All Relations between microtubule-associated protein tau and microglial cell

Reference Sentence Publish Date Extraction Date Species
Carolina Osorio, Adonis Sfera, Jonathan J Anton, Karina G Thomas, Christina V Andronescu, Erica Li, Rayan W Yahia, Andrea Garc\\xc3\\xada Avalos, Zisis Kozlakidi. Virus-Induced Membrane Fusion in Neurodegenerative Disorders. Frontiers in cellular and infection microbiology vol 12 issue 2022 35531328 virus-induced pathological syncytia may provide a unified framework for conceptualizing neuronal cell cycle reentry, aneuploidy, somatic mosaicism, viral spreading of pathological tau and elimination of viable synapses and neurons by neurotoxic astrocytes and microglia. 2022-05-09 2022-05-12 Not clear
Chao Wang, Li Fan, Rabia R Khawaja, Bangyan Liu, Lihong Zhan, Lay Kodama, Marcus Chin, Yaqiao Li, David Le, Yungui Zhou, Carlo Condello, Lea T Grinberg, William W Seeley, Bruce L Miller, Sue-Ann Mok, Jason E Gestwicki, Ana Maria Cuervo, Wenjie Luo, Li Ga. Microglial NF-\\xce\\xbaB drives tau spreading and toxicity in a mouse model of tauopathy. Nature communications vol 13 issue 1 2022 35413950 how microglia activation contributes to tau toxicity remains largely unknown. 2022-04-13 2022-04-14 Not clear
Chao Wang, Li Fan, Rabia R Khawaja, Bangyan Liu, Lihong Zhan, Lay Kodama, Marcus Chin, Yaqiao Li, David Le, Yungui Zhou, Carlo Condello, Lea T Grinberg, William W Seeley, Bruce L Miller, Sue-Ann Mok, Jason E Gestwicki, Ana Maria Cuervo, Wenjie Luo, Li Ga. Microglial NF-\\xce\\xbaB drives tau spreading and toxicity in a mouse model of tauopathy. Nature communications vol 13 issue 1 2022 35413950 inhibition of nf-\xce\xbab activation enhanced the retention while reduced the release of internalized pathogenic tau fibrils from primary microglia and rescued microglial autophagy deficits. 2022-04-13 2022-04-14 Not clear
Chenghuan Song, Jiyun Shi, Pingao Zhang, Yongfang Zhang, Jianrong Xu, Lanxue Zhao, Rui Zhang, Hao Wang, Hongzhuan Che. Immunotherapy for Alzheimer's disease: targeting \\xce\\xb2-amyloid and beyond. Translational neurodegeneration vol 11 issue 1 2022 35300725 meanwhile, immunotherapies based on other targets such as tau, microglia and gut-brain axis are also under development. 2022-03-18 2022-04-14 Not clear
Chenghuan Song, Jiyun Shi, Pingao Zhang, Yongfang Zhang, Jianrong Xu, Lanxue Zhao, Rui Zhang, Hao Wang, Hongzhuan Che. Immunotherapy for Alzheimer's disease: targeting \\xce\\xb2-amyloid and beyond. Translational neurodegeneration vol 11 issue 1 2022 35300725 in this review, we focus on the immunotherapies based on a\xce\xb2, tau and microglia and their mechanisms of action in ad. 2022-03-18 2022-04-14 Not clear
Sonja Fixemer, Corrado Ameli, Ga\\xc3\\xabl Hammer, Luis Salamanca, Oihane Uriarte Huarte, Chantal Schwartz, Jean-Jacques G\\xc3\\xa9rardy, Naguib Mechawar, Alexander Skupin, Michel Mittelbronn, David S Bouvie. Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-\\xce\\xb2 and \\xce\\xb1-synuclein pathologies in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies. Acta neuropathologica communications vol 10 issue 1 2022 35296366 microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-\xce\xb2 and \xce\xb1-synuclein pathologies in the hippocampus of patients with alzheimer's disease and dementia with lewy bodies. 2022-03-17 2022-04-14 Not clear
Toshihiko Tashim. Delivery of Intravenously Administered Antibodies Targeting Alzheimer's Disease-Relevant Tau Species into the Brain Based on Receptor-Mediated Transcytosis. Pharmaceutics vol 14 issue 2 2022 35214143 these cross the blood-brain barrier (bbb) based on receptor-mediated transcytosis and are subsequently cleared by microglia based on fc-mediated endocytosis after binding to tau and lysosomal degradation. 2022-02-26 2022-02-28 Not clear
