All Relations between microtubule-associated protein tau and hippocampus

Reference Sentence Publish Date Extraction Date Species
Seong Su Kang, Eun Hee Ahn, Xia Liu, Matthew Bryson, Gary W Miller, David Weinshenker, Keqiang Y. ApoE4 inhibition of VMAT2 in the locus coeruleus exacerbates Tau pathology in Alzheimer's disease. Acta neuropathologica vol 142 issue 1 2022 33895869 Our data reveal that ApoE4 boosts Tau neurotoxicity via VMAT2 inhibition, reduces hippocampal volume, and induces cognitive dysfunction in an AEP- and Tau N368-dependent manner, while conversely ApoE3 binds Tau and protects it from cleavage. 2022-01-05 2022-01-08 Not clear
V J De-Paula, O V Forlenz. Lithium modulates multiple tau kinases with distinct effects in cortical and hippocampal neurons according to concentration ranges. Naunyn-Schmiedeberg's archives of pharmacology vol 395 issue 1 2021 34751792 Lithium modulates multiple tau kinases with distinct effects in cortical and hippocampal neurons according to concentration ranges. 2021-12-31 2022-01-08 Not clear
V J De-Paula, O V Forlenz. Lithium modulates multiple tau kinases with distinct effects in cortical and hippocampal neurons according to concentration ranges. Naunyn-Schmiedeberg's archives of pharmacology vol 395 issue 1 2021 34751792 The aim of the present study is to determine the effect of chronic lithium treatment on the protein expression of tau and its major kinases in cortical and hippocampal neurons, at distinct working concentrations. 2021-12-31 2022-01-08 Not clear
V J De-Paula, O V Forlenz. Lithium modulates multiple tau kinases with distinct effects in cortical and hippocampal neurons according to concentration ranges. Naunyn-Schmiedeberg's archives of pharmacology vol 395 issue 1 2021 34751792 Statistically significant increments in the protein expression of tau and CaMKII were observed both in cortical and hippocampal neurons treated with subtherapeutic doses of lithium. 2021-12-31 2022-01-08 Not clear
V J De-Paula, O V Forlenz. Lithium modulates multiple tau kinases with distinct effects in cortical and hippocampal neurons according to concentration ranges. Naunyn-Schmiedeberg's archives of pharmacology vol 395 issue 1 2021 34751792 Distinct patterns of changes in the expression of the remaining tau tau-kinases were observed: in cortical neurons, lithium treatment was associated with consistent decrements in Akt and PKA, whereas hippocampal neurons displayed increased protein expression of Akt and decreased PKA. 2021-12-31 2022-01-08 Not clear
Adam P Mecca, Ming-Kai Chen, Ryan S O'Dell, Mika Naganawa, Takuya Toyonaga, Tyler A Godek, Joanna E Harris, Hugh H Bartlett, Wenzhen Zhao, Emmie R Banks, Gessica S Ni, Kelly Rogers, Jean Dominique Gallezot, Jim Ropchan, Paul R Emery, Nabeel B Nabulsi, Brent C Vander Wyk, Amy F T Arnsten, Yiyun Huang, Richard E Carson, Christopher H van Dyc. Association of entorhinal cortical tau deposition and hippocampal synaptic density in older individuals with normal cognition and early Alzheimer's disease. Neurobiology of aging vol 111 issue 2021 34963063 Association of entorhinal cortical tau deposition and hippocampal synaptic density in older individuals with normal cognition and early Alzheimer's disease. 2021-12-28 2022-01-08 human
Takashi Ando, Yuichi Riku, Akio Akagi, Hiroaki Miyahara, Mitsuaki Hirano, Toshimasa Ikeda, Hiroyuki Yabata, Ryuichi Koizumi, Chisato Oba, Saori Morozumi, Keizo Yasui, Atsuko Goto, Taiji Katayama, Satoko Sakakibara, Ikuko Aiba, Motoko Sakai, Masaaki Konagaya, Keiko Mori, Yasuhiro Ito, Hiroyuki Yuasa, Masayo Nomura, Kristine Joyce L Porto, Jun Mitsui, Shoji Tsuji, Maya Mimuro, Yoshio Hashizume, Masahisa Katsuno, Yasushi Iwasaki, Mari Yoshid. Multiple system atrophy variant with severe hippocampal pathology. Brain pathology (Zurich, Switzerland) vol 32 issue 1 2021 34255887 Immunohistochemistry for hyperphosphorylated tau and phosphorylated TDP-43 revealed minimal aggregations in the hippocampus of the hippocampal MSA patients. 2021-12-28 2022-01-08 Not clear
