| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shinya Iwasaki, Hiroki Ishiguro, Susumu Higuchi, Emmanuel S Onaivi, Tadao Arinam. Association study between alcoholism and endocannabinoid metabolic enzyme genes encoding fatty acid amide hydrolase and monoglyceride lipase in a Japanese population. Psychiatric genetics. vol 17. issue 4. 2007-09-17. PMID:17621164. |
fatty acid amide hydrolase (faah) and monoglyceride lipase (mgll) are the major endocannabinoid metabolic enzymes. |
2007-09-17 |
2023-08-12 |
Not clear |
| Shinya Iwasaki, Hiroki Ishiguro, Susumu Higuchi, Emmanuel S Onaivi, Tadao Arinam. Association study between alcoholism and endocannabinoid metabolic enzyme genes encoding fatty acid amide hydrolase and monoglyceride lipase in a Japanese population. Psychiatric genetics. vol 17. issue 4. 2007-09-17. PMID:17621164. |
owing to the importance of endocannabinoid system in addiction, the pro129thr polymorphism in the faah gene has reportedly been associated with substance abuse and dependence in a caucasian population. |
2007-09-17 |
2023-08-12 |
Not clear |
| Shoichiro Tsuyama, Daichi Oikawa, Yasuko Yamasaki, Sayuri Takagi, Hironori Ando, Mitsuhiro Furus. Expression of endocannabinoid synthetic enzyme mRnas is correlated with cannabinoid 1 receptor mRNA in the mouse brain. Nutritional neuroscience. vol 10. issue 1-2. 2007-09-12. PMID:17539482. |
phospholipase d (pld), fatty acid amide hydrolase (faah), diacyl-glycerol lipase (dagl), monoacyl-glycerol lipase (magl) and cannabinoid 1 (cb1) receptor mrna expressions were determined in the whole brain. |
2007-09-12 |
2023-08-12 |
mouse |
| Natalia Battista, Monica Bari, Alessia Tarditi, Caterina Mariotti, Anne-Catherine Bachoud-Lévi, Chiara Zuccato, Alessandro Finazzi-Agrò, Silvia Genitrini, Marc Peschanski, Stefano Di Donato, Elena Cattaneo, Mauro Maccarron. Severe deficiency of the fatty acid amide hydrolase (FAAH) activity segregates with the Huntington's disease mutation in peripheral lymphocytes. Neurobiology of disease. vol 27. issue 1. 2007-09-06. PMID:17553686. |
we assayed peripheral lymphocytes from hd patients and healthy controls, and found that the activity of the fatty acid amide hydrolase (faah), the enzyme that degrades the endocannabinoid anandamide (aea), was dramatically decreased (down to less than 10%) in hd compared to healthy subjects. |
2007-09-06 |
2023-08-12 |
human |
| Rachel F Tyndale, Jennifer I Payne, Alexandra L Gerber, Jack C Sip. The fatty acid amide hydrolase C385A (P129T) missense variant in cannabis users: studies of drug use and dependence in Caucasians. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 5. 2007-08-30. PMID:17290447. |
faah is a mammalian enzyme that inactivates neuromodulatory-signaling lipids including the endogenous cannabinoid 1 receptor agonist anandamide. |
2007-08-30 |
2023-08-12 |
human |
| Roberto Russo, Jesse Loverme, Giovanna La Rana, Timothy R Compton, Jeff Parrott, Andrea Duranti, Andrea Tontini, Marco Mor, Giorgio Tarzia, Antonio Calignano, Daniele Piomell. The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice. The Journal of pharmacology and experimental therapeutics. vol 322. issue 1. 2007-08-30. PMID:17412883. |
fatty acid amide hydrolase (faah) is an intracellular serine hydrolase that catalyzes the cleavage of bioactive fatty acid ethanolamides, such as the endogenous cannabinoid agonist anandamide. |
2007-08-30 |
2023-08-12 |
mouse |
| Roberto Russo, Jesse Loverme, Giovanna La Rana, Timothy R Compton, Jeff Parrott, Andrea Duranti, Andrea Tontini, Marco Mor, Giorgio Tarzia, Antonio Calignano, Daniele Piomell. The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice. The Journal of pharmacology and experimental therapeutics. vol 322. issue 1. 2007-08-30. PMID:17412883. |
