All Relations between microtubule-associated protein tau and neuroglial cell

Reference Sentence Publish Date Extraction Date Species
Chunxia Huang, John Man-Tak Chu, Yan Liu, Raymond Chuen-Chung Chang, Gordon Tin-Chun Won. Varenicline reduces DNA damage, tau mislocalization and post surgical cognitive impairment in aged mice. Neuropharmacology vol 143 issue 2019 30273594 glia activation, aberrant tau phosphorylation (at8) and accumulation of phosphorylated h2ax in the hippocampus were detectable up to postoperative day 14, with neuronal apoptosis seen in the hippocampus. 2019-02-25 2022-01-13 Not clear
Mansi R Khanna, Jane Kovalevich, Virginia M-Y Lee, John Q Trojanowski, Kurt R Brunde. Therapeutic strategies for the treatment of tauopathies: Hopes and challenges. Alzheimer's & dementia : the journal of the Alzheimer's Association vol 12 issue 10 2017 27751442 tau is normally a microtubule (mt)-associated protein that appears to play an important role in ensuring proper axonal transport, but in tauopathies tau becomes hyperphosphorylated and disengages from mts, with consequent misfolding and deposition into inclusions that mainly affect neurons but also glia. 2017-10-30 2022-01-12 Not clear
Najiba Mammadova, Shivani Ghaisas, Gary Zenitsky, Donald S Sakaguchi, Anumantha G Kanthasamy, Justin J Greenlee, M Heather West Greenle. Lasting Retinal Injury in a Mouse Model of Blast-Induced Trauma. The American journal of pathology vol 187 issue 7 2017 28606756 primary blast wave pressure resulted in activation of m\xc3\xbcller glia, loss of photoreceptor cells, and an increase in phosphorylated tau in retinal neurons and glia. 2017-10-13 2022-01-13 Not clear
Rui Lu, Qian He, Junfeng Wan. TRPC Channels and Alzheimer's Disease. Advances in experimental medicine and biology vol 976 issue 2017 28508314 besides, tau protein accumulation, calcium homeostasis disruption, and glial cell activation are also remarkable features in ad. 2017-09-22 2022-01-13 Not clear
Hongjun Fu, S Abid Hussaini, Susanne Wegmann, Caterina Profaci, Jacob D Daniels, Mathieu Herman, Sheina Emrani, Helen Y Figueroa, Bradley T Hyman, Peter Davies, Karen E Duf. 3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice. PloS one vol 11 issue 7 2017 27466814 no evidence for uptake and accumulation of tau by glia was observed. 2017-07-18 2022-01-12 Not clear
Jennifer S Yokoyama, Celeste M Karch, Chun C Fan, Luke W Bonham, Naomi Kouri, Owen A Ross, Rosa Rademakers, Jungsu Kim, Yunpeng Wang, G\\xc3\\xbcnter U H\\xc3\\xb6glinger, Ulrich M\\xc3\\xbcller, Raffaele Ferrari, John Hardy, Parastoo Momeni, Leo P Sugrue, Christopher P Hess, A James Barkovich, Adam L Boxer, William W Seeley, Gil D Rabinovici, Howard J Rosen, Bruce L Miller, Nicholas J Schmansky, Bruce Fischl, Bradley T Hyman, Dennis W Dickson, Gerard D Schellenberg, Ole A Andreassen, Anders M Dale, Rahul S Desika. Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia. Acta neuropathologica vol 133 issue 5 2017 28271184 corticobasal degeneration (cbd), progressive supranuclear palsy (psp) and a subset of frontotemporal dementia (ftd) are neurodegenerative disorders characterized by tau inclusions in neurons and glia (tauopathies). 2017-04-20 2022-01-13 Not clear
R Constantinescu, D Kr\\xc3\\xbdsl, F Bergquist, K Andr\\xc3\\xa9n, C Malmestr\\xc3\\xb6m, F Aszt\\xc3\\xa9ly, M Axelsson, E B Menachem, K Blennow, L Rosengren, H Zetterber. Cerebrospinal fluid markers of neuronal and glial cell damage to monitor disease activity and predict long-term outcome in patients with autoimmune encephalitis. European journal of neurology vol 23 issue 4 2016 26822123 the value of cerebrospinal fluid (csf) markers of neuronal [neurofilament light chain protein (nfl), and total tau protein (t-tau)] and glial cell [glial fibrillary acidic protein (gfap)] damage in patients with autoimmune encephalitis was investigated. 2016-12-13 2022-01-12 Not clear