Zhiyong Zhao, Lei Zhang, Qingqing Wen, Wanrong Luo, Weihao Zheng, Tingting Liu, Yi Zhang, Keqing Zhu, Dan W. The effect of beta-amyloid and tau protein aggregations on magnetic susceptibility of anterior hippocampal laminae in Alzheimer's diseases. NeuroImage vol 244 issue 2021 34537383 The effect of beta-amyloid and tau protein aggregations on magnetic susceptibility of anterior hippocampal laminae in Alzheimer's diseases. 2021-12-21 2022-01-08 Not clear
Zhiyong Zhao, Lei Zhang, Qingqing Wen, Wanrong Luo, Weihao Zheng, Tingting Liu, Yi Zhang, Keqing Zhu, Dan W. The effect of beta-amyloid and tau protein aggregations on magnetic susceptibility of anterior hippocampal laminae in Alzheimer's diseases. NeuroImage vol 244 issue 2021 34537383 We manually segmented each sample into seven layers, including four layers in the cornu ammonis1 (CA1) and three layers in the dentate gyrus (DG), and then evaluated AD-related alterations of susceptibility and T2* values and their correlations with A\xce\xb2 and tau in each hippocampal layer. 2021-12-21 2022-01-08 Not clear
Jamie M Walker, Yelena Fudym, Kurt Farrell, Megan A Iida, Kevin F Bieniek, Sudha Seshadri, Charles L White, John F Crary, Timothy E Richardso. Asymmetry of Hippocampal Tau Pathology in Primary Age-Related Tauopathy and Alzheimer Disease. Journal of neuropathology and experimental neurology vol 80 issue 5 2021 33860327 Asymmetry of Hippocampal Tau Pathology in Primary Age-Related Tauopathy and Alzheimer Disease. 2021-12-20 2022-01-08 Not clear
Alireza Salami, Rolf Adolfsson, Micael Andersson, Kaj Blennow, Anders Lundquist, Annelie Nordin Adolfsson, Michael Sch\\xc3\\xb6ll, Henrik Zetterberg, Lars Nyber. Association of APOE \\xc9\\x9b4 and Plasma p-tau181 with Preclinical Alzheimer's Disease and Longitudinal Change in Hippocampus Function. Journal of Alzheimer's disease : JAD vol issue 2021 34924376 However, it remains unknown whether elevated tau accumulation on hippocampal functional changes would be more pronounced for APOE \xc9\x9b4 carriers. 2021-12-20 2022-01-08 Not clear
David S Priemer, Rebecca D Folkert. Dementia in the Forensic Setting: Diagnoses Obtained Using a Condensed Protocol at the Office of Chief Medical Examiner, New York City. Journal of neuropathology and experimental neurology vol 80 issue 8 2021 34388235 Others included age-related tau astrogliopathy, hippocampal sclerosis of aging, progressive supranuclear palsy, multiple system atrophy, amyotrophic lateral sclerosis, argyrophilic grain disease, and Creutzfeldt-Jakob disease. 2021-12-20 2022-01-08 Not clear
Benjamin Combs, Kyle R Christensen, Collin Richards, Andrew Kneynsberg, Rebecca L Mueller, Sarah L Morris, Gerardo A Morfini, Scott T Brady, Nicholas M Kanaa. Frontotemporal Lobar Dementia Mutant Tau Impairs Axonal Transport through a Protein Phosphatase 1\\xce\\xb3-Dependent Mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 41 issue 45 2021 34607969 We evaluated interactions of wild-type or mutant tau with specific PP1 isoforms (\xce\xb1, \xce\xb2, and \xce\xb3) to examine how the interaction contributes to this toxic effect using primary rat hippocampal neurons from both sexes. 2021-12-20 2022-01-08 Not clear
Kurt A Jellinge. Recent update on the heterogeneity of the Alzheimer's disease spectrum. Journal of neural transmission (Vienna, Austria : 1996) vol issue 2021 34919190 In addition to four major subtypes based on the distribution of tau pathology and brain atrophy (typical, limbic predominant, hippocampal sparing, and minimal atrophy), several other clinical variants (non-amnestic, corticobasal, behavioral/dysexecutive, posterior cortical variants, etc.) 2021-12-17 2022-01-08 Not clear
