| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoru Dong, Dingang Zhang, Rongzhe Zhu, Xiaochen Liu, Yonghong Ye, Yan Jian. Spatio-temporal effects of acute alcohol intoxication on endocannabinoid system in rat brain and blood. Alcohol (Fayetteville, N.Y.). vol 88. 2021-09-15. PMID:32738384. |
we have closely monitored the critical indicators reflecting changes of the ecs during the entire process from alcohol absorption to its metabolization, after acute alcohol (4.5 g/kg) intake by intragastric administration, including two key endocannabinoids (arachidonoylethanolamide and 2-arachidonoylglycerol) and their hydrolytic enzymes (fatty acid amide hydrolase and monoacylglycerol lipase) in blood and three brain regions, as well as a crucial and abundant receptor (cannabinoid 1 receptor) of the ecs in the three brain regions. |
2021-09-15 |
2023-08-13 |
human |
| Noëlle van Egmond, Verena M Straub, Mario van der Stel. Targeting Endocannabinoid Signaling: FAAH and MAG Lipase Inhibitors. Annual review of pharmacology and toxicology. vol 61. 2021-09-09. PMID:32867595. |
targeting endocannabinoid signaling: faah and mag lipase inhibitors. |
2021-09-09 |
2023-08-13 |
Not clear |
| Lucinda M Sisk, Kristina M Rapuano, May I Conley, Abigail S Greene, Corey Horien, Monica D Rosenberg, Dustin Scheinost, R Todd Constable, Charles E Glatt, B J Casey, Dylan G Ge. Genetic variation in endocannabinoid signaling is associated with differential network-level functional connectivity in youth. Journal of neuroscience research. 2021-09-08. PMID:34496065. |
the fatty acid amide hydrolase (faah) c385a polymorphism, which is associated with enhanced endocannabinoid signaling in the brain, has been identified across species as a potential protective factor from anxiety. |
2021-09-08 |
2023-08-13 |
human |
| Dorsa Rafiei, Nathan J Koll. Elevated Brain Fatty Acid Amide Hydrolase Induces Depressive-Like Phenotypes in Rodent Models: A Review. International journal of molecular sciences. vol 22. issue 3. 2021-09-06. PMID:33494322. |
altered activity of fatty acid amide hydrolase (faah), an enzyme of the endocannabinoid system, has been implicated in several neuropsychiatric disorders, including major depressive disorder (mdd). |
2021-09-06 |
2023-08-13 |
Not clear |
| Zubeyir Elmazoglu, Edgar Rangel-López, Omar Noel Medina-Campos, José Pedraza-Chaverri, Isaac Túnez, Michael Aschner, Abel Santamaría, Çimen Karas. Cannabinoid-profiled agents improve cell survival via reduction of oxidative stress and inflammation, and Nrf2 activation in a toxic model combining hyperglycemia+Aβ Neurochemistry international. vol 140. 2021-09-02. PMID:32781098. |
here we characterized the protective properties of the endocannabinoids arachidonylethanolamide (aea) and 2-arachidonoylglycerol (2-ag), the synthetic cannabinoids cp 55-940 and win 55,212-2, and the fatty acid amide hydrolase (faah) inhibitor urb597, on a combined hyperglycemia + oligomeric amyloid β peptide (aβ |
2021-09-02 |
2023-08-13 |
Not clear |
| Adrián Bartoll, Ana Toledano-Zaragoza, Josefina Casas, Manuel Guzmán, Edward H Schuchman, María Dolores Ledesm. Inhibition of fatty acid amide hydrolase prevents pathology in neurovisceral acid sphingomyelinase deficiency by rescuing defective endocannabinoid signaling. EMBO molecular medicine. vol 12. issue 11. 2021-08-18. PMID:33016621. |
inhibition of fatty acid amide hydrolase prevents pathology in neurovisceral acid sphingomyelinase deficiency by rescuing defective endocannabinoid signaling. |
2021-08-18 |
2023-08-13 |
mouse |
| A R Tejeda-Martínez, J M Viveros-Paredes, G V Hidalgo-Franco, E Pardo-González, V Chaparro-Huerta, R E González-Castañeda, M E Flores-Sot. Chronic Inhibition of FAAH Reduces Depressive-Like Behavior and Improves Dentate Gyrus Proliferation after Chronic Unpredictable Stress Exposure. Behavioural neurology. vol 2021. 2021-08-18. PMID:33833828. |
levels of the endocannabinoid anandamide (aea) seem to affect these depression-by-stress-related features and could be modulated by fatty acid amide hydrolase (faah). |