Ryuichi Harada, Shozo Furumoto, Yukitsuka Kudo, Kazuhiko Yanai, Victor L Villemagne, Nobuyuki Okamur. Imaging of Reactive Astrogliosis by Positron Emission Tomography. Frontiers in neuroscience vol 16 issue 2022 35210989 in postmortem ad brains, reactive astrocytes and activated microglia are observed surrounding a\xce\xb2 plaques and tau tangles. 2022-02-25 2022-02-27 Not clear
Juan R Perea, Esther Garc\\xc3\\xada, Laura Vall\\xc3\\xa9s-Saiz, Raquel Cuadros, F\\xc3\\xa9lix Hern\\xc3\\xa1ndez, Marta Bol\\xc3\\xb3s, Jes\\xc3\\xbas Avil. p38 activation occurs mainly in microglia in the P301S Tauopathy mouse model. Scientific reports vol 12 issue 1 2022 35136118 on the basis of our findings, we propose that rod microglia might have a neuroprotective phenotype in the context of tau pathology. 2022-02-09 2022-02-10 Not clear
Chenfei Wang, Wei Huang, Jia Lu, Hongzhuan Chen, Zhihua Y. TRPV1-Mediated Microglial Autophagy Attenuates Alzheimer's Disease-Associated Pathology and Cognitive Decline. Frontiers in pharmacology vol 12 issue 2022 35115924 trpv1 agonist capsaicin decreased amyloid and phosphorylated tau pathology and reversed memory deficits by promoting microglia activation, metabolism, and autophagy in 3xtg mice. 2022-02-04 2022-02-06 Not clear
Chiara Burgaletto, Chiara Bianca Maria Platania, Giulia Di Benedetto, Antonio Munaf\\xc3\\xb2, Giovanni Giurdanella, Concetta Federico, Rosario Caltabiano, Salvatore Saccone, Federica Conti, Renato Bernardini, Claudio Bucolo, Giuseppina Cantarell. Targeting the miRNA-155/TNFSF10 network restrains inflammatory response in the retina in a mouse model of Alzheimer's disease. Cell death & disease vol 12 issue 10 2021 34611142 moreover, the fine-tuned mechanism related to tnfsf10 immunoneutralization was tightly linked to modulation of tnfsf10 itself and its death receptor tnfrsf10b, along with cytokine production by microglia, reactive gliosis, and specific ad-related neuropathological hallmarks (i.e., a\xce\xb2 deposition and tau phosphorylation) in the retina of 3xtg-ad mice. 2022-02-03 2022-01-13 Not clear
Dan Xia, Steve Lianoglou, Thomas Sandmann, Meredith Calvert, Jung Suh, Elliot Thomsen, Jason Dugas, Michelle E Pizzo, Sarah L DeVos, Timothy K Earr, Chia-Ching Lin, Sonnet Davis, Connie Ha, Hoang Nguyen, Roni Chau, Ernie Yulyaningsih, Hilda Solanoy, Shababa T Masoud, Richard Liang, Karin Lin, Robert G Thorne, Dylan Garceau, Jennifer D Whitesell, Michael Sasner, Julie A Harris, Kimberly Scearce-Levie, Joseph W Lewcock, Gilbert Di Paolo, Pascal E Sanche. Fibrillar A\\xce\\xb2 causes profound microglial metabolic perturbations in a novel APP knock-in mouse model. Alzheimer's & dementia : the journal of the Alzheimer's Association vol 17 Suppl 3 issue 2022 35109044 microglia respond to various pathogenic drivers of ad, including amyloid-\xc3\x9f (a\xc3\x9f) and tau, but the mechanisms by which microglia may become dysfunctional and contribute to disease remain unclear. 2022-02-03 2022-02-06 Not clear
Mark Stephen Kindy, Dorothy K. GM6 attenuates Alzheimer's disease pathology through a reduction in fibrinogen levels and by regulation of A\\xce\\xb2, p-tau and inflammation. Alzheimer's & dementia : the journal of the Alzheimer's Association vol 17 Suppl 3 issue 2022 35109082 alzheimer's disease (ad) is characterized by cerebral amyloid-b (ab) deposition, vascular alterations, tau pathology, microglia activation, and inflammation. 2022-02-03 2022-02-06 Not clear
