| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jonathan D Cherry, Soong Ho Kim, Thor D Stein, Morgan J Pothast, Raymond Nicks, Gaoyuan Meng, Bertrand R Huber, Jesse Mez, Michael L Alosco, Yorghos Tripodis, Kurt Farrell, Victor E Alvarez, Ann C McKee, John F Crar. Evolution of neuronal and glial tau isoforms in chronic traumatic encephalopathy. Brain pathology (Zurich, Switzerland). vol 30. issue 5. 2021-08-16. PMID:32500646. |
chronic traumatic encephalopathy (cte) is a neurodegenerative tauopathy characterized by accumulation of hyperphosphorylated tau (p-tau) in perivascular aggregates in neurons and glia at the depths of neocortical sulci and progresses to diffuse neocortical, allocortical and brainstem structures. |
2021-08-16 |
2023-08-13 |
human |
| M Verny, C Duyckaert. Cognitive deficit, and neuropathological correlates, in the oldest-old. Revue neurologique. vol 176. issue 9. 2021-07-29. PMID:32178879. |
tau inclusions in cortical glia have also been shown to participate to the intellectual deficit. |
2021-07-29 |
2023-08-13 |
Not clear |
| Susan C Schwerin, Mitali Chatterjee, Elizabeth B Hutchinson, Francis T Djankpa, Regina C Armstrong, Joseph T McCabe, Daniel P Perl, Sharon L Julian. Expression of GFAP and Tau Following Blast Exposure in the Cerebral Cortex of Ferrets. Journal of neuropathology and experimental neurology. vol 80. issue 2. 2021-06-22. PMID:33421075. |
in this study, ferrets received compressed air shock waves and subsequent evaluation of glia and forms of tau following survival of up to 12 weeks. |
2021-06-22 |
2023-08-13 |
human |
| Guilherme Lopes Dornelles, Juliana Sorraila de Oliveira, Erin John Rieger de Almeida, Camila Benaduce Emanuelli Mello, Bernardo Rodrigues E Rodrigues, Cássia Bagolin da Silva, Letícia Dos Santos Petry, Micheli Mainardi Pillat, Taís Vidal Palma, Cinthia Melazzo de Andrad. Ellagic Acid Inhibits Neuroinflammation and Cognitive Impairment Induced by Lipopolysaccharides. Neurochemical research. vol 45. issue 10. 2021-06-01. PMID:32779097. |
the present study investigated the effects of ellagic acid in the object recognition test, oxidative stress, cholinergic neurotransmission, glial cell expression, and phosphorylated tau protein expression. |
2021-06-01 |
2023-08-13 |
rat |
| Guilherme Lopes Dornelles, Juliana Sorraila de Oliveira, Erin John Rieger de Almeida, Camila Benaduce Emanuelli Mello, Bernardo Rodrigues E Rodrigues, Cássia Bagolin da Silva, Letícia Dos Santos Petry, Micheli Mainardi Pillat, Taís Vidal Palma, Cinthia Melazzo de Andrad. Ellagic Acid Inhibits Neuroinflammation and Cognitive Impairment Induced by Lipopolysaccharides. Neurochemical research. vol 45. issue 10. 2021-06-01. PMID:32779097. |
the results showed that the treatment with ea in the lps group was able to inhibit cognitive impairment, modulate the immune system response by significantly reducing glial cell expression, attenuating phosphorylated tau and oxidative damage with consequent improvement in the antioxidant system, as well as preventing the increase of acetylcholinesterase activity. |
2021-06-01 |
2023-08-13 |
rat |
| Hariharakrishnan Chidambaram, Subashchandrabose Chinnathamb. G-Protein Coupled Receptors and Tau-different Roles in Alzheimer's Disease. Neuroscience. vol 438. 2021-05-14. PMID:32335218. |
tau aggregates undergo trans-cellular propagation by the release of fibrillar species into the extra-cellular environment from damaged and infected neurons that can be internalized by neighbouring neuronal and glia cells and promotes aggregation in healthy cells. |
2021-05-14 |
2023-08-13 |
Not clear |
| Connor M Wander, Jui-Heng Tseng, Sheng Song, Heba A Al Housseiny, Dalton S Tart, Aditi Ajit, Yen-Yu Ian Shih, Rebecca Lobrovich, Juan Song, Rick B Meeker, David J Irwin, Todd J Cohe. The Accumulation of Tau-Immunoreactive Hippocampal Granules and Corpora Amylacea Implicates Reactive Glia in Tau Pathogenesis during Aging. iScience. vol 23. issue 7. 2021-05-11. PMID:32585593. |
