| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael Fassler, Clara Benaim, Jacob Georg. TREM2 Agonism with a Monoclonal Antibody Attenuates Tau Pathology and Neurodegeneration. Cells. vol 12. issue 11. 2023-06-11. PMID:37296669. |
ab-t1 enhanced the uptake of misfolded tau to microglia and induced a non-cell autonomous attenuation of spontaneous tau seeding and phosphorylation in primary neurons from human tau transgenic mice. |
2023-06-11 |
2023-08-14 |
mouse |
| Michael Fassler, Clara Benaim, Jacob Georg. TREM2 Agonism with a Monoclonal Antibody Attenuates Tau Pathology and Neurodegeneration. Cells. vol 12. issue 11. 2023-06-11. PMID:37296669. |
collectively, these observations show that trem2 engagement with an agonistic antibody result in reduced tau burden concomitant with attenuated neurodegeneration ascribed to the education of resident microglia. |
2023-06-11 |
2023-08-14 |
mouse |
| Deniz Karabag, Hannah Scheiblich, Angelika Griep, Francesco Santarelli, Stephanie Schwartz, Michael T Heneka, Christina Isin. Characterizing microglial senescence: Tau as a key player. Journal of neurochemistry. 2023-06-06. PMID:37278117. |
while the contribution of senescent microglia to the development of tauopathies and other neurodegenerative diseases is a growing area of research, the effect of tau on microglial senescence remains elusive. |
2023-06-06 |
2023-08-14 |
mouse |
| Deniz Karabag, Hannah Scheiblich, Angelika Griep, Francesco Santarelli, Stephanie Schwartz, Michael T Heneka, Christina Isin. Characterizing microglial senescence: Tau as a key player. Journal of neurochemistry. 2023-06-06. PMID:37278117. |
here, we exposed primary microglia to 5 and 15 nanomolar (nm) of monomeric tau for 18 h, followed by a recovery period of 48 h. |
2023-06-06 |
2023-08-14 |
mouse |
| Subashchandrabose Chinnathambi, Rashmi Da. Microglia degrade Tau oligomers deposit via purinergic P2Y12-associated podosome and filopodia formation and induce chemotaxis. Cell & bioscience. vol 13. issue 1. 2023-05-23. PMID:37221563. |
microglia degrade tau oligomers deposit via purinergic p2y12-associated podosome and filopodia formation and induce chemotaxis. |
2023-05-23 |
2023-08-14 |
Not clear |
| Subashchandrabose Chinnathambi, Rashmi Da. Microglia degrade Tau oligomers deposit via purinergic P2Y12-associated podosome and filopodia formation and induce chemotaxis. Cell & bioscience. vol 13. issue 1. 2023-05-23. PMID:37221563. |
microglia are the immune cells in the central nervous system, sense the extracellular tau via various cell surface receptors. |
2023-05-23 |
2023-08-14 |
Not clear |
| Risako Fujikawa, Makoto Tsud. The Functions and Phenotypes of Microglia in Alzheimer's Disease. Cells. vol 12. issue 8. 2023-05-16. PMID:37190116. |
in this review, we systematically summarize the microglial response to amyloid-β and tau tangles, and the risk factor genes expressed in microglia. |
2023-05-16 |
2023-08-14 |
Not clear |
| Giulia Bivona, Matilda Iemmolo, Giulio Ghers. CX3CL1 Pathway as a Molecular Target for Treatment Strategies in Alzheimer's Disease. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175935. |
cx3cl1 has an effect on aβ clearance and tau phosphorylation, as well as in microglia activation and priming. |
2023-05-14 |
2023-08-14 |
Not clear |
| Davin Devara, Yashmit Choudhary, Subodh Kuma. Role of MicroRNA-502-3p in Human Diseases. Pharmaceuticals (Basel, Switzerland). vol 16. issue 4. 2023-04-28. PMID:37111289. |
