| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marta Baranowska-Kuczko, Hanna Kozłowska, Monika Kloza, Ewa Harasim-Symbor, Michał Biernacki, Irena Kasacka, Barbara Malinowsk. Beneficial Changes in Rat Vascular Endocannabinoid System in Primary Hypertension and under Treatment with Chronic Inhibition of Fatty Acid Amide Hydrolase by URB597. International journal of molecular sciences. vol 22. issue 9. 2021-06-22. PMID:34063297. |
beneficial changes in rat vascular endocannabinoid system in primary hypertension and under treatment with chronic inhibition of fatty acid amide hydrolase by urb597. |
2021-06-22 |
2023-08-13 |
rat |
| Marta Baranowska-Kuczko, Hanna Kozłowska, Monika Kloza, Ewa Harasim-Symbor, Michał Biernacki, Irena Kasacka, Barbara Malinowsk. Beneficial Changes in Rat Vascular Endocannabinoid System in Primary Hypertension and under Treatment with Chronic Inhibition of Fatty Acid Amide Hydrolase by URB597. International journal of molecular sciences. vol 22. issue 9. 2021-06-22. PMID:34063297. |
our study aimed to examine the effects of hypertension and the chronic administration of the fatty acid amide hydrolase (faah) inhibitor urb597 on vascular function and the endocannabinoid system in spontaneously hypertensive rats (shr). |
2021-06-22 |
2023-08-13 |
rat |
| Andrea Pirone, Giulia Lazzarini, Carla Lenzi, Elisabetta Giannessi, Vincenzo Miragliott. Immunolocalization of cannabinoid receptor 1 (CB1), monoglyceride lipase (MGL) and fatty-acid amide hydrolase 1 (FAAH) in the pig claustrum. Journal of chemical neuroanatomy. vol 109. 2021-06-14. PMID:32599254. |
in an attempt to better understand the role of the ecs within the cl circuitry, we undertook an immunohistochemical analysis to describe the distribution of the cb1 and of the endogenous cannabinoids degrading enzymes mgl and faah in the pig cl as well as their relationship with both the catecholaminergic system and with parvalbumin (pv) expressing neurons. |
2021-06-14 |
2023-08-13 |
Not clear |
| Ruhan Deniz Topuz, Özgur Gündüz, Çetin Hakan Karadağ, Ahmet Ulugö. Non-opioid Analgesics and the Endocannabinoid System Balkan medical journal. vol 37. issue 6. 2021-06-09. PMID:32551466. |
non-opioid analgesics and their metabolites may activate cannabinoid receptors, as well as elevate endocannabinoid levels through different mechanisms: reduction of endocannabinoid degradation via fatty acid amide hydrolase and/or cyclooxygenase-2 inhibition, mobilization of arachidonic acid for the biosynthesis of endocannabinoids due to cyclooxygenase inhibition, inhibition of endocannabinoid cellular uptake directly or through the inhibition of nitric oxide synthase production, and induction of endocannabinoid release. |
2021-06-09 |
2023-08-13 |
Not clear |
| Darryl C Gidyk, Mustansir Diwan, Flavia Venetucci Gouveia, Peter Giacobbe, Nir Lipsman, Clement Haman. Investigating the role of CB1 endocannabinoid transmission in the anti-fear and anxiolytic-like effects of ventromedial prefrontal cortex deep brain stimulation. Journal of psychiatric research. vol 135. 2021-05-14. PMID:33513472. |
first, we examined type-1 cannabinoid (cb1) receptor and fatty acid amide hydrolase (faah) expression in the vmpfc and bla and found reduced cb1 expression in both loci in rats treated with dbs. |
2021-05-14 |
2023-08-13 |
rat |
| C M Diester, A H Lichtman, S S Negu. Behavioral Battery for Testing Candidate Analgesics in Mice. II. Effects of Endocannabinoid Catabolic Enzyme Inhibitors and ∆9-Tetrahydrocannabinol. The Journal of pharmacology and experimental therapeutics. vol 377. issue 2. 2021-05-13. PMID:33622769. |
enhanced signaling of the endocannabinoid (ecb) system through inhibition of the catabolic enzymes monoacylglycerol lipase (magl) and fatty acid amide hydrolase (faah) has received increasing interest for development of candidate analgesics. |
2021-05-13 |
2023-08-13 |
mouse |
