| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marek Zubrzycki, Maria Zubrzycka, Grzegorz Wysiadecki, Janusz Szemraj, Hanna Jerczynska, Mariusz Stasiole. Effect of Fatty Acid Amide Hydrolase Inhibitor URB597 on Orofacial Pain Perception in Rats. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35563056. |
we have shown that increasing endocannabinoid aea levels by both central and peripheral inhibition of faah inhibitor by urb597 has an antinociceptive effect on the trigemino-hypoglossal reflex mediated by cb1r and influences the activation of the brain areas studied. |
2022-05-14 |
2023-08-13 |
rat |
| Pritha Shah, Aqsa Siddique, Ami Thakkar, Sankalp Gharat, Angel Godad, Pravin Kale, Gaurav Dosh. An update on novel therapeutic intervention in Rheumatoid arthritis. International immunopharmacology. vol 109. 2022-05-03. PMID:35504203. |
prostaglandins, leukotrienes, platelet-activating factor, cannabinoids, and specific fatty acid amide hydrolase are all examples of small molecular metabolites. |
2022-05-03 |
2023-08-13 |
Not clear |
| Adriana Della Pietra, Juha Savinainen, Rashid Giniatulli. Inhibiting Endocannabinoid Hydrolysis as Emerging Analgesic Strategy Targeting a Spectrum of Ion Channels Implicated in Migraine Pain. International journal of molecular sciences. vol 23. issue 8. 2022-04-23. PMID:35457225. |
we describe here: (i) migraine pain signaling pathways, which could serve as specific targets for antinociception; (ii) a divergent distribution of magl and faah activities in the key regions of the pns and cns implicated in migraine pain signaling; (iii) a complexity of anti-nociceptive effects of endocbs mediated by cannabinoid receptors and through a direct modulation of ion channels in nociceptive neurons; and (iv) the spectrum of emerging potent magl and faah inhibitors which efficiently increase endocbs levels. |
2022-04-23 |
2023-08-13 |
Not clear |
| Lakhan S Khara, Md Ruhul Amin, Declan W Al. Inhibiting the endocannabinoid degrading enzymes FAAH and MAGL during zebrafish embryogenesis alters sensorimotor function. The Journal of experimental biology. 2022-04-19. PMID:35438163. |
inhibiting the endocannabinoid degrading enzymes faah and magl during zebrafish embryogenesis alters sensorimotor function. |
2022-04-19 |
2023-08-13 |
zebrafish |
| Shivanshu Bajaj, Saima Zameer, Shreshta Jain, Vaishali Yadav, Divya Vohor. Effect of the MAGL/FAAH Dual Inhibitor JZL-195 on Streptozotocin-Induced Alzheimer's Disease-like Sporadic Dementia in Mice with an Emphasis on Aβ, HSP-70, Neuroinflammation, and Oxidative Stress. ACS chemical neuroscience. 2022-03-22. PMID:35316021. |
recently, pharmacological inhibition of endocannabinoid (ecb)-degrading enzymes, fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), is being investigated to modulate the pathology of alzheimer's disease. |
2022-03-22 |
2023-08-13 |
mouse |
| Erin Jordan, Gia-Nam Nguyen, Alexander Piechot, Oliver Kayse. Cannabinoids as New Drug Candidates for the Treatment of Glaucoma. Planta medica. 2022-03-17. PMID:35299275. |
especially the role of the endocannabinoid system (fatty acid amide hydrolase, monoacylglycerol lipase) impacting the prostaglandin network (cyclooxygenase, pge, pgf) and neuroprotection by inhibition of nitric oxide radical formation is in the focus of this review. |
2022-03-17 |
2023-08-13 |
Not clear |
| Changqing Xu, Barkha J Yadav-Samudrala, Callie Xu, Bhupendra Nath, Twisha Mistry, Wei Jiang, Micah J Niphakis, Benjamin F Cravatt, Somnath Mukhopadhyay, Aron H Lichtman, Bogna M Ignatowska-Jankowska, Sylvia Fittin. Inhibitory Neurotransmission Is Sex-Dependently Affected by Tat Expression in Transgenic Mice and Suppressed by the Fatty Acid Amide Hydrolase Enzyme Inhibitor PF3845 via Cannabinoid Type-1 Receptor Mechanisms. Cells. vol 11. issue 5. 2022-03-10. PMID:35269478. |
inhibitory neurotransmission is sex-dependently affected by tat expression in transgenic mice and suppressed by the fatty acid amide hydrolase enzyme inhibitor pf3845 via cannabinoid type-1 receptor mechanisms. |
