All Relations between fatty acid amide hydrolase and cannabinoids

Publication Sentence Publish Date Extraction Date Species
Heather M Haughey, Erin Marshall, Joseph P Schacht, Ashleigh Louis, Kent E Hutchiso. Marijuana withdrawal and craving: influence of the cannabinoid receptor 1 (CNR1) and fatty acid amide hydrolase (FAAH) genes. Addiction (Abingdon, England). vol 103. issue 10. 2008-12-19. PMID:18705688. to examine whether withdrawal after abstinence and cue-elicited craving were associated with polymorphisms within two genes involved in regulating the endocannabinoid system, cannabinoid receptor 1 (cnr1) and fatty acid amide hydrolase (faah). 2008-12-19 2023-08-12 Not clear
Heather M Haughey, Erin Marshall, Joseph P Schacht, Ashleigh Louis, Kent E Hutchiso. Marijuana withdrawal and craving: influence of the cannabinoid receptor 1 (CNR1) and fatty acid amide hydrolase (FAAH) genes. Addiction (Abingdon, England). vol 103. issue 10. 2008-12-19. PMID:18705688. two single nucleotide polymorphisms (snps) in the cnr1 (rs2023239) and faah (rs324420) genes, associated previously with substance abuse and functional changes in cannabinoid regulation, were examined in a sample of daily marijuana smokers. 2008-12-19 2023-08-12 Not clear
John E Casida, Daniel K Nomura, Sarah C Vose, Kazutoshi Fujiok. Organophosphate-sensitive lipases modulate brain lysophospholipids, ether lipids and endocannabinoids. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18495101. monoacylglycerol lipase and fatty acid amide hydrolase regulate endocannabinoid levels with roles in motility, pain and memory. 2008-12-10 2023-08-12 mouse
Michelle Roche, John P Kelly, Maeve O'Driscoll, David P Fin. Augmentation of endogenous cannabinoid tone modulates lipopolysaccharide-induced alterations in circulating cytokine levels in rats. Immunology. vol 125. issue 2. 2008-12-04. PMID:18393970. this study investigated the effects of urb597, a selective inhibitor of fatty acid amide hydrolase (faah), the enzyme catalysing degradation of the endogenous cannabinoid anandamide, and am404, an inhibitor of anandamide transport, on lipopolysaccharide (lps)-induced increases in plasma cytokine levels in rats. 2008-12-04 2023-08-12 rat
Giorgio Ortar, Tiziana Bisogno, Alessia Ligresti, Enrico Morera, Marianna Nalli, Vincenzo Di Marz. Tetrahydrolipstatin analogues as modulators of endocannabinoid 2-arachidonoylglycerol metabolism. Journal of medicinal chemistry. vol 51. issue 21. 2008-11-28. PMID:18831576. three of the novel compounds, i.e., 11, 13, and 15, inhibited 2-ag formation via the diacylglycerol lipase alpha (daglalpha) with ic 50 values lower than 50 nm (ic 50 of thl = 1 microm) and were between 23- and 375-fold selective vs 2-ag hydrolysis by monoacylglycerol lipase (magl) as well as vs cannabinoid cb 1 and cb 2 receptors and anandamide hydrolysis by fatty acid amide hydrolase (faah). 2008-11-28 2023-08-12 Not clear
M López-Gallardo, R Llorente, A Llorente-Berzal, E M Marco, C Prada, V Di Marzo, M P Vivero. Neuronal and glial alterations in the cerebellar cortex of maternally deprived rats: gender differences and modulatory effects of two inhibitors of endocannabinoid inactivation. Developmental neurobiology. vol 68. issue 12. 2008-11-26. PMID:18726913. further, we analyzed the modulatory actions of two inhibitors of endocannabinoids inactivation, the fatty acid amide hydrolase inhibitor n-arachidonoyl-serotonin, aa-5-ht, and the endocannabinoid reuptake inhibitor, omdm-2 (daily subcutaneous injections during the postnatal period 7-12). 2008-11-26 2023-08-12 rat
P Adamczyk, A Gołda, A C McCreary, M Filip, E Przegalińsk. Activation of endocannabinoid transmission induces antidepressant-like effects in rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 59. issue 2. 2008-11-25. PMID:18622041. the present study examined the effects of the ecb uptake inhibitor 4-hydroxyphenyl-5z,8z,11z,14z-eicosatetraenamide (am404; 0.1-3 mg/kg), the fatty acid amide hydrolase (faah) inhibitor cyclohexylcarbamic acid 3-carbamoylbiphenyl-3-yl ester (urb597; 0.03-0.3 mg/kg), the cannabinoid cb(1) receptor agonist (-)-cis-3-[2-hydroxy-4-(1,1-dimethylheptyl) phenyl]-trans-4-(3-hydroxypropyl)-cyclohexanol (cp55,940; 0.03-0.3 mg/kg) and the cb(1) receptor antagonist rimonabant (0.3-3 mg/kg) on immobility time in the forced swim test (fst) in rats. 2008-11-25 2023-08-12 rat