Yunpeng Wang, H\\xc3\\xa5kon Grydeland, James M Roe, Mengyu Pan, Fredrik Magnussen, Inge K Amlien, Leiv Otto Watne, Ane-Victoria Idland, Lars Bertram, Thomas E Gundersen, Alvaro Pascual-Leone, Maria Cabello-Toscano, Jose M Tormos, David Bartres-Faz, Christian A Drevon, Anders M Fjell, Kristine W Walhov. Associations of circulating C-reactive proteins, APOE \\xce\\xb54, and brain markers for Alzheimer's disease in healthy samples across the lifespan. Brain, behavior, and immunity vol issue 2021 34920091 Hippocampal volume, brain amyloid-\xce\xb2 (A\xce\xb2) plaque levels, cerebrospinal fluid (CSF) levels of A\xce\xb2 and tau species, and neurofilament protein light protein (NFL) were used as AD biomarkers in subsamples. 2021-12-17 2022-01-08 Not clear
Anna Pensalfini, Seonil Kim, Shivakumar Subbanna, Cynthia Bleiwas, Chris N Goulbourne, Philip H Stavrides, Ying Jiang, Ju-Hyun Lee, Sandipkumar Darji, Monika Pawlik, Chunfeng Huo, James Peddy, Martin J Berg, John F Smiley, Balapal S Basavarajappa, Ralph A Nixo. Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease. Cell reports vol 33 issue 8 2021 33238112 Modest neuron-specific transgenic Rab5 expression inducing hyperactivation of Rab5 comparable to that in AD brain reproduces AD-related Rab5-endosomal enlargement and mistrafficking, hippocampal synaptic plasticity deficits via accelerated AMPAR endocytosis and dendritic spine loss, and tau hyperphosphorylation via activated glycogen synthase kinase-3\xce\xb2. 2021-12-16 2022-01-08 Not clear
Mohamed A Salem, Barbara Budzy\\xc5\\x84ska, Joanna Kowalczyk, Nesrine S El Sayed, Suzan M Mansou. Tadalafil and bergapten mitigate streptozotocin-induced sporadic Alzheimer's disease in mice via modulating neuroinflammation, PI3K/Akt, Wnt/\\xce\\xb2-catenin, AMPK/mTOR signaling pathways. Toxicology and applied pharmacology vol 429 issue 2021 34428446 Administration of TAD or BG at doses of 20 and 25\xc2\xa0mg/kg, respectively, for 21 consecutive days attenuated STZ-induced hippocampal insult, preserved neuronal integrity, and improved cognitive function in the Morris water maze and object recognition tests paralleled by reduction in A\xce\xb2 expression by 79 and 89% and tau hyperphosphorylation by 60 and 61%, respectively. 2021-12-15 2022-01-08 mouse
David Berron, Jacob W Vogel, Philip S Insel, Joana B Pereira, Long Xie, Laura E M Wisse, Paul A Yushkevich, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Erik Stomrud, Ruben Smith, Olof Strandberg, Oskar Hansso. Early stages of tau pathology and its associations with functional connectivity, atrophy and memory. Brain : a journal of neurology vol 144 issue 9 2021 33725124 Finally, in patients with mild cognitive impairment, the association of tau load in the hippocampus with memory performance was partially mediated by posterior hippocampal atrophy. 2021-12-14 2022-01-08 Not clear
David Berron, Jacob W Vogel, Philip S Insel, Joana B Pereira, Long Xie, Laura E M Wisse, Paul A Yushkevich, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Erik Stomrud, Ruben Smith, Olof Strandberg, Oskar Hansso. Early stages of tau pathology and its associations with functional connectivity, atrophy and memory. Brain : a journal of neurology vol 144 issue 9 2021 33725124 While tau pathology might affect memory performance in cognitively unimpaired individuals via reduced functional connectivity in critical medial temporal lobe-cortical networks, memory impairment in mild cognitively impaired patients is associated with posterior hippocampal atrophy. 2021-12-14 2022-01-08 Not clear