2021-08-18 |
2023-08-13 |
mouse |
| Juan Suárez, Sophia Khom, Francisco Alén, Luis A Natividad, Florence P Varodayan, Reesha R Patel, Dean Kirson, Rocío Arco, Antonio Ballesta, Michal Bajo, Leticia Rubio, Rémi Martin-Fardon, Fernando Rodríguez de Fonseca, Marisa Robert. Cessation of fluoxetine treatment increases alcohol seeking during relapse and dysregulates endocannabinoid and glutamatergic signaling in the central amygdala. Addiction biology. vol 25. issue 5. 2021-08-11. PMID:31339221. |
the increase in ethanol self-administration was associated with (a) reductions in levels of the endocannabinoids n-arachidonoylethanolomine and 2-arachidonoylglycerol in the cea, (b) increased amygdalar gene expression of cannabinoid type-1 receptor (cb1), n-acyl phosphatidylethanolamine phospholipase d (nape-pld), fatty acid amid hydrolase (faah), (c) decreased amygdalar gene expression of ionotropic ampa (glua2 and glua4) and metabotropic (mglu3) glutamate receptors, and (d) increased glutamatergic receptor function. |
2021-08-11 |
2023-08-13 |
Not clear |
| Luca Carnevali, Rosario Statello, Federica Vacondio, Francesca Ferlenghi, Gilberto Spadoni, Silvia Rivara, Marco Mor, Andrea Sgoif. Antidepressant-like effects of pharmacological inhibition of FAAH activity in socially isolated female rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 32. 2021-08-10. PMID:31948828. |
pharmacological inhibition of the enzyme fatty acid amide hydrolase (faah), which terminates signaling of the endocannabinoid n-arachidonoylethanolamine (or anandamide, aea), exerts favourable effects in rodent models of stress-related depression. |
2021-08-10 |
2023-08-13 |
rat |
| Lisa E Flannery, Daniel M Kerr, Edel M Hughes, Colm Kelly, Jonathan Costello, Aoife M Thornton, Rachel M Humphrey, David P Finn, Michelle Roch. N-acylethanolamine regulation of TLR3-induced hyperthermia and neuroinflammatory gene expression: A role for PPARα. Journal of neuroimmunology. vol 358. 2021-08-09. PMID:34265624. |
synthetic cannabinoids and enhancing cannabinoid tone via inhibition of fatty acid amide hydrolase (faah) has been demonstrated to modulate tlr3-induced neuroimmune responses and associated sickness behaviour. |
2021-08-09 |
2023-08-13 |
Not clear |
| Shivani Jaiswal, Senthil Raja Ayyanna. Anticancer Potential of Small-Molecule Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase. ChemMedChem. vol 16. issue 14. 2021-07-19. PMID:33834617. |
both faah and magl are the endocannabinoid degrading enzymes that hydrolyze several endogenous ligands, mainly anandamide (aea) and 2-arachidonic glycerol (2-ag), which regulate various pathophysiological conditions in the body such as emotion, cognition, energy balance, pain sensation, neuroinflammation, and cancer cell proliferation. |
2021-07-19 |
2023-08-13 |
Not clear |
| Catarina Micaelo-Fernandes, Joseph Bouskila, Jean-François Bouchard, Maurice Ptit. Presence of the Endocannabinoid System in the Inferior Pulvinar of the Vervet Monkey. Brain sciences. vol 11. issue 6. 2021-07-05. PMID:34200554. |
the expression of the endocannabinoid (ecb) system, including cannabinoid receptor type 1 (cb1r) and the cannabinoid synthesizing (nape-pld) and degrading (faah) enzymes, has been well-characterized in the retina of rodents and monkeys. |
2021-07-05 |
2023-08-13 |
monkey |
| Stewart Christie, Rebecca O'Rielly, Hui Li, Gary A Wittert, Amanda J Pag. High fat diet induced obesity alters endocannabinoid and ghrelin mediated regulation of components of the endocannabinoid system in nodose ganglia. Peptides. vol 131. 2021-06-30. PMID:32659299. |
therefore, the current study aimed to determine the effects of ghrelin and aea on vagal afferent cell body mrna content of cannabinoid 1 receptor (cb1), ghrelin receptor (ghsr), trpv1, and the enzyme responsible for the breakdown of aea, fatty acid amide hydrolase (faah). |
2021-06-30 |
2023-08-13 |
Not clear |
