| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Silvano Presciuttini, Giancarlo Carli, Enrica L Santarcangel. HYPNOTIZABILITY-RELATED FAAH C385A POLYMORPHISM: POSSIBLE ENDOCANNABINOID CONTRIBUTION TO SUGGESTION-INDUCED ANALGESIA. The International journal of clinical and experimental hypnosis. vol 68. issue 1. 2021-01-21. PMID:31914367. |
fatty acid amide hydrolase (faah) degrades the endogenous endocannabinoid (ecb) anandamide and might be involved in the response to suggestions of analgesia in subjects with high hypnotizability scores ( |
2021-01-21 |
2023-08-13 |
human |
| Rosaria Greco, Chiara Demartini, Anna Maria Zanaboni, Elena Tumelero, Angelo Reggiani, Alessandra Misto, Daniele Piomelli, Cristina Tassorell. FAAH inhibition as a preventive treatment for migraine: A pre-clinical study. Neurobiology of disease. vol 134. 2021-01-13. PMID:31629892. |
fatty-acid amide hydrolase (faah) is an intracellular serine hydrolase that catalyzes the cleavage of endogenous fatty-acid amides, including the endocannabinoid anandamide (aea). |
2021-01-13 |
2023-08-13 |
Not clear |
| Leah M Mayo, Anna Asratian, Johan Lindé, Maria Morena, Roosa Haataja, Valter Hammar, Gaëlle Augier, Matthew N Hill, Markus Heili. Elevated Anandamide, Enhanced Recall of Fear Extinction, and Attenuated Stress Responses Following Inhibition of Fatty Acid Amide Hydrolase: A Randomized, Controlled Experimental Medicine Trial. Biological psychiatry. vol 87. issue 6. 2021-01-06. PMID:31590924. |
in rodents, elevation of the endocannabinoid anandamide due to inhibition of fatty acid amide hydrolase (faah) facilitates fear extinction and protects against the anxiogenic effects of stress. |
2021-01-06 |
2023-08-13 |
Not clear |
| Neta Maymon, Tomer Mizrachi Zer-Aviv, Esther L Sabban, Irit Akira. Neuropeptide Y and cannabinoids interaction in the amygdala after exposure to shock and reminders model of PTSD. Neuropharmacology. vol 162. 2021-01-06. PMID:31622603. |
immediately after shock exposure rats were microinjected into the bla with urb597, a selective inhibitor of fatty acid amide hydrolase (faah) that increases the levels of the endocannabinoid anandamide or with the npy1 receptor agonist leu |
2021-01-06 |
2023-08-13 |
rat |
| Ana Charrua, Rita Matos, Raquel Oliveira, Tim Marczylo, Istvan Nagy, Francisco Cru. Fatty acid amide hydrolase inhibition normalises bladder function and reduces pain through normalising the anandamide/palmitoylethanolamine ratio in the inflamed bladder of rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 393. issue 2. 2021-01-04. PMID:31522241. |
fatty acid amide hydrolase inhibition may be used to control bladder function and pain by modulating endocannabinoid levels in cystitis. |
2021-01-04 |
2023-08-13 |
rat |
| Ana Charrua, Rita Matos, Raquel Oliveira, Tim Marczylo, Istvan Nagy, Francisco Cru. Fatty acid amide hydrolase inhibition normalises bladder function and reduces pain through normalising the anandamide/palmitoylethanolamine ratio in the inflamed bladder of rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 393. issue 2. 2021-01-04. PMID:31522241. |
fatty acid amide hydrolase inhibition results in complex changes in bladder endocannabinoid levels. |
2021-01-04 |
2023-08-13 |
rat |
| Glauce Crivelaro do Nascimento, Daniele Pereira Ferrari, Francisco Silveira Guimaraes, Elaine Aparecida Del Bel, Mariza Bortolanza, Nilson Carlos Ferreira-Junio. Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson's disease. Neuropharmacology. vol 163. 2021-01-04. PMID:31706993. |
further, we investigated the pathway involved in the analgesic effect of the cbd through the co-administration with a fatty acid amide hydrolase (faah) inhibitor, increasing the endogenous anandamide levels, and possible targets from anandamide, i.e., the cannabinoid receptors subtype 1 and 2 (cb1 and cb2) and the transient receptor potential vanilloid type 1 (trpv1). |
