| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francesca Intranuovo, Leonardo Brunetti, Pietro DelRe, Giuseppe Felice Mangiatordi, Angela Stefanachi, Antonio Laghezza, Mauro Niso, Francesco Leonetti, Fulvio Loiodice, Alessia Ligresti, Magdalena Kostrzewa, Jose Brea, Maria Isabel Loza, Eddy Sotelo, Michele Saviano, Nicola Antonio Colabufo, Chiara Riganti, Carmen Abate, Marialessandra Contin. Development of Journal of medicinal chemistry. 2022-12-21. PMID:36542836. |
fatty acid amide hydrolase (faah) is an enzyme responsible for the degradation of the main endocannabinoid anandamide; thus, the simultaneous cb2r activation and faah inhibition may be a synergistic anti-inflammatory strategy. |
2022-12-21 |
2023-08-14 |
Not clear |
| Mariarosaria Cammarota, Francesca Ferlenghi, Federica Vacondio, Fabrizio Vincenzi, Katia Varani, Annalida Bedini, Silvia Rivara, Marco Mor, Francesca Bosci. Combined targeting of fatty acid amide hydrolase (FAAH) and melatonin receptors promotes neuroprotection and stimulates inflammation resolution in rats. British journal of pharmacology. 2022-12-16. PMID:36526591. |
enhancing the endocannabinoid (ec) tone by inhibiting the catabolic enzyme faah or stimulating melatonin receptors have therapeutic potential to treat neuropathological states in which neuroinflammation plays a central role. |
2022-12-16 |
2023-08-14 |
rat |
| Mariangela Pucci, Claudio D'Addario, Emanuela Micioni Di Bonaventura, Francesca Mercante, Eugenia Annunzi, Federico Fanti, Manuel Sergi, Luca Botticelli, Giacomo Einaudi, Carlo Cifani, Maria Vittoria Micioni Di Bonaventur. Endocannabinoid System Regulation in Female Rats with Recurrent Episodes of Binge Eating. International journal of molecular sciences. vol 23. issue 23. 2022-12-11. PMID:36499556. |
we detected, in rats showing the be behavior, an up-regulated gene expression of cannabinoid type-1 receptor (cb1), sn-1-specific diacylglycerol lipase, as well as fatty acid amide hydrolase ( |
2022-12-11 |
2023-08-14 |
rat |
| Meipeng Zhu, Qian Guo, Honglei Kang, Renpeng Peng, Yimin Dong, Yayun Zhang, Sibo Wang, Haiyang Liu, Hongjian Zhao, Zijian Dong, Kehan Song, Shimeng Xu, Pengju Wang, Liangxi Chen, Jian Liu, Feng L. Inhibition of FAAH suppresses RANKL-induced osteoclastogenesis and attenuates ovariectomy-induced bone loss partially through repressing the IL17 pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 1. 2022-12-05. PMID:36468880. |
fatty amide hydrolase (faah) is a key degradation enzyme of the endocannabinoid system, mainly responsible for the hydrolysis of arachidonic acid ethanolamine (aea). |
2022-12-05 |
2023-08-14 |
mouse |
| Alessandro Papa, Silvia Pasquini, Francesca Galvani, Mariarosaria Cammarota, Chiara Contri, Gabriele Carullo, Sandra Gemma, Anna Ramunno, Stefania Lamponi, Beatrice Gorelli, Simona Saponara, Katia Varani, Marco Mor, Giuseppe Campiani, Francesca Boscia, Fabrizio Vincenzi, Alessio Lodola, Stefania Butin. Development of potent and selective FAAH inhibitors with improved drug-like properties as potential tools to treat neuroinflammatory conditions. European journal of medicinal chemistry. vol 246. 2022-12-03. PMID:36462439. |
the neuroprotective performance against neuroinflammation of the endocannabinoid system (ecs) can be remarkably improved by indirect stimulation mediated by the pharmacological inhibition of the key ecs catabolic enzyme fatty acid amide hydrolase (faah). |
2022-12-03 |
2023-08-14 |
mouse |
| Jamie L Myers, Hui Xia, Manuel Y Caballero, Sandra Valtier, G Jilani Chaudr. A Military Community Cohort Study Reveals Single Nucleotide Polymorphisms in Inflammation Mediator Genes That Associate With Type 2 Diabetes. Military medicine. 2022-11-24. PMID:36420960. |
the snps analyzed in this work occur in nine different genes, comprising six interleukin (il) genes (il1a, il1b, il4, il6, il10, and il18), fatty acid amide hydrolase (faah) gene, and cannabinoid receptors 1 and 2 genes (cnr1, cnr2). |
2022-11-24 |
2023-08-14 |
human |
| Laura López-Gómez, Agata Szymaszkiewicz, Marta Zielińska, Raquel Abal. The Enteric Glia and Its Modulation by the Endocannabinoid System, a New Target for Cannabinoid-Based Nutraceuticals? Molecules (Basel, Switzerland). vol 27. issue 19. 2022-10-14. PMID:36235308. |
