 μg/mouse) produced antidepressant-like effect dose-dependently, whereas influenced the mbb in a biphasic manner (produced a u-shaped dose-response curve). |
2011-10-18 |
2023-08-12 |
mouse |
| D A de Luis, M González Sagrado, R Aller, O Izaola, R Cond. Relation of C358A polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) with obesity and insulin resistance. Nutricion hospitalaria. vol 25. issue 6. 2011-09-01. PMID:21519771. |
relation of c358a polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (faah) with obesity and insulin resistance. |
2011-09-01 |
2023-08-12 |
Not clear |
| Kay Ahn, Sarah E Smith, Marya B Liimatta, David Beidler, Nalini Sadagopan, David T Dudley, Tim Young, Paul Wren, Yanhua Zhang, Steven Swaney, Keri Van Becelaere, Jacqueline L Blankman, Daniel K Nomura, Shobha N Bhattachar, Cory Stiff, Tyzoon K Nomanbhoy, Eranthie Weerapana, Douglas S Johnson, Benjamin F Cravat. Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain. The Journal of pharmacology and experimental therapeutics. vol 338. issue 1. 2011-08-30. PMID:21505060. |
the endogenous cannabinoid (endocannabinoid) anandamide is principally degraded by the integral membrane enzyme fatty acid amide hydrolase (faah). |
2011-08-30 |
2023-08-12 |
mouse |
| Kay Ahn, Sarah E Smith, Marya B Liimatta, David Beidler, Nalini Sadagopan, David T Dudley, Tim Young, Paul Wren, Yanhua Zhang, Steven Swaney, Keri Van Becelaere, Jacqueline L Blankman, Daniel K Nomura, Shobha N Bhattachar, Cory Stiff, Tyzoon K Nomanbhoy, Eranthie Weerapana, Douglas S Johnson, Benjamin F Cravat. Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain. The Journal of pharmacology and experimental therapeutics. vol 338. issue 1. 2011-08-30. PMID:21505060. |
pharmacological blockade of faah has emerged as a potentially attractive strategy for augmenting endocannabinoid signaling and retaining the beneficial effects of cannabinoid receptor activation, while avoiding the undesirable side effects, such as weight gain and impairments in cognition and motor control, observed with direct cannabinoid receptor 1 agonists. |
2011-08-30 |
2023-08-12 |
mouse |
| Niklas Schuelert, Michael P Johnson, Jennifer L Oskins, Karandeep Jassal, Mark G Chambers, Jason J McDougal. Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis. Pain. vol 152. issue 5. 2011-08-23. PMID:21185649. |
the present study examined whether enhancement of endogenous cannabinoid levels by administration of the fatty acid amide hydrolase inhibitor urb597 could modulate joint nociception in 2 rodent models of osteoarthritis (oa). |
2011-08-23 |
2023-08-12 |
rat |
| Daniel K Nomura, John E Casid. Activity-based protein profiling of organophosphorus and thiocarbamate pesticides reveals multiple serine hydrolase targets in mouse brain. Journal of agricultural and food chemistry. vol 59. issue 7. 2011-08-17. PMID:21341672. |
among the secondary targets identified, enzymes involved in the degradation of endocannabinoid signaling lipids, monoacylglycerol lipase, and fatty acid amide hydrolase were inhibited by several op and tc pesticides. |
2011-08-17 |
2023-08-12 |
mouse |
| Daniela Hauer, Patrizia Ratano, Maria Morena, Sergio Scaccianoce, Isabel Briegel, Maura Palmery, Vincenzo Cuomo, Benno Roozendaal, Gustav Schelling, Patrizia Campolong. Propofol enhances memory formation via an interaction with the endocannabinoid system. Anesthesiology. vol 114. issue 6. 2011-08-09. PMID:21532463. |
these effects might be mediated by propofol's inhibitory action on fatty acid amide hydrolase, the enzyme that degrades the endocannabinoid anandamide. |
2011-08-09 |
2023-08-12 |
Not clear |
| Vinogran Naidoo, Spyros P Nikas, David A Karanian, Jeannie Hwang, Jianhong Zhao, JodiAnne T Wood, Shakiru O Alapafuja, Subramanian K Vadivel, David Butler, Alexandros Makriyannis, Ben A Bah. A new generation fatty acid amide hydrolase inhibitor protects against kainate-induced excitotoxicity. Journal of molecular neuroscience : MN. vol 43. issue 3. 2011-07-21. PMID:21069475. |
to modulate the endocannabinoid response during events of excitotoxicity in vitro and in vivo, we utilized a new generation compound (am5206) that selectively inhibits the aea deactivating enzyme fatty acid amide hydrolase (faah). |
2011-07-21 |
2023-08-12 |
rat |
| Eva María Marco, Cinzia Rapino, Antonio Caprioli, Franco Borsini, Mauro Maccarrone, Giovanni Laviol. Social encounter with a novel partner in adolescent rats: activation of the central endocannabinoid system. Behavioural brain research. vol 220. issue 1. 2011-07-15. PMID:21295077. |
