| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christian Rungsted Andersson, Jeppe Falsig, Jeffrey B Stavenhagen, Søren Christensen, Fredrik Kartberg, Nina Rosenqvist, Bente Finsen, Jan Torleif Pederse. Antibody-mediated clearance of tau in primary mouse microglial cultures requires Fcγ-receptor binding and functional lysosomes. Scientific reports. vol 9. issue 1. 2020-10-01. PMID:30874605. |
by subjecting primary microglia cultured in vitro to anti-phospho-tau antibodies in complex with pathological tau, we show that microglia internalise and degrade tau in a manner that is dependent on fcγr interaction and functional lysosomes. |
2020-10-01 |
2023-08-13 |
mouse |
| Christian Rungsted Andersson, Jeppe Falsig, Jeffrey B Stavenhagen, Søren Christensen, Fredrik Kartberg, Nina Rosenqvist, Bente Finsen, Jan Torleif Pederse. Antibody-mediated clearance of tau in primary mouse microglial cultures requires Fcγ-receptor binding and functional lysosomes. Scientific reports. vol 9. issue 1. 2020-10-01. PMID:30874605. |
we further demonstrate that microglia activation alone is not sufficient to induce significant tau clearance. |
2020-10-01 |
2023-08-13 |
mouse |
| Juan Ramón Perea, Esther López, José Carlos Díez-Ballesteros, Jesús Ávila, Félix Hernández, Marta Boló. Extracellular Monomeric Tau Is Internalized by Astrocytes. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31118883. |
however, in a group of neurodegenerative diseases named tauopathies - characterized by an increase in aggregated and/or hyperphosphorylated tau - the protein accumulates inside other cells, such as astrocytes and microglia. |
2020-10-01 |
2023-08-13 |
Not clear |
| Juan Ramón Perea, Esther López, José Carlos Díez-Ballesteros, Jesús Ávila, Félix Hernández, Marta Boló. Extracellular Monomeric Tau Is Internalized by Astrocytes. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31118883. |
here we studied whether monomeric tau, which has been observed to be internalized by glial cells such as microglia, was also taken up by astrocytes. |
2020-10-01 |
2023-08-13 |
Not clear |
| Christiane Muth, Alexander Hartmann, Diego Sepulveda-Falla, Markus Glatzel, Susanne Kraseman. Phagocytosis of Apoptotic Cells Is Specifically Upregulated in ApoE4 Expressing Microglia Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31130847. |
phagocytosis of apoptotic cells is specifically upregulated in apoe4 expressing microglia alzheimer's disease (ad) is characterized by intracellular tau aggregates and extracellular deposition of amyloid-β (aβ). |
2020-10-01 |
2023-08-13 |
human |
| Marianna Alves, Aidan Kenny, Gioacchino de Leo, Edward H Beamer, Tobias Enge. Tau Phosphorylation in a Mouse Model of Temporal Lobe Epilepsy. Frontiers in aging neuroscience. vol 11. 2020-10-01. PMID:31780921. |
chronic epilepsy in mice also resulted in a strong localization of at8 phospho-tau to microglia, indicating a distinct pattern of tau hyperphosphorylation during chronic epilepsy compared to status epilepticus. |
2020-10-01 |
2023-08-13 |
mouse |
| Rahma Hassan-Abdi, Alexandre Brenet, Mohamed Bennis, Constantin Yanicostas, Nadia Soussi-Yanicosta. Neurons Expressing Pathological Tau Protein Trigger Dramatic Changes in Microglial Morphology and Dynamics. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31787873. |
however, microglia response in tau pathologies remains poorly understood. |
2020-10-01 |
2023-08-13 |
zebrafish |
| Seung-Hoon Yan. Cellular and Molecular Mediators of Neuroinflammation in Alzheimer Disease. International neurourology journal. vol 23. issue Suppl 2. 2020-10-01. PMID:31795604. |
abnormalities of aβ and tau cause activity of pattern recognition receptors on the brain's immune cells, including microglia and astrocytes, and trigger the innate immune system by releasing inflammatory mediators in the pathogenesis of ad. |
2020-10-01 |
2023-08-13 |
Not clear |
| Juan D Rodriguez-Callejas, Eberhard Fuchs, Claudia Perez-Cru. Corrigendum: Evidence of Tau Hyperphosphorylation and Dystrophic Microglia in the Common Marmoset. Frontiers in aging neuroscience. vol 9. 2020-09-30. PMID:28232798. |
corrigendum: evidence of tau hyperphosphorylation and dystrophic microglia in the common marmoset. |
2020-09-30 |
2023-08-13 |
marmoset |
| Honghua Zheng, Baoying Cheng, Yanfang Li, Xin Li, Xiaofen Chen, Yun-Wu Zhan. TREM2 in Alzheimer's Disease: Microglial Survival and Energy Metabolism. Frontiers in aging neuroscience. vol 10. 2020-09-30. PMID:30532704. |
trem2 is specifically expressed in brain microglia and modulates microglial functions in response to key ad pathologies such as amyloid-β (aβ) plaques and tau tangles. |
2020-09-30 |
2023-08-13 |
Not clear |
| Sonia Podvin, Miles C Miller, Ryan Rossi, Jasmine Chukwueke, John E Donahue, Conrad E Johanson, Andrew Baird, Edward G Stop. The Orphan C2orf40 Gene is a Neuroimmune Factor in Alzheimer's Disease. JSM Alzheimer's disease and related dementia. vol 3. issue 1. 2020-09-29. PMID:27990492. |
