Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Lu Wang, Yingjuan Wei, Zhenzhou Sun, Lin-Hua Jiang, Yaling Yin, Panpan Zheng, Yun Fu, Hongwei Wang, Changzheng Li, Jian-Zhi Wan. DpdtpA, A Multi-Metal Ion Chelator, Attenuates Tau Phosphorylation and Microglial Inflammatory Response via Regulating the PI3K/AKT/GSK-3β Signal Pathways. Neuroscience. 2023-07-07. PMID:37419407. |
extracellular tau induces primary phagocytosis of stressed neurons and neuronal loss by activating microglia. |
2023-07-07 |
2023-08-14 |
human |
Lu Wang, Yingjuan Wei, Zhenzhou Sun, Lin-Hua Jiang, Yaling Yin, Panpan Zheng, Yun Fu, Hongwei Wang, Changzheng Li, Jian-Zhi Wan. DpdtpA, A Multi-Metal Ion Chelator, Attenuates Tau Phosphorylation and Microglial Inflammatory Response via Regulating the PI3K/AKT/GSK-3β Signal Pathways. Neuroscience. 2023-07-07. PMID:37419407. |
collectively, these results show that dpdtpa can attenuate tau phosphorylation and inflammatory responses of microglia by regulating the pi3k/akt/gsk-3β signal pathways, providing a new option to alleviate neuroinflammation for the treatment of ad. |
2023-07-07 |
2023-08-14 |
human |
Donghee Lee, Ji Eun Ryoo, Seungpyo Hong, Hye Yun Kim, YoungSoo Ki. Carprofen alleviates Alzheimer-like phenotypes of 5XFAD transgenic mice by targeting the pathological hallmarks induced by amyloid-β aggregation. Scientific reports. vol 13. issue 1. 2023-07-05. PMID:37407605. |
aβ monomers transform into aβ oligomers, which are toxic species, inducing tau hyperphosphorylation and the downstream effects on microglia and astrocytes, triggering synaptic and cognitive dysfunctions. |
2023-07-05 |
2023-08-14 |
mouse |
Katryna Pampuscenko, Ramune Morkuniene, Lukas Krasauskas, Vytautas Smirnovas, Guy C Brown, Vilmante Borutait. Extracellular tau stimulates phagocytosis of living neurons by activated microglia via Toll-like 4 receptor-NLRP3 inflammasome-caspase-1 signalling axis. Scientific reports. vol 13. issue 1. 2023-07-04. PMID:37402829. |
extracellular tau stimulates phagocytosis of living neurons by activated microglia via toll-like 4 receptor-nlrp3 inflammasome-caspase-1 signalling axis. |
2023-07-04 |
2023-08-14 |
Not clear |
Katryna Pampuscenko, Ramune Morkuniene, Lukas Krasauskas, Vytautas Smirnovas, Guy C Brown, Vilmante Borutait. Extracellular tau stimulates phagocytosis of living neurons by activated microglia via Toll-like 4 receptor-NLRP3 inflammasome-caspase-1 signalling axis. Scientific reports. vol 13. issue 1. 2023-07-04. PMID:37402829. |
we have previously shown that extracellular tau protein (2n4r isoform) can stimulate microglia to phagocytose live neurons, i.e. |
2023-07-04 |
2023-08-14 |
Not clear |
Katryna Pampuscenko, Ramune Morkuniene, Lukas Krasauskas, Vytautas Smirnovas, Guy C Brown, Vilmante Borutait. Extracellular tau stimulates phagocytosis of living neurons by activated microglia via Toll-like 4 receptor-NLRP3 inflammasome-caspase-1 signalling axis. Scientific reports. vol 13. issue 1. 2023-07-04. PMID:37402829. |
overall, our data indicate that extracellular tau protein stimulates microglia to phagocytose live neurons via toll-like 4 receptor-nlrp3 inflammasome-caspase-1 axis and nadph oxidase, each of which may serve as a potential molecular target for pharmacological treatment of tauopathies. |
2023-07-04 |
2023-08-14 |
Not clear |
Jasvinder Singh Bhatti, Satinder Kaur, Jayapriya Mishra, Harikrishnareddy Dibbanti, Arti Singh, Arubala P Reddy, Gurjit Kaur Bhatti, P Hemachandra Redd. Targeting dynamin-related protein-1 as a potential therapeutic approach for mitochondrial dysfunction in Alzheimer's disease. Biochimica et biophysica acta. Molecular basis of disease. 2023-07-01. PMID:37392948. |
alzheimer's disease (ad) is a neurodegenerative disease that manifests its pathology through synaptic damage, mitochondrial abnormalities, microrna deregulation, hormonal imbalance, increased astrocytes & microglia, accumulation of amyloid β (aβ) and phosphorylated tau in the brains of ad patients. |
2023-07-01 |
2023-08-14 |
Not clear |
Audrey Lee-Gosselin, Nur Jury-Garfe, Yanwen You, Luke Dabin, Disha Soni, Sayan Dutta, Jean-Christophe Rochet, Jungsu Kim, Adrian L Oblak, Cristian A Lasagna-Reeve. TREM2-Deficient Microglia Attenuate Tau Spreading In Vivo. Cells. vol 12. issue 12. 2023-06-28. PMID:37371067. |
trem2-deficient microglia attenuate tau spreading in vivo. |
2023-06-28 |
2023-08-14 |
mouse |
Khoren K Epremyan, Dmitry V Mamaev, Renata A Zvyagilskay. Alzheimer's Disease: Significant Benefit from the Yeast-Based Models. International journal of molecular sciences. vol 24. issue 12. 2023-06-28. PMID:37372938. |
alzheimer's disease (ad) is an age-related, multifaceted neurological disorder associated with accumulation of aggregated proteins (amyloid aβ and hyperphosphorylated tau), loss of synapses and neurons, and alterations in microglia. |