the endogenous cannabinoid system (ecs) includes endogenous classical cannabinoids (anandamide, 2-arachidonoylglycerol), cannabinoid-like ligands (oleoylethanolamide (oea) and palmitoylethanolamide (pea)), enzymes involved in their metabolism (faah, magl, cox-2) and classical (cb1 and cb2) and non-classical (trpv1, gpr55, ppar) receptors. |
2022-10-14 |
2023-08-14 |
Not clear |
| Ana Clara Casadoumecq, José Javier Fernández-Solari, Juan Carlos Elverdin, Pablo Alejandro Rodríguez, Claudia Ester Moh. The role of the endocannabinoid system in tooth eruption: An ex vivo study. Australian endodontic journal : the journal of the Australian Society of Endodontology Inc. 2022-10-13. PMID:36226979. |
messenger rna expression of components of the ecs as cannabinoid receptors (cbr1 and cbr2), and anandamide synthetizing (nape-pld) and degradation (faah) enzymes were measured by rt-pcr. |
2022-10-13 |
2023-08-14 |
Not clear |
| María Victoria Noya-Riobó, Constanza Ágata Miguel, Delia Beatriz Soriano, Pablo Rodolfo Brumovsky, Marcelo José Villar, María Florencia Corone. Changes in the expression of endocannabinoid system components in an experimental model of chemotherapy-induced peripheral neuropathic pain: Evaluation of sex-related differences. Experimental neurology. 2022-09-30. PMID:36179876. |
the mrna levels corresponding to cannabinoid receptors (cb1, cb2), cannabinoid-related receptors (gpr55, 5ht1a, trpv1) and to the main enzymes involved in the synthesis (dagl, dagl, nape-pld) and degradation (mgl, faah) of endocannabinoids were assessed in lumbar dorsal root ganglia (drgs) and spinal cord by using real time rt-pcr. |
2022-09-30 |
2023-08-14 |
rat |
| Victoria Woyach, Katherine Sherman, Cecilia J Hillard, Francis A Hopp, Quinn H Hogan, Caron Dea. Fatty acid amide hydrolase activity in the dorsal PAG attenuates neuropathic pain and associated dysautonomia. American journal of physiology. Regulatory, integrative and comparative physiology. 2022-09-26. PMID:36154489. |
inhibition of fatty acid amide hydrolase (faah) increases brain concentrations of the endocannabinoid n-arachidonoylethanolamine (aea) and reduces pain-related behaviors in neuropathic pain models. |
2022-09-26 |
2023-08-14 |
rat |
| Yangyang Zhu, Hao Zhang, Huawei Mao, Suqin Zhong, Yubing Huang, Sirong Chen, Kai Yan, Zhibin Zhao, Xiaohan Hao, Yue Zhang, Han Yao, Xiaowan Huang, Meimei Wang, Wenbin Zhang, Juan Li, Guangxun Meng, Xiaohua Qin, Zhiming Ye, Jiani Shen, Yang Song, Youcui Xu, Zhenyu Yang, Liansheng Wang, Yunjiao Zhang, Longping We. FAAH served a key membrane-anchoring and stabilizing role for NLRP3 protein independently of the endocannabinoid system. Cell death and differentiation. 2022-09-14. PMID:36104448. |
faah served a key membrane-anchoring and stabilizing role for nlrp3 protein independently of the endocannabinoid system. |
2022-09-14 |
2023-08-14 |
mouse |
| Yangyang Zhu, Hao Zhang, Huawei Mao, Suqin Zhong, Yubing Huang, Sirong Chen, Kai Yan, Zhibin Zhao, Xiaohan Hao, Yue Zhang, Han Yao, Xiaowan Huang, Meimei Wang, Wenbin Zhang, Juan Li, Guangxun Meng, Xiaohua Qin, Zhiming Ye, Jiani Shen, Yang Song, Youcui Xu, Zhenyu Yang, Liansheng Wang, Yunjiao Zhang, Longping We. FAAH served a key membrane-anchoring and stabilizing role for NLRP3 protein independently of the endocannabinoid system. Cell death and differentiation. 2022-09-14. PMID:36104448. |
here, we show that fatty acid amide hydrolase (faah), the key integral membrane enzyme in the endocannabinoid system, unexpectedly served the critical membrane-anchoring and stabilizing role for nlrp3. |
2022-09-14 |
2023-08-14 |
mouse |
| Kelsey Andreis, Jenna Billingsley, Kian Naimi Shirazi, Jim Wager-Miller, Clare Johnson, Heather Bradshaw, Alex Straike. Cannabinoid CB1 receptors regulate salivation. Scientific reports. vol 12. issue 1. 2022-08-19. PMID:35986066. |
we also found that fatty acid amide hydrolase (faah), the enzyme that metabolizes the endocannabinoid anandamide and related lipids, regulates salivation. |
2022-08-19 |
2023-08-14 |
mouse |
| Vikram Thakur, Mohammad Bashashati, Josue Enriquez, Munmun Chattopadhya. Inhibiting Fatty Acid Amide Hydrolase Ameliorates Enteropathy in Diabetic Mice: A Cannabinoid 1 Receptor Mediated Mechanism. Veterinary sciences. vol 9. issue 7. 2022-07-25. PMID:35878381. |
