| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaofei Sun, Haibin Wang, Masaru Okabe, Kenneth Mackie, Philip J Kingsley, Lawrence J Marnett, Benjamin F Cravatt, Sudhansu K De. Genetic loss of Faah compromises male fertility in mice. Biology of reproduction. vol 80. issue 2. 2009-03-27. PMID:18987328. |
herein we show that genetic loss of faah, which encodes fatty acid amide hydrolase (faah), results in elevated levels of anandamide, an endocannabinoid, in the male reproductive system, leading to compromised fertilizing capacity of sperm. |
2009-03-27 |
2023-08-12 |
mouse |
| Anuradha Nallapaneni, Jing Liu, Subramanya Karanth, Carey Pop. Pharmacological enhancement of endocannabinoid signaling reduces the cholinergic toxicity of diisopropylfluorophosphate. Neurotoxicology. vol 29. issue 6. 2009-03-26. PMID:18765251. |
we first evaluated the relative in vitro and in vivo (2.5mg/kg, sc) effects of dfp on cholinesterase, fatty acid amide hydrolase (faah, an endocannabinoid degrading enzyme), monoacylglycerol lipase (magl, another endocannabinoid degrading enzyme) and cannabinoid receptor (cb1) binding in rat hippocampus. |
2009-03-26 |
2023-08-12 |
rat |
| Anuradha Nallapaneni, Jing Liu, Subramanya Karanth, Carey Pop. Pharmacological enhancement of endocannabinoid signaling reduces the cholinergic toxicity of diisopropylfluorophosphate. Neurotoxicology. vol 29. issue 6. 2009-03-26. PMID:18765251. |
the effects of win 55212-2 (cannabinoid receptor agonist, 1.5mg/kg), urb597 (faah inhibitor, 3mg/kg), urb602 (magl inhibitor, 10mg/kg) or am404 (endocannabinoid uptake inhibitor, 10mg/kg) on dfp toxicity were then examined. |
2009-03-26 |
2023-08-12 |
rat |
| Hui-Ching Lin, Sheng-Chun Mao, Chun-Lin Su, Po-Wu Gea. The role of prefrontal cortex CB1 receptors in the modulation of fear memory. Cerebral cortex (New York, N.Y. : 1991). vol 19. issue 1. 2009-03-09. PMID:18477688. |
the effect of cannabinoid agonists was mimicked by endocannabinoid uptake or fatty acid amide hydrolase inhibitors. |
2009-03-09 |
2023-08-12 |
rat |
| Xueqing Wang, Katerina Sarris, Karen Kage, Di Zhang, Scott P Brown, Teodozyi Kolasa, Carol Surowy, Odile F El Kouhen, Steven W Muchmore, Jorge D Brioni, Andrew O Stewar. Synthesis and evaluation of benzothiazole-based analogues as novel, potent, and selective fatty acid amide hydrolase inhibitors. Journal of medicinal chemistry. vol 52. issue 1. 2009-02-06. PMID:19072118. |
these compounds may provide useful tools for the study of faah and the endocannabinoid system. |
2009-02-06 |
2023-08-12 |
rat |
| Vito de Novellis, Enza Palazzo, Francesca Rossi, Luciano De Petrocellis, Stefania Petrosino, Francesca Guida, Livio Luongo, Annalucia Migliozzi, Luigia Cristino, Ida Marabese, Katarzyna Starowicz, Vincenzo Di Marzo, Sabatino Maion. The analgesic effect of N-arachidonoyl-serotonin, a FAAH inhibitor and TRPV1 receptor antagonist, associated with changes in rostral ventromedial medulla and locus coeruleus cell activity in rats. Neuropharmacology. vol 55. issue 7. 2009-01-26. PMID:18616956. |
we evaluated the effects of intra-periaqueductal grey (pag) n-arachidonoyl-serotonin (aa-5-ht), a compound with a "dual" ability to inhibit the fatty acid amide hydrolase (faah) and to antagonize transient receptor vanilloid type 1 (trpv1) receptors, on endocannabinoid levels, rostral ventromedial medulla (rvm) on and off cell activities, thermal nociception (tail flick in anaesthetized rats) and formalin-induced nocifensive responses in awake rats. |
2009-01-26 |
2023-08-12 |
rat |
| Christian Sinning, Bernhard Watzer, Ovidiu Coste, Rolf M Nüsing, Ingo Ott, Alessia Ligresti, Vincenzo Di Marzo, Peter Immin. New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide. Journal of medicinal chemistry. vol 51. issue 24. 2009-01-22. PMID:19053765. |