| Tetsuo Kiso, Tomonari Watabiki, Toshihiro Sekizaw. ASP8477, a fatty acid amide hydrolase inhibitor, exerts analgesic effects in rat models of neuropathic and dysfunctional pain. European journal of pharmacology. vol 881. 2021-05-12. PMID:32445705. |
fatty acid amide hydrolase (faah) is a primary catabolic enzyme for anandamide, an endogenous cannabinoid agonist. |
2021-05-12 |
2023-08-13 |
rat |
| Thibaut R Pardo-García, Nadira Yusif-Rodriguez, Guillermo Yudowski, Carmen S Maldonado-Vlaa. Blockade of the endovanilloid receptor, TRPV1, and of the endocannabinoid enzyme, FAAH, within the nucleus accumbens shell elicits anxiolytic-like effects in male rats. Neuroscience letters. vol 732. 2021-04-27. PMID:32422166. |
blockade of the endovanilloid receptor, trpv1, and of the endocannabinoid enzyme, faah, within the nucleus accumbens shell elicits anxiolytic-like effects in male rats. |
2021-04-27 |
2023-08-13 |
rat |
| Domenico Fazio, Emanuele Criscuolo, Alessandra Piccoli, Barbara Barboni, Filomena Fezza, Mauro Maccarron. Advances in the discovery of fatty acid amide hydrolase inhibitors: what does the future hold? Expert opinion on drug discovery. vol 15. issue 7. 2021-04-07. PMID:32292082. |
fatty acid amide hydrolase (faah) is a membrane-bound enzyme, that inactivates endogenous signaling lipids of the fatty acid amide family, including the endocannabinoid anandamide ( |
2021-04-07 |
2023-08-13 |
Not clear |
| Andrea Toschi, Benedetta Tugnoli, Barbara Rossi, Andrea Piva, Ester Grill. Thymol modulates the endocannabinoid system and gut chemosensing of weaning pigs. BMC veterinary research. vol 16. issue 1. 2021-04-06. PMID:32787931. |
gene expression of cannabinoid receptors (cb1 and cb2), transient receptor potential vanilloid 1 (trpv1), the olfactory receptor or1g1, diacylglycerol lipases (dgl-α and dgl-β), fatty acid amine hydrolase (faah), and cytokines was measured, and elisas of pro-inflammatory cytokines levels were performed. |
2021-04-06 |
2023-08-13 |
Not clear |
| Enrico Dainese, Sergio Oddi, Monica Simonetti, Annalaura Sabatucci, Clotilde B Angelucci, Alice Ballone, Beatrice Dufrusine, Filomena Fezza, Gianni De Fabritiis, Mauro Maccarron. Author Correction: The endocannabinoid hydrolase FAAH is an allosteric enzyme. Scientific reports. vol 10. issue 1. 2021-03-31. PMID:32235840. |
author correction: the endocannabinoid hydrolase faah is an allosteric enzyme. |
2021-03-31 |
2023-08-13 |
Not clear |
| Esmaeil Mansouri, José N Nobrega, Matthew N Hill, Rachel F Tyndale, Francis S Lee, Christian S Hendershot, Laura M Best, Patricia Di Ciano, Georgia Balsevich, Mathew E Sloan, Stephen J Kish, Junchao Tong, Bernard Le Foll, Isabelle Boilea. D3 dopamine receptors and a missense mutation of fatty acid amide hydrolase linked in mouse and men: implication for addiction. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 5. 2021-03-30. PMID:31775159. |
we investigated a potential interaction between genetically inherited variation in fatty acid amide hydrolase (faah, c385a), which metabolizes the cannabis-like endocannabinoid anandamide, and dopaminergic system, measured by dopamine receptor levels and mrna. |
2021-03-30 |
2023-08-13 |
mouse |
| Karla Chavira-Ramos, Mario Orozco-Morales, Çimen Karasu, Alexey A Tinkov, Michael Aschner, Abel Santamaría, Ana Laura Colín-Gonzále. URB597 Prevents the Short-Term Excitotoxic Cell Damage in Rat Cortical Slices: Role of Cannabinoid 1 Receptors. Neurotoxicity research. vol 39. issue 2. 2021-03-10. PMID:33141426. |
the effects of urb597, an inhibitor of the fatty acid amide hydrolase (faah), were tested against the quinolinic acid (quin)-induced early toxic effects in rat cortical slices, and compared with those effects exerted by the endocannabinoid anandamide (aea). |
2021-03-10 |
2023-08-13 |
rat |
| Lu Hou, Jian Rong, Ahmed Haider, Daisuke Ogasawara, Cassis Varlow, Michael A Schafroth, Linjing Mu, Jiefeng Gan, Hao Xu, Christopher J Fowler, Ming-Rong Zhang, Neil Vasdev, Simon Ametamey, Benjamin F Cravatt, Lu Wang, Steven H Lian. Positron Emission Tomography Imaging of the Endocannabinoid System: Opportunities and Challenges in Radiotracer Development. Journal of medicinal chemistry. vol 64. issue 1. 2021-03-08. PMID:33379862. |
