| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Subramanian K Vadivel, Sundararaman Vardarajan, Richard I Duclos, JodiAnne T Wood, Jianxin Guo, Alexandros Makriyanni. Conformationally constrained analogues of 2-arachidonoylglycerol. Bioorganic & medicinal chemistry letters. vol 17. issue 21. 2008-02-05. PMID:17826996. |
these head group constrained and conformationally restricted analogues of 2-ag as well as the 1-keto precursors were evaluated as substrates for the endocannabinoid deactivating hydrolytic enzymes monoacylglycerol lipase (mgl) and fatty acid amide hydrolase (faah), and also were tested for their affinities for cb1 and cb2 cannabinoid receptors. |
2008-02-05 |
2023-08-12 |
Not clear |
| Christoph W Michalski, Florian E Oti, Mert Erkan, Danguole Sauliunaite, Frank Bergmann, Pal Pacher, Sandor Batkai, Michael W Müller, Nathalia A Giese, Helmut Friess, Jörg Kleef. Cannabinoids in pancreatic cancer: correlation with survival and pain. International journal of cancer. vol 122. issue 4. 2008-01-17. PMID:17943729. |
in our study, we quantitatively evaluated the immunoreactivity for cannabinoid-1 (cb1) and cannabinoid-2 (cb2) receptors as well as for the endocannabinoid metabolizing enzymes fatty acid amide hydrolase (faah) and monoacyl glycerol lipase (mgll). |
2008-01-17 |
2023-08-12 |
Not clear |
| Kyunghye Ahn, Douglas S Johnson, Laura R Fitzgerald, Marya Liimatta, Andrea Arendse, Tracy Stevenson, Eric T Lund, Richard A Nugent, Tyzoon K Nomanbhoy, Jessica P Alexander, Benjamin F Cravat. Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity. Biochemistry. vol 46. issue 45. 2007-12-27. PMID:17949010. |
fatty acid amide hydrolase (faah) is an integral membrane enzyme that degrades the fatty acid amide family of signaling lipids, including the endocannabinoid anandamide. |
2007-12-27 |
2023-08-12 |
Not clear |
| Cristina Benito, Estefanía Núñez, María Ruth Pazos, Rosa María Tolón, Julián Romer. The endocannabinoid system and Alzheimer's disease. Molecular neurobiology. vol 36. issue 1. 2007-12-18. PMID:17952652. |
in particular, other elements of the ecs, such as the fatty acid amide hydrolase (faah) or the cb(2) cannabinoid receptor are now considered as promising pharmacological targets for some diseases and new cannabinoids have been incorporated as therapeutic tools. |
2007-12-18 |
2023-08-12 |
human |
| Paul Cavuoto, Andrew J McAinch, George Hatzinikolas, Alena Janovská, Philip Game, Gary A Witter. The expression of receptors for endocannabinoids in human and rodent skeletal muscle. Biochemical and biophysical research communications. vol 364. issue 1. 2007-11-26. PMID:17935697. |
the most abundant endogenous endocannabinoid, anandamide, has been shown to activate the cannabinoid receptor type 1 (cb1) and type 2 (cb2) as well as the 'non-cannabinoid' transient receptor potential channel-vanilloid sub-family member 1 (trpv1), before being rapidly metabolised by fatty acid amide hydrolase (faah). |
2007-11-26 |
2023-08-12 |
human |
| E Soria-Gómez, I Matias, P E Rueda-Orozco, M Cisneros, S Petrosino, L Navarro, V Di Marzo, O Prospéro-Garcí. Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus. British journal of pharmacology. vol 151. issue 7. 2007-11-02. PMID:17549045. |
we aimed to evaluate potential orexigenic effects of the endocannabinoid anandamide and of aa5ht, a fatty acid amide hydrolase (faah) inhibitor, and omdm-1, an inhibitor of anandamide uptake, injected in the nacs, as well as the effect of these treatments on activation of hypothalamic nuclei. |
2007-11-02 |
2023-08-12 |
Not clear |
| A Lenman, C J Fowle. Interaction of ligands for the peroxisome proliferator-activated receptor gamma with the endocannabinoid system. British journal of pharmacology. vol 151. issue 8. 2007-10-31. PMID:17592505. |
