| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Swathi Beladakere Ramaswamy, Sachin M Bhagavan, Harleen Kaur, Gema E Giler, Duraisamy Kempuraj, Ramasamy Thangavel, Mohammad Ejaz Ahmed, Govindhasamy Pushpavathi Selvakumar, Sudhanshu P Raikwar, Smita Zaheer, Shankar S Iyer, Raghav Govindarajan, Asgar Zahee. Glia Maturation Factor in the Pathogenesis of Alzheimer's disease. Open access journal of neurology & neurosurgery. vol 12. issue 3. 2020-09-28. PMID:32775957. |
glial fibrillary acidic protein (gfap), reactive astrocytes, ionized calcium binding adaptor molecule-1 (iba-1) labelled activated microglia and gmf immunoreactive glial cells are increased in the entorhinal cortical layers especially at the sites of aps and tau containing nfts indicating a role for gmf. |
2020-09-28 |
2023-08-13 |
Not clear |
| Hariharakrishnan Chidambaram, Rashmi Das, Subashchandrabose Chinnathamb. Interaction of Tau with the chemokine receptor, CX3CR1 and its effect on microglial activation, migration and proliferation. Cell & bioscience. vol 10. 2020-09-28. PMID:32944223. |
in microglia, phagocytosis and internalization of extracellular tau species occurs in the presence of a chemokine receptor, cx3cr1 which binds directly to tau and promotes its internalization. |
2020-09-28 |
2023-08-13 |
Not clear |
| Alireza Faridar, Aaron D Thome, Weihua Zhao, Jason R Thonhoff, David R Beers, Belen Pascual, Joseph C Masdeu, Stanley H Appe. Restoring regulatory T-cell dysfunction in Alzheimer's disease through Brain communications. vol 2. issue 2. 2020-09-28. PMID:32954348. |
while neuroprotective microglia are important for containment/clearance of amyloid plaques and maintaining neuronal survival, alzheimer inflammatory microglia may play a detrimental role by eliciting tau pathogenesis and accelerating neurotoxicity. |
2020-09-28 |
2023-08-13 |
Not clear |
| M A Berezutsky, N A Durnova, T A Andronova, O V Sinichkin. [Alzheimer's disease: experimental and clinical researches of Chinese herbal medicine neurobiological effects (a review).] Advances in gerontology = Uspekhi gerontologii. vol 33. issue 2. 2020-09-22. PMID:32593241. |
various neurobiological effects of various herbal decoctions in the cells of hippocampus were demonstrated - the inhibition of amyloid β peptides aggregation, increasing of neurons quantity with normal morphology and decreasing of apoptotic cells, decreasing of inducible nitric oxide synthase (inos) production, decreasing of reactive expression level of rage and increasing reactive expression level of lrp-1, decreasing of tau protein phosphorylation at thr231 and ser422, inhibition of expression of gsk-3β and cdk-5, decreasing of activation and inflammation of microglia, production of 15 types of n-glycans in the cerebral cortex layers, which are absent in experimental animals. |
2020-09-22 |
2023-08-13 |
mouse |
| Dominic M Walsh, Dennis J Selko. Amyloid β-protein and beyond: the path forward in Alzheimer's disease. Current opinion in neurobiology. vol 61. 2020-09-15. PMID:32197217. |
basic research on the biological mechanism of alzheimer's disease has focused for decades on the age-related aggregation of the amyloid β-protein and its apparent downstream effects on microglia, astrocytes and neurons, including the posttranslational modification of the tau protein that seems necessary for symptom expression. |
2020-09-15 |
2023-08-13 |
Not clear |
| Keenan A Walker, Bronte N Ficek, Reyhan Westbroo. Understanding the Role of Systemic Inflammation in Alzheimer's Disease. ACS chemical neuroscience. vol 10. issue 8. 2020-08-18. PMID:31241312. |
