| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juan Suárez, Francisco Javier Bermúdez-Silva, Ken Mackie, Catherine Ledent, Andreas Zimmer, Benjamin F Cravatt, Fernando Rodríguez de Fonsec. Immunohistochemical description of the endogenous cannabinoid system in the rat cerebellum and functionally related nuclei. The Journal of comparative neurology. vol 509. issue 4. 2008-09-02. PMID:18521853. |
with regard to the cerebellar cortex, these data confirm several published reports on the distribution of cannabinoid cb(1) receptors, dagl alpha, magl, and faah, which suggests a role of endocannabinoids as retrograde messengers in the synapses of the purkinje cells by either parallel fibers of granule cells or climbing fibers from the inferior olive or gabaergic interneuron. |
2008-09-02 |
2023-08-12 |
rat |
| Lisa L Merritt, B R Martin, C Walters, A H Lichtman, M Imad Dama. The endogenous cannabinoid system modulates nicotine reward and dependence. The Journal of pharmacology and experimental therapeutics. vol 326. issue 2. 2008-08-12. PMID:18451315. |
in contrast, genetic deletion, or pharmacological inhibition of fatty acid amide hydrolase (faah), the enzyme responsible for catabolism of the endocannabinoid anandamide, enhanced the expression of nicotine cpp. |
2008-08-12 |
2023-08-12 |
mouse |
| Filomena Fezza, Sergio Oddi, Monia Di Tommaso, Chiara De Simone, Cinzia Rapino, Nicoletta Pasquariello, Enrico Dainese, Alessandro Finazzi-Agrò, Mauro Maccarron. Characterization of biotin-anandamide, a novel tool for the visualization of anandamide accumulation. Journal of lipid research. vol 49. issue 6. 2008-08-05. PMID:18316795. |
conversely, b-aea does not interact or interfere with the other components of the endocannabinoid system, such as type-1 and type-2 cannabinoid receptors, vanilloid receptor, aea synthetase (n-acylphosphatidylethanolamine-hydrolyzing phospholipase d), or aea hydrolase (fatty acid amide hydrolase). |
2008-08-05 |
2023-08-12 |
Not clear |
| Venkatesh L Hegde, Shweta Hegde, Benjamin F Cravatt, Lorne J Hofseth, Mitzi Nagarkatti, Prakash S Nagarkatt. Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: involvement of regulatory T cells. Molecular pharmacology. vol 74. issue 1. 2008-07-25. PMID:18388242. |
in addition, deficiency or inhibition of endocannabinoid hydrolyzing enzyme fatty acid amide hydrolase (faah), which leads to increased levels of endogenous cannabinoids, resulted in decreased liver injury upon cona challenge. |
2008-07-25 |
2023-08-12 |
mouse |
| Venkatesh L Hegde, Shweta Hegde, Benjamin F Cravatt, Lorne J Hofseth, Mitzi Nagarkatti, Prakash S Nagarkatt. Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: involvement of regulatory T cells. Molecular pharmacology. vol 74. issue 1. 2008-07-25. PMID:18388242. |
our data demonstrate that targeting cannabinoid receptors using exogenous or endogenous cannabinoids and use of faah inhibitors may constitute novel therapeutic modalities to treat immune-mediated liver inflammation. |
2008-07-25 |
2023-08-12 |
mouse |
| M Dalle Carbonare, E Del Giudice, A Stecca, D Colavito, M Fabris, A D'Arrigo, D Bernardini, M Dam, A Leo. A saturated N-acylethanolamine other than N-palmitoyl ethanolamine with anti-inflammatory properties: a neglected story... Journal of neuroendocrinology. vol 20 Suppl 1. 2008-07-18. PMID:18426496. |
a saturated n-acylethanolamine other than n-palmitoyl ethanolamine with anti-inflammatory properties: a neglected story... n-acylethanolamines, which include the endocannabinoid anandamide and the cannabinoid receptor-inactive saturated compounds n-palmitoyl ethanolamine and n-stearoyl ethanolamine, are ethanolamines of long-chain fatty acids degraded by fatty acid amide hydrolase (faah) known to accumulate in degenerating tissues and cells. |
2008-07-18 |
2023-08-12 |
Not clear |
