| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maud Gratuze, Cheryl Eg Leyns, Andrew D Sauerbeck, Marie-Kim St-Pierre, Monica Xiong, Nayeon Kim, Javier Remolina Serrano, Marie-Ève Tremblay, Terrance T Kummer, Marco Colonna, Jason D Ulrich, David M Holtzma. Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration. The Journal of clinical investigation. vol 130. issue 9. 2021-02-08. PMID:32544086. |
beyond tau and aβ, evidence suggests that microglia play an important role in ad pathogenesis. |
2021-02-08 |
2023-08-13 |
mouse |
| Alberto Serrano-Pozo, Sudeshna Das, Bradley T Hyma. APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches. The Lancet. Neurology. vol 20. issue 1. 2021-01-28. PMID:33340485. |
although initial studies causally linked apoe with amyloid-β peptide aggregation and clearance, over the past 5 years our understanding of apoe pathogenesis has expanded beyond amyloid-β peptide-centric mechanisms to tau neurofibrillary degeneration, microglia and astrocyte responses, and blood-brain barrier disruption. |
2021-01-28 |
2023-08-13 |
mouse |
| Smita Eknath Desale, Subashchandrabose Chinnathamb. Role of dietary fatty acids in microglial polarization in Alzheimer's disease. Journal of neuroinflammation. vol 17. issue 1. 2021-01-06. PMID:32209097. |
we hypothesize that tuning microglia towards anti-inflammatory phenotype would reduce the propagation of tau in alzheimer's disease. |
2021-01-06 |
2023-08-13 |
Not clear |
| Darryll M A Oliver, P Hemachandra Redd. Molecular Basis of Alzheimer's Disease: Focus on Mitochondria. Journal of Alzheimer's disease : JAD. vol 72. issue s1. 2020-11-30. PMID:30932888. |
morphological and pathological studies revealed that ad is associated with the loss of synapses, defective mitochondria, and the proliferation of reactive astrocytes and microglia, in addition to the presence amyloid-β and phosphorylated tau in learning and memory regions of the brain in ad patients. |
2020-11-30 |
2023-08-13 |
Not clear |
| Daniel C Shippy, Tyler K Ullan. Microglial Immunometabolism in Alzheimer's Disease. Frontiers in cellular neuroscience. vol 14. 2020-11-17. PMID:33192310. |
in response to aβ and tau aggregates, microglia, the primary innate immune cells of the central nervous system (cns), facilitate aβ and tau clearance and contribute to neuroinflammation that damages neurons. |
2020-11-17 |
2023-08-13 |
Not clear |
| Jacob S Friedberg, Nurgul Aytan, Jonathan D Cherry, Weiming Xia, Oliver J Standring, Victor E Alvarez, Raymond Nicks, Sarah Svirsky, Gaoyuan Meng, Gyungah Jun, Hoon Ryu, Rhoda Au, Thor D Stei. Associations between brain inflammatory profiles and human neuropathology are altered based on apolipoprotein E ε4 genotype. Scientific reports. vol 10. issue 1. 2020-11-12. PMID:32076055. |
cellular density of iba1, a marker of microglia, was positively associated with tau pathology only in apoe ε4 positive participants (p = 0.001). |
2020-11-12 |
2023-08-13 |
human |
| Rashmi Das, Abhishek Ankur Balmik, Subashchandrabose Chinnathamb. Phagocytosis of full-length Tau oligomers by Actin-remodeling of activated microglia. Journal of neuroinflammation. vol 17. issue 1. 2020-11-09. PMID:31915009. |
phagocytosis of full-length tau oligomers by actin-remodeling of activated microglia. |
2020-11-09 |
2023-08-13 |
Not clear |
| Lei Zhu, Zhen Zhang, Xiao-Jie Hou, Yong-Feng Wang, Jing-Yu Yang, Chun-Fu W. Inhibition of PDE5 attenuates streptozotocin-induced neuroinflammation and tau hyperphosphorylation in a streptozotocin-treated rat model. Brain research. vol 1722. 2020-10-21. PMID:31344367. |
in summary, these data suggested that yonk significantly reversed stz-induced memory deficits by inhibiting the over-activation of microglia and astrocytes, as well as ameliorated the levels of pro-inflammatory makers and tau hyperphosphorylation through regulating gsk3β signalling pathway. |
2020-10-21 |
2023-08-13 |
mouse |
| Andrea Crotti, Hameetha Rajamohamend Sait, Kathleen M McAvoy, Karol Estrada, Ayla Ergun, Suzanne Szak, Galina Marsh, Luke Jandreski, Michael Peterson, Taylor L Reynolds, Isin Dalkilic-Liddle, Andrew Cameron, Ellen Cahir-McFarland, Richard M Ransohof. BIN1 favors the spreading of Tau via extracellular vesicles. Scientific reports. vol 9. issue 1. 2020-10-13. PMID:31263146. |
genetic deletion of bin1 from microglia resulted in reduction of tau secretion via extracellular vesicles in vitro, and in decrease of tau spreading in vivo in male, but not female, mice, in the context of ps19 background. |
2020-10-13 |
2023-08-13 |
mouse |
| Andrea Crotti, Hameetha Rajamohamend Sait, Kathleen M McAvoy, Karol Estrada, Ayla Ergun, Suzanne Szak, Galina Marsh, Luke Jandreski, Michael Peterson, Taylor L Reynolds, Isin Dalkilic-Liddle, Andrew Cameron, Ellen Cahir-McFarland, Richard M Ransohof. BIN1 favors the spreading of Tau via extracellular vesicles. Scientific reports. vol 9. issue 1. 2020-10-13. PMID:31263146. |
interestingly, ablation of bin1 in microglia of male mice resulted in significant reduction in the expression of heat-shock proteins, previously implicated in tau proteostasis. |
