| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carolina Osorio, Adonis Sfera, Jonathan J Anton, Karina G Thomas, Christina V Andronescu, Erica Li, Rayan W Yahia, Andrea García Avalos, Zisis Kozlakidi. Virus-Induced Membrane Fusion in Neurodegenerative Disorders. Frontiers in cellular and infection microbiology. vol 12. 2022-05-09. PMID:35531328. |
virus-induced pathological syncytia may provide a unified framework for conceptualizing neuronal cell cycle reentry, aneuploidy, somatic mosaicism, viral spreading of pathological tau and elimination of viable synapses and neurons by neurotoxic astrocytes and microglia. |
2022-05-09 |
2023-08-13 |
human |
| Qin-Yuan Yu, Ling-Qi Ye, Hong-Lei L. Molecular interaction of stress granules with Tau and autophagy in Alzheimer's disease. Neurochemistry international. 2022-04-24. PMID:35461975. |
in this review, we summarized the regulation of sgs and their relationship with tau protein and autophagy, as well as the pathological mechanisms of ad such as rna splicing, microglial cell proliferation and phagocytosis. |
2022-04-24 |
2023-08-13 |
Not clear |
| Chao Wang, Li Fan, Rabia R Khawaja, Bangyan Liu, Lihong Zhan, Lay Kodama, Marcus Chin, Yaqiao Li, David Le, Yungui Zhou, Carlo Condello, Lea T Grinberg, William W Seeley, Bruce L Miller, Sue-Ann Mok, Jason E Gestwicki, Ana Maria Cuervo, Wenjie Luo, Li Ga. Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy. Nature communications. vol 13. issue 1. 2022-04-13. PMID:35413950. |
how microglia activation contributes to tau toxicity remains largely unknown. |
2022-04-13 |
2023-08-13 |
mouse |
| Chao Wang, Li Fan, Rabia R Khawaja, Bangyan Liu, Lihong Zhan, Lay Kodama, Marcus Chin, Yaqiao Li, David Le, Yungui Zhou, Carlo Condello, Lea T Grinberg, William W Seeley, Bruce L Miller, Sue-Ann Mok, Jason E Gestwicki, Ana Maria Cuervo, Wenjie Luo, Li Ga. Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy. Nature communications. vol 13. issue 1. 2022-04-13. PMID:35413950. |
inhibition of nf-κb activation enhanced the retention while reduced the release of internalized pathogenic tau fibrils from primary microglia and rescued microglial autophagy deficits. |
2022-04-13 |
2023-08-13 |
mouse |
| Chenghuan Song, Jiyun Shi, Pingao Zhang, Yongfang Zhang, Jianrong Xu, Lanxue Zhao, Rui Zhang, Hao Wang, Hongzhuan Che. Immunotherapy for Alzheimer's disease: targeting β-amyloid and beyond. Translational neurodegeneration. vol 11. issue 1. 2022-03-18. PMID:35300725. |
meanwhile, immunotherapies based on other targets such as tau, microglia and gut-brain axis are also under development. |
2022-03-18 |
2023-08-13 |
Not clear |
| Chenghuan Song, Jiyun Shi, Pingao Zhang, Yongfang Zhang, Jianrong Xu, Lanxue Zhao, Rui Zhang, Hao Wang, Hongzhuan Che. Immunotherapy for Alzheimer's disease: targeting β-amyloid and beyond. Translational neurodegeneration. vol 11. issue 1. 2022-03-18. PMID:35300725. |
in this review, we focus on the immunotherapies based on aβ, tau and microglia and their mechanisms of action in ad. |
2022-03-18 |
2023-08-13 |
Not clear |
| Sonja Fixemer, Corrado Ameli, Gaël Hammer, Luis Salamanca, Oihane Uriarte Huarte, Chantal Schwartz, Jean-Jacques Gérardy, Naguib Mechawar, Alexander Skupin, Michel Mittelbronn, David S Bouvie. Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies. Acta neuropathologica communications. vol 10. issue 1. 2022-03-17. PMID:35296366. |
microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with alzheimer's disease and dementia with lewy bodies. |
2022-03-17 |
2023-08-13 |
Not clear |
| Toshihiko Tashim. Delivery of Intravenously Administered Antibodies Targeting Alzheimer's Disease-Relevant Tau Species into the Brain Based on Receptor-Mediated Transcytosis. Pharmaceutics. vol 14. issue 2. 2022-02-26. PMID:35214143. |
these cross the blood-brain barrier (bbb) based on receptor-mediated transcytosis and are subsequently cleared by microglia based on fc-mediated endocytosis after binding to tau and lysosomal degradation. |
2022-02-26 |
2023-08-13 |
Not clear |
| Ryuichi Harada, Shozo Furumoto, Yukitsuka Kudo, Kazuhiko Yanai, Victor L Villemagne, Nobuyuki Okamur. Imaging of Reactive Astrogliosis by Positron Emission Tomography. Frontiers in neuroscience. vol 16. 2022-02-25. PMID:35210989. |
in postmortem ad brains, reactive astrocytes and activated microglia are observed surrounding aβ plaques and tau tangles. |
2022-02-25 |
2023-08-13 |
Not clear |
| Juan R Perea, Esther García, Laura Vallés-Saiz, Raquel Cuadros, Félix Hernández, Marta Bolós, Jesús Avil. p38 activation occurs mainly in microglia in the P301S Tauopathy mouse model. Scientific reports. vol 12. issue 1. 2022-02-09. PMID:35136118. |
on the basis of our findings, we propose that rod microglia might have a neuroprotective phenotype in the context of tau pathology. |
2022-02-09 |
2023-08-13 |
mouse |