through each of these routes, systemic inflammation is believed to induce reactive, proinflammatory microglia and astrocytic phenotypes which can promote tau hyperphosphorylation, β-amyloid oligomerization, complement activation, and the breakdown of neurotransmitters into potentially harmful bioactive metabolites. |
2020-08-18 |
2023-08-13 |
human |
| Taylor W Schmitz, Hermona Soreq, Judes Poirier, R Nathan Spren. Longitudinal Basal Forebrain Degeneration Interacts with TREM2/C3 Biomarkers of Inflammation in Presymptomatic Alzheimer's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 9. 2020-08-17. PMID:31915256. |
because microglia are involved in clearing amyloid and tau pathology from the central nervous system, we hypothesized that cholinergic input originating from the basal forebrain might similarly regulate inflammatory immune responses to these pathologies in the aging brain. |
2020-08-17 |
2023-08-13 |
human |
| Malvindar K Singh-Bains, Vanessa Linke, Micah D R Austria, Adelie Y S Tan, Emma L Scotter, Nasim F Mehrabi, Richard L M Faull, Mike Draguno. Altered microglia and neurovasculature in the Alzheimer's disease cerebellum. Neurobiology of disease. vol 132. 2020-08-06. PMID:31454549. |
immunoreactivity was compared between control and ad groups for neuropathological hallmarks (amyloid-β, tau, ubiquitin), purkinje cells (calbindin), microglia (iba1, hla-dr), astrocytes (gfap) basement-membrane associated molecules (fibronectin, collagen iv), endothelial cells (cd31/pecam-1) and mural cells (pdgfrβ, αsma). |
2020-08-06 |
2023-08-13 |
human |
| Daria Bortolotti, Valentina Gentili, Antonella Rotola, Elisabetta Caselli, Roberta Rizz. HHV-6A infection induces amyloid-beta expression and activation of microglial cells. Alzheimer's research & therapy. vol 11. issue 1. 2020-08-06. PMID:31831060. |
we evaluated the effect of hhv-6a infection on microglial cell expression aβ and the activation status, determined by trem2, apoe, cytokines, and tau expression. |
2020-08-06 |
2023-08-13 |
Not clear |
| Stefan Prokop, Kelly R Miller, Sergio R Labra, Rose M Pitkin, Kevt'her Hoxha, Sneha Narasimhan, Lakshmi Changolkar, Alyssa Rosenbloom, Virginia M-Y Lee, John Q Trojanowsk. Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer's disease patient brain samples. Acta neuropathologica. vol 138. issue 4. 2020-08-04. PMID:31350575. |
comprehensive analysis of microglia in different stages of ad in human brains revealed microglia activation to follow the progression of ad neuropathological changes and requiring the co-occurrence of beta-amyloid (aβ) and tau pathology. |
2020-08-04 |
2023-08-13 |
human |
| Stefan Prokop, Kelly R Miller, Sergio R Labra, Rose M Pitkin, Kevt'her Hoxha, Sneha Narasimhan, Lakshmi Changolkar, Alyssa Rosenbloom, Virginia M-Y Lee, John Q Trojanowsk. Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer's disease patient brain samples. Acta neuropathologica. vol 138. issue 4. 2020-08-04. PMID:31350575. |
carriers of ad-associated risk variants in trem2 (triggering receptor expressed on myeloid cells 2) showed a reduction of plaque-associated microglia and a substantial increase in dystrophic neurites and overall pathological tau compared with age and disease stage matched ad patients without trem2 risk variants. |
2020-08-04 |
2023-08-13 |
human |
| Thomas Vogels, Adriana-Natalia Murgoci, Tomáš Hromádk. Intersection of pathological tau and microglia at the synapse. Acta neuropathologica communications. vol 7. issue 1. 2020-07-30. PMID:31277708. |
intersection of pathological tau and microglia at the synapse. |
2020-07-30 |
2023-08-13 |
Not clear |
| Thomas Vogels, Adriana-Natalia Murgoci, Tomáš Hromádk. Intersection of pathological tau and microglia at the synapse. Acta neuropathologica communications. vol 7. issue 1. 2020-07-30. PMID:31277708. |
