| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eleni Gkini, Dimitris Anagnostopoulos, Mary Mavri-Vavayianni, Athanasia Siafaka-Kapada. Metabolism of 2-acylglycerol in rabbit and human platelets. Involvement of monoacylglycerol lipase and fatty acid amide hydrolase. Platelets. vol 20. issue 6. 2010-06-17. PMID:19811221. |
in conclusion, the endocannabinoid 2-ag, as well as other 2-acylglycerols, are substrates of both faah and magl; the latter was characterized for the first time in platelets. |
2010-06-17 |
2023-08-12 |
human |
| D De Filippis, A D'Amico, M Cipriano, S Petrosino, P Orlando, V Di Marzo, T Iuvon. Levels of endocannabinoids and palmitoylethanolamide and their pharmacological manipulation in chronic granulomatous inflammation in rats. Pharmacological research. vol 61. issue 4. 2010-06-17. PMID:19931394. |
the endocannabinoids anandamide and 2-arachidonoylglycerol, and the anandamide-congener, palmitoylethanolamide, are all substrates for the enzyme fatty acid amide hydrolase, and are endowed with anti-inflammatory actions exerted via cannabinoid receptors or, in the case of palmitoylethanolamide, also via other targets. |
2010-06-17 |
2023-08-12 |
rat |
| D De Filippis, A D'Amico, M Cipriano, S Petrosino, P Orlando, V Di Marzo, T Iuvon. Levels of endocannabinoids and palmitoylethanolamide and their pharmacological manipulation in chronic granulomatous inflammation in rats. Pharmacological research. vol 61. issue 4. 2010-06-17. PMID:19931394. |
granuloma formation was accompanied by a significant decrease in endocannabinoid and palmitoylethanolamide levels paralleled by increased levels of the fatty acid amide hydrolase, responsible for their breakdown. |
2010-06-17 |
2023-08-12 |
rat |
| Shinobu Yasuo, Marco Koch, Helmut Schmidt, Simone Ziebell, Joerg Bojunga, Gerd Geisslinger, Horst-Werner Kor. An endocannabinoid system is localized to the hypophysial pars tuberalis of Syrian hamsters and responds to photoperiodic changes. Cell and tissue research. vol 340. issue 1. 2010-06-15. PMID:20165884. |
by means of in situ hybrization, the pt was found to express n-acylphosphatidylethanolamine-specific phospholipase d (nape-pld), fatty acid amide hydrolase (faah), sn-1-selective diacylglycerol lipases (daglalpha and daglbeta), and monoacylglycerol lipase (magl), enzymes involved in endocannabinoid synthesis and degradation. |
2010-06-15 |
2023-08-12 |
Not clear |
| Daniele Amadio, Filomena Fezza, Giuseppina Catanzaro, Ottaviano Incani, Guus van Zadelhoff, Alessandro Finazzi Agrò, Mauro Maccarron. Methylation and acetylation of 15-hydroxyanandamide modulate its interaction with the endocannabinoid system. Biochimie. vol 92. issue 4. 2010-06-08. PMID:20096328. |
among these derivatives, 15-haea has been shown to be an effective (k(i) approximately 0.6 mum) faah inhibitor, that blocks also type-1 cannabinoid receptor (cb1r) but not other components of the "endocannabinoid system (ecs)", like the aea transporter (amt) or cb2r. |
2010-06-08 |
2023-08-12 |
Not clear |
| Sonia Gattinoni, Chiara De Simone, Sabrina Dallavalle, Filomena Fezza, Raffaella Nannei, Daniele Amadio, Patrizia Minetti, Gianandrea Quattrociocchi, Antonio Caprioli, Franco Borsini, Walter Cabri, Sergio Penco, Lucio Merlini, Mauro Maccarron. Enol carbamates as inhibitors of fatty acid amide hydrolase (FAAH) endowed with high selectivity for FAAH over the other targets of the endocannabinoid system. ChemMedChem. vol 5. issue 3. 2010-05-26. PMID:20112328. |
enol carbamates as inhibitors of fatty acid amide hydrolase (faah) endowed with high selectivity for faah over the other targets of the endocannabinoid system. |
2010-05-26 |
2023-08-12 |
Not clear |
