All Relations between fatty acid amide hydrolase and cannabinoids

Publication Sentence Publish Date Extraction Date Species
S T Glaser, M Kaczoch. Temporal changes in mouse brain fatty acid amide hydrolase activity. Neuroscience. vol 163. issue 2. 2009-12-14. PMID:19555737. fatty acid amide hydrolase (faah) activity is known to mediate the tone of endogenous fatty acid amides including the endocannabinoid anandamide. 2009-12-14 2023-08-12 mouse
Laura E Wise, John P Harloe, Aron H Lichtma. Fatty acid amide hydrolase (FAAH) knockout mice exhibit enhanced acquisition of an aversive, but not of an appetitive, Barnes maze task. Neurobiology of learning and memory. vol 92. issue 4. 2009-12-09. PMID:19524055. consistent with these findings is that genetic deletion or pharmacological inhibition of fatty acid amide hydrolase (faah), the primary catabolic enzyme of the endogenous cannabinoid anandamide (aea), accelerates acquisition as well as extinction in aversive conditioning tasks. 2009-12-09 2023-08-12 mouse
Mauro Mileni, Joie Garfunkle, Jessica K DeMartino, Benjamin F Cravatt, Dale L Boger, Raymond C Steven. Binding and inactivation mechanism of a humanized fatty acid amide hydrolase by alpha-ketoheterocycle inhibitors revealed from cocrystal structures. Journal of the American Chemical Society. vol 131. issue 30. 2009-12-07. PMID:19722626. the cocrystal x-ray structures of two isomeric alpha-ketooxazole inhibitors (1 (ol-135) and 2) bound to fatty acid amide hydrolase (faah), a key enzymatic regulator of endocannabinoid signaling, are disclosed. 2009-12-07 2023-08-12 Not clear
F Francavilla, N Battista, A Barbonetti, M R C Vassallo, C Rapino, C Antonangelo, N Pasquariello, G Catanzaro, B Barboni, M Maccarron. Characterization of the endocannabinoid system in human spermatozoa and involvement of transient receptor potential vanilloid 1 receptor in their fertilizing ability. Endocrinology. vol 150. issue 10. 2009-10-22. PMID:19608651. both aea-binding receptors (cb1 and trpv1) exhibited a functional binding activity; enzymatic activity was demonstrated for nape-pld, faah, and the purported endocannabinoid membrane transporter (emt). 2009-10-22 2023-08-12 human
Mikko J Myllymäki, Heikki Käsnänen, Antti O Kataja, Maija Lahtela-Kakkonen, Susanna M Saario, Antti Poso, Ari M P Koskine. Chiral 3-(4,5-dihydrooxazol-2-yl)phenyl alkylcarbamates as novel FAAH inhibitors: Insight into FAAH enantioselectivity by molecular docking and interaction fields. European journal of medicinal chemistry. vol 44. issue 10. 2009-10-14. PMID:19539407. fatty acid amide hydrolase (faah) and monoglyceride lipase (mgl) are the main enzymes responsible for the hydrolysis of endogenous cannabinoids n-arachidonoylethanolamide (aea) and 2-arachidonoylglycerol (2-ag), respectively. 2009-10-14 2023-08-12 Not clear
E Trabucco, G Acone, A Marenna, R Pierantoni, G Cacciola, T Chioccarelli, K Mackie, S Fasano, N Colacurci, R Meccariello, G Cobellis, L Cobelli. Endocannabinoid system in first trimester placenta: low FAAH and high CB1 expression characterize spontaneous miscarriage. Placenta. vol 30. issue 6. 2009-09-30. PMID:19419760. endocannabinoid system in first trimester placenta: low faah and high cb1 expression characterize spontaneous miscarriage. 2009-09-30 2023-08-12 human
S G Kinsey, J Z Long, S T O'Neal, R A Abdullah, J L Poklis, D L Boger, B F Cravatt, A H Lichtma. Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain. The Journal of pharmacology and experimental therapeutics. vol 330. issue 3. 2009-09-21. PMID:19502530. alternatively, inhibiting fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), the principal enzymes responsible for the degradation of the respective endogenous cannabinoids, anandamide (aea) and 2-arachydonylglycerol (2-ag), reduce nociception in a variety of nociceptive assays, with no or minimal behavioral effects. 2009-09-21 2023-08-12 mouse