Lars Kr\\xc3\\xbcger, Eva Maria Mandelko. Tau neurotoxicity and rescue in animal models of human Tauopathies. Current opinion in neurobiology vol 36 issue 2016 26431808 beside tau's main function in stabilizing microtubules for axonal transport, a variety of novel functions for neurons and glia have emerged recently. 2016-11-01 2022-01-12 Not clear
Gabor G Kovacs, Isidro Ferrer, Lea T Grinberg, Irina Alafuzoff, Johannes Attems, Herbert Budka, Nigel J Cairns, John F Crary, Charles Duyckaerts, Bernardino Ghetti, Glenda M Halliday, James W Ironside, Seth Love, Ian R Mackenzie, David G Munoz, Melissa E Murray, Peter T Nelson, Hitoshi Takahashi, John Q Trojanowski, Olaf Ansorge, Thomas Arzberger, Atik Baborie, Thomas G Beach, Kevin F Bieniek, Eileen H Bigio, Istvan Bodi, Brittany N Dugger, Mel Feany, Ellen Gelpi, Stephen M Gentleman, Giorgio Giaccone, Kimmo J Hatanpaa, Richard Heale, Patrick R Hof, Monika Hofer, Tibor Hortob\\xc3\\xa1gyi, Kurt Jellinger, Gregory A Jicha, Paul Ince, Julia Kofler, Enik\\xc3\\xb6 K\\xc3\\xb6vari, Jillian J Kril, David M Mann, Radoslav Matej, Ann C McKee, Catriona McLean, Ivan Milenkovic, Thomas J Montine, Shigeo Murayama, Edward B Lee, Jasmin Rahimi, Roberta D Rodriguez, Annemieke Rozem\\xc3\\xbcller, Julie A Schneider, Christian Schultz, William Seeley, Danielle Seilhean, Colin Smith, Fabrizio Tagliavini, Masaki Takao, Dietmar Rudolf Thal, Jon B Toledo, Markus Tolnay, Juan C Troncoso, Harry V Vinters, Serge Weis, Stephen B Wharton, Charles L White, Thomas Wisniewski, John M Woulfe, Masahito Yamada, Dennis W Dickso. Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy. Acta neuropathologica vol 131 issue 1 2016 26659578 tau-immunoreactive astrocytes in artag include thorn-shaped astrocytes at the glia limitans and in white matter, as well as solitary or clustered astrocytes with perinuclear cytoplasmic tau immunoreactivity that extends into the astroglial processes as fine fibrillar or granular immunopositivity, typically in gray matter. 2016-09-29 2022-01-12 Not clear
Pawel Tacik, Monica Sanchez-Contreras, Rosa Rademakers, Dennis W Dickson, Zbigniew K Wszole. Genetic Disorders with Tau Pathology: A Review of the Literature and Report of Two Patients with Tauopathy and Positive Family Histories. Neuro-degenerative diseases vol 16 issue 1-2 2016 26550830 tauopathies are a group of neurodegenerative disorders characterized by the pathological accumulation of hyperphosphorylated and insoluble tau protein within neurons and glia. 2016-09-20 2022-01-12 Not clear
Vanessa J Hall, Maiken M Lindblad, Jannik E Jakobsen, Anders Gunnarsson, Mette Schmidt, Mikkel A Rasmussen, Daniela Volke, Thole Zuchner, Poul Hytte. Impaired APP activity and altered Tau splicing in embryonic stem cell-derived astrocytes obtained from an APPsw transgenic minipig. Disease models & mechanisms vol 8 issue 10 2016 26398935 these outcomes also highlight that radial glia could be a potentially useful population of cells for drug discovery, and that altered app expression and altered tau phosphorylation can be detected in an in vitro model of the disease. 2016-07-19 2022-01-12 Not clear
Zhihui Yang, Ping Wang, Drake Morgan, Dan Lin, Jianchun Pan, Fan Lin, Kevin H Strang, Tyler M Selig, Pablo D Perez, Marcelo Febo, Binggong Chang, Richard Rubenstein, Kevin K W Wan. Temporal MRI characterization, neurobiochemical and neurobehavioral changes in a mouse repetitive concussive head injury model. Scientific reports vol 5 issue 2016 26058556 dynamic changes in mri, neurobiochemical markers (tau hyperphosphorylation and glia activation in brain tissues) and neurobehavioral functions such as anxiety, depression, motor function and cognitive function at various acute/subacute (1-7 day post-injury) and chronic (14-60 days post-injury) time points were examined. 2016-04-12 2022-01-12 Not clear