| Si-Yu Ren, Zhen-Zhen Wang, Yi Zhang, Nai-Hong Che. Potential application of endocannabinoid system agents in neuropsychiatric and neurodegenerative diseases-focusing on FAAH/MAGL inhibitors. Acta pharmacologica Sinica. vol 41. issue 10. 2021-06-28. PMID:32203086. |
the inhibitors of two endocannabinoid hydrolases, i.e., fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), have the capacity to increase the level of endocannabinoids indirectly, causing fewer side effects than those associated with direct supplementation of cannabinoids. |
2021-06-28 |
2023-08-13 |
Not clear |
| Jennifer Spohrs, Martin Ulrich, Georg Grön, Michael Prost, Paul Lukas Plener, Jörg Michael Fegert, Laura Bindila, Birgit Able. Fear extinction learning and anandamide: an fMRI study in healthy humans. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33723207. |
so far, one prominent target was inhibition of fatty acid amino hydrolase (faah), the degrading enzyme of the endocannabinoid anandamide (aea). |
2021-06-28 |
2023-08-13 |
Not clear |
| Chandni Hindocha, Tom P Freeman, Grainne Schafer, Chelsea Gardner, Michael A P Bloomfield, Elvira Bramon, Celia J A Morgan, H Valerie Curra. Acute effects of cannabinoids on addiction endophenotypes are moderated by genes encoding the CB1 receptor and FAAH enzyme. Addiction biology. vol 25. issue 3. 2021-06-24. PMID:31013550. |
acute effects of cannabinoids on addiction endophenotypes are moderated by genes encoding the cb1 receptor and faah enzyme. |
2021-06-24 |
2023-08-13 |
Not clear |
| Laura M Best, Belinda Williams, Bernard Le Foll, Esmaeil Mansouri, Richard P Bazinet, Lin Lin, Vincenzo De Luca, Dina Lagzdins, Pablo Rusjan, Rachel F Tyndale, Alan A Wilson, Christian S Hendershot, Markus Heilig, Sylvain Houle, Junchao Tong, Stephen J Kish, Isabelle Boilea. Lower brain fatty acid amide hydrolase in treatment-seeking patients with alcohol use disorder: a positron emission tomography study with [C-11]CURB. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 8. 2021-06-23. PMID:31910433. |
the endocannabinoid enzyme, fatty acid amide hydrolase (faah), has been proposed as a therapeutic target for alcohol use disorder (aud) and co-morbid psychiatric illnesses. |
2021-06-23 |
2023-08-13 |
human |
| Nathan J Kolla, R Mizrahi, K Karas, C Wang, R M Bagby, S McMain, A I Simpson, P M Rusjan, R Tyndale, S Houle, I Boilea. Elevated fatty acid amide hydrolase in the prefrontal cortex of borderline personality disorder: a [ Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 11. 2021-06-23. PMID:32521537. |
fatty acid amide hydrolase (faah), the major catabolic enzyme for the endocannabinoid anandamide, has been proposed as a key regulator of the amygdala-pfc circuit that subserves emotion regulation. |
2021-06-23 |
2023-08-13 |
Not clear |
| Martin P Paulus, Murray B Stein, Alan N Simmons, Victoria B Risbrough, Robin Halter, Sandra R Chapla. The effects of FAAH inhibition on the neural basis of anxiety-related processing in healthy male subjects: a randomized clinical trial. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 5. 2021-06-23. PMID:33335310. |
acute pharmacological inhibition of the anandamide-degrading enzyme, fatty acid amide hydrolase (faah), prolongs the regulatory effects of endocannabinoids and reverses the stress-induced anxiety state in a cannabinoid receptor-dependent manner. |
2021-06-23 |
2023-08-13 |
human |
| Zhen Chen, Lu Hou, Jiefeng Gan, Qijun Cai, Weijian Ye, Jiahui Chen, Zhiqiang Tan, Chao Zheng, Guocong Li, Hao Xu, Christopher J Fowler, Steven H Liang, Lu Wan. Synthesis and preliminary evaluation of a novel positron emission tomography (PET) ligand for imaging fatty acid amide hydrolase (FAAH). Bioorganic & medicinal chemistry letters. vol 30. issue 21. 2021-06-22. PMID:32860981. |
fatty acid amide hydrolase (faah) exerts its main function in the catabolism of the endogenous chemical messenger anandamide (aea), thus modulating the endocannabinoid (ecb) pathway. |
2021-06-22 |
2023-08-13 |
Not clear |