| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Methasit Jaisa-Aad, Clara Muñoz-Castro, Molly A Healey, Bradley T Hyman, Alberto Serrano-Poz. Characterization of monoamine oxidase-B (MAO-B) as a biomarker of reactive astrogliosis in Alzheimer's disease and related dementias. Acta neuropathologica. vol 147. issue 1. 2024-04-03. PMID:38568475. |
we sought to: (1) identify the primary cell type(s) expressing mao-b in control and ad brains; (2) quantify mao-b immunoreactivity in multiple brain regions of control and ad donors as a proxy for pet radiotracer uptake; (3) correlate mao-b level with local ad neuropathological changes, reactive glia, and cortical atrophy; (4) determine whether the maob rs1799836 snp genotype impacts mao-b expression level; (5) compare mao-b immunoreactivity across ad/adrd, including lewy body diseases (lbd) and frontotemporal lobar degenerations with tau (ftld-tau) and tdp-43 (ftld-tdp). |
2024-04-03 |
2024-04-05 |
Not clear |
| Zhengzhong Zeng, Hu Zhang, Xianping Wang, Jiawen Shen, Danyang Che. Fasting, a Potential Intervention in Alzheimer's Disease. Journal of integrative neuroscience. vol 23. issue 3. 2024-03-27. PMID:38538214. |
the clinical efficacy of fasting in addressing ad and related disorders might be grounded in its influence on various molecular mechanisms, including neuroinflammation, glial cell activation, insulin resistance, autophagy regulation, nerve regeneration, the gut microbiome, and accumulations of amyloid-β and tau proteins. |
2024-03-27 |
2024-03-30 |
human |
| Haichao Wei, Joseph Withrow, Jyotirmoy Rakshit, Faiz Ul Amin, Joshua Nahm, Francesca E Mowry, Zhengmei Mao, Meenakshi B Bhattacharjee, Jay-Jiguang Zhu, Yongjie Yang, Jia Qian W. The identification of a Distinct Astrocyte Subtype that Diminishes in Alzheimer's Disease. Aging and disease. 2024-03-19. PMID:38502590. |
there is a growing body of evidence suggesting that astrocytes, a type of glial cell in the brain, play crucial roles in clearing aβ and binding to tau proteins. |
2024-03-19 |
2024-03-23 |
mouse |
| Megan E Bosch, Hemraj B Dodiya, Julia Michalkiewicz, Choonghee Lee, Shabana M Shaik, Ian Q Weigle, Can Zhang, Jack Osborn, Aishwarya Nambiar, Priyam Patel, Samira Parhizkar, Xiaoqiong Zhang, Marie L Laury, Prasenjit Mondal, Ashley Gomm, Matthew John Schipma, Dania Mallah, Oleg Butovsky, Eugene B Chang, Rudolph E Tanzi, Jack A Gilbert, David M Holtzman, Sangram S Sisodi. Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner. Molecular neurodegeneration. vol 19. issue 1. 2024-02-16. PMID:38365827. |
we have previously demonstrated that antibiotic-mediated gut microbiota perturbations lead to attenuation of aβ deposition, phosphorylated tau accumulation, and disease-associated glial cell phenotypes in a sex-dependent manner. |
2024-02-16 |
2024-02-19 |
mouse |
| Jiuyang Ding, Jun Wu, Xiaotao Hou, Li Yang, Yingdong Gao, Juan Zheng, Nannan Jia, Zheng He, Hui Zhang, Chengfei Wang, Xiaolan Qi, Jiang Huang, Xianglin Pei, Jiawen Wan. α-synuclein-lack expression rescues methamphetamine-induced mossy fiber degeneration in dorsal hippocampal CA3. Neurotoxicology. vol 101. 2024-02-07. PMID:38311184. |
chronic meth exposure decreased mossy fiber density but upregulatedα-syn and phosphorylated tau (tau-pser396) in hippocampal ca3, associated with glial cell overactivation, axonal neuropathies, and memory impairment. |
2024-02-07 |
2024-02-10 |
Not clear |
| Kentaro Yoshida, Tadashi Adachi, Yuki Suzuki, Mayuko Sakuwa, Hiroki Fukuda, Masato Hasegawa, Yoshiki Adachi, Hiroshi Miura, Ritsuko Hanajim. Corticobasal degeneration with visual hallucination as an initial symptom: A case report. Neuropathology : official journal of the Japanese Society of Neuropathology. 2024-01-31. PMID:38291581. |
the superficial cortical layers lacked ballooned neurons and spongiosis, and tau deposition was greater in glia than in neurons. |
2024-01-31 |
2024-02-02 |