inhibiting fatty acid amide hydrolase ameliorates enteropathy in diabetic mice: a cannabinoid 1 receptor mediated mechanism. |
2022-07-25 |
2023-08-14 |
mouse |
| Vikram Thakur, Mohammad Bashashati, Josue Enriquez, Munmun Chattopadhya. Inhibiting Fatty Acid Amide Hydrolase Ameliorates Enteropathy in Diabetic Mice: A Cannabinoid 1 Receptor Mediated Mechanism. Veterinary sciences. vol 9. issue 7. 2022-07-25. PMID:35878381. |
cannabinoid 1 receptor antagonist, am251 blocked the effects of urb597, which may demonstrate that faah inhibitor is a potential remedial strategy for gi dysmotility. |
2022-07-25 |
2023-08-14 |
mouse |
| Chaoling Chen, Weili Wang, Justin L Poklis, Aron H Lichtman, Joseph K Ritter, Gaizun Hu, Dengpiao Xie, Ningjun L. Inactivation of fatty acid amide hydrolase protects against ischemic reperfusion injury-induced renal fibrogenesis. Biochimica et biophysica acta. Molecular basis of disease. 2022-06-16. PMID:35710061. |
although cannabinoid receptors (cb) are recognized as targets for renal fibrosis, the role of endogenous cannabinoid anandamide (aea) and its primary hydrolytic enzyme, fatty acid amide hydrolase (faah), in renal fibrogenesis remains unclear. |
2022-06-16 |
2023-08-14 |
mouse |
| Farinaz Ghaderi, Fattah Sotoodehnejadnematalahi, Zahra Hajebrahimi, Abolfazl Fateh, Seyed Davar Siada. Effects of active, inactive, and derivatives of Akkermansia muciniphila on the expression of the endocannabinoid system and PPARs genes. Scientific reports. vol 12. issue 1. 2022-06-15. PMID:35705595. |
this study aimed to investigate the effects of active and heat-inactivated forms of akkermansia muciniphila, bacterium-derived outer membrane vesicles (omvs), and cell-free supernatant on the transcription of endocannabinoid system (ecs) members, including cannabinoid receptors 1 and 2 (cb1 and cb2), fatty acid amide hydrolase (faah), and peroxisome proliferator-activated receptors (ppars) genes (i.e., α, β/δ, and δ) in caco-2 and hepg-2 cell lines. |
2022-06-15 |
2023-08-14 |
Not clear |
| Veronica Lunerti, Hongwu Li, Federica Benvenuti, Qianwei Shen, Ana Domi, Laura Soverchia, Rita Maria Concetta Di Martino, Giovanni Bottegoni, Carolina L Haass-Koffler, Nazzareno Cannell. The multitarget FAAH inhibitor/D3 partial agonist ARN15381 decreases nicotine self-administration in male rats. European journal of pharmacology. 2022-06-11. PMID:35690082. |
inhibition of the fatty acid amide hydrolase (faah), the enzyme responsible for the degradation of the endocannabinoid anandamide (aea), palmitoylethanolamide (pea) and oleoylethanolamide (oea), reduces nicotine-enhanced dopamine transmission and acquisition of nicotine self-administration in rats. |
2022-06-11 |
2023-08-14 |
rat |
| Marek Zubrzycki, Maria Zubrzycka, Grzegorz Wysiadecki, Janusz Szemraj, Hanna Jerczynska, Mariusz Stasiole. Release of Endocannabinoids into the Cerebrospinal Fluid during the Induction of the Trigemino-Hypoglossal Reflex in Rats. Current issues in molecular biology. vol 44. issue 5. 2022-06-09. PMID:35678693. |
since the specific effects of endocannabinoids within the orofacial area are largely unknown, we aimed to determine whether an increase in the endocannabinoid concentration in the cerebrospinal fluid (csf) caused by the peripheral administration of the faah inhibitor urb597 and tooth pulp stimulation would affect the transmission of impulses between the sensory and motor centers localized in the vicinity of the third and fourth cerebral ventricles. |
2022-06-09 |
2023-08-14 |
rat |
| Marek Zubrzycki, Maria Zubrzycka, Grzegorz Wysiadecki, Janusz Szemraj, Hanna Jerczynska, Mariusz Stasiole. Effect of Fatty Acid Amide Hydrolase Inhibitor URB597 on Orofacial Pain Perception in Rats. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35563056. |
the levels of the investigated mediators anandamide (aea), 2-arachidonyl glycerol (2-ag), substance p (sp), calcitonin-gene-related peptide (cgrp), endomorphin-2 (em-2) and fatty acid amide hydrolase (faah) inhibitor by urb597 and receptors cannabinoid type-1 receptors (cb1r), cannabinoid type-2 receptors (cb2r) and µ-opioid receptors (mor) were determined in the mesencephalon, thalamus and hypothalamus tissues. |
2022-05-14 |
2023-08-13 |
rat |