| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kevin Carvalho, Elodie Martin, Aurélia Ces, Nadège Sarrazin, Pauline Lagouge-Roussey, Caroline Nous, Leyna Boucherit, Ihsen Youssef, Annick Prigent, Emilie Faivre, Sabiha Eddarkaoui, Thibaut Gauvrit, Didier Vieau, Susana Boluda, Vincent Huin, Bertrand Fontaine, Luc Buée, Benoît Delatour, Patrick Dutar, Florian Sennlaub, Xavier Guillonneau, David Blum, Cécile Delarass. P2X7-deficiency improves plasticity and cognitive abilities in a mouse model of Tauopathy. Progress in neurobiology. vol 206. 2021-11-11. PMID:34391810. |
indeed, while p2x7-deficiency had a moderate effect on tau pathology itself, we observed a significant reduction of microglia activation and of tau-related inflammatory mediators, particularly ccl4. |
2021-11-11 |
2023-08-13 |
mouse |
| You Jung Kang, Hsih-Yin Tan, Charles Y Lee, Hansang Ch. An Air Particulate Pollutant Induces Neuroinflammation and Neurodegeneration in Human Brain Models. Advanced science (Weinheim, Baden-Wurttemberg, Germany). vol 8. issue 21. 2021-11-11. PMID:34561961. |
finally, it is observed that additional proinflammatory mediators and nitric oxide released from the m1 microglia exacerbate neuronal damages, such as synaptic impairment, phosphoric tau accumulation, and neuronal death. |
2021-11-11 |
2023-08-13 |
human |
| Vanessa Laversenne, Sameer Nazeeruddin, Emma C Källstig, Philippe Colin, Christel Voize, Bernard L Schneide. Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology. Acta neuropathologica communications. vol 8. issue 1. 2021-11-09. PMID:33225991. |
anti-aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology. |
2021-11-09 |
2023-08-13 |
mouse |
| Vanessa Laversenne, Sameer Nazeeruddin, Emma C Källstig, Philippe Colin, Christel Voize, Bernard L Schneide. Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology. Acta neuropathologica communications. vol 8. issue 1. 2021-11-09. PMID:33225991. |
remarkably, the presence of human tau reduces microglial clustering in proximity to the aβ plaques, which may affect the barrier role of microglia. |
2021-11-09 |
2023-08-13 |
mouse |
| Chiara Burgaletto, Chiara Bianca Maria Platania, Giulia Di Benedetto, Antonio Munafò, Giovanni Giurdanella, Concetta Federico, Rosario Caltabiano, Salvatore Saccone, Federica Conti, Renato Bernardini, Claudio Bucolo, Giuseppina Cantarell. Targeting the miRNA-155/TNFSF10 network restrains inflammatory response in the retina in a mouse model of Alzheimer's disease. Cell death & disease. vol 12. issue 10. 2021-11-09. PMID:34611142. |
moreover, the fine-tuned mechanism related to tnfsf10 immunoneutralization was tightly linked to modulation of tnfsf10 itself and its death receptor tnfrsf10b, along with cytokine production by microglia, reactive gliosis, and specific ad-related neuropathological hallmarks (i.e., aβ deposition and tau phosphorylation) in the retina of 3xtg-ad mice. |
2021-11-09 |
2023-08-13 |
mouse |
| Maud Gratuze, Yun Chen, Samira Parhizkar, Nimansha Jain, Michael R Strickland, Javier Remolina Serrano, Marco Colonna, Jason D Ulrich, David M Holtzma. Activated microglia mitigate Aβ-associated tau seeding and spreading. The Journal of experimental medicine. vol 218. issue 8. 2021-11-02. PMID:34100905. |
activated microglia mitigate aβ-associated tau seeding and spreading. |
2021-11-02 |
2023-08-13 |
mouse |
| Maud Gratuze, Yun Chen, Samira Parhizkar, Nimansha Jain, Michael R Strickland, Javier Remolina Serrano, Marco Colonna, Jason D Ulrich, David M Holtzma. Activated microglia mitigate Aβ-associated tau seeding and spreading. The Journal of experimental medicine. vol 218. issue 8. 2021-11-02. PMID:34100905. |