| S Engel. Dysregulation of the endocannabinoid system in obesity. Journal of neuroendocrinology. vol 20 Suppl 1. 2008-07-18. PMID:18426509. |
for example, most data show decreased fatty acid amide hydrolase (faah) expression and/or activity as a result of obesity or high-fat intake, but the endocannabinoid predominantly increased in tissues is 2-arachidonoylglycerol (2-ag), which is not degraded by faah in vivo. |
2008-07-18 |
2023-08-12 |
human |
| E Cottone, A Guastalla, K Mackie, M F Franzon. Endocannabinoids affect the reproductive functions in teleosts and amphibians. Molecular and cellular endocrinology. vol 286. issue 1-2 Suppl 1. 2008-07-11. PMID:18343023. |
the fact that cb1-li-ir was found indeed in the fsh gonadotrophs of the xenopus pituitary gland and cb1 receptors together with the fatty acid amide hydrolase, the degradative enzyme of the endocannabinoid anandamide, were demonstrated in both bonyfish and frog gonads, strongly suggests that endocannabinoids are involved in central and peripheral gonadotropic functions of teleosts and amphibians. |
2008-07-11 |
2023-08-12 |
xenopus_laevis |
| Palmiero Monteleone, Alfonso Tortorella, Vassilis Martiadis, Carmela Di Filippo, Benedetta Canestrelli, Mario Ma. The cDNA 385C to A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) is associated with overweight/obesity but not with binge eating disorder in overweight/obese women. Psychoneuroendocrinology. vol 33. issue 4. 2008-07-01. PMID:18295974. |
the cdna 385c to a missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (faah) is associated with overweight/obesity but not with binge eating disorder in overweight/obese women. |
2008-07-01 |
2023-08-12 |
human |
| E Núñez, C Benito, R M Tolón, C J Hillard, W S T Griffin, J Romer. Glial expression of cannabinoid CB(2) receptors and fatty acid amide hydrolase are beta amyloid-linked events in Down's syndrome. Neuroscience. vol 151. issue 1. 2008-04-22. PMID:18068305. |
glial expression of cannabinoid cb(2) receptors and fatty acid amide hydrolase are beta amyloid-linked events in down's syndrome. |
2008-04-22 |
2023-08-12 |
human |
| E Núñez, C Benito, R M Tolón, C J Hillard, W S T Griffin, J Romer. Glial expression of cannabinoid CB(2) receptors and fatty acid amide hydrolase are beta amyloid-linked events in Down's syndrome. Neuroscience. vol 151. issue 1. 2008-04-22. PMID:18068305. |
specifically, data obtained in human brain tissue sections from alzheimer's disease patients showed that the expression of cannabinoid receptors of the cb(2) type is induced in activated microglial cells while fatty acid amide hydrolase (faah) expression is increased in reactive astrocytes. |
2008-04-22 |
2023-08-12 |
human |
| Laura E Wise, Roberta Cannavacciulo, Benjamin F Cravatt, Billy F Martin, Aron H Lichtma. Evaluation of fatty acid amides in the carrageenan-induced paw edema model. Neuropharmacology. vol 54. issue 1. 2008-04-18. PMID:17675189. |
on the other hand, genetic deletion of fatty acid amide hydrolase (faah), the enzyme responsible for degradation of fatty acid amides, including endogenous cannabinoid n-arachidonoyl ethanolamine (anandamide; aea), n-palmitoyl ethanolamine (pea), n-oleoyl ethanolamine (oea), and oleamide, also elicits anti-edema, but does not produce any apparent cannabinoid effects. |
2008-04-18 |
2023-08-12 |
mouse |
| Maria Scherma, Julie Medalie, Walter Fratta, Subramanian K Vadivel, Alexandros Makriyannis, Daniele Piomelli, Eva Mikics, Jozsef Haller, Sevil Yasar, Gianluigi Tanda, Steven R Goldber. The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition. Neuropharmacology. vol 54. issue 1. 2008-04-18. PMID:17904589. |
the endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (faah) inhibition. |
2008-04-18 |
2023-08-12 |
rat |
