All Relations between fatty acid amide hydrolase and cannabinoids

Publication Sentence Publish Date Extraction Date Species
Amy K Dickason-Chesterfield, Stephanie R Kidd, Steven A Moore, John M Schaus, Bin Liu, George G Nomikos, Christian C Felde. Pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors. Cellular and molecular neurobiology. vol 26. issue 4-6. 2007-04-24. PMID:16736384. a more direct comparison of multiple inhibitors could be made in these three assay systems performed in the same laboratory, revealing more information about the selectivity of these compounds and the relationship between the putative endocannabinoid transport protein and faah. 2007-04-24 2023-08-12 Not clear
Laura E Wise, Christopher C Shelton, Benjamin F Cravatt, Billy R Martin, Aron H Lichtma. Assessment of anandamide's pharmacological effects in mice deficient of both fatty acid amide hydrolase and cannabinoid CB1 receptors. European journal of pharmacology. vol 557. issue 1. 2007-04-12. PMID:17217945. assessment of anandamide's pharmacological effects in mice deficient of both fatty acid amide hydrolase and cannabinoid cb1 receptors. 2007-04-12 2023-08-12 mouse
Laura E Wise, Christopher C Shelton, Benjamin F Cravatt, Billy R Martin, Aron H Lichtma. Assessment of anandamide's pharmacological effects in mice deficient of both fatty acid amide hydrolase and cannabinoid CB1 receptors. European journal of pharmacology. vol 557. issue 1. 2007-04-12. PMID:17217945. the behavioral effects of anandamide were evaluated in mice that lacked both fatty acid amide hydrolase (faah) and cannabinoid cb(1) receptors (dko) as compared to faah (-/-), cannabinoid cb(1) (-/-), and wild type mice. 2007-04-12 2023-08-12 mouse
Gianna Rossi, Valeria Gasperi, Rita Paro, Daniela Barsacchi, Sandra Cecconi, Mauro Maccarron. Follicle-stimulating hormone activates fatty acid amide hydrolase by protein kinase A and aromatase-dependent pathways in mouse primary Sertoli cells. Endocrinology. vol 148. issue 3. 2007-04-04. PMID:17110429. altogether these data suggest that faah is the only target of fsh among the elements of the endocannabinoid system, and that its regulation by pka and aromatase-dependent pathways impacts sertoli cell proliferation. 2007-04-04 2023-08-12 mouse
Haibin Wang, Huirong Xie, Xiaofei Sun, Philip J Kingsley, Lawrence J Marnett, Benjamin F Cravatt, Sudhansu K De. Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation. Prostaglandins & other lipid mediators. vol 83. issue 1-2. 2007-03-29. PMID:17259073. we also provide evidence that region- and stage-specific uterine expression of n-acylphosphatidylethanolamine-specific phospholipase d (nape-pld) and fatty acid amide hydrolase (faah), and sn-1-diacylglycerol (dag) lipase alpha (daglalpha) and monoacylglycerol lipase (magl) for synthesis and hydrolysis of anandamide and 2-ag, respectively, creates endocannabinoid gradients conducive to implantation. 2007-03-29 2023-08-12 mouse
Cristina Benito, Juan Pablo Romero, Rosa María Tolón, Diego Clemente, Fabián Docagne, Cecilia J Hillard, Camen Guaza, Julián Romer. Cannabinoid CB1 and CB2 receptors and fatty acid amide hydrolase are specific markers of plaque cell subtypes in human multiple sclerosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 9. 2007-03-19. PMID:17329437. cannabinoid cb1 and cb2 receptors and fatty acid amide hydrolase are specific markers of plaque cell subtypes in human multiple sclerosis. 2007-03-19 2023-08-12 human
Cristina Benito, Juan Pablo Romero, Rosa María Tolón, Diego Clemente, Fabián Docagne, Cecilia J Hillard, Camen Guaza, Julián Romer. Cannabinoid CB1 and CB2 receptors and fatty acid amide hydrolase are specific markers of plaque cell subtypes in human multiple sclerosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 9. 2007-03-19. PMID:17329437. however, most experimental data come from animal models of ms. we investigated the status of cannabinoid cb1 and cb2 receptors and fatty acid amide hydrolase (faah) enzyme in brain tissue samples obtained from ms patients. 2007-03-19 2023-08-12 human
