All Relations between microtubule-associated protein tau and microglial cell

Publication Sentence Publish Date Extraction Date Species
Yanting Chen, Tingting Hong, Feng Chen, Yuanhong Sun, Yan Wang, Lili Cu. Interplay Between Microglia and Alzheimer's Disease-Focus on the Most Relevant Risks: APOE Genotype, Sex and Age. Frontiers in aging neuroscience. vol 13. 2021-04-28. PMID:33897406. apoe-expressing microglia accumulates around aβ plaques, and the presence of apoe4 may disrupt the phagocytosis of aβ aggregates and aggravate neurodegeneration in tau disease models. 2021-04-28 2023-08-13 Not clear
Md Sahab Uddin, Md Tanvir Kabir, Abdullah Al Mamun, Tapan Behl, Rasha A Mansouri, Akram Ahmed Aloqbi, Asma Perveen, Abdul Hafeez, Ghulam Md Ashra. Exploring Potential of Alkaloidal Phytochemicals Targeting Neuroinflammatory Signaling of Alzheimer's Disease. Current pharmaceutical design. vol 27. issue 3. 2021-04-26. PMID:32473620. the sustained activation of the microglia, the brain's resident macrophages, and other immune cells has been shown to aggravate both tau and amyloid pathology and may consider as a connection in the ad pathogenesis. 2021-04-26 2023-08-13 Not clear
Kevin Clayton, Jean Christophe Delpech, Shawn Herron, Naotoshi Iwahara, Maria Ericsson, Takashi Saito, Takaomi C Saido, Seiko Ikezu, Tsuneya Ikez. Correction to: Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Molecular neurodegeneration. vol 16. issue 1. 2021-04-18. PMID:33853665. correction to: plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized app mouse model. 2021-04-18 2023-08-13 mouse
Huifangjie Li, William C Knight, Pengfei Yang, Yingqiu Guo, Joel S Perlmutter, John C Morris, Randall J Bateman, Tammie L S Benzinger, Jinbin X. Microglia Implicated in Tauopathy in the Striatum of Neurodegenerative Disease Patients from Genotype to Phenotype. International journal of molecular sciences. vol 21. issue 17. 2021-04-09. PMID:32842621. to test the correlations of microglia dystrophy and tauopathy, we quantified translocator protein (tspo) and tau fibrils using autoradiography. 2021-04-09 2023-08-13 Not clear
Rebecca M Fleeman, Elizabeth A Procto. Astrocytic Propagation of Tau in the Context of Alzheimer's Disease. Frontiers in cellular neuroscience. vol 15. 2021-04-06. PMID:33815065. while the contribution of microglia to tau processing and propagation is beginning to be recognized and understood, astrocytes, glial cells in the brain important for maintaining neuronal metabolic, synaptic, trophic, and immune function which can produce, internalize, degrade, and propagate tau are understudied in their ability to affect ad progression through tau pathology. 2021-04-06 2023-08-13 Not clear
Smita Eknath Desale, Subashchandrabose Chinnathamb. α- Linolenic acid modulates phagocytosis and endosomal pathways of extracellular Tau in microglia. Cell adhesion & migration. vol 15. issue 1. 2021-04-02. PMID:33724164. α- linolenic acid modulates phagocytosis and endosomal pathways of extracellular tau in microglia. 2021-04-02 2023-08-13 Not clear
Smita Eknath Desale, Subashchandrabose Chinnathamb. α- Linolenic acid modulates phagocytosis and endosomal pathways of extracellular Tau in microglia. Cell adhesion & migration. vol 15. issue 1. 2021-04-02. PMID:33724164. the extracellular burden of amyloid-β plaques and tau seed fabricate the activation of microglia. 2021-04-02 2023-08-13 Not clear
Smita Eknath Desale, Subashchandrabose Chinnathamb. α- Linolenic acid modulates phagocytosis and endosomal pathways of extracellular Tau in microglia. Cell adhesion & migration. vol 15. issue 1. 2021-04-02. PMID:33724164. the increased phagocytosis of extracellular tau monomer and aggregates have been observed upon ala exposure to microglia cells. 2021-04-02 2023-08-13 Not clear
Smita Eknath Desale, Subashchandrabose Chinnathamb. α- Linolenic acid modulates phagocytosis and endosomal pathways of extracellular Tau in microglia. Cell adhesion & migration. vol 15. issue 1. 2021-04-02. PMID:33724164. our results suggest that microglia could be influenced to reduce extracellular tau seed with dietary fatty acids. 2021-04-02 2023-08-13 Not clear
Junling Yang, Leslie Wise, Ken-Ichiro Fukuch. TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease. Frontiers in immunology. vol 11. 2021-03-31. PMID:32391019. aβ fibrils and tau aggregates in the brain are closely associated with neuroinflammation and synapse loss, characterized by activated microglia and dystrophic neurites. 2021-03-31 2023-08-13 Not clear