am404 inhibits endocannabinoid cellular uptake, binds weakly to cb1 and cb2 cannabinoid receptors, and is formed by fatty acid amide hydrolase (faah) in vivo. |
2009-01-22 |
2023-08-12 |
mouse |
| Christian Sinning, Bernhard Watzer, Ovidiu Coste, Rolf M Nüsing, Ingo Ott, Alessia Ligresti, Vincenzo Di Marzo, Peter Immin. New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide. Journal of medicinal chemistry. vol 51. issue 24. 2009-01-22. PMID:19053765. |
we prepared three derivatives of this new (endo)cannabinoid using bioisosteric replacement (1), homology (2), and derivatization (3) of the 4-aminophenol moiety in am404 and tested them against cb1, cb2, and faah. |
2009-01-22 |
2023-08-12 |
mouse |
| S Maione, E Morera, I Marabese, A Ligresti, L Luongo, G Ortar, V Di Marz. Antinociceptive effects of tetrazole inhibitors of endocannabinoid inactivation: cannabinoid and non-cannabinoid receptor-mediated mechanisms. British journal of pharmacology. vol 155. issue 5. 2009-01-16. PMID:18660824. |
tetrazoles were recently developed as inhibitors of the cellular uptake of the endocannabinoid anandamide or of its hydrolysis by fatty acid amide hydrolase (faah), but were proposed to act also on non-endocannabinoid-related serine hydrolases. |
2009-01-16 |
2023-08-12 |
Not clear |
| Jonathan Z Long, Weiwei Li, Lamont Booker, James J Burston, Steven G Kinsey, Joel E Schlosburg, Franciso J Pavón, Antonia M Serrano, Dana E Selley, Loren H Parsons, Aron H Lichtman, Benjamin F Cravat. Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Nature chemical biology. vol 5. issue 1. 2009-01-15. PMID:19029917. |
endocannabinoid signaling is terminated by enzymatic hydrolysis, a process that for anandamide is mediated by fatty acid amide hydrolase (faah), and for 2-ag is thought to involve monoacylglycerol lipase (magl). |
2009-01-15 |
2023-08-12 |
mouse |
| Jonathan Z Long, Weiwei Li, Lamont Booker, James J Burston, Steven G Kinsey, Joel E Schlosburg, Franciso J Pavón, Antonia M Serrano, Dana E Selley, Loren H Parsons, Aron H Lichtman, Benjamin F Cravat. Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Nature chemical biology. vol 5. issue 1. 2009-01-15. PMID:19029917. |
faah inhibitors produce a select subset of the behavioral effects observed with cb1 agonists, which suggests a functional segregation of endocannabinoid signaling pathways in vivo. |
2009-01-15 |
2023-08-12 |
mouse |
| Miriam Melis, Giuliano Pillolla, Antonio Luchicchi, Anna Lisa Muntoni, Sevil Yasar, Steven R Goldberg, Marco Pisti. Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic dopamine neurons through nuclear receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 51. 2009-01-12. PMID:19091987. |
we discovered that pharmacological inhibition of fatty acid amide hydrolase (faah), the enzyme that catabolizes fatty acid ethanolamides, among which the endocannabinoid anandamide (aea) is the best known, suppressed nicotine-induced excitation of dopamine cells. |
2009-01-12 |
2023-08-12 |
Not clear |
| Riccardo Sarzani, Marica Bordicchia, Fabio Salvi, Giovanna Cola, Eliana Franchi, Ilaria Battistoni, Lucia Mancinelli, Andrea Giovagnoli, Paolo Dessì-Fulgheri, Alessandro Rappell. A human fatty acid amide hydrolase (FAAH) functional gene variant is associated with lower blood pressure in young males. American journal of hypertension. vol 21. issue 8. 2009-01-09. PMID:18497731. |
fatty acid amide hydrolase (faah) inhibitors, preventing endocannabinoid (ec) degradation, reduce blood pressure (bp) and heart rate in young male (ym) hypertensive rodents. |
2009-01-09 |
2023-08-12 |
human |