whether this aβ-enhanced tau seeding/spreading is due to loss of microglial function or a toxic gain of function in trem2-deficient microglia is unclear. |
2021-11-02 |
2023-08-13 |
mouse |
| Maud Gratuze, Yun Chen, Samira Parhizkar, Nimansha Jain, Michael R Strickland, Javier Remolina Serrano, Marco Colonna, Jason D Ulrich, David M Holtzma. Activated microglia mitigate Aβ-associated tau seeding and spreading. The Journal of experimental medicine. vol 218. issue 8. 2021-11-02. PMID:34100905. |
interestingly, although repopulated microglia clustered around plaques, they had a reduction in disease-associated microglia (dam) gene expression and elevated tau seeding/spreading. |
2021-11-02 |
2023-08-13 |
mouse |
| Jack H Brelstaff, Matthew Mason, Taxiarchis Katsinelos, William A McEwan, Bernardino Ghetti, Aviva M Tolkovsky, Maria Grazia Spillantin. Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates. Science advances. vol 7. issue 43. 2021-10-30. PMID:34669475. |
microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with p301s tau aggregates. |
2021-10-30 |
2023-08-13 |
Not clear |
| Juciano Gasparotto, Mario Roberto Senger, Emilio Telles de Sá Moreira, Pedro Ozorio Brum, Flávio Gabriel Carazza Kessler, Daniel Oppermann Peixoto, Alana Castro Panzenhagen, Lin Kooi Ong, Marlene Campos Soares, Patricia Alves Reis, Giuliana Viegas Schirato, Walter César Góes Valente, Bogar Omar Araújo Montoya, Floriano P Silva, José Claudio Fonseca Moreira, Felipe Dal-Pizzol, Hugo C Castro-Faria-Neto, Daniel Pens Gelai. Neurological impairment caused by Schistosoma mansoni systemic infection exhibits early features of idiopathic neurodegenerative disease. The Journal of biological chemistry. vol 297. issue 2. 2021-10-29. PMID:34303703. |
we observed that systemic infection with s. mansoni led to astrocyte and microglia activation, expression of oxidative stress-induced transcription factor nrf2, oxidative damage, tau phosphorylation, and amyloid-β peptide accumulation in the prefrontal cortex of infected animals. |
2021-10-29 |
2023-08-13 |
Not clear |
| D Boche, J A R Nicol. Invited Review - Understanding cause and effect in Alzheimer's pathophysiology: Implications for clinical trials. Neuropathology and applied neurobiology. vol 46. issue 7. 2021-10-28. PMID:32643143. |
it is proposed that different therapeutic targets are required for different stages of the disease process: aβ for primary prevention, microglia for secondary prevention, and tau for established disease. |
2021-10-28 |
2023-08-13 |
human |
| Shwetha Nanjundaiah, Hariharakrishnan Chidambaram, Madhura Chandrashekar, Subashchandrabose Chinnathamb. Role of Microglia in Regulating Cholesterol and Tau Pathology in Alzheimer's Disease. Cellular and molecular neurobiology. vol 41. issue 4. 2021-10-06. PMID:32468440. |
role of microglia in regulating cholesterol and tau pathology in alzheimer's disease. |
2021-10-06 |
2023-08-13 |
Not clear |
| Shwetha Nanjundaiah, Hariharakrishnan Chidambaram, Madhura Chandrashekar, Subashchandrabose Chinnathamb. Role of Microglia in Regulating Cholesterol and Tau Pathology in Alzheimer's Disease. Cellular and molecular neurobiology. vol 41. issue 4. 2021-10-06. PMID:32468440. |
the current review provides an overview of (1) cholesterol synthesis in the brain, neurons, astrocytes, and microglia; (2) the mechanism involved in modulating cholesterol concentration between the astrocytes and brain; (3) major mechanisms involved in the hyperphosphorylation of tau and amyloid-β protein; and (4) microglial involvement in its regulation. |