Cristina Benito, Juan Pablo Romero, Rosa María Tolón, Diego Clemente, Fabián Docagne, Cecilia J Hillard, Camen Guaza, Julián Romer. Cannabinoid CB1 and CB2 receptors and fatty acid amide hydrolase are specific markers of plaque cell subtypes in human multiple sclerosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 9. 2007-03-19. PMID:17329437. as seen for other neuroinflammatory conditions, selective glial expression of cannabinoid cb1 and cb2 receptors and faah enzyme is induced in ms, thus supporting a role for the endocannabinoid system in the pathogenesis and/or evolution of this disease. 2007-03-19 2023-08-12 human
Yuki Hashimotodani, Takako Ohno-Shosaku, Masanobu Kan. Presynaptic monoacylglycerol lipase activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 5. 2007-03-16. PMID:17267577. in contrast, inhibitors of other endocannabinoid hydrolyzing enzymes, fatty acid amide hydrolase and cyclooxygenase-2, had no effect on the 2-ag-induced ipsc suppression. 2007-03-16 2023-08-12 Not clear
Alessio Lodola, Marco Mor, Jolanta Zurek, Giorgio Tarzia, Daniele Piomelli, Jeremy N Harvey, Adrian J Mulhollan. Conformational effects in enzyme catalysis: reaction via a high energy conformation in fatty acid amide hydrolase. Biophysical journal. vol 92. issue 2. 2007-02-28. PMID:17098788. this unusual finding has important implications for fatty acid amide hydrolase, a key enzyme in the endocannabinoid system. 2007-02-28 2023-08-12 Not clear
Ivan Tubert-Brohman, Orlando Acevedo, William L Jorgense. Elucidation of hydrolysis mechanisms for fatty acid amide hydrolase and its Lys142Ala variant via QM/MM simulations. Journal of the American Chemical Society. vol 128. issue 51. 2007-02-20. PMID:17177441. fatty acid amide hydrolase (faah) is a serine hydrolase that degrades anandamide, an endocannabinoid, and oleamide, a sleep-inducing lipid, and has potential applications as a therapeutic target for neurological disorders. 2007-02-20 2023-08-12 Not clear
Bela Szabo, Michal J Urbanski, Tiziana Bisogno, Vincenzo Di Marzo, Aitziber Mendiguren, Wolfram U Baer, Ilka Freima. Depolarization-induced retrograde synaptic inhibition in the mouse cerebellar cortex is mediated by 2-arachidonoylglycerol. The Journal of physiology. vol 577. issue Pt 1. 2007-01-23. PMID:16973696. thus, three kinds of observations identified 2-ag as the endocannabinoid involved in dsi in the mouse cerebellum: dsi was abolished by diacylglycerol lipase inhibitors; dsi was potentiated by a monoglyceride lipase inhibitor; and dsi was not changed by an inhibitor of fatty acid amide hydrolase. 2007-01-23 2023-08-12 mouse
Ben Paylor, Sandra Holt, Christopher J Fowle. The potency of the fatty acid amide hydrolase inhibitor URB597 is dependent upon the assay pH. Pharmacological research. vol 54. issue 6. 2007-01-23. PMID:16997568. inhibitors of the enzyme fatty acid amide hydrolase (faah), the principal enzyme involved in the metabolism of the endogenous cannabinoid anandamide, have potential utility in the treatment of disorders including inflammation and inflammatory pain. 2007-01-23 2023-08-12 rat
Jason R Clapper, Andrea Duranti, Andrea Tontini, Marco Mor, Giorgio Tarzia, Daniele Piomell. The fatty-acid amide hydrolase inhibitor URB597 does not affect triacylglycerol hydrolysis in rat tissues. Pharmacological research. vol 54. issue 5. 2007-01-10. PMID:16935521. the o-arylcarbamate urb597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester; also referred to as kds-4103) is a potent inhibitor of fatty-acid amide hydrolase (faah), an intracellular serine hydrolase responsible for the inactivation of the endogenous cannabinoid anandamide. 2007-01-10 2023-08-12 mouse
Matthias Blüher, Stefan Engeli, Nora Klöting, Janin Berndt, Mathias Fasshauer, Sándor Bátkai, Pál Pacher, Michael R Schön, Jens Jordan, Michael Stumvol. Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity. Diabetes. vol 55. issue 11. 2007-01-04. PMID:17065342. we further measured expression of the cannabinoid type 1 (cb(1)) receptor and fatty acid amide hydrolase (faah) genes in paired samples of subcutaneous and visceral adipose tissue in all 60 subjects. 2007-01-04 2023-08-12 human