Kubra Celik Topkara, Erkan Kilinc, Ayhan Cetinkaya, Asl\\xc4\\xb1han Saylan, Serif Demi. Therapeutic effects of carvacrol on beta-amyloid-induced impairments in in-vitro and in-vivo models of Alzheimer's disease. The European journal of neuroscience vol issue 2021 34904309 Oxidant-antioxidant parameters (MDA, H2O2, SOD, and CAT) and Tau, A\xce\xb21-40 and A\xce\xb21-42 peptide levels in in-vitro supernatant or in-vivo serum and hippocampal samples were measured using ELISA. 2021-12-14 2022-01-08 Not clear
Angie K Torres, Claudia Jara, Margrethe A Olesen, Cheril Tapia-Roja. Pathologically phosphorylated tau at S396/404 (PHF-1) is accumulated inside of hippocampal synaptic mitochondria of aged Wild-type mice. Scientific reports vol 11 issue 1 2021 33627790 Pathologically phosphorylated tau at S396/404 (PHF-1) is accumulated inside of hippocampal synaptic mitochondria of aged Wild-type mice. 2021-12-14 2022-01-08 mouse
Angie K Torres, Claudia Jara, Margrethe A Olesen, Cheril Tapia-Roja. Pathologically phosphorylated tau at S396/404 (PHF-1) is accumulated inside of hippocampal synaptic mitochondria of aged Wild-type mice. Scientific reports vol 11 issue 1 2021 33627790 Most importantly, we showed that tau PHF-1 is located in hippocampal mitochondria and accumulates in the mitochondria of old mice. 2021-12-14 2022-01-08 mouse
Naihao Shi, Yuwen Lin, Binbin Yan, Xiaowei Jiao, Xiaobao Ding, Yuqing Wu, Chenghua Zho. Hippocampal SIRT1 improves cognitive impairment by deacetylating tau protein in diabetic models. European journal of pharmacology vol 914 issue 2021 34861210 Hippocampal SIRT1 improves cognitive impairment by deacetylating tau protein in diabetic models. 2021-12-13 2022-01-08 rat
Jianfeng Wu, Qunxi Dong, Jie Zhang, Yi Su, Teresa Wu, Richard J Caselli, Eric M Reiman, Jieping Ye, Natasha Lepore, Kewei Chen, Paul M Thompson, Yalin Wan. Federated Morphometry Feature Selection for Hippocampal Morphometry Associated Beta-Amyloid and Tau Pathology. Frontiers in neuroscience vol 15 issue 2021 34899166 Federated Morphometry Feature Selection for Hippocampal Morphometry Associated Beta-Amyloid and Tau Pathology. 2021-12-13 2022-01-08 human
Bora Yoon, Tengfei Guo, Karine Provost, Deniz Korman, Tyler J Ward, Susan M Landau, William J Jagus. Abnormal tau in amyloid PET negative individuals. Neurobiology of aging vol 109 issue 2021 34715443 We compared A-T- (n\xc2\xa0=\xc2\xa0316), A-T+ (n\xc2\xa0=\xc2\xa063), and A+T+ (n\xc2\xa0=\xc2\xa0182) individuals on demographics, amyloid, tau, hippocampal volumes, and cognition. 2021-12-13 2022-01-08 human
Bora Yoon, Tengfei Guo, Karine Provost, Deniz Korman, Tyler J Ward, Susan M Landau, William J Jagus. Abnormal tau in amyloid PET negative individuals. Neurobiology of aging vol 109 issue 2021 34715443 The severity of tau deposition, hippocampal atrophy, and cognitive dysfunction in the A-T+ group was intermediate between A-T- and A+T+ (all p < 0.001). 2021-12-13 2022-01-08 human
Ryan A Wirt, Lauren A Crew, Andrew A Ortiz, Adam M McNeela, Emmanuel Flores, Jefferson W Kinney, James M Hyma. Altered theta rhythm and hippocampal-cortical interactions underlie working memory deficits in a hyperglycemia risk factor model of Alzheimer's disease. Communications biology vol 4 issue 1 2021 34480097 It is thought that chronic hyperglycemia leads to neuroinflammation and tau hyperphosphorylation in the hippocampus leading to cognitive decline, but effects on hippocampal network activity are unknown. 2021-12-08 2022-01-08 human