the accumulation of tau-immunoreactive hippocampal granules and corpora amylacea implicates reactive glia in tau pathogenesis during aging. |
2021-05-11 |
2023-08-13 |
mouse |
| M Catarina Silva, Stephen J Haggart. Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies. International journal of molecular sciences. vol 21. issue 23. 2021-03-05. PMID:33255694. |
tauopathies are neurodegenerative diseases characterized by the pathological accumulation of microtubule-associated protein tau (mapt) in the form of neurofibrillary tangles and paired helical filaments in neurons and glia, leading to brain cell death. |
2021-03-05 |
2023-08-13 |
Not clear |
| Justyna Zareba-Paslawska, Kalicharan Patra, Luca Kluzer, Tamas Revesz, Per Svenningsso. Tau Isoform-Driven CBD Pathology Transmission in Oligodendrocytes in Humanized Tau Mice. Frontiers in neurology. vol 11. 2021-02-02. PMID:33519674. |
the aggregation of abnormally phosphorylated tau protein in neurons and glia is a neuropathological hallmark of several neurodegenerative disorders, collectively known as tauopathies. |
2021-02-02 |
2023-08-13 |
mouse |
| b' Elisabetta Lauretti, Ozlem Dincer, Domenico Pratic\\xc3\\xb. Regional and temporal miRNAs expression profile in a transgenic mouse model of tauopathy: implication for its pathogenesis. Molecular psychiatry. 2021-01-26. PMID:31988432.' |
studies have shown that the expression level of different micrornas (mirnas) is altered in neurodegenerative disorders including tauopathies, a group of diseases pathologically defined by accumulation of tau protein in neurons and glia cells. |
2021-01-26 |
2023-08-13 |
mouse |
| Hui Mai, Weihao Fan, Yan Wang, Yujie Cai, Xiaohui Li, Feng Chen, Xiongjin Chen, Jingqi Yang, Pei Tang, Huiyi Chen, Ting Zou, Tingting Hong, Conghua Wan, Bin Zhao, Lili Cu. Intranasal Administration of miR-146a Agomir Rescued the Pathological Process and Cognitive Impairment in an AD Mouse Model. Molecular therapy. Nucleic acids. vol 18. 2021-01-10. PMID:31707205. |
in this study, using a noninvasive nasal administration, we discovered that a mir-146a agomir (m146ag) rescued cognitive impairment in the app/ps1 transgenic mouse and alleviated the overall pathological process in the ad mouse model, including neuroinflammation, glia activation, aβ deposit, and tau phosphorylation in hippocampi. |
2021-01-10 |
2023-08-13 |
mouse |
| Khalid Bashir Dar, Aashiq Hussain Bhat, Shajrul Amin, Bilal Ahmad Reshi, Mohammad Afzal Zargar, Akbar Masood, Showkat Ahmad Gani. Elucidating Critical Proteinopathic Mechanisms and Potential Drug Targets in Neurodegeneration. Cellular and molecular neurobiology. vol 40. issue 3. 2020-12-07. PMID:31584139. |
we explicate the role of key neuroproteomic drug targets notably aβ, tau, alpha synuclein, prions, secretases, acetylcholinesterase (ache), lrrk2, molecular chaperones, a2a receptors, muscarinic acetylcholine receptors (machr), n-methyl-d-aspartate receptor (nmdar), glial cell line-derived neurotrophic factor (gdnf) family ligands (gfls) and mitochondrial/oxidative stress-related proteins for combating neurodegeneration and associated cognitive and motor impairment. |
2020-12-07 |
2023-08-13 |
Not clear |
| Lu Wang, Lin Yu Wei, Ran Ding, Yanyan Feng, Dongliang Li, Chaokun Li, Philippa Malko, Sharifah A Syed Mortadza, Weidong Wu, Yaling Yin, Lin-Hua Jian. Predisposition to Alzheimer's and Age-Related Brain Pathologies by PM2.5 Exposure: Perspective on the Roles of Oxidative Stress and TRPM2 Channel. Frontiers in physiology. vol 11. 2020-09-28. PMID:32174842. |
studies have also documented that pm2.5 exposure causes ad-linked molecular and cellular alterations, such as mitochondrial dysfunction, synaptic deficits, impaired neurite growth, neuronal cell death, glial cell activation, neuroinflammation, and neurovascular dysfunction, in addition to elevated levels of amyloid β (aβ) and tau phosphorylation. |