tau pathology is additionally associated with chronic neuroinflammatory processes, such as reactive microglia, astrocytes, and increased levels of pro-inflammatory molecules (e.g. |
2020-07-30 |
2023-08-13 |
Not clear |
| Thomas Vogels, Adriana-Natalia Murgoci, Tomáš Hromádk. Intersection of pathological tau and microglia at the synapse. Acta neuropathologica communications. vol 7. issue 1. 2020-07-30. PMID:31277708. |
recent studies show that as the principal immune cells of the brain, microglia play a particularly important role in the initiation and progression of tau pathology and associated neurodegeneration. |
2020-07-30 |
2023-08-13 |
Not clear |
| Thomas Vogels, Adriana-Natalia Murgoci, Tomáš Hromádk. Intersection of pathological tau and microglia at the synapse. Acta neuropathologica communications. vol 7. issue 1. 2020-07-30. PMID:31277708. |
furthermore, ad risk genes such as triggering receptor expressed on myeloid cells 2 (trem2) and apolipoprotein e (apoe) are enriched in the innate immune system and modulate the neuroinflammatory response of microglia to tau pathology. |
2020-07-30 |
2023-08-13 |
Not clear |
| Thomas Vogels, Adriana-Natalia Murgoci, Tomáš Hromádk. Intersection of pathological tau and microglia at the synapse. Acta neuropathologica communications. vol 7. issue 1. 2020-07-30. PMID:31277708. |
microglia can play an active role in synaptic dysfunction by abnormally phagocytosing synaptic compartments of neurons with tau pathology. |
2020-07-30 |
2023-08-13 |
Not clear |
| Thomas Vogels, Adriana-Natalia Murgoci, Tomáš Hromádk. Intersection of pathological tau and microglia at the synapse. Acta neuropathologica communications. vol 7. issue 1. 2020-07-30. PMID:31277708. |
furthermore, microglia are involved in synaptic spreading of tau - a process which is thought to underlie the progressive nature of tau pathology propagation through the brain. |
2020-07-30 |
2023-08-13 |
Not clear |
| b' Miroslava Kac\\xc3\\xad\\xc5\\x99ov\\xc3\\xa1, Anna Zme\\xc5\\xa1kalov\\xc3\\xa1, Lucia Ko\\xc5\\x99\\xc3\\xadnkov\\xc3\\xa1, Blanka \\xc5\\xbdelezn\\xc3\\xa1, Jaroslav Kune\\xc5\\xa1, Lenka Malet\\xc3\\xadnsk\\xc3\\xa. Inflammation: major denominator of obesity, Type 2 diabetes and Alzheimer\'s disease-like pathology? Clinical science (London, England : 1979). vol 134. issue 5. 2020-07-20. PMID:32167154.' |
in addition to the accumulation of misfolded amyloid beta (aβ) peptide and the formation of the neurofibrillary tangles of hyperphosphorylated tau protein in the brain, activated microglia and reactive astrocytes are the main indicators of ad progression. |
2020-07-20 |
2023-08-13 |
Not clear |
| Jing Zhang, Baian Chen, Jing Lu, Yi Wu, Shubo Wang, Zitong Yao, Liming Zhu, Yanhua Qiao, Quan Sun, Wei Qin, Qiao Zhao, Jianping Jia, Cuibai We. Brains of rhesus monkeys display Aβ deposits and glial pathology while lacking Aβ dimers and other Alzheimer's pathologies. Aging cell. vol 18. issue 4. 2020-07-07. PMID:31165579. |
the aβ deposits, which were devoid of aβ dimers, induced glial pathology (microgliosis, abnormal microglia morphology, and astrocytosis), but not the subsequent downstream pathologies of ad, including tau pathology, neurodegeneration, and synapse loss. |
2020-07-07 |
2023-08-13 |
monkey |
| Etay Aloni, Efrat Oni-Biton, Micheal Tsoory, Dalia H Moallem, Menahem Sega. Synaptopodin Deficiency Ameliorates Symptoms in the 3xTg Mouse Model of Alzheimer's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 20. 2020-06-15. PMID:30872324. |
in addition, there was a marked reduction in 3xtg-associated phosphorylated tau, amyloid β plaques, and activated microglia in 3xtg/spko male and female mice. |
2020-06-15 |
2023-08-13 |
mouse |