| Timo Dirk Müller, Kathrin Reichwald, Günter Brönner, Jeanette Kirschner, Thuy Trang Nguyen, André Scherag, Wolfgang Herzog, Beate Herpertz-Dahlmann, Peter Lichtner, Thomas Meitinger, Matthias Platzer, Helmut Schäfer, Johannes Hebebrand, Anke Hinne. Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa. Child and adolescent psychiatry and mental health. vol 2. issue 1. 2010-05-20. PMID:19014633. |
several lines of evidence indicate that the central cannabinoid receptor 1 (cnr1) as well as the major endocannabinoid degrading enzymes fatty acid amide hydrolase (faah), n-acylethanolamine-hydrolyzing acid amidase (naaa) and monoglyceride lipase (mgll) are implicated in mediating the orexigenic effects of cannabinoids. |
2010-05-20 |
2023-08-12 |
Not clear |
| Jeannie Hwang, Crista Adamson, David Butler, David R Janero, Alexandros Makriyannis, Ben A Bah. Enhancement of endocannabinoid signaling by fatty acid amide hydrolase inhibition: a neuroprotective therapeutic modality. Life sciences. vol 86. issue 15-16. 2010-04-15. PMID:19527737. |
enhancement of endocannabinoid signaling by fatty acid amide hydrolase inhibition: a neuroprotective therapeutic modality. |
2010-04-15 |
2023-08-12 |
Not clear |
| Timo D Müller, Günter Brönner, Melanie Wandolski, Jophia Carrie, Trang T Nguyen, Brandon H Greene, André Scherag, Harald Grallert, Carla Ig Vogel, Susann Scherag, Winfried Rief, Hans-Erich Wichmann, Thomas Illig, Helmut Schäfer, Johannes Hebebrand, Anke Hinne. Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity. BMC medical genetics. vol 11. 2010-03-30. PMID:20044928. |
the orexigenic effects of cannabinoids are limited by activation of the endocannabinoid degrading enzyme fatty acid amide hydrolase (faah). |
2010-03-30 |
2023-08-12 |
Not clear |
| Stefania Petrosino, Vincenzo Di Marz. FAAH and MAGL inhibitors: therapeutic opportunities from regulating endocannabinoid levels. Current opinion in investigational drugs (London, England : 2000). vol 11. issue 1. 2010-03-23. PMID:20047159. |
faah and magl inhibitors: therapeutic opportunities from regulating endocannabinoid levels. |
2010-03-23 |
2023-08-12 |
Not clear |
| Jonathan Z Long, Xin Jin, Alexander Adibekian, Weiwei Li, Benjamin F Cravat. Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases. Journal of medicinal chemistry. vol 53. issue 4. 2010-03-23. PMID:20099888. |
piperidine/piperazine carbamates show excellent in vivo activity, raising brain endocannabinoid levels and producing cb1-dependent behavioral effects in mice, suggesting that they represent a promising class of inhibitors for studying the endogenous functions of magl and faah. |
2010-03-23 |
2023-08-12 |
mouse |
| Y S Weems, A W Lewis, D A Neuendorff, R D Randel, C W Weem. Endocannabinoid 1 and 2 (CB(1); CB(2)) receptor agonists affect negatively cow luteal function in vitro. Prostaglandins & other lipid mediators. vol 90. issue 3-4. 2010-02-25. PMID:19765667. |
the objective of this experiment was to determine the effects of endocannabinoid type 1 and 2 receptor agonists and receptor antagonists or a fatty acid amide hydrolase (faah; catabolizes endocannabinoids) inhibitor, pge(1), or pgf(2)alpha on bovine luteal secretion of progesterone, pge, and pgf(2)alphain vitro. |
2010-02-25 |
2023-08-12 |
cattle |
| Jonathan Z Long, Daniel K Nomura, Robert E Vann, D Matthew Walentiny, Lamont Booker, Xin Jin, James J Burston, Laura J Sim-Selley, Aron H Lichtman, Jenny L Wiley, Benjamin F Cravat. Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 48. 2010-02-18. PMID:19918051. |
dual blockade of faah and magl identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. |
2010-02-18 |
2023-08-12 |
Not clear |
| Jonathan Z Long, Daniel K Nomura, Robert E Vann, D Matthew Walentiny, Lamont Booker, Xin Jin, James J Burston, Laura J Sim-Selley, Aron H Lichtman, Jenny L Wiley, Benjamin F Cravat. Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 48. 2010-02-18. PMID:19918051. |