Yan Wei, Xu Wang, Ling Wan. Presence and regulation of cannabinoid receptors in human retinal pigment epithelial cells. Molecular vision. vol 15. 2009-09-14. PMID:19547718. here we analyzed the expression of and changes in cannabinoid receptors (cb1 and cb2) and one enzyme responsible for endocannabinoid hydrolysis, fatty acid amide hydrolase (faah), in rpe cell oxidative damage process, a cellular model of armd. 2009-09-14 2023-08-12 human
Paola Grimaldi, Gianna Rossi, Giuseppina Catanzaro, Mauro Maccarron. Modulation of the endocannabinoid-degrading enzyme fatty acid amide hydrolase by follicle-stimulating hormone. Vitamins and hormones. vol 81. 2009-09-10. PMID:19647115. recently, we have shown that treatment of mouse primary sertoli cells with fsh enhances the activity of the aea hydrolase (fatty acid amide hydrolase, faah), whereas it does not affect the enzymes that synthesize aea, nor the level of the aea-binding type-2 cannabinoid and type-1 vanilloid receptors. 2009-09-10 2023-08-12 mouse
Paola Grimaldi, Gianna Rossi, Giuseppina Catanzaro, Mauro Maccarron. Modulation of the endocannabinoid-degrading enzyme fatty acid amide hydrolase by follicle-stimulating hormone. Vitamins and hormones. vol 81. 2009-09-10. PMID:19647115. taken together, these data identify faah as the only target of fsh among the elements of the endocannabinoid system, with a critical impact on sertoli cell proliferation, and thus spermatogenesis and male reproduction. 2009-09-10 2023-08-12 mouse
Ahmad R Hariri, Adam Gorka, Luke W Hyde, Mark Kimak, Indrani Halder, Francesca Ducci, Robert E Ferrell, David Goldman, Stephen B Manuc. Divergent effects of genetic variation in endocannabinoid signaling on human threat- and reward-related brain function. Biological psychiatry. vol 66. issue 1. 2009-08-31. PMID:19103437. fatty acid amide hydrolase (faah) is a key enzyme in regulating endocannabinoid (ecb) signaling. 2009-08-31 2023-08-12 human
Joel E Schlosburg, Brittany L A Carlson, Divya Ramesh, Rehab A Abdullah, Jonathan Z Long, Benjamin F Cravatt, Aron H Lichtma. Inhibitors of endocannabinoid-metabolizing enzymes reduce precipitated withdrawal responses in THC-dependent mice. The AAPS journal. vol 11. issue 2. 2009-08-12. PMID:19430909. however, new genetic and pharmacological tools are available to increase endocannabinoid levels by targeting fatty acid amide hydrolase (faah) or monoacylglycerol lipase (magl), the enzymes responsible for the degradation of the endogenous cannabinoid ligands anandamide and 2-arachidonoylglycerol, respectively. 2009-08-12 2023-08-12 mouse
Joel E Schlosburg, Brittany L A Carlson, Divya Ramesh, Rehab A Abdullah, Jonathan Z Long, Benjamin F Cravatt, Aron H Lichtma. Inhibitors of endocannabinoid-metabolizing enzymes reduce precipitated withdrawal responses in THC-dependent mice. The AAPS journal. vol 11. issue 2. 2009-08-12. PMID:19430909. in the present study, we investigated whether increasing endogenous cannabinoids levels, through the use of faah (-/-) mice as well as the faah inhibitor urb597 or the magl inhibitor jzl184, would reduce the intensity of withdrawal signs precipitated by the cb(1) receptor antagonist rimonabant in thc-dependent mice. 2009-08-12 2023-08-12 mouse
David R Janero, Subramanian K Vadivel, Alexandros Makriyanni. Pharmacotherapeutic modulation of the endocannabinoid signalling system in psychiatric disorders: drug-discovery strategies. International review of psychiatry (Abingdon, England). vol 21. issue 2. 2009-08-04. PMID:19367506. two endocannabinoid deactivating enzymes, fatty acid amide hydrolase (faah) and soluble monoacylglycerol lipase (mgl), are increasingly prominent targets for inhibitors that indirectly potentiate endocannabinoid-system signalling. 2009-08-04 2023-08-12 Not clear