| Vincenzo Micale, Carmen Mazzola, Filippo Drag. Endocannabinoids and neurodegenerative diseases. Pharmacological research. vol 56. issue 5. 2008-04-08. PMID:17950616. |
the cannabinoid cb1 and cb2 receptors, the endogenous endocannabinoid (ec) ligands anandamide (aea) and 2-arachidonylethanolamide, and the degradative enzymes fatty acid amide hydrolase (faah) and monoglyceride lipase (ml) are key elements of the ec system implicated in different physiological functions including cognition, motor activity and immune responses. |
2008-04-08 |
2023-08-12 |
Not clear |
| Vincenzo Micale, Carmen Mazzola, Filippo Drag. Endocannabinoids and neurodegenerative diseases. Pharmacological research. vol 56. issue 5. 2008-04-08. PMID:17950616. |
decrease of neuronal cannabinoid cb1 receptors, increase of glial cannabinoid cb2 receptors and over-expression of faah in astrocytes) in experimental models of ad as well as in post-mortem brain tissue of ad patients, suggesting its possible role in inflammatory processes and in neuroprotection. |
2008-04-08 |
2023-08-12 |
Not clear |
| M Paola Castelli, A Paola Piras, Antonella D'Agostino, Fabio Pibiri, Simona Perra, Gian Luigi Gessa, Mauro Maccarrone, Marco Pisti. Dysregulation of the endogenous cannabinoid system in adult rats prenatally treated with the cannabinoid agonist WIN 55,212-2. European journal of pharmacology. vol 573. issue 1-3. 2008-03-13. PMID:17644084. |
we determined whether prenatal exposure to win 55,212-2, a potent cannabinoid receptor agonist, affected (1) density, affinity and/or function of cannabinoid cb(1) receptors, (2) endogenous levels of the endocannabinoid anandamide, (3) activities of the major anandamide synthesising and hydrolysing enzymes, n-acyl-phosphatidylethanolamine-specific phospholipase d (nape-pld) and fatty acid amide hydrolase (faah), respectively, in brain areas of adult male offspring rats. |
2008-03-13 |
2023-08-12 |
rat |
| M D Jhaveri, D Richardson, V Chapma. Endocannabinoid metabolism and uptake: novel targets for neuropathic and inflammatory pain. British journal of pharmacology. vol 152. issue 5. 2008-02-25. PMID:17704819. |
an alternative approach that can be used to harness the potential therapeutic effects of cannabinoids is to maximise the effects of the endocannabinoids, the actions of which are terminated by re-uptake and metabolism by various enzymes, including fatty acid amide hydrolase (faah), monoacylglycerol lipase (magl) and cyclooxygenase type 2 (cox2). |
2008-02-25 |
2023-08-12 |
Not clear |
| Michael Camilleri, Paula Carlson, Sanna McKinzie, April Grudell, Irene Busciglio, Duane Burton, Kari Baxter, Michael Ryks, Alan R Zinsmeiste. Genetic variation in endocannabinoid metabolism, gastrointestinal motility, and sensation. American journal of physiology. Gastrointestinal and liver physiology. vol 294. issue 1. 2008-02-21. PMID:17962356. |
the endocannabinoid, anandamide, is inactivated by fatty acid amide hydrolase (faah). |
2008-02-21 |
2023-08-12 |
human |
| P Massi, M Valenti, A Vaccani, V Gasperi, G Perletti, E Marras, F Fezza, M Maccarrone, D Parolar. 5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid. Journal of neurochemistry. vol 104. issue 4. 2008-02-14. PMID:18028339. |
5-lipoxygenase and anandamide hydrolase (faah) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid. |
2008-02-14 |
2023-08-12 |
mouse |
| P Massi, M Valenti, A Vaccani, V Gasperi, G Perletti, E Marras, F Fezza, M Maccarrone, D Parolar. 5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid. Journal of neurochemistry. vol 104. issue 4. 2008-02-14. PMID:18028339. |
in addition, in vivo treatment with cbd markedly stimulated ( approximately 175%) the activity of fatty acid amide hydrolase (faah), the main anandamide-degrading enzyme, while decreasing anandamide content ( approximately 30%) and binding to cb1 cannabinoid receptors ( approximately 25%). |
2008-02-14 |
2023-08-12 |
mouse |