Bess Frost, J\\xc3\\xbcrgen G\\xc3\\xb6tz, Mel B Fean. Connecting the dots between tau dysfunction and neurodegeneration. Trends in cell biology vol 25 issue 1 2015 25172552 tauopathies are devastating and ultimately fatal neurodegenerative diseases, which are histopathologically defined by insoluble filamentous deposits of abnormally phosphorylated tau protein within neurons and glia. 2015-08-17 2022-01-12 Not clear
Mari Yoshid. Astrocytic inclusions in progressive supranuclear palsy and corticobasal degeneration. Neuropathology : official journal of the Japanese Society of Neuropathology vol 34 issue 6 2015 25124031 the characteristics of tau accumulation in both neurons and glia suggest a different underlying mechanism with regard to the sites of tau aggregation and fibril formation between psp and cbd: proximal-dominant aggregation of tas and formation of filamentous nfts in psp in contrast to the distal-dominant aggregation of aps and formation of less filamentous pretangles in cbd. 2015-08-03 2022-01-12 Not clear
Isidre Ferrer, Andrea Legati, J Carlos Garc\\xc3\\xada-Monco, Marian Gomez-Beldarrain, Margarita Carmona, Rosa Blanco, William W Seeley, Giovanni Coppol. Familial behavioral variant frontotemporal dementia associated with astrocyte-predominant tauopathy. Journal of neuropathology and experimental neurology vol 74 issue 4 2015 25756587 the neuropathologic examination revealed massive accumulation of abnormally hyperphosphorylated, conformational, truncated tau at aspartic acid 421, ubiquitinated and nitrated tau at tyr29 in cortical astrocyte (including their perivascular foot processes), and bergmann glia. 2015-06-15 2022-01-12 Not clear
Takahiko Tokud. [Differential diagnosis of corticobasal syndrome (CBS) and its biomarkers]. Rinsho shinkeigaku = Clinical neurology vol 53 issue 11 2015 24291870 abnormal accumulations of the microtubule-associated tau protein are found in both neurons and glia, and cbd is thus considered one of the tauopathies. 2015-04-13 2022-01-12 Not clear
Sanju Lama, Roland N Auer, Randy Tyson, Clare N Gallagher, Boguslaw Tomanek, Garnette R Sutherlan. Lactate storm marks cerebral metabolism following brain trauma. The Journal of biological chemistry vol 289 issue 29 2014 24849602 histopathology of the model showed severe brain injury with subarachnoid and hemorrhage together with glial cell activation and positive staining for tau at 90 min post-trauma. 2014-10-06 2022-01-12 Not clear
Mariangela Iovino, Ulrich Pfisterer, Janice L Holton, Tammaryn Lashley, Robert J Swingler, Laura Calo, Rebecca Treacy, Tamas Revesz, Malin Parmar, Michel Goedert, Miratul M K Muqit, Maria Grazia Spillantin. The novel MAPT mutation K298E: mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons. Acta neuropathologica vol 127 issue 2 2014 24292008 neuropathological studies of post-mortem brain showed widespread neuronal loss and gliosis and abundant deposition of hyperphosphorylated tau in neurons and glia. 2014-09-30 2022-01-12 Not clear
D Seilhean, F Bielle, I Plu, C Duyckaert. Frontotemporal lobar degeneration: diversity of FTLD lesions. Revue neurologique vol 169 issue 10 2014 24035575 the neuropathologic classification is now based on identification of the protein that accumulates in neurons and glia: tau, tar dna binding protein 43 (tdp-43), and fused in sarcoma (fus). 2014-07-31 2022-01-12 Not clear
Naoki Fujii, Tomihiro Wakamiya, Akihiro Watanabe, Hirokazu Furuya, Kensuke Sasaki, Toru Iwak. [An autopsy case of Alzheimer's disease presenting with corticobasal syndrome]. Rinsho shinkeigaku = Clinical neurology vol 53 issue 10 2014 24225565 the findings of tauopathy of the glia were poor, and the tau lesion of the brainstem was milder than that of the cerebral cortex. 2014-06-23 2022-01-12 Not clear
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