Cem S\\xc3\\xbcer, Nurbanu Y\\xc4\\xb1ld\\xc4\\xb1z, \\xc3\\x96zlem Barut\\xc3\\xa7u, Burak Tan, Nurcan Dursu. Long-term depression-related tau phosphorylation is enhanced by methylene blue in healthy rat hippocampus. Pharmacological reports : PR vol 73 issue 3 2021 33797746 The present study examined whether inhibition of guanylate cyclase (GC) is associated with the plasticity-related microtubule-stabilizing protein tau phosphorylation in the dentate gyrus (DG) of hippocampal formation. 2021-12-07 2022-01-08 Not clear
Jonathan D Cherry, Camille D Esnault, Zachary H Baucom, Yorghos Tripodis, Bertrand R Huber, Victor E Alvarez, Thor D Stein, Dennis W Dickson, Ann C McKe. Tau isoforms are differentially expressed across the hippocampus in chronic traumatic encephalopathy and Alzheimer's disease. Acta neuropathologica communications vol 9 issue 1 2021 33980303 While the neuropathologic hallmark of CTE is found in the cortex, hippocampal tau has proven to be an important neuropathologic feature to examine the extent of disease severity. 2021-12-03 2022-01-08 Not clear
Jonathan D Cherry, Camille D Esnault, Zachary H Baucom, Yorghos Tripodis, Bertrand R Huber, Victor E Alvarez, Thor D Stein, Dennis W Dickson, Ann C McKe. Tau isoforms are differentially expressed across the hippocampus in chronic traumatic encephalopathy and Alzheimer's disease. Acta neuropathologica communications vol 9 issue 1 2021 33980303 CTE demonstrated high levels of tau in hippocampal subfields CA2 and CA3 compared to CA1. 2021-12-03 2022-01-08 Not clear
Jonathan D Cherry, Camille D Esnault, Zachary H Baucom, Yorghos Tripodis, Bertrand R Huber, Victor E Alvarez, Thor D Stein, Dennis W Dickson, Ann C McKe. Tau isoforms are differentially expressed across the hippocampus in chronic traumatic encephalopathy and Alzheimer's disease. Acta neuropathologica communications vol 9 issue 1 2021 33980303 Overall, this work demonstrates that the relative deposition of tau isoforms among hippocampal subfields can aid in differential diagnosis of AD and CTE, and might help improve specificity of biomarkers for in vivo diagnosis. 2021-12-03 2022-01-08 Not clear
Mara A Guzm\\xc3\\xa1n-Ruiz, Amor Herrera-Gonz\\xc3\\xa1lez, Adriana Jim\\xc3\\xa9nez, Alan Candelas-Ju\\xc3\\xa1rez, Crystal Quiroga-Lozano, Claudia Castillo-D\\xc3\\xadaz, Erika Orta-Salazar, Diana Organista-Ju\\xc3\\xa1rez, Sof\\xc3\\xada D\\xc3\\xadaz-Cintra, Rosalinda Guevara-Guzm\\xc3\\xa1. Protective effects of intracerebroventricular adiponectin against olfactory impairments in an amyloid \\xce\\xb2 BMC neuroscience vol 22 issue 1 2021 33653273 Studies have demonstrated that APN administration decreases A\xce\xb2 neurotoxicity and Tau hyperphosphorylation in the HIPP, reducing cognitive impairment. 2021-12-03 2022-01-08 Not clear
Philip Regan, Scott J Mitchell, Seung-Chan Kim, Younbok Lee, Jee Hyun Yi, Saviana A Barbati, Christopher Shaw, Kwangwook Ch. Regulation of Synapse Weakening through Interactions of the Microtubule Associated Protein Tau with PACSIN1. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 41 issue 34 2021 34290082 Using combined molecular and electrophysiological analysis with in vitro genetic knock-in of phosphorylation mutant human tau in male rat CA1 hippocampal neurons, we show an interplay between tau and protein kinase C and casein kinase substrate in neurons protein 1 (PACSIN1) that regulates synapse function. 2021-12-03 2022-01-08 Not clear
Jean-Christophe Delpech, Dhruba Pathak, Merina Varghese, Srinidhi Venkatesan Kalavai, Emma C Hays, Patrick R Hof, W Evan Johnson, Seiko Ikezu, Maria Medalla, Jennifer I Luebke, Tsuneya Ikez. Wolframin-1-expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice. Science translational medicine vol 13 issue 611 2021 34524859 Wolframin-1-expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice. 2021-11-01 2022-01-09 mouse