Angelo Jayamanne, Ruth Greenwood, Vanessa A Mitchell, Sevda Aslan, Daniele Piomelli, Christopher W Vaugha. Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models. British journal of pharmacology. vol 147. issue 3. 2006-12-26. PMID:16331291. these findings suggest that the faah inhibitor urb597 produces cannabinoid cb1 and cb2 receptor-mediated analgesia in inflammatory pain states, without causing the undesirable side effects associated with cannabinoid receptor activation. 2006-12-26 2023-08-12 rat
Josée Guindon, Jesse LoVerme, André De Léan, Daniele Piomelli, Pierre Beaulie. Synergistic antinociceptive effects of anandamide, an endocannabinoid, and nonsteroidal anti-inflammatory drugs in peripheral tissue: a role for endogenous fatty-acid ethanolamides? European journal of pharmacology. vol 550. issue 1-3. 2006-12-15. PMID:17027744. nonsteroidal anti-inflammatory drugs (nsaids) inhibit fatty-acid amide hydrolase (faah), the enzyme responsible for the metabolism of anandamide, an endocannabinoid. 2006-12-15 2023-08-12 Not clear
Magdalena Zaniewska, Andrew C McCreary, Edmund Przegaliński, Małgorzata Fili. Evaluation of the role of nicotinic acetylcholine receptor subtypes and cannabinoid system in the discriminative stimulus effects of nicotine in rats. European journal of pharmacology. vol 540. issue 1-3. 2006-12-11. PMID:16730696. during test sessions the following drugs were coadministered with saline (substitution studies) or nicotine (0.025-0.4 mg/kg; combination studies): the alpha4beta2 nicotinic acetylcholine receptor subtype antagonist dihydro-beta-erythroidine (dhbetae), the non-selective nicotinic acetylcholine receptor subtype antagonist mecamylamine, the alpha7 nicotinic acetylcholine receptor subtype antagonist methyllycaconitine (mla), the alpha4beta2 nicotinic acetylcholine receptor subtype agonist 5-iodo-3-(2(s)-azetidinylmethoxy)pyridine (5-ia), the cannabinoid cb1 receptor antagonist/partial agonist rimonabant, the cannabinoid cb2 receptor antagonist n-[(1s)-endo-1,3,3-trimethylbicyclo-[2.2.1]heptan-2-yl]5-(4-chloro-3-methyl-phenyl)-1-(4-methybenzyl)pyrazole-3-carboxamide (sr 144528), the cannabinoid cb1/2 receptor agonists (-)-cis-3-[2-hydroxy-4-(1,1-dimethylheptyl)-phenyl]-trans-4-(3-hydroxy-propyl)cyclohexanol (cp 55,940) or r(+)-[2,3-dihydro-5-methyl-3-[(morpholinyl)methyl]-pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-(1-naphthalenyl)-methanone mesylate (win 55,212-2), the endogenous cannabinoid agonist and non-competitive alpha7 nicotinic acetylcholine receptor subtype antagonist anandamide, the anandamide uptake and fatty acid amide hydrolase inhibitor n-(4-hydroxyphenyl)-5z,8z,11z,14z-eicosatetraenamide (am-404), the fatty acid amide hydrolase inhibitor cyclohexylcarbamic acid 3'-carbamoyl-biphenyl-3-yl ester (urb 597), am-404+anandamide or urb 597+anandamide. 2006-12-11 2023-08-12 rat
Anuradha Nallapaneni, Jing Liu, Subramanya Karanth, Carey Pop. Modulation of paraoxon toxicity by the cannabinoid receptor agonist WIN 55,212-2. Toxicology. vol 227. issue 1-2. 2006-11-29. PMID:16956707. several studies suggest that some organophosphorus toxicants can potentially modify cannabinergic signaling by direct binding to cannabinoid receptors and inhibition of enzymes responsible for cannabinoid degradation (i.e., fatty acid amide hydrolase and monoacylglycerol lipase). 2006-11-29 2023-08-12 rat
Anke M Mulder, Benjamin F Cravat. Endocannabinoid metabolism in the absence of fatty acid amide hydrolase (FAAH): discovery of phosphorylcholine derivatives of N-acyl ethanolamines. Biochemistry. vol 45. issue 38. 2006-11-08. PMID:16981687. endocannabinoid metabolism in the absence of fatty acid amide hydrolase (faah): discovery of phosphorylcholine derivatives of n-acyl ethanolamines. 2006-11-08 2023-08-12 mouse