2020-10-13 |
2023-08-13 |
mouse |
| Andrea Crotti, Hameetha Rajamohamend Sait, Kathleen M McAvoy, Karol Estrada, Ayla Ergun, Suzanne Szak, Galina Marsh, Luke Jandreski, Michael Peterson, Taylor L Reynolds, Isin Dalkilic-Liddle, Andrew Cameron, Ellen Cahir-McFarland, Richard M Ransohof. BIN1 favors the spreading of Tau via extracellular vesicles. Scientific reports. vol 9. issue 1. 2020-10-13. PMID:31263146. |
these observations suggest that bin1 could contribute to the progression of ad-related tau pathology by altering tau clearance and promoting release of tau-enriched extracellular vesicles by microglia. |
2020-10-13 |
2023-08-13 |
mouse |
| Anurag K Singh, Gaurav Mishra, Anand Maurya, Rajendra Awasthi, Komal Kumari, Abhimanyu Thakur, Arati Rai, Gopal Kumar Rai, Bhupesh Sharma, Giriraj T Kulkarni, Santosh Kumar Sing. Role of TREM2 in Alzheimer's Disease and its Consequences on β- Amyloid, Tau and Neurofibrillary Tangles. Current Alzheimer research. vol 16. issue 13. 2020-10-06. PMID:31481003. |
however, whether decrease level of trem2 assists pathology of tau through changed clearance and pathological escalation of tau or through direct contact between microglia and neuron and any alternative possible mechanisms need to examine. |
2020-10-06 |
2023-08-13 |
Not clear |
| Juan D Rodriguez-Callejas, Eberhard Fuchs, Claudia Perez-Cru. Evidence of Tau Hyperphosphorylation and Dystrophic Microglia in the Common Marmoset. Frontiers in aging neuroscience. vol 8. 2020-10-01. PMID:28066237. |
evidence of tau hyperphosphorylation and dystrophic microglia in the common marmoset. |
2020-10-01 |
2023-08-13 |
marmoset |
| Liping Chen, Chunhui Huang, Jieyi Shentu, Minjun Wang, Sicheng Yan, Fei Zhou, Zaijun Zhang, Chuang Wang, Yifan Han, Qinwen Wang, Wei Cu. Indirubin Derivative 7-Bromoindirubin-3-Oxime (7Bio) Attenuates Aβ Oligomer-Induced Cognitive Impairments in Mice. Frontiers in molecular neuroscience. vol 10. 2020-10-01. PMID:29234273. |
those results suggested that 7bio could potently inhibit aβ oligomer-induced neuroinflammation, synaptic impairments, tau hyper-phosphorylation, and activation of astrocytes and microglia, which may contribute to the neuroprotective effects of 7bio. |
2020-10-01 |
2023-08-13 |
mouse |
| Kanchan Bisht, Kaushik Sharma, Marie-Ève Trembla. Chronic stress as a risk factor for Alzheimer's disease: Roles of microglia-mediated synaptic remodeling, inflammation, and oxidative stress. Neurobiology of stress. vol 9. 2020-10-01. PMID:29992181. |
while microglia have been causally linked to amyloid beta (aβ) accumulation, tau pathology, neurodegeneration, and synaptic loss in ad, they were also attributed beneficial roles, notably in the phagocytic elimination of aβ. |
2020-10-01 |
2023-08-13 |
Not clear |
| Juan R Perea, María Llorens-Martín, Jesús Ávila, Marta Boló. The Role of Microglia in the Spread of Tau: Relevance for Tauopathies. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:30042659. |
the role of microglia in the spread of tau: relevance for tauopathies. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ricardo B Maccioni, Andrea González, Víctor Andrade, Nicole Cortés, José Pablo Tapia, Leonardo Guzmán-Martíne. Alzheimer´s Disease in the Perspective of Neuroimmunology. The open neurology journal. vol 12. 2020-10-01. PMID:30069256. |
in the ad, a continuous activation state of microglia appears to generate neuronal injury and neurodegeneration, producing the outflow of pathological tau from the inner of neurons to the extraneuronal space. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ricardo B Maccioni, Andrea González, Víctor Andrade, Nicole Cortés, José Pablo Tapia, Leonardo Guzmán-Martíne. Alzheimer´s Disease in the Perspective of Neuroimmunology. The open neurology journal. vol 12. 2020-10-01. PMID:30069256. |
released tau, together with the contribution of apoe4 protein, would then produce reactivation of microglia, thus inducing a positive feedback that stimulates the vicious cycle in neurodegeneration. |
2020-10-01 |
2023-08-13 |
Not clear |
| Atsuko Katsumoto, Hideyuki Takeuchi, Keita Takahashi, Fumiaki Tanak. Microglia in Alzheimer's Disease: Risk Factors and Inflammation. Frontiers in neurology. vol 9. 2020-10-01. PMID:30498474. |
we also discuss the mechanisms of inflammasomes and neurotransmitters in microglia, which accelerate the development of amyloid-β and tau pathology. |
2020-10-01 |
2023-08-13 |
mouse |
| Christian Rungsted Andersson, Jeppe Falsig, Jeffrey B Stavenhagen, Søren Christensen, Fredrik Kartberg, Nina Rosenqvist, Bente Finsen, Jan Torleif Pederse. Antibody-mediated clearance of tau in primary mouse microglial cultures requires Fcγ-receptor binding and functional lysosomes. Scientific reports. vol 9. issue 1. 2020-10-01. PMID:30874605. |
anti-tau antibodies have been shown to reduce tau pathology in in vivo models and antibody-mediated clearance of tau exerted by microglia has been proposed as a contributing factor. |
2020-10-01 |
2023-08-13 |
mouse |