Julie Pilliod, Alexandre Desjardins, Camille Pern\\xc3\\xa8gre, H\\xc3\\xa9l\\xc3\\xa8ne Jamann, Catherine Larochelle, Edward A Fon, Nicole Lecler. Clearance of intracellular tau protein from neuronal cells via VAMP8-induced secretion. The Journal of biological chemistry vol 295 issue 51 2021 33454017 Increased tau secretion by VAMP8 was also observed in murine hippocampal slices. 2021-04-01 2022-01-08 Not clear
Heidi I L Jacobs, Jean C Augustinack, Aaron P Schultz, Bernard J Hanseeuw, Joseph Locascio, Rebecca E Amariglio, Kathryn V Papp, Dorene M Rentz, Reisa A Sperling, Keith A Johnso. The presubiculum links incipient amyloid and tau pathology to memory function in older persons. Neurology vol 94 issue 18 2020 32273431 To identify the hippocampal subregions linking initial amyloid and tau pathology to memory performance in clinically normal older individuals, reflecting preclinical Alzheimer disease (AD). 2020-08-21 2022-01-08 Not clear
Andrew J Aschenbrenner, Brian A Gordon, Tammie L S Benzinger, John C Morris, Jason J Hassensta. Influence of tau PET, amyloid PET, and hippocampal volume on cognition in Alzheimer disease. Neurology vol 91 issue 9 2019 30068637 Influence of tau PET, amyloid PET, and hippocampal volume on cognition in Alzheimer disease. 2019-08-19 2022-01-08 Not clear
Lindsay R Clark, Sara E Berman, Derek Norton, Rebecca L Koscik, Erin Jonaitis, Kaj Blennow, Barbara B Bendlin, Sanjay Asthana, Sterling C Johnson, Henrik Zetterberg, Cynthia M Carlsso. Age-accelerated cognitive decline in asymptomatic adults with CSF \\xce\\xb2-amyloid. Neurology vol 90 issue 15 2019 29523644 Compare cognitive and hippocampal volume trajectories in asymptomatic middle-aged and older adults with positive CSF markers of \xce\xb2-amyloid (A\xce\xb2) or tau to adults without an Alzheimer disease (AD)-associated biomarker profile. 2019-08-07 2022-01-08 Not clear
X Bi, T S Haque, J Zhou, A G Skillman, B Lin, C E Lee, I D Kuntz, J A Ellman, G Lync. Novel cathepsin D inhibitors block the formation of hyperphosphorylated tau fragments in hippocampus. Journal of neurochemistry vol 74 issue 4 2000 10737603 Partial lysosomal dysfunction was induced in cultured hippocampal slices with a selective inhibitor of cathepsins B and L. This led within 48 h to hyperphosphorylated tau protein fragments recognized by antibodies against human tangles. 2000-04-11 2022-01-08 Not clear
C X Gong, T Lidsky, J Wegiel, L Zuck, I Grundke-Iqbal, K Iqba. Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease. The Journal of biological chemistry vol 275 issue 8 2000 10681533 Immunocytochemical staining revealed hyperphosphorylated tau accumulation in pyramidal neurons in cornu ammonis and in neocortical neurons. 2000-03-30 2022-01-08 Not clear
M Rapoport, A Ferreir. PD98059 prevents neurite degeneration induced by fibrillar beta-amyloid in mature hippocampal neurons. Journal of neurochemistry vol 74 issue 1 2000 10617113 We have previously shown that the addition of fibrillar beta-amyloid (Abeta) to mature hippocampal neurons results in progressive neuritic degeneration accompanied by the enhanced phosphorylation of adult tau isoforms. 2000-01-18 2022-01-08 Not clear
R Wolter, U Tauer, E Fuchs, B Vol. Mapping of cytoskeletal components in the hippocampal formation of the tree shrew (Tupaia belangeri). Journal of chemical neuroanatomy vol 17 issue 2 1999 10585159 Our findings show the elaborate expression of cytoskeletal proteins in the hippocampal formation of the tree shrew, relatively similar to what is seen in other species but with also some important differences, such as the immunonegativity of the axonal compartment for Tau in the tree shrew, which is contrary to what we see in the mouse (unpublished data). 1999-12-15 2022-01-08 Not clear