2022-03-10 |
2023-08-13 |
mouse |
| Sarah E Melford, Anthony H Taylor, Justin C Konj. Nitric oxide positively affects endometrial receptivity via FAAH and NAPE-PLD Reproduction & fertility. vol 2. issue 2. 2022-02-07. PMID:35128447. |
nitric oxide positively affects endometrial receptivity via faah and nape-pld to determine if models of human 'receptive' and 'non-receptive endometrium' differ in their responses to nitric oxide (no) supplementation by measuring the levels of the enzymes of the endocannabinoid system (ecs) (fatty acid amide hydrolase (faah) and n-acylphosphatidylethanolamine-specific phospholipase d (nape-pld)), which control the 'anandamide tone' essential for successful pregnancy. |
2022-02-07 |
2023-08-13 |
human |
| Terri A deRoon-Cassini, Carisa L Bergner, Samantha A Chesney, Nicholas R Schumann, Tara Sander Lee, Karen J Brasel, Cecilia J Hillar. Circulating endocannabinoids and genetic polymorphisms as predictors of posttraumatic stress disorder symptom severity: heterogeneity in a community-based cohort. Translational psychiatry. vol 12. issue 1. 2022-02-02. PMID:35105857. |
serum concentrations of the endocannabinoids n-arachidonoylethanolamine (aea) and 2-arachidonoylglycerol (2-ag) were determined at both time points and selected genetic polymorphisms in endocannabinoid genes, including rs324420 in fatty acid amide hydrolase, were assessed. |
2022-02-02 |
2023-08-13 |
human |
| Maximilian Barth, Stefan Rudolph, Jan Kampschulze, Imke Meyer Zu Vilsendorf, Walburga Hanekamp, Dennis Mulac, Klaus Langer, Matthias Leh. Hexafluoroisopropyl carbamates as selective MAGL and dual MAGL/FAAH inhibitors: biochemical and physicochemical properties. ChemMedChem. 2022-01-24. PMID:35072346. |
a series of hexafluoroisopropyl carbamates with indolyl-alkyl- and azaindolylalkyl-substituents at the carbamate nitrogen was synthesized and evaluated for inhibition of the endocannabinoid degrading enzymes fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl). |
2022-01-24 |
2023-08-13 |
Not clear |
| Nathan J Kolla, Isabelle Boileau, R Michael Bagb. Higher trait neuroticism is associated with greater fatty acid amide hydrolase binding in borderline and antisocial personality disorders. Scientific reports. vol 12. issue 1. 2022-01-22. PMID:35064143. |
fatty acid amide hydrolase (faah), an enzyme of the endocannabinoid system (ecs), has been linked to regulation of mood through modulation of anandamide, an endocannabinoid. |
2022-01-22 |
2023-08-13 |
human |
| Szymon Hryhorowicz, Marta Kaczmarek-Ryś, Aleksandra Zielińska, Rodney J Scott, Ryszard Słomski, Andrzej Pławsk. Endocannabinoid System as a Promising Therapeutic Target in Inflammatory Bowel Disease - A Systematic Review. Frontiers in immunology. vol 12. 2022-01-10. PMID:35003109. |
it consists of cannabinoid receptors (cb1 and cb2), transporters for cellular uptake of endocannabinoid ligands, endogenous bioactive lipids (anandamide and 2-arachidonoylglycerol), and the enzymes responsible for their synthesis and degradation (fatty acid amide hydrolase and monoacylglycerol lipase), the manipulation of which through agonists and antagonists of the system, shows a potential therapeutic role for ecs in inflammatory bowel disease. |
2022-01-10 |
2023-08-13 |
Not clear |
| Shrouq I Farah, Samantha Hilston, Ngan Tran, Nikolai Zvonok, Alexandros Makriyanni. 1-, 2- and 3-AG as substrates of the endocannabinoid enzymes and endogenous ligands of the cannabinoid receptor 1. Biochemical and biophysical research communications. vol 591. 2022-01-07. PMID:34995983. |
here, we present the interaction profiles of 2-ag and its isomerization products, 1- and 3-ag, with the endocannabinoid mgl, abhd6 and faah enzymes as well as the cb1 receptor. |
2022-01-07 |
2023-08-13 |
Not clear |