Valerie L Joers, Hannah Staley, Maclean Bassett, Brenda D Moore, Malu Gamez Tanse. The role of cannabinoid receptor 2 in microglial clearance of human tau. Alzheimer's & dementia : the journal of the Alzheimer's Association vol 17 Suppl 3 issue 2022 35109165 microglia have been implicated in tauopathies as they may contribute to tau phosphorylation and aggregation and the uptake and spread of seed-competent tau to healthy neurons due to dysfunctional degradation. 2022-02-03 2022-02-06 Not clear
Kaidong Wang, Baofu Zhang, Tian Tian, Bingyang Zhang, Ge Shi, Chunhui Zhang, Guoliang Li, Min Huan. Taurine protects dopaminergic neurons in paraquat-induced Parkinson's disease mouse model through PI3K/Akt signaling pathways. Amino acids vol issue 2021 34837554 our study showed that pd mice with tau intervention recovered motor and non-motor functions to some extent, and the number of dopaminergic (dac) neurons in the substantia nigra and the level of dopamine (da) secretion in the striatum were also significantly increased compared with the pq-dyed group, and the protein content of pi3k and pdk-1 and the phosphorylation level of akt were reduced in parallel with the reduction in the expression of microglia and related inflammatory factors. 2022-02-02 2022-01-13 Not clear
Yasir H Qureshi, Diego E Berman, Samuel E Marsh, Ronald L Klein, Vivek M Patel, Sabrina Simoes, Suvarnambiga Kannan, Gregory A Petsko, Beth Stevens, Scott A Smal. The neuronal retromer can regulate both neuronal and microglial phenotypes of Alzheimer's disease. Cell reports vol 38 issue 3 2022 35045281 finally, the neuronal and, in part, the microglia responses to vps35 depletion were found to occur independent of tau. 2022-02-02 2022-01-27 Not clear
Matylda Barbara Mielcarska, Katarzyna Skowro\\xc5\\x84ska, Zbigniew Wy\\xc5\\xbcewski, Felix Ngosa Tok. Disrupting Neurons and Glial Cells Oneness in the Brain-The Possible Causal Role of Herpes Simplex Virus Type 1 (HSV-1) in Alzheimer's Disease. International journal of molecular sciences vol 23 issue 1 2022 35008671 we describe the changes in neurons, astrocytes, microglia, and oligodendrocytes related to the production of inflammatory factors, transition of glial cells into a reactive state, oxidative damage, a\xce\xb2 secretion, tau hyperphosphorylation, apoptosis, and autophagy. 2022-02-01 2022-01-13 Not clear
Lei Cao, Yanyan Kong, Bin Ji, Yutong Ren, Yihui Guan, Ruiqing N. Positron Emission Tomography in Animal Models of Tauopathies. Frontiers in aging neuroscience vol 13 issue 2022 35082657 the advance in pet and imaging tracers have enabled non-invasive detection of the accumulation and spread of tau, the associated microglia activation, metabolic, and neurotransmitter receptor alterations in disease animal models. 2022-01-27 2022-02-06 Not clear
Yasir H Qureshi, Diego E Berman, Samuel E Marsh, Ronald L Klein, Vivek M Patel, Sabrina Simoes, Suvarnambiga Kannan, Gregory A Petsko, Beth Stevens, Scott A Smal. The neuronal retromer can regulate both neuronal and microglial phenotypes of Alzheimer's disease. Cell reports vol 38 issue 3 2022 35045281 finally, the neuronal and, in part, the microglia responses to vps35 depletion were found to occur independent of tau. 2022-01-19 2022-01-27 Not clear
Matylda Barbara Mielcarska, Katarzyna Skowro\\xc5\\x84ska, Zbigniew Wy\\xc5\\xbcewski, Felix Ngosa Tok. Disrupting Neurons and Glial Cells Oneness in the Brain-The Possible Causal Role of Herpes Simplex Virus Type 1 (HSV-1) in Alzheimer's Disease. International journal of molecular sciences vol 23 issue 1 2022 35008671 we describe the changes in neurons, astrocytes, microglia, and oligodendrocytes related to the production of inflammatory factors, transition of glial cells into a reactive state, oxidative damage, a\xce\xb2 secretion, tau hyperphosphorylation, apoptosis, and autophagy. 2022-01-11 2022-01-13 Not clear
Page: 
1   2   3   4   5   6   7   8   9   10   11   12   13   14   15   16   17