Not clear |
| Kristen Whitney, Won-Min Song, Abhijeet Sharma, Diana K Dangoor, Kurt Farrell, Margaret M Krassner, Hadley W Ressler, Thomas D Christie, Ruth H Walker, Melissa J Nirenberg, Bin Zhang, Steven J Frucht, Giulietta M Riboldi, John F Crary, Ana C Pereir. Single-cell transcriptomic and neuropathologic analysis reveals dysregulation of the integrated stress response in progressive supranuclear palsy. bioRxiv : the preprint server for biology. 2023-11-28. PMID:38014079. |
progressive supranuclear palsy (psp) is a sporadic neurodegenerative tauopathy variably affecting brainstem and cortical structures and characterized by tau inclusions in neurons and glia. |
2023-11-28 |
2023-11-29 |
human |
| Alexandra Litvinchuk, Jung H Suh, Jing L Guo, Karin Lin, Sonnet S Davis, Nga Bien-Ly, Eric Tycksen, G Travis Tabor, Javier Remolina Serrano, Melissa Manis, Xin Bao, Choonghee Lee, Megan Bosch, Enmanuel J Perez, Carla M Yuede, Anil G Cashikar, Jason D Ulrich, Gilbert Di Paolo, David M Holtzma. Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist. Neuron. 2023-11-23. PMID:37995685. |
increasing lipid efflux in glia via an lxr agonist or abca1 overexpression strongly attenuates tau pathology and neurodegeneration in p301s/apoe4 mice. |
2023-11-23 |
2023-11-29 |
mouse |
| Yuhao Min, Xue Wang, Özkan İş, Tulsi A Patel, Junli Gao, Joseph S Reddy, Zachary S Quicksall, Thuy Nguyen, Shu Lin, Frederick Q Tutor-New, Jessica L Chalk, Adriana O Mitchell, Julia E Crook, Peter T Nelson, Linda J Van Eldik, Todd E Golde, Minerva M Carrasquillo, Dennis W Dickson, Ke Zhang, Mariet Allen, Nilüfer Ertekin-Tane. Cross species systems biology discovers glial DDR2, STOM, and KANK2 as therapeutic targets in progressive supranuclear palsy. Nature communications. vol 14. issue 1. 2023-11-03. PMID:37919278. |
progressive supranuclear palsy (psp) is a neurodegenerative parkinsonian disorder characterized by cell-type-specific tau lesions in neurons and glia. |
2023-11-03 |
2023-11-08 |
mouse |
| Dandan Chu, Xingyue Yang, Jing Wang, Yan Zhou, Jin-Hua Gu, Jin Miao, Feng Wu, Fei Li. Tau truncation in the pathogenesis of Alzheimer's disease: a narrative review. Neural regeneration research. vol 19. issue 6. 2023-10-31. PMID:37905868. |
in addition, tau truncations cause extensive impairments to neural and glial cell functions and animal cognition and behavior in a fragment-dependent manner. |
2023-10-31 |
2023-11-08 |
Not clear |
| Yuchao Zhang, Zhihuai Zhang, Sijie Zhu, Liangyu Liu, Xudong Liu, Xu Yan. Acetyl Tributyl Citrate Exposure at Seemingly Safe Concentrations Induces Adverse Effects in Different Genders of Type 2 Diabetes Mice, Especially Brain Tissue. Toxics. vol 11. issue 10. 2023-10-27. PMID:37888727. |
in this study, glycolipid metabolism, cognitive deficits, brain tissue damage, levels of neurotransmitters, beta-amyloid plaques (aβ), hyperphosphorylated tau protein (p-tau), oxidative stress and inflammation, as well as glial cell homeostatic levels in the brain tissue of type 2 diabetes (t2dm) mice, were determined after atbc exposure (0, 2, 20, and 200 mg/kg/day) for 90 days. |
2023-10-27 |
2023-11-08 |
mouse |
| Laura Vidal-Palencia, Cristina Font, Agustín Rebollada-Merino, Gabriel Santpere, Pol Andrés-Benito, Isidro Ferrer, Martí Pumarol. Primary Feline Tauopathy: Clinical, Morphological, Immunohistochemical, and Genetic Studies. Animals : an open access journal from MDPI. vol 13. issue 18. 2023-09-28. PMID:37760385. |
tauopathies are a group of neurodegenerative diseases characterized by the pathological aggregation of hyperphosphorylated tau in neurons and glia. |
2023-09-28 |
2023-10-07 |
cat |
| Asuman Kaplan Algin, Canberk Tomruk, Çiğdem Gözde Aslan, Sinan Şaban Akkurt, Gülcihan Mehtap Çinar, Sezgin Ulukaya, Yiğit Uyanikgil, Yasemin Akça. Effects of ozone treatment to the levels of neurodegeneration biomarkers after rotenone induced rat model of Parkinson's disease. Neuroscience letters. 2023-08-19. PMID:37597740. |
