All Relations between microtubule-associated protein tau and microglial cell

Publication Sentence Publish Date Extraction Date Species
Hariharakrishnan Chidambaram, Smita Eknath Desale, Tazeen Qureshi, Subashchandrabose Chinnathamb. Microglial Uptake of Extracellular Tau by Actin-Mediated Phagocytosis. Methods in molecular biology (Clifton, N.J.). vol 2761. 2024-03-01. PMID:38427240. the 3-dimensional, orthogonal and gallery wise representation of these phagocytic structures provides an overview of the phagocytic mechanism of extracellular tau by microglia. 2024-03-01 2024-03-03 Not clear
Smita Eknath Desale, Hariharakrishnan Chidambaram, Tazeen Qureshi, Subashchandrabose Chinnathamb. Internalization and Endosomal Trafficking of Extracellular Tau in Microglia Improved by α-Linolenic Acid. Methods in molecular biology (Clifton, N.J.). vol 2761. 2024-03-01. PMID:38427241. internalization and endosomal trafficking of extracellular tau in microglia improved by α-linolenic acid. 2024-03-01 2024-03-03 Not clear
Smita Eknath Desale, Hariharakrishnan Chidambaram, Tazeen Qureshi, Subashchandrabose Chinnathamb. Internalization and Endosomal Trafficking of Extracellular Tau in Microglia Improved by α-Linolenic Acid. Methods in molecular biology (Clifton, N.J.). vol 2761. 2024-03-01. PMID:38427241. in this study, we focused on analyzing the ability of α-linolenic acid (ala) as a regulator of actin dynamics to balance the signaling pathways in microglia, including endocytosis of extracellular tau burden in ad. 2024-03-01 2024-03-03 Not clear
G Nicola. Lessons from genetic studies in Alzheimer disease. Revue neurologique. 2024-03-01. PMID:38429159. the role of neuroinflammation, microglia, and tau pathology modulation are important sources of research for disease modification. 2024-03-01 2024-03-04 Not clear
Carlos Cruchaga, Muhammad Ali, Yuanyuan Shen, Anh Do, Lihua Wang, Daniel Western, Menghan Liu, Aleksandra Beric, John Budde, Jen Gentsch, Suzanne Schindler, John Morris, David Holtzman, Maria Fernández, Agustín Ruiz, Ignacio Alvarez, Miquel Aguilar, Pau Pastor, Jarod Rutledge, Hamilton Oh, Edward Wilson, Yann Le Guen, Rana Khalid, Chloe Robins, David Pulford, Laura Ibanez, Tony Wyss-Coray, Yun Ju Sun. Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures for asymptomatic and symptomatic Alzheimer's disease. Research square. 2024-02-27. PMID:38410465. the associated proteins cluster in four different protein pseudo-trajectories groups spanning the ad continuum and were enrichment in specific pathways including neuronal death, apoptosis and tau phosphorylation (early stages), microglia dysregulation and endolysosomal dysfuncton(mid-stages), brain plasticity and longevity (mid-stages) and late microglia-neuron crosstalk (late stages). 2024-02-27 2024-03-02 Not clear
Roxane Gruel, Baukje Bijnens, Johanna Van Den Daele, Sofie Thys, Roland Willems, Dirk Wuyts, Debby Van Dam, Peter Verstraelen, Rosanne Verboven, Jana Roels, Niels Vandamme, Renzo Mancuso, Juan Diego Pita-Almenar, Winnok H De Vo. S100A8-enriched microglia populate the brain of tau-seeded and accelerated aging mice. Aging cell. 2024-02-26. PMID:38403918. we found that widespread tau pathology in k18-seeded p301l mice caused a significant change in the number and morphology of microglia, but only a mild overrepresentation of disease-associated microglia. 2024-02-26 2024-02-28 mouse
Zenghui Ten. Novel Development and Prospects in Pathogenesis, Diagnosis, and Therapy of Alzheimer's Disease. Journal of Alzheimer's disease reports. vol 8. issue 1. 2024-02-26. PMID:38405339. and neuroinflammation brought on by activated microglia was found to be one risk factor contributing to changes in aβ and tau pathology. 2024-02-26 2024-02-28 Not clear