2021-10-06 |
2023-08-13 |
Not clear |
| Shwetha Nanjundaiah, Hariharakrishnan Chidambaram, Madhura Chandrashekar, Subashchandrabose Chinnathamb. Role of Microglia in Regulating Cholesterol and Tau Pathology in Alzheimer's Disease. Cellular and molecular neurobiology. vol 41. issue 4. 2021-10-06. PMID:32468440. |
thus, the answering key questions will provide an in-depth information on microglia involvement in managing the pathogenesis of cholesterol-modulated hyperphosphorylated tau protein. |
2021-10-06 |
2023-08-13 |
Not clear |
| Rashmi Das, Abhishek Ankur Balmik, Subashchandrabose Chinnathamb. Melatonin Reduces GSK3β-Mediated Tau Phosphorylation, Enhances Nrf2 Nuclear Translocation and Anti-Inflammation. ASN neuro. vol 12. 2021-10-06. PMID:33342257. |
together, these findings suggest that melatonin remediated the cytokine profile of tau-exposed microglia, reduced tau hyperphosphorylation by downregulating gsk3β level, and alleviated oxidative stress |
2021-10-06 |
2023-08-13 |
Not clear |
| Jing Li, Junxiang Wang, Yuan-Liang Wang, Zhousong Luo, Chunyan Zheng, Guangxia Yu, Siying Wu, Fuli Zheng, Huangyuan L. NOX2 activation contributes to cobalt nanoparticles-induced inflammatory responses and Tau phosphorylation in mice and microglia. Ecotoxicology and environmental safety. vol 225. 2021-10-05. PMID:34492628. |
nox2 activation contributes to cobalt nanoparticles-induced inflammatory responses and tau phosphorylation in mice and microglia. |
2021-10-05 |
2023-08-13 |
mouse |
| Francesca Romana Buccellato, Marianna D'Anca, Chiara Fenoglio, Elio Scarpini, Daniela Galimbert. Role of Oxidative Damage in Alzheimer's Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery. Antioxidants (Basel, Switzerland). vol 10. issue 9. 2021-10-01. PMID:34572985. |
oxidative damage is involved in the molecular mechanisms which link the accumulation of amyloid-β and neurofibrillary tangles, containing hyperphosphorylated tau, to microglia response. |
2021-10-01 |
2023-08-13 |
human |
| Rebecca Wrigh. Microglia set the pace for tau spread. Nature neuroscience. vol 24. issue 10. 2021-10-01. PMID:34588697. |
microglia set the pace for tau spread. |
2021-10-01 |
2023-08-13 |
Not clear |
| Jonathan D Cherry, Gaoyuan Meng, Sarah Daley, Weiming Xia, Sarah Svirsky, Victor E Alvarez, Raymond Nicks, Morgan Pothast, Hunter Kelley, Bertrand Huber, Yorghos Tripodis, Michael L Alosco, Jesse Mez, Ann C McKee, Thor D Stei. CCL2 is associated with microglia and macrophage recruitment in chronic traumatic encephalopathy. Journal of neuroinflammation. vol 17. issue 1. 2021-09-30. PMID:33278887. |
past work has implicated early and sustained activation of microglia as a potential driver of tau pathology within the frontal cortex in cte. |
2021-09-30 |
2023-08-13 |
Not clear |
| Muñoz-Cabrera Jonathan, Sandoval-Hernández Adrián, Arboleda Gonzal. Type II nuclear receptors with potential role in Alzheimer disease. Molecular aspects of medicine. vol 78. 2021-09-24. PMID:33397589. |
this disease is characterized by the progressive accumulation of amyloid-beta peptides and hyperphosphorylated tau protein that can explain alterations in synaptic transmission and plasticity; loss of dendritic spines; increased in reactive microglia and inflammation; reduction of neuronal stem cells number; myelin and vascular alterations that finally leads to increased neuronal death. |
2021-09-24 |
2023-08-13 |
Not clear |