All Relations between microtubule-associated protein tau and microglial cell

Publication Sentence Publish Date Extraction Date Species
Mara Mathe. Noradrenaline in the aging brain: Promoting cognitive reserve or accelerating Alzheimer's disease? Seminars in cell & developmental biology. vol 116. 2021-08-23. PMID:34099360. via its inhibitory and excitatory effects on neurons and microglia, noradrenaline sometimes prevents and sometimes accelerates the production and accumulation of amyloid-β and tau in various brain regions. 2021-08-23 2023-08-13 Not clear
Keying Zhu, Melanie Pieber, Jinming Han, Klas Blomgren, Xing-Mei Zhang, Robert A Harris, Harald Lun. Absence of microglia or presence of peripherally-derived macrophages does not affect tau pathology in young or old hTau mice. Glia. vol 68. issue 7. 2021-08-18. PMID:32039516. absence of microglia or presence of peripherally-derived macrophages does not affect tau pathology in young or old htau mice. 2021-08-18 2023-08-13 mouse
Keying Zhu, Melanie Pieber, Jinming Han, Klas Blomgren, Xing-Mei Zhang, Robert A Harris, Harald Lun. Absence of microglia or presence of peripherally-derived macrophages does not affect tau pathology in young or old hTau mice. Glia. vol 68. issue 7. 2021-08-18. PMID:32039516. while the role of microglia and peripheral macrophages in regulating amyloid beta pathology has been well characterized, the impact of these distinct cell subsets on tau pathology remains poorly understood. 2021-08-18 2023-08-13 mouse
Keying Zhu, Melanie Pieber, Jinming Han, Klas Blomgren, Xing-Mei Zhang, Robert A Harris, Harald Lun. Absence of microglia or presence of peripherally-derived macrophages does not affect tau pathology in young or old hTau mice. Glia. vol 68. issue 7. 2021-08-18. PMID:32039516. we undertook the current study to investigate the regulation of tau pathology by microglia and peripheral macrophages using htau transgenic mice, which do not exhibit microglial activation/pathology or macrophage engraftment. 2021-08-18 2023-08-13 mouse
Keying Zhu, Melanie Pieber, Jinming Han, Klas Blomgren, Xing-Mei Zhang, Robert A Harris, Harald Lun. Absence of microglia or presence of peripherally-derived macrophages does not affect tau pathology in young or old hTau mice. Glia. vol 68. issue 7. 2021-08-18. PMID:32039516. to assess the direct impact of microglia on tau pathology we developed a protocol for long-term microglial depletion in cx3cr1 2021-08-18 2023-08-13 mouse
Patrick Jarmo Paasila, Danielle Suzanne Davies, Greg Trevor Sutherland, Claire Goldsbur. Clustering of activated microglia occurs before the formation of dystrophic neurites in the evolution of Aβ plaques in Alzheimer's disease. Free neuropathology. vol 1. 2021-08-17. PMID:34396367. this shows that tau positive neuritic plaques begin early in ad which is likely of pathogenic importance, however major tau deposition follows the accumulation of aβ and clustering of activated microglia. 2021-08-17 2023-08-13 human
Yuanlin Dong, Feng Liang, Lining Huang, Fang Fang, Guang Yang, Rudolph E Tanzi, Yiying Zhang, Qimin Quan, Zhongcong Xi. The anesthetic sevoflurane induces tau trafficking from neurons to microglia. Communications biology. vol 4. issue 1. 2021-08-12. PMID:33980987. the anesthetic sevoflurane induces tau trafficking from neurons to microglia. 2021-08-12 2023-08-13 mouse