Jiangxia Chen, Lijun Zhou, Qingchun Zhao, Zhentong Q. A New Cell Model Overexpressing sTGFBR3 for Studying Alzheimer's Disease in vitro. Current pharmaceutical design. 2024-02-16. PMID:38362698. stgfbr3 (a shed extracellular domain of the transforming growth factor type iii receptor) is a newly identified target of microglia polarization dysregulation, whose overexpression can cause abnormal accumulation of transforming growth factor β1 (tgf-β1), promoting aβ, tau, and neuroinflammatory pathology. 2024-02-16 2024-02-18 Not clear
Aaron Y Lai, Dustin Loren V Almanza, Jessica A Ribeiro, Mary E Hill, Matthew Mandrozos, Margaret M Koletar, Bojana Stefanovic, JoAnne McLauri. Obesity Facilitates Sex-Specific Improvement In Cognition And Neuronal Function In A Rat Model Of Alzheimer's Disease. bioRxiv : the preprint server for biology. 2024-02-08. PMID:38328066. after 6 months on the high-carbohydrate-high-fat diet, detrimental effects on density of neurons, amyloid-beta plaques, and tau inclusions persisted while the beneficial effects on myelin, microglia, and cognitive functions remained albeit with a lower effect size. 2024-02-08 2024-02-10 human
Yun Guo, Cheng-Kun Sun, Lian Tang, Meng-Shan Ta. Microglia PTK2B/Pyk2 in the Pathogenesis of Alzheimer's Disease. Current Alzheimer research. 2024-02-07. PMID:38321895. consequently, it is reasonable to presume that pyk2 in microglia contributes to amyloid-induced tau pathology in ad via a neuroinflammatory pathway. 2024-02-07 2024-02-09 Not clear
Xu-Jia Chen, Zhou Deng, Le-Le Zhang, Yan Pan, Jia Fu, Liang Zou, Zhaofang Bai, Xiaohe Xiao, Feiya Shen. Therapeutic potential of the medicinal mushroom Ganoderma lucidum against Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 172. 2024-02-04. PMID:38310653. the underlying mechanisms mainly include inhibiting tau hyperphosphorylation, inhibiting aβ formation, affecting activated microglia, regulating nf-κb/mapk signalling pathway, inhibiting neuronal apoptosis, modulating immune system, and inhibiting acetylcholinesterase, etc. 2024-02-04 2024-02-07 Not clear
Paul Ediso. Astroglial activation: Current concepts and future directions. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-02-02. PMID:38305570. activated astrocytes exhibit diverse phenotypes in a region-specific manner in brain and interact with β-amyloid, tau, and α-synuclein species as well as with microglia and neuronal circuits. 2024-02-02 2024-02-04 Not clear
Samantha M Rossano, Aubrey S Johnson, Anna Smith, Galen Ziaggi, Andrew Roetman, Diana Guzman, Amarachukwu Okafor, Julia Klein, Zeljko Tomljanovic, Yaakov Stern, Adam M Brickman, Seonjoo Lee, William C Kreisl, Patrick La. Microglia measured by TSPO PET are associated with Alzheimer's disease pathology and mediate key steps in a disease progression model. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-02-01. PMID:38298155. we characterized microglia with translocator protein (tspo) positron emission tomography (pet) within an ad progression model where global amyloid beta (aβ) precedes local tau and neurodegeneration, resulting in cognitive impairment. 2024-02-01 2024-02-03 Not clear
André F Batista, Khyrul A Khan, Maria-Tzousi Papavergi, Cynthia A Lemer. The Importance of Complement-Mediated Immune Signaling in Alzheimer's Disease Pathogenesis. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38255891. in this review, we provide an overview of previously known and newly established roles for the complement cascade in the cns and we explore how complement interactions with microglia, astrocytes, and other risk factors such as trem2 and apoe4 modulate the processes of neurodegeneration in both amyloid and tau models of ad. 2024-01-23 2024-01-25 Not clear