2020-09-28 |
2023-08-13 |
mouse |
| Hamza Ayaydın, Adnan Kirmit, Hakim Çelik, İsmail Akaltun, İsmail Koyuncu, Şermin Bilgen Ulga. High Serum Levels of Serum 100 Beta Protein, Neuron-specific Enolase, Tau, Active Caspase-3, M30 and M65 in Children with Autism Spectrum Disorders. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology. vol 18. issue 2. 2020-09-28. PMID:32329316. |
the purpose of this study was therefore to investigate whether neuronal, axonal, and glial cell markers (neuron-specific enolase [nse], tau, serum 100 beta protein [s100b], respectively) and apoptosis markers (active caspase 3, m30, m65) and whether these parameters can be used as diagnostic biomarkers in autism spectrum disorders (asd). |
2020-09-28 |
2023-08-13 |
Not clear |
| David W Hampton, Sandra Amor, David Story, Megan Torvell, Malika Bsibsi, Johannes M van Noort, Siddarthan Chandra. HspB5 Activates a Neuroprotective Glial Cell Response in Experimental Tauopathy. Frontiers in neuroscience. vol 14. 2020-09-28. PMID:32595446. |
counteracting such pathogenic effects of tau by simultaneously inhibiting protein aggregation as well as pro-inflammatory glial cell responses would be of significant therapeutic interest. |
2020-09-28 |
2023-08-13 |
mouse |
| Sneha Narasimhan, Lakshmi Changolkar, Dawn M Riddle, Alexandra Kats, Anna Stieber, Sarah A Weitzman, Bin Zhang, Zhiyong Li, Erik D Roberson, John Q Trojanowski, Virginia M Y Le. Human tau pathology transmits glial tau aggregates in the absence of neuronal tau. The Journal of experimental medicine. vol 217. issue 2. 2020-09-09. PMID:31826239. |
tauopathies are characterized by abnormal accumulation of tau protein in neurons and glia. |
2020-09-09 |
2023-08-13 |
mouse |
| Lary C Walke. Glial tauopathy: Neurons optional? The Journal of experimental medicine. vol 217. issue 2. 2020-08-26. PMID:31830204. |
testing the hypothesis that the aggregated tau in glia derives from neurons, narasimhan et al. |
2020-08-26 |
2023-08-13 |
Not clear |
| Nobutaka Sakae, Keith A Josephs, Irene Litvan, Melissa E Murray, Ranjan Duara, Ryan J Uitti, Zbigniew K Wszolek, Neil R Graff-Radford, Dennis W Dickso. Neuropathologic basis of frontotemporal dementia in progressive supranuclear palsy. Movement disorders : official journal of the Movement Disorder Society. vol 34. issue 11. 2020-07-08. PMID:31433871. |
progressive supranuclear palsy (psp) is a neurodegenerative disorder characterized by neuronal loss in the extrapyramidal system with pathologic accumulation of tau in neurons and glia. |
2020-07-08 |
2023-08-13 |
Not clear |
| Joonki Kim, Sharmelee Selvaraji, Sung Wook Kang, Wei Thye Lee, Christopher Li-Hsian Chen, Hyungwon Choi, Edward H Koo, Dong-Gyu Jo, Kah Leong Lim, Yun-An Lim, Thiruma V Arumuga. Cerebral transcriptome analysis reveals age-dependent progression of neuroinflammation in P301S mutant tau transgenic male mice. Brain, behavior, and immunity. vol 80. 2020-05-21. PMID:30980950. |
aggregation of the microtubule-associated protein, tau, can lead to neurofibrillary tangle formation in neurons and glia which is the hallmark of tauopathy. |
2020-05-21 |
2023-08-13 |
mouse |
| Kee Chan Ahn, Cameron R Learman, Glen B Baker, Charles L Weaver, Phil Sang Chung, Hyung Gun Kim, Mee Sook Son. Regulation of Diabetes: a Therapeutic Strategy for Alzheimer's Disease? Journal of Korean medical science. vol 34. issue 46. 2020-05-14. PMID:31779058. |
in this article, we will discuss the well-known pathologies of ad, including aβ plaques and tau tangles, as well as other mechanisms shared in ad and diabetes including reactive glia and the breakdown of blood brain barrier in order to evaluate the presence of any potential, indirect or direct links of pre-diabetic conditions to ad pathology. |
2020-05-14 |
2023-08-13 |
Not clear |