α-synuclein, amyloid-β, tau, phosphorylated tau, as well as tyrosine hydroxylase(+), nnos(+), and glial cell counts were used to evaluate neurodegeneration in the substantia nigra pars compacta and ventral tegmental area. |
2023-08-19 |
2023-09-07 |
rat |
| Debashis Dutta, Malabendu Jana, Ramesh Kumar Paidi, Moumita Majumder, Sumita Raha, Sridevi Dasarathy, Kalipada Paha. Tau fibrils induce glial inflammation and neuropathology via TLR2 in Alzheimer's disease-related mouse models. The Journal of clinical investigation. 2023-08-08. PMID:37552543. |
however, the mechanism behind tau fibril and glia interaction is poorly understood. |
2023-08-08 |
2023-08-16 |
mouse |
| Keerti Sitani, Sandhya Mangalore, Nitish Kamble, Pramod Kumar Pal, Vikram Venkayappa Holl. A Rare Case of Asymmetric Progressive Supra Nuclear Palsy Diagnosed Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India. vol 38. issue 2. 2023-07-17. PMID:37456195. |
a rare case of asymmetric progressive supra nuclear palsy diagnosed psp and cbd are usually multi system sporadic disorders characterized by tau inclusions in neurons and glia. |
2023-07-17 |
2023-08-14 |
Not clear |
| Yijun Chen, Yang Y. Tau and neuroinflammation in Alzheimer's disease: interplay mechanisms and clinical translation. Journal of neuroinflammation. vol 20. issue 1. 2023-07-14. PMID:37452321. |
here, we review recent evidence on the interaction between tau pathology, focusing on tau post-translational modification and dissemination, and neuroinflammatory responses, including glial cell activation and inflammatory signaling pathways. |
2023-07-14 |
2023-08-14 |
Not clear |
| Shunsuke Koga, Aya Murakami, Alexandra I Soto-Beasley, Ronald L Walton, Matthew C Baker, Monica Castanedes-Casey, Keith A Josephs, Owen A Ross, Dennis W Dickso. Diffuse argyrophilic grain disease with TDP-43 proteinopathy and neuronal intermediate filament inclusion disease: FTLD with mixed tau, TDP-43 and FUS pathologies. Acta neuropathologica communications. vol 11. issue 1. 2023-07-06. PMID:37415197. |
ftld can be further subdivided into three main subtypes, ftld-tau, ftld-tdp and ftld-fus based which of the three major proteins - tau, tdp-43 or fus - forms pathological inclusions in neurons and glia. |
2023-07-06 |
2023-08-14 |
Not clear |
| Francesco Panza, Vittorio Dibello, Rodolfo Sardone, Fabio Castellana, Roberta Zupo, Luisa Lampignano, Ilaria Bortone, Roberta Stallone, Nicoletta Cirillo, Christian Damiani, Mario Altamura, Antonello Bellomo, Antonio Daniele, Vincenzo Solfrizzi, Madia Lozupon. Clinical Development of Passive Tau-Based Immunotherapeutics for Treating Primary and Secondary Tauopathies. Expert opinion on investigational drugs. 2023-07-05. PMID:37405389. |
tauopathies are clinicopathological entities with increased and pathological deposition in glia and/or neurons of hyperphosphorylated aggregates of the microtubule-binding protein tau. |
2023-07-05 |
2023-08-14 |
Not clear |
| Timothy Wu, Jennifer M Deger, Hui Ye, Caiwei Guo, Justin Dhindsa, Brandon T Pekarek, Rami Al-Ouran, Zhandong Liu, Ismael Al-Ramahi, Juan Botas, Joshua M Shulma. Tau polarizes an aging transcriptional signature to excitatory neurons and glia. eLife. vol 12. 2023-05-23. PMID:37219079. |
tau polarizes an aging transcriptional signature to excitatory neurons and glia. |
2023-05-23 |
2023-08-14 |
Not clear |
| Connor Langworth-Green, Saisha Patel, Zane Jaunmuktane, Edwin Jabbari, Huw Morris, Maria Thom, Andrew Lees, John Hardy, Michael Zandi, Karen Duf. Chronic effects of inflammation on tauopathies. The Lancet. Neurology. vol 22. issue 5. 2023-04-14. PMID:37059510. |
tauopathies are a heterogeneous group of neurodegenerative disorders that are characterised by the aggregation of the microtubule-associated protein tau into filamentous inclusions within neurons and glia. |
2023-04-14 |
2023-08-14 |
Not clear |