Veronica Astillero-Lopez, Sandra Villar-Conde, Melania Gonzalez-Rodriguez, Alicia Flores-Cuadrado, Isabel Ubeda-Banon, Daniel Saiz-Sanchez, Alino Martinez-Marco. Proteomic analysis identifies HSP90AA1, PTK2B, and ANXA2 in the human entorhinal cortex in Alzheimer's disease: Potential role in synaptic homeostasis and Aβ pathology through microglial and astroglial cells. Brain pathology (Zurich, Switzerland). 2024-01-22. PMID:38247340. all these proteins showed colocalization with neurons and/or astroglia and microglia and with pathological aβ and tau proteins. 2024-01-22 2024-01-24 human
Cristina Nuñez-Diaz, Emelie Andersson, Nina Schultz, Dovilė Pocevičiūtė, Oskar Hansson, K Peter R Nilsson, Malin Wennströ. The fluorescent ligand bTVBT2 reveals increased p-tau uptake by retinal microglia in Alzheimer's disease patients and App Alzheimer's research & therapy. vol 16. issue 1. 2024-01-03. PMID:38167557. the fluorescent ligand btvbt2 reveals increased p-tau uptake by retinal microglia in alzheimer's disease patients and app amyloid beta (aβ) deposits and hyperphosphorylated tau (p-tau) accumulation have been identified in the retina of alzheimer's disease (ad) patients and transgenic ad mice. 2024-01-03 2024-01-06 mouse
Roshni C Lalwani, Claude-Henry Volmar, Claes Wahlestedt, Keith A Webster, Lina A Shehade. Contextualizing the Role of Osteopontin in the Inflammatory Responses of Alzheimer's Disease. Biomedicines. vol 11. issue 12. 2023-12-23. PMID:38137453. tau and aβ complexes spread from the entorhinal cortex of the brain to interconnected regions, where they bind pattern recognition receptors on microglia and astroglia to trigger inflammation and neurotoxicity that ultimately lead to neurodegeneration and clinical ad. 2023-12-23 2023-12-25 Not clear
Hana Cho, Bo Young Choi, Young-Hee Shin, Sang Won Suh, Seung Bum Par. Neuroinflammation-Modulating Agent SB1617 Enhances LC3-Associated Phagocytosis to Mitigate Tau Pathology. ACS chemical neuroscience. 2023-11-28. PMID:38014902. tau protein aggregation and propagation in neurons and surrounding microglia are well-known risk factors for neurodegenerative diseases. 2023-11-28 2023-11-29 Not clear
Marcel S Woo, Johanna Nilsson, Joseph Therriault, Nesrine Rahmouni, Ann Brinkmalm, Andrea L Benedet, Nicholas J Ashton, Arthur C Macedo, Stijn Servaes, Yi-Ting Wang, Cécile Tissot, Jaime Fernandez Arias, Seyyed Ali Hosseini, Mira Chamoun, Firoza Z Lussier, Thomas K Karikari, Jenna Stevenson, Christina Mayer, João Pedro Ferrari-Souza, Eliane Kobayashi, Gassan Massarweh, Manuel A Friese, Tharick A Pascoal, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Net. 14-3-3 [Formula: see text]-reported early synaptic injury in Alzheimer's disease is independently mediated by sTREM2. Journal of neuroinflammation. vol 20. issue 1. 2023-11-24. PMID:38001539. synaptic loss is closely associated with tau aggregation and microglia activation in later stages of alzheimer's disease (ad). 2023-11-24 2023-11-28 Not clear
Marcel S Woo, Johanna Nilsson, Joseph Therriault, Nesrine Rahmouni, Ann Brinkmalm, Andrea L Benedet, Nicholas J Ashton, Arthur C Macedo, Stijn Servaes, Yi-Ting Wang, Cécile Tissot, Jaime Fernandez Arias, Seyyed Ali Hosseini, Mira Chamoun, Firoza Z Lussier, Thomas K Karikari, Jenna Stevenson, Christina Mayer, João Pedro Ferrari-Souza, Eliane Kobayashi, Gassan Massarweh, Manuel A Friese, Tharick A Pascoal, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Net. 14-3-3 [Formula: see text]-reported early synaptic injury in Alzheimer's disease is independently mediated by sTREM2. Journal of neuroinflammation. vol 20. issue 1. 2023-11-24. PMID:38001539. it remains unclear whether microglia activation independently causes synaptic cleavage before tau aggregation appears. 2023-11-24 2023-11-28 Not clear