| Chenfei Wang, Wei Huang, Jia Lu, Hongzhuan Chen, Zhihua Y. TRPV1-Mediated Microglial Autophagy Attenuates Alzheimer's Disease-Associated Pathology and Cognitive Decline. Frontiers in pharmacology. vol 12. 2022-02-04. PMID:35115924. |
trpv1 agonist capsaicin decreased amyloid and phosphorylated tau pathology and reversed memory deficits by promoting microglia activation, metabolism, and autophagy in 3xtg mice. |
2022-02-04 |
2023-08-13 |
mouse |
| Dan Xia, Steve Lianoglou, Thomas Sandmann, Meredith Calvert, Jung Suh, Elliot Thomsen, Jason Dugas, Michelle E Pizzo, Sarah L DeVos, Timothy K Earr, Chia-Ching Lin, Sonnet Davis, Connie Ha, Hoang Nguyen, Roni Chau, Ernie Yulyaningsih, Hilda Solanoy, Shababa T Masoud, Richard Liang, Karin Lin, Robert G Thorne, Dylan Garceau, Jennifer D Whitesell, Michael Sasner, Julie A Harris, Kimberly Scearce-Levie, Joseph W Lewcock, Gilbert Di Paolo, Pascal E Sanche. Fibrillar Aβ causes profound microglial metabolic perturbations in a novel APP knock-in mouse model. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109044. |
microglia respond to various pathogenic drivers of ad, including amyloid-ß (aß) and tau, but the mechanisms by which microglia may become dysfunctional and contribute to disease remain unclear. |
2022-02-03 |
2023-08-13 |
mouse |
| Mark Stephen Kindy, Dorothy K. GM6 attenuates Alzheimer's disease pathology through a reduction in fibrinogen levels and by regulation of Aβ, p-tau and inflammation. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109082. |
alzheimer's disease (ad) is characterized by cerebral amyloid-b (ab) deposition, vascular alterations, tau pathology, microglia activation, and inflammation. |
2022-02-03 |
2023-08-13 |
Not clear |
| Valerie L Joers, Hannah Staley, Maclean Bassett, Brenda D Moore, Malu Gamez Tanse. The role of cannabinoid receptor 2 in microglial clearance of human tau. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109165. |
microglia have been implicated in tauopathies as they may contribute to tau phosphorylation and aggregation and the uptake and spread of seed-competent tau to healthy neurons due to dysfunctional degradation. |
2022-02-03 |
2023-08-13 |
human |
| Lei Cao, Yanyan Kong, Bin Ji, Yutong Ren, Yihui Guan, Ruiqing N. Positron Emission Tomography in Animal Models of Tauopathies. Frontiers in aging neuroscience. vol 13. 2022-01-27. PMID:35082657. |
the advance in pet and imaging tracers have enabled non-invasive detection of the accumulation and spread of tau, the associated microglia activation, metabolic, and neurotransmitter receptor alterations in disease animal models. |
2022-01-27 |
2023-08-13 |
mouse |
| Yasir H Qureshi, Diego E Berman, Samuel E Marsh, Ronald L Klein, Vivek M Patel, Sabrina Simoes, Suvarnambiga Kannan, Gregory A Petsko, Beth Stevens, Scott A Smal. The neuronal retromer can regulate both neuronal and microglial phenotypes of Alzheimer's disease. Cell reports. vol 38. issue 3. 2022-01-19. PMID:35045281. |
finally, the neuronal and, in part, the microglia responses to vps35 depletion were found to occur independent of tau. |
2022-01-19 |
2023-08-13 |
mouse |
| Matylda Barbara Mielcarska, Katarzyna Skowrońska, Zbigniew Wyżewski, Felix Ngosa Tok. Disrupting Neurons and Glial Cells Oneness in the Brain-The Possible Causal Role of Herpes Simplex Virus Type 1 (HSV-1) in Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 1. 2022-01-11. PMID:35008671. |
we describe the changes in neurons, astrocytes, microglia, and oligodendrocytes related to the production of inflammatory factors, transition of glial cells into a reactive state, oxidative damage, aβ secretion, tau hyperphosphorylation, apoptosis, and autophagy. |
2022-01-11 |
2023-08-13 |
Not clear |
| Smita Eknath Desale, Subashchandrabose Chinnathamb. α-Linolenic acid induces clearance of Tau seeds via Actin-remodeling in Microglia. Molecular biomedicine. vol 2. issue 1. 2022-01-10. PMID:35006402. |
α-linolenic acid induces clearance of tau seeds via actin-remodeling in microglia. |
2022-01-10 |
2023-08-13 |
Not clear |
| Juan R Perea, Marta Bolós, Raquel Cuadros, Esther García, Vega García-Escudero, Félix Hernández, Róisín M McManus, Michael T Heneka, Jesús Avil. p38 Inhibition Decreases Tau Toxicity in Microglia and Improves Their Phagocytic Function. Molecular neurobiology. 2022-01-10. PMID:35006531. |
p38 inhibition decreases tau toxicity in microglia and improves their phagocytic function. |
2022-01-10 |
2023-08-13 |
Not clear |
| Juan R Perea, Marta Bolós, Raquel Cuadros, Esther García, Vega García-Escudero, Félix Hernández, Róisín M McManus, Michael T Heneka, Jesús Avil. p38 Inhibition Decreases Tau Toxicity in Microglia and Improves Their Phagocytic Function. Molecular neurobiology. 2022-01-10. PMID:35006531. |
alzheimer's disease (ad) and other tauopathies are histopathologically characterized by tau aggregation, along with a chronic inflammatory response driven by microglia. |
2022-01-10 |
2023-08-13 |
Not clear |