| L W Chamley, A Bhalla, P R Stone, H Liddell, S O'Carroll, C Kearn, M Glas. Nuclear localisation of the endocannabinoid metabolizing enzyme fatty acid amide hydrolase (FAAH) in invasive trophoblasts and an association with recurrent miscarriage. Placenta. vol 29. issue 11. 2009-01-09. PMID:18805581. |
nuclear localisation of the endocannabinoid metabolizing enzyme fatty acid amide hydrolase (faah) in invasive trophoblasts and an association with recurrent miscarriage. |
2009-01-09 |
2023-08-12 |
mouse |
| L W Chamley, A Bhalla, P R Stone, H Liddell, S O'Carroll, C Kearn, M Glas. Nuclear localisation of the endocannabinoid metabolizing enzyme fatty acid amide hydrolase (FAAH) in invasive trophoblasts and an association with recurrent miscarriage. Placenta. vol 29. issue 11. 2009-01-09. PMID:18805581. |
the endocannabinoid anandamide, is metabolized by the enzyme fatty acid amide hydrolase (faah), and insufficient levels of this enzyme have been implicated in spontaneous miscarriage in women and implantation failure in mice. |
2009-01-09 |
2023-08-12 |
mouse |
| Nicholas V Dipatrizio, Kenny J Simansk. Inhibiting parabrachial fatty acid amide hydrolase activity selectively increases the intake of palatable food via cannabinoid CB1 receptors. American journal of physiology. Regulatory, integrative and comparative physiology. vol 295. issue 5. 2009-01-06. PMID:18768763. |
inhibiting parabrachial fatty acid amide hydrolase activity selectively increases the intake of palatable food via cannabinoid cb1 receptors. |
2009-01-06 |
2023-08-12 |
rat |
| Nicholas V Dipatrizio, Kenny J Simansk. Inhibiting parabrachial fatty acid amide hydrolase activity selectively increases the intake of palatable food via cannabinoid CB1 receptors. American journal of physiology. Regulatory, integrative and comparative physiology. vol 295. issue 5. 2009-01-06. PMID:18768763. |
arachidonoyl serotonin (aa5ht), an inhibitor of the endocannabinoid degradative enzyme, fatty acid amide hydrolase (faah), was infused into the parabrachial nucleus of male sprague-dawley rats, and intakes of high-fat/sucrose pellets and standard rodent chow were subsequently evaluated under various feeding schedules. |
2009-01-06 |
2023-08-12 |
rat |
| Nicholas V Dipatrizio, Kenny J Simansk. Inhibiting parabrachial fatty acid amide hydrolase activity selectively increases the intake of palatable food via cannabinoid CB1 receptors. American journal of physiology. Regulatory, integrative and comparative physiology. vol 295. issue 5. 2009-01-06. PMID:18768763. |
the cannabinoid cb1 receptor antagonist, am251, blocked the orexigenic actions of aa5ht, implicating cb1 receptors in mediating the feeding responses to faah inactivation. |
2009-01-06 |
2023-08-12 |
rat |
| Marco Koch, Iris Habazettl, Faramarz Dehghani, Horst-Werner Kor. The rat pineal gland comprises an endocannabinoid system. Journal of pineal research. vol 45. issue 4. 2008-12-24. PMID:18554250. |
immunohistochemical and immunoblot analyses revealed the presence of cb1 and cb2 receptor proteins, of n-acyl phosphatidyl ethanolamine hydrolyzing phospholipase d (nape-pld), an enzyme catalyzing endocannabinoid biosynthesis and of fatty acid amide hydrolase (faah), an endocannabinoid catabolizing enzyme, in pinealocytes, and in pineal sympathetic nerve fibers identified by double immunofluorescence with an antibody against tyrosine hydroxylase. |
2008-12-24 |
2023-08-12 |
rat |
| Filomena Fezza, Chiara De Simone, Daniele Amadio, Mauro Maccarron. Fatty acid amide hydrolase: a gate-keeper of the endocannabinoid system. Sub-cellular biochemistry. vol 49. 2008-12-24. PMID:18751909. |
fatty acid amide hydrolase: a gate-keeper of the endocannabinoid system. |
2008-12-24 |
2023-08-12 |
human |