Andrea Cippitelli, Nazzareno Cannella, Simone Braconi, Andrea Duranti, Andrea Tontini, Ainhoa Bilbao, Fernando Rodríguez Defonseca, Daniele Piomelli, Roberto Ciccociopp. Increase of brain endocannabinoid anandamide levels by FAAH inhibition and alcohol abuse behaviours in the rat. Psychopharmacology. vol 198. issue 4. 2008-11-17. PMID:18446329. increase of brain endocannabinoid anandamide levels by faah inhibition and alcohol abuse behaviours in the rat. 2008-11-17 2023-08-12 rat
M Cella, G F Leguizamón, M S Sordelli, M Cervini, T Guadagnoli, M L Ribeiro, A M Franchi, M G Farin. Dual effect of anandamide on rat placenta nitric oxide synthesis. Placenta. vol 29. issue 8. 2008-11-13. PMID:18561998. we found that cannabinoids receptors (cb1 and cb2), faah and trpv1 were expressed in chorio-allantoic placenta. 2008-11-13 2023-08-12 rat
James J Burston, Laura J Sim-Selley, John P Harloe, Anu Mahadevan, Raj K Razdan, Dana E Selley, Jenny L Wile. N-arachidonyl maleimide potentiates the pharmacological and biochemical effects of the endocannabinoid 2-arachidonylglycerol through inhibition of monoacylglycerol lipase. The Journal of pharmacology and experimental therapeutics. vol 327. issue 2. 2008-11-13. PMID:18682568. inhibition of the metabolism of the endocannabinoids, anandamide (aea) and 2-arachidonyl glycerol (2-ag), by their primary metabolic enzymes, fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), respectively, has the potential to increase understanding of the physiological functions of the endocannabinoid system. 2008-11-13 2023-08-12 mouse
Maria Scherma, Leigh V Panlilio, Paola Fadda, Liana Fattore, Islam Gamaleddin, Bernard Le Foll, Zuzana Justinová, Eva Mikics, Jozsef Haller, Julie Medalie, Jessica Stroik, Chanel Barnes, Sevil Yasar, Gianluigi Tanda, Daniele Piomelli, Walter Fratta, Steven R Goldber. Inhibition of anandamide hydrolysis by cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester (URB597) reverses abuse-related behavioral and neurochemical effects of nicotine in rats. The Journal of pharmacology and experimental therapeutics. vol 327. issue 2. 2008-11-13. PMID:18725543. a more functionally selective way to alter endocannabinoid activity is to inhibit fatty acid amide hydrolase (faah), thereby magnifying and prolonging the effects of the endocannabinoid anandamide only when and where it is synthesized and released on demand. 2008-11-13 2023-08-12 rat
Sabrina F Lisboa, Leonardo B M Resstel, Daniele C Aguiar, Francisco S Guimarãe. Activation of cannabinoid CB1 receptors in the dorsolateral periaqueductal gray induces anxiolytic effects in rats submitted to the Vogel conflict test. European journal of pharmacology. vol 593. issue 1-3. 2008-11-12. PMID:18691568. the animals received a first microinjection of vehicle (0.2 microl) or am251 (a cannabinoid cb(1) receptor antagonist; 100 pmol) followed, 5 min later, by a second microinjection of vehicle, anandamide (an endocannabinoid, 5 pmol), am404 (an inhibitor of anandamide uptake, 50 pmol) or urb597 (an inhibitor of fatty acid amide hydrolase, 0.01 or 0.1 nmol). 2008-11-12 2023-08-12 rat
Matthew N Hill, Erica J Carrier, Ryan J McLaughlin, Anna C Morrish, Sarah E Meier, Cecilia J Hillard, Boris B Gorzalk. Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatment. Journal of neurochemistry. vol 106. issue 6. 2008-11-07. PMID:18643796. we determined the effects of cus, with or without concurrent treatment with the antidepressant imipramine (10 mg/kg), on cp55940 binding to the cannabinoid cb(1) receptor; whole tissue endocannabinoid content; and fatty acid amide hydrolase (faah) activity in the prefrontal cortex, hippocampus, hypothalamus, amygdala, midbrain and ventral striatum. 2008-11-07 2023-08-12 rat