the present study was designed to test whether the reverse is true, namely whether peroxisome proliferator-activated receptor gamma ligands have direct effects upon the activity of the endocannabinoid metabolizing enzyme fatty acid amide hydrolase. |
2007-10-31 |
2023-08-12 |
Not clear |
| Mikko J Myllymäki, Susanna M Saario, Antti O Kataja, Joel A Castillo-Melendez, Tapio Nevalainen, Risto O Juvonen, Tomi Järvinen, Ari M P Koskine. Design, synthesis, and in vitro evaluation of carbamate derivatives of 2-benzoxazolyl- and 2-benzothiazolyl-(3-hydroxyphenyl)-methanones as novel fatty acid amide hydrolase inhibitors. Journal of medicinal chemistry. vol 50. issue 17. 2007-10-29. PMID:17665899. |
fatty acid amide hydrolase (faah) is an intracellular serine hydrolase, which catalyzes the hydrolysis of the endocannabinoid n-arachidonoylethanolamide to arachidonic acid and ethanolamine. |
2007-10-29 |
2023-08-12 |
Not clear |
| Mikko J Myllymäki, Susanna M Saario, Antti O Kataja, Joel A Castillo-Melendez, Tapio Nevalainen, Risto O Juvonen, Tomi Järvinen, Ari M P Koskine. Design, synthesis, and in vitro evaluation of carbamate derivatives of 2-benzoxazolyl- and 2-benzothiazolyl-(3-hydroxyphenyl)-methanones as novel fatty acid amide hydrolase inhibitors. Journal of medicinal chemistry. vol 50. issue 17. 2007-10-29. PMID:17665899. |
faah also hydrolyzes another endocannabinoid, 2-arachidonoylglycerol (2-ag). |
2007-10-29 |
2023-08-12 |
Not clear |
| Mikko J Myllymäki, Susanna M Saario, Antti O Kataja, Joel A Castillo-Melendez, Tapio Nevalainen, Risto O Juvonen, Tomi Järvinen, Ari M P Koskine. Design, synthesis, and in vitro evaluation of carbamate derivatives of 2-benzoxazolyl- and 2-benzothiazolyl-(3-hydroxyphenyl)-methanones as novel fatty acid amide hydrolase inhibitors. Journal of medicinal chemistry. vol 50. issue 17. 2007-10-29. PMID:17665899. |
inhibition of faah or magl activity might lead to beneficial effects in many physiological disorders such as pain, inflammation, and anxiety due to increased endocannabinoid-induced activation of cannabinoid receptors cb1 and cb2. |
2007-10-29 |
2023-08-12 |
Not clear |
| Ryan J McLaughlin, Matthew N Hill, Anna C Morrish, Boris B Gorzalk. Local enhancement of cannabinoid CB1 receptor signalling in the dorsal hippocampus elicits an antidepressant-like effect. Behavioural pharmacology. vol 18. issue 5-6. 2007-10-23. PMID:17762511. |
systemic administration of direct cannabinoid cb1 receptor agonists and inhibitors of the hydrolytic enzyme fatty acid amide hydrolase have been shown to elicit antidepressant effects. |
2007-10-23 |
2023-08-12 |
rat |
| Ryan J McLaughlin, Matthew N Hill, Anna C Morrish, Boris B Gorzalk. Local enhancement of cannabinoid CB1 receptor signalling in the dorsal hippocampus elicits an antidepressant-like effect. Behavioural pharmacology. vol 18. issue 5-6. 2007-10-23. PMID:17762511. |
male sprague-dawley rats were bilaterally implanted with cannulae directed at the dentate gyrus of the dorsal hippocampus and subsequently received three infusions of either the cannabinoid cb1 receptor agonist hu-210 (1 and 2.5 microg), the fatty acid amide hydrolase inhibitor urb597 (0.5 and 1 microg), the cannabinoid cb1 receptor antagonist am251 (1 and 2.5 microg), or vehicle (dimethyl sulfoxide) and were assessed in the forced swim test. |
2007-10-23 |
2023-08-12 |
rat |
| G Murdolo, K Kempf, A Hammarstedt, C Herder, U Smith, P-A Jansso. Insulin differentially modulates the peripheral endocannabinoid system in human subcutaneous abdominal adipose tissue from lean and obese individuals. Journal of endocrinological investigation. vol 30. issue 8. 2007-10-23. PMID:17923791. |