Yuanlin Dong, Feng Liang, Lining Huang, Fang Fang, Guang Yang, Rudolph E Tanzi, Yiying Zhang, Qimin Quan, Zhongcong Xi. The anesthetic sevoflurane induces tau trafficking from neurons to microglia. Communications biology. vol 4. issue 1. 2021-08-12. PMID:33980987. we hypothesized that tau traffics from neurons to microglia via extracellular vesicles (evs), leading to il-6 generation and cognitive impairment. 2021-08-12 2023-08-13 mouse
Yuanlin Dong, Feng Liang, Lining Huang, Fang Fang, Guang Yang, Rudolph E Tanzi, Yiying Zhang, Qimin Quan, Zhongcong Xi. The anesthetic sevoflurane induces tau trafficking from neurons to microglia. Communications biology. vol 4. issue 1. 2021-08-12. PMID:33980987. microglia from tau knockout mice took up tau and p-tau when treated with sevoflurane-conditioned neuron culture medium, leading to il-6 generation. 2021-08-12 2023-08-13 mouse
Yuanlin Dong, Feng Liang, Lining Huang, Fang Fang, Guang Yang, Rudolph E Tanzi, Yiying Zhang, Qimin Quan, Zhongcong Xi. The anesthetic sevoflurane induces tau trafficking from neurons to microglia. Communications biology. vol 4. issue 1. 2021-08-12. PMID:33980987. thus, tau trafficking could occur from neurons to microglia to generate il-6, leading to cognitive impairment. 2021-08-12 2023-08-13 mouse
Kevin Clayton, Jean Christophe Delpech, Shawn Herron, Naotoshi Iwahara, Maria Ericsson, Takashi Saito, Takaomi C Saido, Seiko Ikezu, Tsuneya Ikez. Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Molecular neurodegeneration. vol 16. issue 1. 2021-07-31. PMID:33752701. plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized app mouse model. 2021-07-31 2023-08-13 mouse
Kevin Clayton, Jean Christophe Delpech, Shawn Herron, Naotoshi Iwahara, Maria Ericsson, Takashi Saito, Takaomi C Saido, Seiko Ikezu, Tsuneya Ikez. Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Molecular neurodegeneration. vol 16. issue 1. 2021-07-31. PMID:33752701. recent studies suggest that microglia contribute to tau pathology progression in alzheimer's disease. 2021-07-31 2023-08-13 mouse
Kevin Clayton, Jean Christophe Delpech, Shawn Herron, Naotoshi Iwahara, Maria Ericsson, Takashi Saito, Takaomi C Saido, Seiko Ikezu, Tsuneya Ikez. Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Molecular neurodegeneration. vol 16. issue 1. 2021-07-31. PMID:33752701. amyloid plaque accumulation transforms microglia, the primary innate immune cells in the brain, into neurodegenerative microglia (mgnd), which exhibit enhanced phagocytosis of plaques, apoptotic neurons and dystrophic neurites containing aggregated and phosphorylated tau (p-tau). 2021-07-31 2023-08-13 mouse
Chunmei Liang, Ting Zou, Miaoping Zhang, Weihao Fan, Tianzhen Zhang, Yuling Jiang, Yujie Cai, Feng Chen, Xiongjin Chen, Yuanhong Sun, Bin Zhao, Yan Wang, Lili Cu. MicroRNA-146a switches microglial phenotypes to resist the pathological processes and cognitive degradation of Alzheimer's disease. Theranostics. vol 11. issue 9. 2021-07-29. PMID:33754051. microglia can be neuroprotective by degrading and removing aβ and tau. 2021-07-29 2023-08-13 mouse
Annerieke Sierksma, Ashley Lu, Renzo Mancuso, Nicola Fattorelli, Nicola Thrupp, Evgenia Salta, Jesus Zoco, David Blum, Luc Buée, Bart De Strooper, Mark Fier. Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology. EMBO molecular medicine. vol 12. issue 3. 2021-07-28. PMID:31951107. novel alzheimer risk genes determine the microglia response to amyloid-β but not to tau pathology. 2021-07-28 2023-08-13 mouse