| Subramaniam Jayanthi, Ritvik Peesapati, Michael T McCoy, Bruce Ladenheim, Jean Lud Cade. Footshock-Induced Abstinence from Compulsive Methamphetamine Self-administration in Rat Model Is Accompanied by Increased Hippocampal Expression of Cannabinoid Receptors (CB1 and CB2). Molecular neurobiology. 2022-01-03. PMID:34978045. |
animals were euthanized 2 h after the last meth sa session and their hippocampi were used to measure mrna levels of cannabinoid receptors (cb/cnr), as well as those of synthesizing (dagl-a, dagl-b, napepld) and metabolizing (mgll, faah, ptgs2) enzymes of the endocannabinoid cascade. |
2022-01-03 |
2023-08-13 |
rat |
| Smita Jain, Akansha Bisht, Kanika Verma, Swarnima Negi, Sarvesh Paliwal, Swapnil Sharm. The role of fatty acid amide hydrolase enzyme inhibitors in Alzheimer's disease. Cell biochemistry and function. 2021-12-21. PMID:34931308. |
fatty acid amide hydrolase (faah) is a prominent enzyme of the endocannabinoid system that degrades endogenous cannabinoid anandamide and oleamide. |
2021-12-21 |
2023-08-13 |
Not clear |
| Shivanshu Bajaj, Shreshta Jain, Preeti Vyas, Sandhya Bawa, Divya Vohor. The role of endocannabinoid pathway in the neuropathology of Alzheimer's disease: Can the inhibitors of MAGL and FAAH prove to be potential therapeutic targets against the cognitive impairment associated with Alzheimer's disease? Brain research bulletin. vol 174. 2021-12-10. PMID:34217798. |
the role of endocannabinoid pathway in the neuropathology of alzheimer's disease: can the inhibitors of magl and faah prove to be potential therapeutic targets against the cognitive impairment associated with alzheimer's disease? |
2021-12-10 |
2023-08-13 |
Not clear |
| Shivanshu Bajaj, Shreshta Jain, Preeti Vyas, Sandhya Bawa, Divya Vohor. The role of endocannabinoid pathway in the neuropathology of Alzheimer's disease: Can the inhibitors of MAGL and FAAH prove to be potential therapeutic targets against the cognitive impairment associated with Alzheimer's disease? Brain research bulletin. vol 174. 2021-12-10. PMID:34217798. |
in order to modulate endocannabinoid system, number of agents have been reported amongst which are inhibitors of the monoacylglycerol (magl) and fatty acid amide hydrolase (faah), the enzymes that hydrolyses 2-ag and aea respectively. |
2021-12-10 |
2023-08-13 |
Not clear |
| A Ronchi, F Grauso, F Zito Marino, V Quagliariello, N Maurea, G Facchini, M Montopoli, R Franco, M Berretta, E M Messall. Endocannabinoid system expression in ovarian epithelial tumors according to the dualistic model of ovarian carcinogenesis. European review for medical and pharmacological sciences. vol 25. issue 14. 2021-12-10. PMID:34337715. |
our study aimed to confirm the expression of the endocannabinoid system in the human epithelial ovarian tumors, assessing the immunohistochemical expression of cannabinoid receptor type 1 and fatty acid amide hydrolase in benign, borderline and malignant tumors. |
2021-12-10 |
2023-08-13 |
human |
| Stacey Herriage, Guangping Chen, Carey Pop. Concentration-dependent effects of chlorpyrifos oxon on peroxisome proliferator-activated receptor signaling in MCF-7 cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 78. 2021-12-10. PMID:34756920. |
ache is critical in regulating cholinergic signaling while faah catalyzes the inactivation of fatty acid signaling lipids including the endocannabinoid (ecb) n-arachidonylethanolamine (anandamide, aea) and ecb-like metabolites (e.g., oleoylethanolamide, oea). |
2021-12-10 |
2023-08-13 |
human |
| Milica Jankovic, Natasa Spasojevic, Harisa Ferizovic, Bojana Stefanovic, Sladjana Dronja. Sex specific effects of the fatty acid amide hydrolase inhibitor URB597 on memory and brain β Neuroscience letters. vol 768. 2021-12-07. PMID:34843876. |
sex specific effects of the fatty acid amide hydrolase inhibitor urb597 on memory and brain β an increasing body of evidence shows significant sex differences in the mammalian brain in multiple behaviours and psychiatric and neurological diseases and as well as that the endocannabinoid system may differ between males and females. |
2021-12-07 |
2023-08-13 |
Not clear |