the results provide new evidence for a role of the endocannabinoid system in pain modulation and reinforce the proposed role of faah as a target for analgesic drug development. |
2007-08-30 |
2023-08-12 |
mouse |
| Marcello Solinas, Maria Scherma, Gianluigi Tanda, Carrie E Wertheim, Walter Fratta, Steven R Goldber. Nicotinic facilitation of delta9-tetrahydrocannabinol discrimination involves endogenous anandamide. The Journal of pharmacology and experimental therapeutics. vol 321. issue 3. 2007-07-30. PMID:17351107. |
in addition, when metabolic degradation of the endogenous cannabinoid anandamide was blocked by the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoylbiphenil-3-yl-ester (urb-597; 0.3 mg/kg i.p.) |
2007-07-30 |
2023-08-12 |
rat |
| Sandra Holt, Ben Paylor, Linda Boldrup, Kirsi Alajakku, Séverine Vandevoorde, Anna Sundström, Maria Teresa Cocco, Valentina Onnis, Christopher J Fowle. Inhibition of fatty acid amide hydrolase, a key endocannabinoid metabolizing enzyme, by analogues of ibuprofen and indomethacin. European journal of pharmacology. vol 565. issue 1-3. 2007-07-26. PMID:17397826. |
inhibition of fatty acid amide hydrolase, a key endocannabinoid metabolizing enzyme, by analogues of ibuprofen and indomethacin. |
2007-07-26 |
2023-08-12 |
human |
| Sandra Holt, Ben Paylor, Linda Boldrup, Kirsi Alajakku, Séverine Vandevoorde, Anna Sundström, Maria Teresa Cocco, Valentina Onnis, Christopher J Fowle. Inhibition of fatty acid amide hydrolase, a key endocannabinoid metabolizing enzyme, by analogues of ibuprofen and indomethacin. European journal of pharmacology. vol 565. issue 1-3. 2007-07-26. PMID:17397826. |
in the present study, a series of analogues of ibuprofen and indomethacin have been investigated with respect to their ability to inhibit fatty acid amide hydrolase, the enzyme responsible for the hydrolysis of the endogenous cannabinoid anandamide. |
2007-07-26 |
2023-08-12 |
human |
| Sandra Holt, Ben Paylor, Linda Boldrup, Kirsi Alajakku, Séverine Vandevoorde, Anna Sundström, Maria Teresa Cocco, Valentina Onnis, Christopher J Fowle. Inhibition of fatty acid amide hydrolase, a key endocannabinoid metabolizing enzyme, by analogues of ibuprofen and indomethacin. European journal of pharmacology. vol 565. issue 1-3. 2007-07-26. PMID:17397826. |
ibu-am5 inhibited the binding of [3h]-cp55,940 to rat brain cb1 and human cb2 cannabinoid receptors more potently than ibuprofen, but the increase in potency was less than the corresponding increase in potency seen for inhibition of faah activity. |
2007-07-26 |
2023-08-12 |
human |
| Matthew N Hill, Eda S Karacabeyli, Boris B Gorzalk. Estrogen recruits the endocannabinoid system to modulate emotionality. Psychoneuroendocrinology. vol 32. issue 4. 2007-07-03. PMID:17391861. |
fatty acid amide hydrolase (faah), the enzyme which degrades the endocannabinoid anandamide, has been shown to be regulated by estrogen. |
2007-07-03 |
2023-08-12 |
human |
| Matthew N Hill, Eda S Karacabeyli, Boris B Gorzalk. Estrogen recruits the endocannabinoid system to modulate emotionality. Psychoneuroendocrinology. vol 32. issue 4. 2007-07-03. PMID:17391861. |
collectively, these data demonstrate that estrogen may elicit changes in emotional behavior through an endocannabinoid mechanism, and suggest that inhibition of faah represents a therapeutic target for anxiety and depression in women. |
2007-07-03 |
2023-08-12 |
human |
| Francis F Y Lam, Phoebe W S Luk, Ethel S K N. Pharmacological characterization of receptor types mediating the dilator action of anandamide on blood vessels of the rat knee joint. Life sciences. vol 80. issue 16. 2007-06-28. PMID:17275857. |