herein, we summarized the recent development of pet tracers for imaging cannabinoid receptors 1 (cb1r) and 2 (cb2r) as well as the key enzymes monoacylglycerol lipase (magl) and fatty acid amide hydrolase (faah), particularly focusing on pet neuroimaging applications. |
2021-03-08 |
2023-08-13 |
human |
| Gaurav Bedse, Mathew N Hill, Sachin Pate. 2-Arachidonoylglycerol Modulation of Anxiety and Stress Adaptation: From Grass Roots to Novel Therapeutics. Biological psychiatry. vol 88. issue 7. 2021-03-03. PMID:32197779. |
although initial preclinical and clinical development efforts focused on pharmacological inhibition of fatty acid amide hydrolase to elevate levels of the endocannabinoid anandamide, more recent efforts have focused on inhibition of monoacylglycerol lipase (magl) to enhance signaling of the most abundant and efficacious endocannabinoid ligand, 2-arachidonoylglycerol (2-ag). |
2021-03-03 |
2023-08-13 |
Not clear |
| Elisabetta Gerace, Elisa Zianni, Elisa Landucci, Tania Scartabelli, Rolando Berlinguer Palmini, Daniela Iezzi, Flavio Moroni, Monica Di Luca, Guido Mannaioni, Fabrizio Gardoni, Domenico E Pellegrini-Giampietr. Differential mechanisms of tolerance induced by NMDA and 3,5-dihydroxyphenylglycine (DHPG) preconditioning. Journal of neurochemistry. vol 155. issue 6. 2021-03-02. PMID:32343420. |
accordingly, the mag-lipase inhibitor urb602, that increases arachidonoylglycerol (2-ag) content, but not the faah inhibitor urb597, that limits the degradation of anandamide, was also able to induce tolerance versus ampa and ogd toxicity, suggesting that 2-ag is responsible for the dhpg-induced tolerance. |
2021-03-02 |
2023-08-13 |
rat |
| Leonardo Brunetti, Antonio Carrieri, Luca Piemontese, Paolo Tortorella, Fulvio Loiodice, Antonio Laghezz. Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors. International journal of molecular sciences. vol 21. issue 19. 2021-02-25. PMID:32987725. |
an increasing body of literature describing the interactions between the endocannabinoid system and ppars has slowly but surely been accumulating over the past decade, and a multitarget approach involving these receptors and endocannabinoid degrading enzyme faah has been proposed for the treatment of inflammatory states, cancer, and alzheimer's disease. |
2021-02-25 |
2023-08-13 |
Not clear |
| Xiangge Tian, Tao Liu, Lu Li, Bo Shao, Dahong Yao, Lei Feng, Jingnan Cui, Tony D James, Xiaochi M. Visual High-Throughput Screening for Developing a Fatty Acid Amide Hydrolase Natural Inhibitor Based on an Enzyme-Activated Fluorescent Probe. Analytical chemistry. vol 92. issue 14. 2021-02-23. PMID:32456414. |
fatty acid amide hydrolase (faah) is an important drug target for the treatment of many disease related conditions such as pain, inflammation, and mood disorders due to its vital role in the metabolism of endocannabinoid. |
2021-02-23 |
2023-08-13 |
Not clear |
| Stewart Christie, Rebecca O'Rielly, Hui Li, Maria Nunez-Salces, Gary A Wittert, Amanda J Pag. Modulatory effect of methanandamide on gastric vagal afferent satiety signals depends on nutritional status. The Journal of physiology. vol 598. issue 11. 2021-02-15. PMID:32237243. |
in individual gastric vagal afferent neurons of diet-induced obese mice the co-expression of components of the endocannabinoid system, including cb1, ghsr, trpv1 and faah, was increased compared with lean mice. |
2021-02-15 |
2023-08-13 |
mouse |
| Silvano Presciuttini, Giancarlo Carli, Enrica L Santarcangel. HYPNOTIZABILITY-RELATED FAAH C385A POLYMORPHISM: POSSIBLE ENDOCANNABINOID CONTRIBUTION TO SUGGESTION-INDUCED ANALGESIA. The International journal of clinical and experimental hypnosis. vol 68. issue 1. 2021-01-21. PMID:31914367. |
hypnotizability-related faah c385a polymorphism: possible endocannabinoid contribution to suggestion-induced analgesia. |
2021-01-21 |
2023-08-13 |
human |