expression of the orphan c2orf40 gene is associated with the aggregation of the neurofibrillary tangle-protein tau in transgenic mice, tumor suppression, the induction of senescence in cns, and the activation of microglia and peripheral mononuclear leukocytes. |
2020-09-29 |
2023-08-13 |
mouse |
| Jun-Wei Li, Yu Zong, Xi-Peng Cao, Lin Tan, Lan Ta. Microglial priming in Alzheimer's disease. Annals of translational medicine. vol 6. issue 10. 2020-09-29. PMID:29951498. |
primed microglia can induce the production of amyloid β (aβ), tau pathology, neuroinflammation and reduce the release of neurotrophic factors, resulting in loss of normal neurons in quantity and function that has immense relationship with ad. |
2020-09-29 |
2023-08-13 |
Not clear |
| Joana R Guedes, Taotao Lao, Ana L Cardoso, Joseph El Khour. Roles of Microglial and Monocyte Chemokines and Their Receptors in Regulating Alzheimer's Disease-Associated Amyloid-β and Tau Pathologies. Frontiers in neurology. vol 9. 2020-09-29. PMID:30158892. |
chemokines and their receptors have been shown to affect amyloid-β (aβ) and tau pathologies in mouse models of alzheimer's disease (ad) by regulating microglia and monocyte-associated neuroinflammation, microglial movement and monocyte recruitment into the brain. |
2020-09-29 |
2023-08-13 |
mouse |
| Jefferson W Kinney, Shane M Bemiller, Andrew S Murtishaw, Amanda M Leisgang, Arnold M Salazar, Bruce T Lam. Inflammation as a central mechanism in Alzheimer's disease. Alzheimer's & dementia (New York, N. Y.). vol 4. 2020-09-29. PMID:30406177. |
the sustained activation of the brain's resident macrophages (microglia) and other immune cells has been demonstrated to exacerbate both amyloid and tau pathology and may serve as a link in the pathogenesis of the disorder. |
2020-09-29 |
2023-08-13 |
Not clear |
| Melissa Demock, Steven Korngut. A Mechanism for the Development of Chronic Traumatic Encephalopathy From Persistent Traumatic Brain Injury. Journal of experimental neuroscience. vol 13. 2020-09-29. PMID:31205424. |
the release of interferon gamma from the microglia and macrophages induces the marked increased expression of hla class i proteins by the neural cells and subsequent redistribution of the tau proteins to the glial and neuronal surface. |
2020-09-29 |
2023-08-13 |
human |
| Yunying Yang, Zhentao Zhan. Microglia and Wnt Pathways: Prospects for Inflammation in Alzheimer's Disease. Frontiers in aging neuroscience. vol 12. 2020-09-28. PMID:32477095. |
for one thing, they degrade amyloid β (aβ) to resist its deposition; for another, microglia release pro-inflammatory and inflammatory factors, contributing to neuroinflammation as well as the spreading of aβ and tau pathology. |
2020-09-28 |
2023-08-13 |
Not clear |
| Dawling A Dionisio-Santos, Adib Behrouzi, John A Olschowka, M Kerry O'Banio. Evaluating the Effect of Interleukin-4 in the 3xTg Mouse Model of Alzheimer's Disease. Frontiers in neuroscience. vol 14. 2020-09-28. PMID:32528242. |
previous research suggests that both anti-inflammatory and inflammatory microglia ameliorate amyloid pathology, but the latter worsen tau pathology. |
2020-09-28 |
2023-08-13 |
mouse |
| Swathi Beladakere Ramaswamy, Sachin M Bhagavan, Harleen Kaur, Gema E Giler, Duraisamy Kempuraj, Ramasamy Thangavel, Mohammad Ejaz Ahmed, Govindhasamy Pushpavathi Selvakumar, Sudhanshu P Raikwar, Smita Zaheer, Shankar S Iyer, Raghav Govindarajan, Asgar Zahee. Glia Maturation Factor in the Pathogenesis of Alzheimer's disease. Open access journal of neurology & neurosurgery. vol 12. issue 3. 2020-09-28. PMID:32775957. |
glial fibrillary acidic protein (gfap), reactive astrocytes, ionized calcium binding adaptor molecule-1 (iba-1) labelled activated microglia and gmf immunoreactive glial cells are increased in the entorhinal cortical layers especially at the sites of aps and tau containing nfts indicating a role for gmf. |
2020-09-28 |
2023-08-13 |
Not clear |
| Hariharakrishnan Chidambaram, Rashmi Das, Subashchandrabose Chinnathamb. Interaction of Tau with the chemokine receptor, CX3CR1 and its effect on microglial activation, migration and proliferation. Cell & bioscience. vol 10. 2020-09-28. PMID:32944223. |
in microglia, phagocytosis and internalization of extracellular tau species occurs in the presence of a chemokine receptor, cx3cr1 which binds directly to tau and promotes its internalization. |
2020-09-28 |
2023-08-13 |
Not clear |
| Alireza Faridar, Aaron D Thome, Weihua Zhao, Jason R Thonhoff, David R Beers, Belen Pascual, Joseph C Masdeu, Stanley H Appe. Restoring regulatory T-cell dysfunction in Alzheimer's disease through Brain communications. vol 2. issue 2. 2020-09-28. PMID:32954348. |
while neuroprotective microglia are important for containment/clearance of amyloid plaques and maintaining neuronal survival, alzheimer inflammatory microglia may play a detrimental role by eliciting tau pathogenesis and accelerating neurotoxicity. |
2020-09-28 |
2023-08-13 |
Not clear |