Lingyun Yue, Pu Liu, Ningtian Ma, Yuxia Xu, Cuiqing Zh. Interaction between extracellular ATP5A1 and LPS alleviates LPS-induced neuroinflammation in mice. Neuroscience letters. vol 758. 2021-07-20. PMID:34098024. furthermore, ratp5a1 suppressed the activation of astrocytes and microglia, il-1β accumulation, and tau phosphorylation induced by lps. 2021-07-20 2023-08-13 mouse
M A Berezutsky, N A Durnova, L E Sigarev. [Neurobiological effects of tenuigenin and the opportunity of it's using in the therapy of Alzheimer's and Parkinson's diseases (literature review).] Advances in gerontology = Uspekhi gerontologii. vol 34. issue 2. 2021-07-13. PMID:34245502. it was noted, that the capacities of the tenuigenin to decrease the secretion of beta amyloid and to protect of neurons from damage by already made beta ameloids, to inhibit the processes of the tau proteins` hyperphosphorylation and inflammations in microglia, as well as increase the main synaptic transmission can be used by the development of effective therapeutic drugs aimed to reduce the pathogenesis of alzheimer`s disease. 2021-07-13 2023-08-13 Not clear
Gai Ayalon, Seung-Hye Lee, Oskar Adolfsson, Corinne Foo-Atkins, Jasvinder K Atwal, Mira Blendstrup, Helen Booler, Joseph Bravo, Robert Brendza, Flavia Brunstein, Ruby Chan, Priya Chandra, Jessica A Couch, Akash Datwani, Barthélemy Demeule, Danielle DiCara, Rich Erickson, James A Ernst, Oded Foreman, Dongping He, Isidro Hötzel, Michael Keeley, Michael C M Kwok, Julien Lafrance-Vanasse, Han Lin, Yanmei Lu, Wilman Luk, Paul Manser, Andreas Muhs, Hai Ngu, Andrea Pfeifer, Maria Pihlgren, Gautham K Rao, Kimberly Scearce-Levie, Stephen P Schauer, William B Smith, Hilda Solanoy, Edmond Teng, Kristin R Wildsmith, Daniela Bumbaca Yadav, Yong Ying, Reina N Fuji, Geoffrey A Kerchne. Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease. Science translational medicine. vol 13. issue 593. 2021-07-12. PMID:33980574. semorinemab binds all six human tau isoforms and protects neurons against tau oligomer neurotoxicity in cocultures of neurons and microglia. 2021-07-12 2023-08-13 mouse
Chritica Lodder, Isabelle Scheyltjens, Ilie Cosmin Stancu, Pablo Botella Lucena, Manuel Gutiérrez de Ravé, Sarah Vanherle, Tim Vanmierlo, Niels Cremers, Hannah Vanrusselt, Bert Brône, Bernard Hanseeuw, Jean-Noël Octave, Astrid Bottelbergs, Kiavash Movahedi, Ilse Dewachte. CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia. Acta neuropathologica communications. vol 9. issue 1. 2021-07-12. PMID:34103079. csf1r inhibition rescues tau pathology and neurodegeneration in an a/t/n model with combined ad pathologies, while preserving plaque associated microglia. 2021-07-12 2023-08-13 Not clear
Chritica Lodder, Isabelle Scheyltjens, Ilie Cosmin Stancu, Pablo Botella Lucena, Manuel Gutiérrez de Ravé, Sarah Vanherle, Tim Vanmierlo, Niels Cremers, Hannah Vanrusselt, Bert Brône, Bernard Hanseeuw, Jean-Noël Octave, Astrid Bottelbergs, Kiavash Movahedi, Ilse Dewachte. CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia. Acta neuropathologica communications. vol 9. issue 1. 2021-07-12. PMID:34103079. the preferential depletion of non-plaque-associated microglia significantly attenuated tau pathology and neuronal atrophy, indicating their detrimental role during atn progression. 2021-07-12 2023-08-13 Not clear