2021-01-04 |
2023-08-13 |
mouse |
| Imdadul Haq, Aruna Kilar. An endocannabinoid catabolic enzyme FAAH and its paralogs in an early land plant reveal evolutionary and functional relationship with eukaryotic orthologs. Scientific reports. vol 10. issue 1. 2020-12-30. PMID:32080293. |
an endocannabinoid catabolic enzyme faah and its paralogs in an early land plant reveal evolutionary and functional relationship with eukaryotic orthologs. |
2020-12-30 |
2023-08-13 |
rat |
| Imdadul Haq, Aruna Kilar. An endocannabinoid catabolic enzyme FAAH and its paralogs in an early land plant reveal evolutionary and functional relationship with eukaryotic orthologs. Scientific reports. vol 10. issue 1. 2020-12-30. PMID:32080293. |
in mammals, anandamide, as an endocannabinoid ligand, mediates several neurological and physiological processes, which are terminated by fatty acid amide hydrolase (faah). |
2020-12-30 |
2023-08-13 |
rat |
| J Maia, B M Fonseca, N Teixeira, G Correia-da-Silv. The fundamental role of the endocannabinoid system in endometrium and placenta: implications in pathophysiological aspects of uterine and pregnancy disorders. Human reproduction update. vol 26. issue 4. 2020-12-08. PMID:32347309. |
the endocannabinoid system (ecs) consists of the cannabinoid receptors cb1 and cb2, the main endocannabinoids anandamide (aea) and 2-arachidonoylglycerol (2-ag) and their metabolic enzymes n-acylphosphatidylethanolamine-specific phospholipase d, fatty acid amide hydrolase, diacylglycerol lipase and monoacylglycerol lipase. |
2020-12-08 |
2023-08-13 |
Not clear |
| Enrico Dainese, Sergio Oddi, Monica Simonetti, Annalaura Sabatucci, Clotilde B Angelucci, Alice Ballone, Beatrice Dufrusine, Filomena Fezza, Gianni De Fabritiis, Mauro Maccarron. The endocannabinoid hydrolase FAAH is an allosteric enzyme. Scientific reports. vol 10. issue 1. 2020-11-20. PMID:32041998. |
the endocannabinoid hydrolase faah is an allosteric enzyme. |
2020-11-20 |
2023-08-13 |
human |
| Francisco J Pavón, Antonia Serrano, David G Stouffer, Ilham Polis, Marisa Roberto, Benjamin F Cravatt, Rémi Martin-Fardon, Fernando Rodríguez de Fonseca, Loren H Parson. Ethanol-induced alterations in endocannabinoids and relevant neurotransmitters in the nucleus accumbens of fatty acid amide hydrolase knockout mice. Addiction biology. vol 24. issue 6. 2020-10-28. PMID:30421483. |
in both genotypes, etoh treatment caused no changes in baseline endocannabinoid levels, although faah ko mice displayed higher baseline n-arachidonoylethanolamine levels than wt mice. |
2020-10-28 |
2023-08-13 |
mouse |
| Ren-Shi Li, Ryo Fukumori, Tomoki Takeda, Yingxia Song, Satoshi Morimoto, Ruri Kikura-Hanajiri, Taku Yamaguchi, Kazuhito Watanabe, Kousuke Aritake, Yoshitaka Tanaka, Hideyuki Yamada, Tsuneyuki Yamamoto, Yuji Ishi. Elevation of endocannabinoids in the brain by synthetic cannabinoid JWH-018: mechanism and effect on learning and memory. Scientific reports. vol 9. issue 1. 2020-10-26. PMID:31270353. |
biochemical analyses revealed that this was the result of suppression of two hydrolases involved in endocannabinoid degradation (fatty acid amide hydrolase [faah] and monoacylglycerol lipase [magl]). |
2020-10-26 |
2023-08-13 |
Not clear |
| Ehrhardt Proksch, Michael Soeberdt, Claudia Neumann, Ana Kilic, Christoph Abel. Modulators of the endocannabinoid system influence skin barrier repair, epidermal proliferation, differentiation and inflammation in a mouse model. Experimental dermatology. vol 28. issue 9. 2020-10-23. PMID:31350927. |
we used wobe440, a selective fatty acid amide hydrolase (faah) inhibitor, wol067-531, an inhibitor of endocannabinoid reuptake with no relevant faah activity, which both signal via cannabinoid receptor-1 and cannabinoid receptor-2 (cb-1r and cb-2r) and compared them to wobe15 which signals via cb-2r. |