J Haller, I Barna, B Barsvari, K Gyimesi Pelczer, S Yasar, L V Panlilio, S Goldber. Interactions between environmental aversiveness and the anxiolytic effects of enhanced cannabinoid signaling by FAAH inhibition in rats. Psychopharmacology. vol 204. issue 4. 2009-07-31. PMID:19259645. interactions between environmental aversiveness and the anxiolytic effects of enhanced cannabinoid signaling by faah inhibition in rats. 2009-07-31 2023-08-12 rat
J Haller, I Barna, B Barsvari, K Gyimesi Pelczer, S Yasar, L V Panlilio, S Goldber. Interactions between environmental aversiveness and the anxiolytic effects of enhanced cannabinoid signaling by FAAH inhibition in rats. Psychopharmacology. vol 204. issue 4. 2009-07-31. PMID:19259645. fatty acid amide hydrolase (faah), the enzyme responsible for degradation of the endocannabinoid anandamide, has emerged as a promising target for anxiety-related disorders. 2009-07-31 2023-08-12 rat
Francis Rodriguez Bambico, Andrea Duranti, Andrea Tontini, Giorgio Tarzia, Gabriella Gobb. Endocannabinoids in the treatment of mood disorders: evidence from animal models. Current pharmaceutical design. vol 15. issue 14. 2009-07-20. PMID:19442178. recent preclinical evidences that cannabinoid agonists and endocannabinoid enhancers, such as the fatty acid amide hydrolase (faah) inhibitors, can impact mood regulation have opened a new line of research in antidepressant drug discovery. 2009-07-20 2023-08-12 mouse
C Robin Hile. Endocannabinoids and the heart. Journal of cardiovascular pharmacology. vol 53. issue 4. 2009-07-16. PMID:19276990. endocannabinoids are largely protective; they decrease tissue damage and arrhythmia in myocardial infarction and may reduce progression of atherosclerosis (cb2 receptor stimulation inhibits lesion progression), and fatty acid amide hydrolase knockout mice (which have enhanced endocannabinoid levels) show decreased cardiac dysfunction with age compared with wild types. 2009-07-16 2023-08-12 mouse
Ricardo Llorente, Alvaro Llorente-Berzal, Stefania Petrosino, Eva-María Marco, Carmen Guaza, Carmen Prada, Meritxell López-Gallardo, Vincenzo Di Marzo, María-Paz Vivero. Gender-dependent cellular and biochemical effects of maternal deprivation on the hippocampus of neonatal rats: a possible role for the endocannabinoid system. Developmental neurobiology. vol 68. issue 11. 2009-07-15. PMID:18666205. in addition, we investigated the putative involvement of the endocannabinoid system by evaluating (a) the effects of md on hippocampal levels of endocannabinoids (b) the modulation of md effects by two inhibitors of endocannabinoids inactivation, the fatty acid amide hydrolase inhibitor n-arachidonoyl-serotonin (aa-5-ht), and the endocannabinoid reuptake inhibitor, omdm-2. 2009-07-15 2023-08-12 rat
Carmen Mazzola, Julie Medalie, Maria Scherma, Leigh V Panlilio, Marcello Solinas, Gianluigi Tanda, Filippo Drago, Jean Lud Cadet, Steven R Goldberg, Sevil Yasa. Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-alpha nuclear receptors. Learning & memory (Cold Spring Harbor, N.Y.). vol 16. issue 5. 2009-07-15. PMID:19403796. inhibitors of fatty acid amide hydrolase (faah) increase endogenous levels of anandamide (a cannabinoid cb(1)-receptor ligand) and oleoylethanolamide and palmitoylethanolamide (oea and pea, ligands for alpha-type peroxisome proliferator-activated nuclear receptors, ppar-alpha) when and where they are naturally released in the brain. 2009-07-15 2023-08-12 rat