the aim of this study was to elucidate the acute in vivo effects of insulin on gene expression of the cannabinoid type 1 (cb-1) and type 2 (cb-2) receptors, as well as of the fatty acid amide hydrolase (faah) in the sc abdominal adipose tissue (scaat). |
2007-10-23 |
2023-08-12 |
human |
| John Williams, JodiAnne Wood, Lakshmipathi Pandarinathan, David A Karanian, Ben A Bahr, Paul Vouros, Alexandros Makriyanni. Quantitative method for the profiling of the endocannabinoid metabolome by LC-atmospheric pressure chemical ionization-MS. Analytical chemistry. vol 79. issue 15. 2007-10-02. PMID:17600384. |
we have obtained an endocannabinoid profile specifically for the frontal cortex of the rat brain and have determined anandamide level differences following the administration of the fatty acid amide hydrolase inhibitor am374. |
2007-10-02 |
2023-08-12 |
rat |
| Geoffray Labar, Catherine Michau. Fatty acid amide hydrolase: from characterization to therapeutics. Chemistry & biodiversity. vol 4. issue 8. 2007-09-28. PMID:17712824. |
fatty acid amide hydrolase (faah) is an integral membrane enzyme within the amidase-signature family that terminates the action of several endogenous lipid messengers, including oleamide and the endocannabinoid anandamide. |
2007-09-28 |
2023-08-12 |
Not clear |
| Kazuhito Tsuboi, Naoko Takezaki, Natsuo Ued. The N-acylethanolamine-hydrolyzing acid amidase (NAAA). Chemistry & biodiversity. vol 4. issue 8. 2007-09-28. PMID:17712833. |
bioactive n-acylethanolamines, including the endocannabinoid anandamide and anti-inflammatory n-palmitoylethanolamine, are hydrolyzed to fatty acids and ethanolamine in animal tissues by the catalysis of fatty acid amide hydrolase (faah). |
2007-09-28 |
2023-08-12 |
mouse |
| Jessica P Alexander, Benjamin F Cravat. The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases. Journal of the American Chemical Society. vol 128. issue 30. 2007-09-21. PMID:16866524. |
the putative endocannabinoid transport blocker ly2183240 is a potent inhibitor of faah and several other brain serine hydrolases. |
2007-09-21 |
2023-08-12 |
Not clear |
| Sándor Bátkai, Mohanraj Rajesh, Partha Mukhopadhyay, György Haskó, Lucas Liaudet, Benjamin F Cravatt, Anna Csiszár, Zoltan Ungvári, Pál Pache. Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase. American journal of physiology. Heart and circulatory physiology. vol 293. issue 2. 2007-09-18. PMID:17434980. |
inhibition of the endocannabinoid anandamide metabolizing enzyme, the fatty acid amide hydrolase (faah), is emerging as a promising novel approach for the treatment of various inflammatory disorders. |
2007-09-18 |
2023-08-12 |
mouse |
| Sándor Bátkai, Mohanraj Rajesh, Partha Mukhopadhyay, György Haskó, Lucas Liaudet, Benjamin F Cravatt, Anna Csiszár, Zoltan Ungvári, Pál Pache. Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase. American journal of physiology. Heart and circulatory physiology. vol 293. issue 2. 2007-09-18. PMID:17434980. |
there was no difference in the myocardial cannabinoid cb(1) and cb(2) receptor gene expression between young and aging faah(-/-) and faah(+/+) mice. |
2007-09-18 |
2023-08-12 |
mouse |
| Shinya Iwasaki, Hiroki Ishiguro, Susumu Higuchi, Emmanuel S Onaivi, Tadao Arinam. Association study between alcoholism and endocannabinoid metabolic enzyme genes encoding fatty acid amide hydrolase and monoglyceride lipase in a Japanese population. Psychiatric genetics. vol 17. issue 4. 2007-09-17. PMID:17621164. |
association study between alcoholism and endocannabinoid metabolic enzyme genes encoding fatty acid amide hydrolase and monoglyceride lipase in a japanese population. |
2007-09-17 |
2023-08-12 |
Not clear |