| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kang Jun Cho, Mamoru Hashimoto, Sergei Karnup, Kanako Matsuoka, Tadanobu Kamijo, Joon Chul Kim, Jun Sung Koh, Naoki Yoshimur. Improvement of lower urinary tract dysfunction by a monoacylglycerol lipase inhibitor in mice with spinal cord injury. Neurourology and urodynamics. 2024-03-27. PMID:38533637. |
we investigated the effect of an magl inhibitor, mjn110, on neurogenic lower urinary tract dysfunction (lutd) in the mouse model of spinal cord injury (sci). |
2024-03-27 |
2024-03-29 |
mouse |
| Adriana Della Pietra, Rashid Giniatullin, Juha R Savinaine. Distinct Activity of Endocannabinoid-Hydrolyzing Enzymes MAGL and FAAH in Key Regions of Peripheral and Central Nervous System Implicated in Migraine. International journal of molecular sciences. vol 22. issue 3. 2021-04-13. PMID:33530477. |
magl activity exceeded faah activity also in drg, spinal cord and brainstem. |
2021-04-13 |
2023-08-13 |
rat |
| Elaine M Jennings, Bright N Okine, Weredeselam M Olango, Michelle Roche, David P Fin. Repeated forced swim stress differentially affects formalin-evoked nociceptive behaviour and the endocannabinoid system in stress normo-responsive and stress hyper-responsive rat strains. Progress in neuro-psychopharmacology & biological psychiatry. vol 64. 2016-05-31. PMID:25988529. |
swim stress increased levels of monoacylglycerol lipase (magl) mrna in the ipsilateral side of the dorsal spinal cord of sd rats, an effect not observed in wky rats. |
2016-05-31 |
2023-08-13 |
rat |
| Noemi Pasquarelli, Christoph Porazik, Johannes Hanselmann, Patrick Weydt, Boris Ferger, Anke Wittin. Comparative biochemical characterization of the monoacylglycerol lipase inhibitor KML29 in brain, spinal cord, liver, spleen, fat and muscle tissue. Neuropharmacology. vol 91. 2015-09-28. PMID:25497453. |
magl expression was highest in fat, liver and brain, whereas the cytosolic phospholipase a2 (cpla2), a further enzyme responsible for arachidonic acid production, was highly expressed in spinal cord, muscle and spleen. |
2015-09-28 |
2023-08-13 |
mouse |
| Noemi Pasquarelli, Christoph Porazik, Johannes Hanselmann, Patrick Weydt, Boris Ferger, Anke Wittin. Comparative biochemical characterization of the monoacylglycerol lipase inhibitor KML29 in brain, spinal cord, liver, spleen, fat and muscle tissue. Neuropharmacology. vol 91. 2015-09-28. PMID:25497453. |
here, we show that oral administration of kml29, a highly selective inhibitor of magl, induced large and dose-dependent changes in 2-ag levels in vivo in brain and spinal cord of mice. |
2015-09-28 |
2023-08-13 |
mouse |
| Noemi Pasquarelli, Christoph Porazik, Johannes Hanselmann, Patrick Weydt, Boris Ferger, Anke Wittin. Comparative biochemical characterization of the monoacylglycerol lipase inhibitor KML29 in brain, spinal cord, liver, spleen, fat and muscle tissue. Neuropharmacology. vol 91. 2015-09-28. PMID:25497453. |
of note, magl inhibition by kml29 induced a decrease in prostaglandin levels in brain and most peripheral tissues but not in the spinal cord. |
2015-09-28 |
2023-08-13 |
mouse |
| Jenny L Wilkerson, Katherine R Gentry, Ellen C Dengler, James A Wallace, Audra A Kerwin, Leisha M Armijo, Megan N Kuhn, Ganesh A Thakur, Alexandros Makriyannis, Erin D Milliga. Intrathecal cannabilactone CB(2)R agonist, AM1710, controls pathological pain and restores basal cytokine levels. Pain. vol 153. issue 5. 2012-08-13. PMID:22425445. |
in cci animals, lumbar dorsal spinal cord and corresponding dorsal root ganglia (drg) were evaluated by immunohistochemistry for expression of il-10, il-1β, phosphorylated p38-mitogen-activated-kinase (p-p38mapk), a pathway associated with proinflammatory cytokine production, glial cell markers, and degradative endocannabinoid enzymes, including monoacylglycerol lipase (magl). |
2012-08-13 |
2023-08-12 |
human |