M Takahashi, K Yasutake, K Tomizaw. Lithium inhibits neurite growth and tau protein kinase I/glycogen synthase kinase-3beta-dependent phosphorylation of juvenile tau in cultured hippocampal neurons. Journal of neurochemistry vol 73 issue 5 1999 10537067 Lithium inhibits neurite growth and tau protein kinase I/glycogen synthase kinase-3beta-dependent phosphorylation of juvenile tau in cultured hippocampal neurons. 1999-11-05 2022-01-08 Not clear
A K Mudher, S T Woolley, V H Perry, J R Green. Induction of hyperphosphorylated tau in living slices of rat hippocampal formation and subsequent detection using an ELISA. Journal of neuroscience methods vol 88 issue 1 1999 10379575 Induction of hyperphosphorylated tau in living slices of rat hippocampal formation and subsequent detection using an ELISA. 1999-07-28 2022-01-08 Not clear
A K Mudher, S T Woolley, V H Perry, J R Green. Induction of hyperphosphorylated tau in living slices of rat hippocampal formation and subsequent detection using an ELISA. Journal of neuroscience methods vol 88 issue 1 1999 10379575 We describe the use of living slices of rat hippocampal formation to study tau phosphorylation. 1999-07-28 2022-01-08 Not clear
B Eppler, T A Patterson, W Zhou, W J Millard, R Dawso. Kainic acid (KA)-induced seizures in Sprague-Dawley rats and the effect of dietary taurine (TAU) supplementation or deficiency. Amino acids vol 16 issue 2 1999 10319185 TAU supplementation significantly increased serum and hippocampal TAU levels, but not TAU content in temporal cortex or striatum. 1999-07-23 2022-01-08 rat
Z Nagy, M M Esiri, M LeGris, P M Matthew. Mitochondrial enzyme expression in the hippocampus in relation to Alzheimer-type pathology. Acta neuropathologica vol 97 issue 4 1999 10208273 Levels of COX IV but not of COX I were related to the amount of hyperphosphorylated tau accumulated in the same hippocampal region but not to the amount of amyloid deposited in sporadic AD. 1999-07-20 2022-01-08 Not clear
Y Tatebayashi, K Iqbal, I Grundke-Iqba. Dynamic regulation of expression and phosphorylation of tau by fibroblast growth factor-2 in neural progenitor cells from adult rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 19 issue 13 1999 10377336 These results demonstrate that proliferating adult rat hippocampal progenitor cells express adult isoforms of tau stably and that FGF-2 upregulates the expression and, by upregulating GSK-3 activity, the phosphorylation of tau. 1999-07-15 2022-01-08 Not clear
T Revesz, J L Holton, B Doshi, B H Anderton, F Scaravilli, G T Plan. Cytoskeletal pathology in familial cerebral amyloid angiopathy (British type) with non-neuritic amyloid plaque formation. Acta neuropathologica vol 97 issue 2 1999 9928828 All hippocampal subregions contained large numbers of NFTs and neuropil threads (NT), which were stained with both phosphorylation-dependent and phosphorylation-independent tau antibodies and ultrastructurally were found to be composed of paired helical filaments (PHFs). 1999-05-18 2022-01-08 Not clear
M H\\xc3\\xbcll, J Eistetter, B L Fiebich, J Baue. Glutamate but not interleukin-6 influences the phosphorylation of tau in primary rat hippocampal neurons. Neuroscience letters vol 261 issue 1-2 1999 10081920 Glutamate but not interleukin-6 influences the phosphorylation of tau in primary rat hippocampal neurons. 1999-05-06 2022-01-08 Not clear
M H\\xc3\\xbcll, J Eistetter, B L Fiebich, J Baue. Glutamate but not interleukin-6 influences the phosphorylation of tau in primary rat hippocampal neurons. Neuroscience letters vol 261 issue 1-2 1999 10081920 We investigated the influence of glutamate and IL-6 on tau phosphorylation in cultured primary rat hippocampal neurons. 1999-05-06 2022-01-08 Not clear