2023-06-28 |
2023-08-14 |
Not clear |
Meshal Alshamran. Recent Trends in Active and Passive Immunotherapies of Alzheimer's Disease. Antibodies (Basel, Switzerland). vol 12. issue 2. 2023-06-27. PMID:37366656. |
potential efforts in the field of pathogenesis have prompted researchers to explore novel therapies such as active and passive vaccines against aβ proteins (aβ immunotherapy), intravenous immunoglobulin, and tau immunotherapy, as well as targets that include microglia and several cytokines for the treatment of ad. |
2023-06-27 |
2023-08-14 |
Not clear |
Anastasie Mate De Gerando, Lindsay A Welikovitch, Anita Khasnavis, Caitlin Commins, Calina Glynn, Joshua E Chun, Romain Perbet, Bradley T Hyma. Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau. Acta neuropathologica. 2023-06-21. PMID:37341831. |
however, the hmw preparation appears to be far more potent in inducing a glial response including clec7a-positive rod microglia in the absence of neurodegeneration or synapse loss and promotes more rapid propagation of misfolded tau to distal, anatomically connected regions, such as entorhinal and perirhinal cortices. |
2023-06-21 |
2023-08-14 |
mouse |
Michael Fassler, Clara Benaim, Jacob Georg. TREM2 Agonism with a Monoclonal Antibody Attenuates Tau Pathology and Neurodegeneration. Cells. vol 12. issue 11. 2023-06-11. PMID:37296669. |
ab-t1 enhanced the uptake of misfolded tau to microglia and induced a non-cell autonomous attenuation of spontaneous tau seeding and phosphorylation in primary neurons from human tau transgenic mice. |
2023-06-11 |
2023-08-14 |
mouse |
Michael Fassler, Clara Benaim, Jacob Georg. TREM2 Agonism with a Monoclonal Antibody Attenuates Tau Pathology and Neurodegeneration. Cells. vol 12. issue 11. 2023-06-11. PMID:37296669. |
collectively, these observations show that trem2 engagement with an agonistic antibody result in reduced tau burden concomitant with attenuated neurodegeneration ascribed to the education of resident microglia. |
2023-06-11 |
2023-08-14 |
mouse |
Deniz Karabag, Hannah Scheiblich, Angelika Griep, Francesco Santarelli, Stephanie Schwartz, Michael T Heneka, Christina Isin. Characterizing microglial senescence: Tau as a key player. Journal of neurochemistry. 2023-06-06. PMID:37278117. |
while the contribution of senescent microglia to the development of tauopathies and other neurodegenerative diseases is a growing area of research, the effect of tau on microglial senescence remains elusive. |
2023-06-06 |
2023-08-14 |
mouse |
Deniz Karabag, Hannah Scheiblich, Angelika Griep, Francesco Santarelli, Stephanie Schwartz, Michael T Heneka, Christina Isin. Characterizing microglial senescence: Tau as a key player. Journal of neurochemistry. 2023-06-06. PMID:37278117. |
here, we exposed primary microglia to 5 and 15 nanomolar (nm) of monomeric tau for 18 h, followed by a recovery period of 48 h. |
2023-06-06 |
2023-08-14 |
mouse |
Subashchandrabose Chinnathambi, Rashmi Da. Microglia degrade Tau oligomers deposit via purinergic P2Y12-associated podosome and filopodia formation and induce chemotaxis. Cell & bioscience. vol 13. issue 1. 2023-05-23. PMID:37221563. |
microglia degrade tau oligomers deposit via purinergic p2y12-associated podosome and filopodia formation and induce chemotaxis. |
2023-05-23 |
2023-08-14 |
Not clear |
Subashchandrabose Chinnathambi, Rashmi Da. Microglia degrade Tau oligomers deposit via purinergic P2Y12-associated podosome and filopodia formation and induce chemotaxis. Cell & bioscience. vol 13. issue 1. 2023-05-23. PMID:37221563. |
microglia are the immune cells in the central nervous system, sense the extracellular tau via various cell surface receptors. |
2023-05-23 |
2023-08-14 |
Not clear |
Risako Fujikawa, Makoto Tsud. The Functions and Phenotypes of Microglia in Alzheimer's Disease. Cells. vol 12. issue 8. 2023-05-16. PMID:37190116. |
in this review, we systematically summarize the microglial response to amyloid-β and tau tangles, and the risk factor genes expressed in microglia. |
2023-05-16 |
2023-08-14 |
Not clear |
Giulia Bivona, Matilda Iemmolo, Giulio Ghers. CX3CL1 Pathway as a Molecular Target for Treatment Strategies in Alzheimer's Disease. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175935. |
cx3cl1 has an effect on aβ clearance and tau phosphorylation, as well as in microglia activation and priming. |
2023-05-14 |
2023-08-14 |
Not clear |
Davin Devara, Yashmit Choudhary, Subodh Kuma. Role of MicroRNA-502-3p in Human Diseases. Pharmaceuticals (Basel, Switzerland). vol 16. issue 4. 2023-04-28. PMID:37111289. |
the most common causes of synapse dysfunction in ad are amyloid beta, hyperphosphorylated tau, and microglia activation. |
2023-04-28 |
2023-08-14 |
human |