2020-10-23 |
2023-08-13 |
mouse |
| Rati Kailash Prasad Tripath. A perspective review on fatty acid amide hydrolase (FAAH) inhibitors as potential therapeutic agents. European journal of medicinal chemistry. vol 188. 2020-10-23. PMID:31945644. |
faah inhibitors form vital approach for discovery of therapeutic agents that are concerned with local elevation of endocannabinoids under certain stimuli, debarring adverse/unwanted secondary effects from global activation of cannabinoid receptors by exogenous cannabimimetics. |
2020-10-23 |
2023-08-13 |
Not clear |
| Patrizia Ratano, Maura Palmery, Viviana Trezza, Patrizia Campolong. Cannabinoid Modulation of Memory Consolidation in Rats: Beyond the Role of Cannabinoid Receptor Subtype 1. Frontiers in pharmacology. vol 8. 2020-10-01. PMID:28446875. |
we found that the synthetic cannabinoid agonist win55,212-2 and the faah inhibitor urb597 both enhanced memory consolidation for inhibitory avoidance training. |
2020-10-01 |
2023-08-13 |
rat |
| Daniel J Liput, James R Pauly, Audra L Stinchcomb, Kimberly Nixo. Binge Alcohol Exposure Transiently Changes the Endocannabinoid System: A Potential Target to Prevent Alcohol-Induced Neurodegeneration. Brain sciences. vol 7. issue 12. 2020-10-01. PMID:29186065. |
therefore, the current study investigated the effects of neurotoxic, binge-like alcohol exposure on components of the endocannabinoid system and related n-acylethanolamines (naes), and then evaluated the efficacy of fatty acid amide hydrolase (faah) inhibition on attenuating alcohol-induced neurodegeneration. |
2020-10-01 |
2023-08-13 |
rat |
| Rosaria Greco, Chiara Demartini, Anna M Zanaboni, Daniele Piomelli, Cristina Tassorell. Endocannabinoid System and Migraine Pain: An Update. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:29615860. |
inhibition of aea degradation via faah is a promising therapeutic target for migraine pain, since it is presumably associated to an increased availability of the endocannabinoid, specifically at the site where its formation is stimulated (e.g., trigeminal ganglion and/or meninges), thus prolonging its action. |
2020-10-01 |
2023-08-13 |
Not clear |
| Eva J van Rooden, Annelot C M van Esbroeck, Marc P Baggelaar, Hui Deng, Bogdan I Florea, André R A Marques, Roelof Ottenhoff, Rolf G Boot, Herman S Overkleeft, Johannes M F G Aerts, Mario van der Stel. Chemical Proteomic Analysis of Serine Hydrolase Activity in Niemann-Pick Type C Mouse Brain. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:30018533. |
the activities of the following endocannabinoid enzymes were quantified: diacylglycerol lipase (dagl) α, α/β-hydrolase domain-containing protein 4, α/β-hydrolase domain-containing protein 6, α/β-hydrolase domain-containing protein 12, fatty acid amide hydrolase, and monoacylglycerol lipase. |
2020-10-01 |
2023-08-13 |
mouse |
| Pinja Leimuranta, Leonard Khiroug, Rashid Giniatulli. Emerging Role of (Endo)Cannabinoids in Migraine. Frontiers in pharmacology. vol 9. 2020-09-30. PMID:29740328. |
individual sections of this review cover key aspects of this topic, such as: (i) the current knowledge on the endocannabinoid system (ecs) with emphasis on expression of its components in migraine related structures; (ii) distinguishing peripheral from central site of action of cannabinoids, (iii) proposed mechanisms of migraine pain and control of nociceptive traffic by cannabinoids at the level of meninges and in brainstem, (iv) therapeutic targeting in migraine of monoacylglycerol lipase and fatty acid amide hydrolase, enzymes which control the level of endocannabinoids; (v) dual (possibly opposing) actions of cannabinoids via anti-nociceptive cb1 and cb2 and pro-nociceptive trpv1 receptors. |
2020-09-30 |
2023-08-13 |
Not clear |