Maulik D Jhaveri, Denise Richardson, Ian Robinson, Michael J Garle, Annie Patel, Yan Sun, Devi R Sagar, Andrew J Bennett, Stephen P H Alexander, David A Kendall, David A Barrett, Victoria Chapma. Inhibition of fatty acid amide hydrolase and cyclooxygenase-2 increases levels of endocannabinoid related molecules and produces analgesia via peroxisome proliferator-activated receptor-alpha in a model of inflammatory pain. Neuropharmacology. vol 55. issue 1. 2008-11-05. PMID:18534634. inhibition of fatty acid amide hydrolase and cyclooxygenase-2 increases levels of endocannabinoid related molecules and produces analgesia via peroxisome proliferator-activated receptor-alpha in a model of inflammatory pain. 2008-11-05 2023-08-12 Not clear
D de Filippis, T Iuvone, A d'amico, G Esposito, L Steardo, A G Herman, P A Pelckmans, B Y de Winter, J G de Ma. Effect of cannabidiol on sepsis-induced motility disturbances in mice: involvement of CB receptors and fatty acid amide hydrolase. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 20. issue 8. 2008-10-27. PMID:18373655. cannabidiol also regulates the activity of fatty acid amide hydrolase (faah) which is the main enzyme involved in endocannabinoid breakdown and which modulates gastrointestinal motility. 2008-10-27 2023-08-12 mouse
Parisa Hasanein, Siamak Shahidi, Alireza Komaki, Naser Miraz. Effects of URB597 as an inhibitor of fatty acid amide hydrolase on modulation of nociception in a rat model of cholestasis. European journal of pharmacology. vol 591. issue 1-3. 2008-10-15. PMID:18593578. considering the interaction that has been shown between the endogenous opioid and endocannabinoid systems in nociception processing, we studied the effects of urb597, a selective inhibitor of faah (fatty acid amide hydrolase), on modulation of nociception in a model of elevated endogenous opioid tone, cholestasis. 2008-10-15 2023-08-12 rat
Parisa Hasanein, Siamak Shahidi, Alireza Komaki, Naser Miraz. Effects of URB597 as an inhibitor of fatty acid amide hydrolase on modulation of nociception in a rat model of cholestasis. European journal of pharmacology. vol 591. issue 1-3. 2008-10-15. PMID:18593578. these data showed that urb597 as a faah inhibitor potentiates antinociception induced by cholestasis in tail-flick test and that the inhibitory effects of urb597 in this model are mediated by cannabinoid cb(1) and not cb(2) receptors. 2008-10-15 2023-08-12 rat
Mauro Mileni, Douglas S Johnson, Zhigang Wang, Daniel S Everdeen, Marya Liimatta, Brandon Pabst, Keshab Bhattacharya, Richard A Nugent, Satwik Kamtekar, Benjamin F Cravatt, Kay Ahn, Raymond C Steven. Structure-guided inhibitor design for human FAAH by interspecies active site conversion. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 35. 2008-10-06. PMID:18753625. the integral membrane enzyme fatty acid amide hydrolase (faah) hydrolyzes the endocannabinoid anandamide and related amidated signaling lipids. 2008-10-06 2023-08-12 human
Juan Suárez, Francisco Javier Bermúdez-Silva, Ken Mackie, Catherine Ledent, Andreas Zimmer, Benjamin F Cravatt, Fernando Rodríguez de Fonsec. Immunohistochemical description of the endogenous cannabinoid system in the rat cerebellum and functionally related nuclei. The Journal of comparative neurology. vol 509. issue 4. 2008-09-02. PMID:18521853. these proteins include the two main cannabinoid receptors (cb(1) and cb(2)), the enzymes involved in cannabinoid biosynthesis (dagl alpha, dagl beta, and nape-pld), and the endocannabinoid-degradating enzymes (faah and magl). 2008-09-02 2023-08-12 rat
Juan Suárez, Francisco Javier Bermúdez-Silva, Ken Mackie, Catherine Ledent, Andreas Zimmer, Benjamin F Cravatt, Fernando Rodríguez de Fonsec. Immunohistochemical description of the endogenous cannabinoid system in the rat cerebellum and functionally related nuclei. The Journal of comparative neurology. vol 509. issue 4. 2008-09-02. PMID:18521853. with regard to the cerebellar cortex, these data confirm several published reports on the distribution of cannabinoid cb(1) receptors, dagl alpha, magl, and faah, which suggests a role of endocannabinoids as retrograde messengers in the synapses of the purkinje cells by either parallel fibers of granule cells or climbing fibers from the inferior olive or gabaergic interneuron. 2008-09-02 2023-08-12 rat