the most common causes of synapse dysfunction in ad are amyloid beta, hyperphosphorylated tau, and microglia activation. |
2023-04-28 |
2023-08-14 |
human |
| Nicole Koutsodendris, Jessica Blumenfeld, Ayushi Agrawal, Michela Traglia, Brian Grone, Misha Zilberter, Oscar Yip, Antara Rao, Maxine R Nelson, Yanxia Hao, Reuben Thomas, Seo Yeon Yoon, Patrick Arriola, Yadong Huan. Neuronal APOE4 removal protects against tau-mediated gliosis, neurodegeneration and myelin deficits. Nature aging. vol 3. issue 3. 2023-04-28. PMID:37118426. |
single-nucleus rna-sequencing revealed that the removal of neuronal apoe4 greatly diminished neurodegenerative disease-associated subpopulations of neurons, oligodendrocytes, astrocytes and microglia whose accumulation correlated to the severity of tau pathology, neurodegeneration and myelin deficits. |
2023-04-28 |
2023-08-14 |
mouse |
| Joana B Pereira, Shorena Janelidze, Olof Strandberg, Christopher D Whelan, Henrik Zetterberg, Kaj Blennow, Sebastian Palmqvist, Erik Stomrud, Niklas Mattsson-Carlgren, Oskar Hansso. Microglial activation protects against accumulation of tau aggregates in nondemented individuals with underlying Alzheimer's disease pathology. Nature aging. vol 2. issue 12. 2023-04-28. PMID:37118533. |
the role of microglia in tau accumulation is currently unclear but could provide an important insight into the mechanisms underlying alzheimer's disease (ad) |
2023-04-28 |
2023-08-14 |
Not clear |
| Joe C Udeochu, Sadaf Amin, Yige Huang, Li Fan, Eileen Ruth S Torres, Gillian K Carling, Bangyan Liu, Hugo McGurran, Guillermo Coronas-Samano, Grant Kauwe, Gergey Alzaem Mousa, Man Ying Wong, Pearly Ye, Ravi Kumar Nagiri, Iris Lo, Julia Holtzman, Carlo Corona, Allan Yarahmady, Michael T Gill, Ravikiran M Raju, Sue-Ann Mok, Shiaoching Gong, Wenjie Luo, Mingrui Zhao, Tara E Tracy, Rajiv R Ratan, Li-Huei Tsai, Subhash C Sinha, Li Ga. Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience. Nature neuroscience. 2023-04-24. PMID:37095396. |
pathogenic tau activates cgas and ifn-i responses in microglia, in part mediated by cytosolic leakage of mitochondrial dna. |
2023-04-24 |
2023-08-14 |
mouse |
| Subashchandrabose Chinnathambi, Rashmi Das, Smita Eknath Desal. Tau aggregates improve the purinergic receptor P2Y12-associated podosome rearrangements in microglial cells. Biochimica et biophysica acta. Molecular cell research. 2023-04-15. PMID:37061007. |
the extracellular release of aggregated tau is sensed by surveilling microglia through the involvement of various cell surface receptors. |
2023-04-15 |
2023-08-14 |
Not clear |
| Charlotte Duwat, Pauline Léal, Audrey Vautheny, Gwennaëlle Aurégan, Charlène Joséphine, Marie-Claude Gaillard, Anne-Sophie Hérard, Caroline Jan, Pauline Gipchtein, Julien Mitja, Stéphane Fouquet, Marie-Laure Niepon, Philippe Hantraye, Emmanuel Brouillet, Gilles Bonvento, Karine Cambon, Alexis-Pierre Bemelman. Development of an AAV-based model of tauopathy targeting retinal ganglion cells and the mouse visual pathway to study the role of microglia in Tau pathology. Neurobiology of disease. 2023-04-13. PMID:37054900. |
development of an aav-based model of tauopathy targeting retinal ganglion cells and the mouse visual pathway to study the role of microglia in tau pathology. |
2023-04-13 |
2023-08-14 |
mouse |
| Jasvinder Singh Bhatti, Naina Khullar, Jayapriya Mishra, Satinder Kaur, Abhishek Sehrawat, Eva Sharma, Gurjit Kaur Bhatti, Ashley Selman, P Hemachandra Redd. Stem cells in the treatment of Alzheimer's disease - Promises and pitfalls. Biochimica et biophysica acta. Molecular basis of disease. 2023-04-08. PMID:37030521. |