these findings suggest the vasodilator action of anandamide in the rat knee joint involved hydrolysis of the compound by faah, production of cox-derived eicosanoid(s), activation of trpv1 receptors, and a small component involved activation of endothelial anandamide/abnormal-cannabidiol receptors; a minor delayed dilator response was mediated by activation of conventional cannabinoid receptors. |
2007-06-28 |
2023-08-12 |
rat |
| Karen L Kage, Paul L Richardson, Linda Traphagen, Jean Severin, Ana Pereda-Lopez, Thomas Lubben, Rachel Davis-Taber, Melissa H Vos, Diane Bartley, Karl Walter, John Harlan, Larry Solomon, Usha Warrior, Thomas F Holzman, Connie Faltynek, Carol S Surowy, Victoria E Scot. A high throughput fluorescent assay for measuring the activity of fatty acid amide hydrolase. Journal of neuroscience methods. vol 161. issue 1. 2007-06-21. PMID:17083980. |
fatty acid amide hydrolase (faah) is the enzyme responsible for the rapid degradation of fatty acid amides such as the endocannabinoid anandamide. |
2007-06-21 |
2023-08-12 |
human |
| Stephen A Varvel, Laura E Wise, Floride Niyuhire, Benjamin F Cravatt, Aron H Lichtma. Inhibition of fatty-acid amide hydrolase accelerates acquisition and extinction rates in a spatial memory task. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 5. 2007-06-05. PMID:17047668. |
here, we test the hypothesis that elevating brain levels of the endogenous cannabinoid anandamide through either genetic deletion or pharmacological inhibition of its primary catabolic enzyme fatty-acid amide hydrolase (faah) will potentiate extinction in a fixed platform water maze task. |
2007-06-05 |
2023-08-12 |
mouse |
| Janet Hoenicka, Guillermo Ponce, Miguel A Jiménez-Arriero, Israel Ampuero, Roberto Rodríguez-Jiménez, Gabriel Rubio, Maria Aragüés, Jose A Ramos, Tomás Palom. Association in alcoholic patients between psychopathic traits and the additive effect of allelic forms of the CNR1 and FAAH endocannabinoid genes, and the 3' region of the DRD2 gene. Neurotoxicity research. vol 11. issue 1. 2007-05-22. PMID:17449448. |
association in alcoholic patients between psychopathic traits and the additive effect of allelic forms of the cnr1 and faah endocannabinoid genes, and the 3' region of the drd2 gene. |
2007-05-22 |
2023-08-12 |
Not clear |
| Marcello Solinas, Gianluigi Tanda, Zuzana Justinova, Carrie E Wertheim, Sevil Yasar, Daniele Piomelli, Subramanian K Vadivel, Alexandros Makriyannis, Steven R Goldber. The endogenous cannabinoid anandamide produces delta-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transport. The Journal of pharmacology and experimental therapeutics. vol 321. issue 1. 2007-05-14. PMID:17210800. |
the endogenous cannabinoid anandamide produces delta-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transport. |
2007-05-14 |
2023-08-12 |
rat |
| Amy K Dickason-Chesterfield, Stephanie R Kidd, Steven A Moore, John M Schaus, Bin Liu, George G Nomikos, Christian C Felde. Pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors. Cellular and molecular neurobiology. vol 26. issue 4-6. 2007-04-24. PMID:16736384. |
pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors. |
2007-04-24 |
2023-08-12 |
Not clear |
| Amy K Dickason-Chesterfield, Stephanie R Kidd, Steven A Moore, John M Schaus, Bin Liu, George G Nomikos, Christian C Felde. Pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors. Cellular and molecular neurobiology. vol 26. issue 4-6. 2007-04-24. PMID:16736384. |
a subset of compounds reported in the literature were tested in our laboratory under common assay conditions to measure their ability to (a) inhibit [(14)c]-anandamide uptake in cells containing (rbl-2h3) or cells lacking (hela) faah, (b) inhibit purified faah hydrolytic activity, and (c) inhibit binding to a putative binding site involved in endocannabinoid transport in both rbl and hela cell membranes. |
2007-04-24 |
2023-08-12 |
Not clear |