comparison of jzl195 to specific faah and magl inhibitors identified behavioral processes that were regulated by a single endocannabinoid pathway (e.g., hypomotility by the 2-ag/magl pathway) and, interestingly, those where disruption of both faah and magl produced additive effects that were reversed by a cb1 antagonist. |
2010-02-18 |
2023-08-12 |
Not clear |
| P Monteleone, M Bifulco, C Di Filippo, P Gazzerro, B Canestrelli, F Monteleone, M C Proto, M Di Genio, C Grimaldi, M Ma. Association of CNR1 and FAAH endocannabinoid gene polymorphisms with anorexia nervosa and bulimia nervosa: evidence for synergistic effects. Genes, brain, and behavior. vol 8. issue 7. 2010-02-12. PMID:19659925. |
association of cnr1 and faah endocannabinoid gene polymorphisms with anorexia nervosa and bulimia nervosa: evidence for synergistic effects. |
2010-02-12 |
2023-08-12 |
Not clear |
| P Monteleone, M Bifulco, C Di Filippo, P Gazzerro, B Canestrelli, F Monteleone, M C Proto, M Di Genio, C Grimaldi, M Ma. Association of CNR1 and FAAH endocannabinoid gene polymorphisms with anorexia nervosa and bulimia nervosa: evidence for synergistic effects. Genes, brain, and behavior. vol 8. issue 7. 2010-02-12. PMID:19659925. |
the rs1049353 (1359 g/a) single nucleotide polymorphism (snp) of the gene coding the endocannabinoid cb1 receptor (cnr1) and the rs324420 (cdna 385c to a) snp of the gene coding fatty acid amide hydrolase (faah), the major degrading enzyme of endocannabinoids, have been suggested to have functional effects on mature proteins. |
2010-02-12 |
2023-08-12 |
Not clear |
| Anna L Bowman, Alexandros Makriyanni. Refined homology model of monoacylglycerol lipase: toward a selective inhibitor. Journal of computer-aided molecular design. vol 23. issue 11. 2010-02-04. PMID:19543978. |
a comparison of the mgl active-site to that of the other principal endocannabinoid metabolizing enzyme, fatty acid amide hydrolase, demonstrates key differences which provide crucial insight toward the design of selective mgl inhibitors as potential drugs. |
2010-02-04 |
2023-08-12 |
Not clear |
| Sevasti Karaliota, Athanasia Siafaka-Kapadai, Chrisanthi Gontinou, Katerina Psarra, Mary Mavri-Vavayann. Anandamide increases the differentiation of rat adipocytes and causes PPARgamma and CB1 receptor upregulation. Obesity (Silver Spring, Md.). vol 17. issue 10. 2010-01-26. PMID:19543211. |
reverse transcription-pcr and western blotting analysis were performed in order to study the effect of aea on peroxisome proliferator-activated receptor (ppar)gamma2, cannabinoid receptors (cbrs), fatty acid amidohydrolase (faah), and cyclooxygenase-2 (cox-2) expression, during the differentiation process. |
2010-01-26 |
2023-08-12 |
rat |
| Sang-Chul Kim, Li Kang, Satish Nagaraj, Elison B Blancaflor, Kirankumar S Mysore, Kent D Chapma. Mutations in Arabidopsis fatty acid amide hydrolase reveal that catalytic activity influences growth but not sensitivity to abscisic acid or pathogens. The Journal of biological chemistry. vol 284. issue 49. 2009-12-22. PMID:19801664. |
fatty acid amide hydrolase (faah) terminates the endocannabinoid signaling pathway that regulates numerous neurobehavioral processes in animals by hydrolyzing n-acylethanolamines (naes). |
2009-12-22 |
2023-08-12 |
rat |
| Benoit Forget, Kathleen M Coen, Bernard Le Fol. Inhibition of fatty acid amide hydrolase reduces reinstatement of nicotine seeking but not break point for nicotine self-administration--comparison with CB(1) receptor blockade. Psychopharmacology. vol 205. issue 4. 2009-12-15. PMID:19484221. |
the endocannabinoid system consists of endocannabinoids (such as anandamide), their target receptors (mostly cannabinoid cb(1) receptors), and the enzymes that degrade those endocannabinoids (fatty-acid-amide-hydrolase (faah) for anandamide). |
2009-12-15 |
2023-08-12 |
Not clear |