Dipro Bose, Punnag Saha, Ayan Mondal, Brian Fanelli, Ratanesh K Seth, Patricia Janulewicz, Kimberly Sullivan, Stephen Lasley, Ronnie Horner, Rita R Colwell, Ashok K Shetty, Nancy Klimas, Saurabh Chatterje. Obesity Worsens Gulf War Illness Symptom Persistence Pathology by Linking Altered Gut Microbiome Species to Long-Term Gastrointestinal, Hepatic, and Neuronal Inflammation in a Mouse Model. Nutrients. vol 12. issue 9. 2021-03-26. PMID:32927823. microbial dysbiosis was also associated with frontal cortex levels of increased il6 and il1β, activated microglia, decreased levels of brain derived neurotrophic factor (bdnf), and higher accumulation of phosphorylated tau, an indicator of neuroinflammation-led increased risk of cognitive deficiencies. 2021-03-26 2023-08-13 mouse
Yanchao Liu, Shujuan Zhang, Xiaoguang Li, Enjie Liu, Xin Wang, Qiuzhi Zhou, Jinwang Ye, Jian-Zhi Wan. Peripheral inflammation promotes brain tau transmission via disrupting blood-brain barrier. Bioscience reports. vol 40. issue 2. 2021-03-16. PMID:32043530. in the ad patients, the abnormal tau accumulation first appeared in entorhinal cortex (ec) and then propagated to the hippocampus with microglia activation and inflammation, but the mechanism is elusive. 2021-03-16 2023-08-13 human
Shouchao Wei, Wanjuan Peng, Yingren Mai, Kanglan Li, Wei Wei, Li Hu, Shaoping Zhu, Haihong Zhou, Wanxin Jie, Zhuangsheng Wei, Chenyao Kang, Ruikai Li, Zhou Liu, Bin Zhao, Zhiyou Ca. Outer membrane vesicles enhance tau phosphorylation and contribute to cognitive impairment. Journal of cellular physiology. vol 235. issue 5. 2021-03-08. PMID:31663118. therefore, omvs increase the permeability of the bbb and promote the activation of astrocytes and microglia, inducing an inflammatory response and tau hyperphosphorylation by activating the gsk-3β pathway and finally leading to cognitive impairment. 2021-03-08 2023-08-13 Not clear
Lisi Flores-Aguilar, M Florencia Iulita, Olivia Kovecses, Maria D Torres, Sarah M Levi, Yian Zhang, Manor Askenazi, Thomas Wisniewski, Jorge Busciglio, A Claudio Cuell. Evolution of neuroinflammation across the lifespan of individuals with Down syndrome. Brain : a journal of neurology. vol 143. issue 12. 2021-03-01. PMID:33206953. moreover, an increase in dystrophic microglia and rod-like microglia aligning to neurons harbouring tau pathology were also observed. 2021-03-01 2023-08-13 human
Maud Gratuze, Cheryl Eg Leyns, Andrew D Sauerbeck, Marie-Kim St-Pierre, Monica Xiong, Nayeon Kim, Javier Remolina Serrano, Marie-Ève Tremblay, Terrance T Kummer, Marco Colonna, Jason D Ulrich, David M Holtzma. Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration. The Journal of clinical investigation. vol 130. issue 9. 2021-02-08. PMID:32544086. beyond tau and aβ, evidence suggests that microglia play an important role in ad pathogenesis. 2021-02-08 2023-08-13 mouse
Alberto Serrano-Pozo, Sudeshna Das, Bradley T Hyma. APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches. The Lancet. Neurology. vol 20. issue 1. 2021-01-28. PMID:33340485. although initial studies causally linked apoe with amyloid-β peptide aggregation and clearance, over the past 5 years our understanding of apoe pathogenesis has expanded beyond amyloid-β peptide-centric mechanisms to tau neurofibrillary degeneration, microglia and astrocyte responses, and blood-brain barrier disruption. 2021-01-28 2023-08-13 mouse
Smita Eknath Desale, Subashchandrabose Chinnathamb. Role of dietary fatty acids in microglial polarization in Alzheimer's disease. Journal of neuroinflammation. vol 17. issue 1. 2021-01-06. PMID:32209097. we hypothesize that tuning microglia towards anti-inflammatory phenotype would reduce the propagation of tau in alzheimer's disease. 2021-01-06 2023-08-13 Not clear
Darryll M A Oliver, P Hemachandra Redd. Molecular Basis of Alzheimer's Disease: Focus on Mitochondria. Journal of Alzheimer's disease : JAD. vol 72. issue s1. 2020-11-30. PMID:30932888. morphological and pathological studies revealed that ad is associated with the loss of synapses, defective mitochondria, and the proliferation of reactive astrocytes and microglia, in addition to the presence amyloid-β and phosphorylated tau in learning and memory regions of the brain in ad patients. 2020-11-30 2023-08-13 Not clear
Daniel C Shippy, Tyler K Ullan. Microglial Immunometabolism in Alzheimer's Disease. Frontiers in cellular neuroscience. vol 14. 2020-11-17. PMID:33192310. in response to aβ and tau aggregates, microglia, the primary innate immune cells of the central nervous system (cns), facilitate aβ and tau clearance and contribute to neuroinflammation that damages neurons. 2020-11-17 2023-08-13 Not clear
Jacob S Friedberg, Nurgul Aytan, Jonathan D Cherry, Weiming Xia, Oliver J Standring, Victor E Alvarez, Raymond Nicks, Sarah Svirsky, Gaoyuan Meng, Gyungah Jun, Hoon Ryu, Rhoda Au, Thor D Stei. Associations between brain inflammatory profiles and human neuropathology are altered based on apolipoprotein E ε4 genotype. Scientific reports. vol 10. issue 1. 2020-11-12. PMID:32076055. cellular density of iba1, a marker of microglia, was positively associated with tau pathology only in apoe ε4 positive participants (p = 0.001). 2020-11-12 2023-08-13 human