the underlying mechanisms of ad include the build-up of amyloid-β and phosphorylated tau, synaptic damage, elevated levels of microglia and astrocytes, abnormal micrornas, mitochondrial dysfunction, hormonal imbalance, and age-related neuronal loss. |
2023-04-08 |
2023-08-14 |
Not clear |
| Lucia A A Giannini, Marjolein Bulk, Boyd Kenkhuis, Ana Rajicic, Shamiram Melhem, Ingrid Hegeman-Kleinn, Lucia Bossoni, Ernst Suidgeest, Elise G P Dopper, John C van Swieten, Louise van der Weerd, Harro Seelaa. Cortical iron accumulation in MAPT- and C9orf 72-associated frontotemporal lobar degeneration. Brain pathology (Zurich, Switzerland). 2023-03-28. PMID:36974379. |
we studied patterns of cortical iron accumulation and its colocalization with the corresponding underlying pathologies (tau and tdp-43), brain cells (microglia and astrocytes), and myelination. |
2023-03-28 |
2023-08-14 |
Not clear |
| Lucia A A Giannini, Marjolein Bulk, Boyd Kenkhuis, Ana Rajicic, Shamiram Melhem, Ingrid Hegeman-Kleinn, Lucia Bossoni, Ernst Suidgeest, Elise G P Dopper, John C van Swieten, Louise van der Weerd, Harro Seelaa. Cortical iron accumulation in MAPT- and C9orf 72-associated frontotemporal lobar degeneration. Brain pathology (Zurich, Switzerland). 2023-03-28. PMID:36974379. |
cortical iron accumulation was associated with the severity of proteinopathy (tau or tdp-43) and neuronal degeneration, in part with clinical severity, and with the presence of activated microglia, reactive astrocytes and myelin loss. |
2023-03-28 |
2023-08-14 |
Not clear |
| Soraya Meftah, Jian Ga. Alzheimer's disease as a synaptopathy: Evidence for dysfunction of synapses during disease progression. Frontiers in synaptic neuroscience. vol 15. 2023-03-27. PMID:36970154. |
other important future avenues of note in this field include the role of non-neuronal cell types such as astrocytes and microglia, and mechanisms of dysfunction independent of amyloid and tau in alzheimer's disease. |
2023-03-27 |
2023-08-14 |
mouse |
| Rebecca L Winfree, Mabel Seto, Logan Dumitrescu, Vilas Menon, Philip De Jager, Yanling Wang, Julie Schneider, David A Bennett, Angela L Jefferson, Timothy J Hohma. TREM2 gene expression associations with Alzheimer's disease neuropathology are region-specific: implications for cortical versus subcortical microglia. Acta neuropathologica. 2023-03-25. PMID:36966244. |
trem2 gene expression of the dorsolateral prefrontal cortex, posterior cingulate cortex, and caudate nucleus was assessed with respect to core pathology of alzheimer's disease (amyloid-β, and tau), cerebrovascular pathology (cerebral infarcts, arteriolosclerosis, atherosclerosis, and cerebral amyloid angiopathy), microglial activation (proportion of activated microglia), and cognitive performance. |
2023-03-25 |
2023-08-14 |
Not clear |
| Moxin Wu, Zhiying Chen, Min Jiang, Bing Bao, Dongling Li, Xiaoping Yin, Xueren Wang, Dan Liu, Ling-Qiang Zh. Friend or foe: role of pathological tau in neuronal death. Molecular psychiatry. 2023-03-15. PMID:36918705. |
in contrast, pathological tau always detaches from microtubules and is implicated in a series of neurological disorders that are characterized by irreversible neuronal death, such as necrosis, apoptosis, necroptosis, pyroptosis, ferroptosis, autophagy-dependent neuronal death and phagocytosis by microglia. |
2023-03-15 |
2023-08-14 |
Not clear |