changes in aea levels appeared to be region-specific, since no changes were observed in the other brain regions analysed, neither were they observed in the activity of the aea-hydrolase (faah) nor in the content of the other major endocannabinoid 2-arachidonylglycerol. |
2011-07-15 |
2023-08-12 |
human |
| Xiaoshan Min, Stephen T Thibault, Amy C Porter, Darin J Gustin, Timothy J Carlson, Haoda Xu, Michelle Lindstrom, Guifen Xu, Craig Uyeda, Zhihua Ma, Yihong Li, Frank Kayser, Nigel P C Walker, Zhulun Wan. Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH). Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 18. 2011-07-15. PMID:21502526. |
fatty acid amide hydrolase (faah), an amidase-signature family member, is an integral membrane enzyme that degrades lipid amides including the endogenous cannabinoid anandamide and the sleep-inducing molecule oleamide. |
2011-07-15 |
2023-08-12 |
Not clear |
| Daniel Antonio de Luis, Manuel Gonzalez Sagrado, Rocio Aller, Olatz Izaola, Rosa Cond. Effects of C358A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase on weight loss after a hypocaloric diet. Metabolism: clinical and experimental. vol 60. issue 5. 2011-07-11. PMID:20716455. |
effects of c358a missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase on weight loss after a hypocaloric diet. |
2011-07-11 |
2023-08-12 |
Not clear |
| Paola Mascia, Marco Pistis, Zuzana Justinova, Leigh V Panlilio, Antonio Luchicchi, Salvatore Lecca, Maria Scherma, Walter Fratta, Paola Fadda, Chanel Barnes, Godfrey H Redhi, Sevil Yasar, Bernard Le Foll, Gianluigi Tanda, Daniele Piomelli, Steven R Goldber. Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors. Biological psychiatry. vol 69. issue 7. 2011-07-01. PMID:20801430. |
inhibition of faah increases levels of several endogenous substances in the brain, including the endocannabinoid anandamide and the noncannabinoid fatty acid ethanolamides oleoylethanolamide (oea) and palmitoylethanolamide, which are ligands for alpha-type peroxisome proliferator-activated nuclear receptors (ppar-α). |
2011-07-01 |
2023-08-12 |
rat |
| Nicole M Tsutahara, Yoshie S Weems, J Alejandro Arreguin-Arevalo, Torrance M Nett, Magen E LaPorte, Janelle Uchida, Janelle Pang, Tonya McBride, Ronald D Randel, Charles W Weem. Effects of endocannabinoid 1 and 2 (CB1; CB2) receptor agonists on luteal weight, circulating progesterone, luteal mRNA for luteinizing hormone (LH) receptors, and luteal unoccupied and occupied receptors for LH in vivo in ewes. Prostaglandins & other lipid mediators. vol 94. issue 1-2. 2011-06-28. PMID:21109016. |
cannabinoid (cb) type 1 (cb1) or type 2 (cb2) receptor agonists and an inhibitor of the enzyme fatty acid amide hydrolase, which catabolizes endocannabinoids, decreased luteal progesterone, prostaglandin e (pge), and prostaglandin f(2α) (pgf(2α)) secretion by the bovine corpus luteum in vitro by 30 percent. |
2011-06-28 |
2023-08-12 |
cattle |
| Raquel Taléns-Visconti, Irene Sanchez-Vera, Jelena Kostic, Maria Amparo Perez-Arago, Slaven Erceg, Miodrag Stojkovic, Consuelo Guerr. Neural differentiation from human embryonic stem cells as a tool to study early brain development and the neuroteratogenic effects of ethanol. Stem cells and development. vol 20. issue 2. 2011-06-24. PMID:20491543. |
we further demonstrate, for the first time, that human nps express the endocannabinoid receptors (cb1 and cb2) and the enzymes involved in endocannabinoids synthesis (nape-pld) and degradation (faah). |
2011-06-24 |
2023-08-12 |
human |
| D Matthew Walentiny, Thomas F Gamage, Jonathan A Warner, Thanh K Nguyen, Darren B Grainger, Jenny L Wiley, Robert E Van. The endogenous cannabinoid anandamide shares discriminative stimulus effects with ∆(9)-tetrahydrocannabinol in fatty acid amide hydrolase knockout mice. European journal of pharmacology. vol 656. issue 1-3. 2011-06-13. PMID:21300050. |
the endogenous cannabinoid anandamide shares discriminative stimulus effects with ∆(9)-tetrahydrocannabinol in fatty acid amide hydrolase knockout mice. |
2011-06-13 |
2023-08-12 |
mouse |
| Alan A Wilson, Armando Garcia, Jun Parkes, Sylvain Houle, Junchao Tong, Neil Vasde. [11C]CURB: Evaluation of a novel radiotracer for imaging fatty acid amide hydrolase by positron emission tomography. Nuclear medicine and biology. vol 38. issue 2. 2011-05-25. PMID:21315280. |
fatty acid amide hydrolase (faah) is the enzyme responsible for metabolising the endogenous cannabinoid, anandamide, and thus represents an important target for molecular imaging. |
2011-05-25 |
2023-08-12 |
rat |