G Rammes, D Swandulla, P Spielmanns, C G Parson. Interactions of GYKI 52466 and NBQX with cyclothiazide at AMPA receptors: experiments with outside-out patches and EPSCs in hippocampal neurones. Neuropharmacology vol 37 issue 10-11 1999 9849667 In outside-out patches from cultured hippocampal neurones, glutamate (1 mM) applied for 1 ms evoked currents which rose rapidly (tau(on) 451 +/- 31 micros) to a peak and then deactivated with slower kinetics (1.95 +/- 0.13 ms). 1999-03-04 2022-01-08 Not clear
H P Horikawa, H Naw. Turnover rates of the AMPA-type glutamate receptor GluR1 measured by transient gene expression. Journal of neuroscience methods vol 84 issue 1-2 1999 9821649 Decay of the receptor protein was monitored by Western blotting probed by an anti-tag antibody: tau 1/2 was 52 h in hippocampal neurons, similar to that in PC12. 1999-01-26 2022-01-08 Not clear
A Takashima, T Honda, K Yasutake, G Michel, O Murayama, M Murayama, K Ishiguro, H Yamaguch. Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons. Neuroscience research vol 31 issue 4 1999 9809590 Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons. 1999-01-05 2022-01-08 Not clear
A Takashima, T Honda, K Yasutake, G Michel, O Murayama, M Murayama, K Ishiguro, H Yamaguch. Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons. Neuroscience research vol 31 issue 4 1999 9809590 To analyze the relationship between the phosphorylation sites of tau and the activation of kinases in response to Abeta, we treated cultured rat hippocampal neurons with a peptide fragment of Abeta, Abeta(25-35). 1999-01-05 2022-01-08 Not clear
A Takashima, T Honda, K Yasutake, G Michel, O Murayama, M Murayama, K Ishiguro, H Yamaguch. Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons. Neuroscience research vol 31 issue 4 1999 9809590 Abeta(25-35) treatment activated tau protein kinase I/glycogen synthase kinase-3beta (TPKI/GSK-3beta) but not glycogen synthase kinase-3alpha (GSK-3alpha) or mitogen activated protein kinase (MAP kinase) in primary culture of hippocampal neurons. 1999-01-05 2022-01-08 Not clear
J Wegiel, H M Wisniewski, Z So\\xc5\\x82tysia. Region- and cell-type-specific pattern of tau phosphorylation in dog brain. Brain research vol 802 issue 1-2 1998 9748620 Strong immunolabeling with mAb Tau-1 of the mossy fibers and perikarya of neurons in sectors CA3 and CA4 of the cornu Ammonis, less intensive staining in the cytoplasm in neocortical and subcortical neurons, and selective staining of some pyramidal cells in sectors CA1 and CA2 show differences in the amount of phosphorylated tau, not only in different types of neurons, but also in different parts of the cell. 1998-12-24 2022-01-08 Not clear
J Pav\\xc3\\xada, M L de Ceballos, F Sanchez de la Cuest. Alzheimer's disease: relationship between muscarinic cholinergic receptors, beta-amyloid and tau proteins. Fundamental & clinical pharmacology vol 12 issue 5 1998 9794144 The existence of a link between beta-amyloid and tau proteins also has been reported; treatment of hippocampal neurones with beta-amyloid, or the 25-35 residue fragment, resulted in an increase in tau protein phosphorylation. 1998-12-22 2022-01-08 rat
M G Spillantini, R A Crowther, W Kamphorst, P Heutink, J C van Swiete. Tau pathology in two Dutch families with mutations in the microtubule-binding region of tau. The American journal of pathology vol 153 issue 5 1998 9811325 Numerous intracytoplasmic tau deposits in neurons, glial cells, and neurites were found in hippocampal formation, neocortex, and substantia nigra. 1998-11-25 2022-01-08 Not clear
S L Kwei, A Clement, A Faissner, R Brand. Differential interactions of MAP2, tau and MAP5 during axogenesis in culture. Neuroreport vol 9 issue 6 1998 9601663 The subcellular interactions of the neuronal microtubule-associated proteins tau, MAP2 and MAP5 were determined in cultured rat hippocampal neurons using differential detergent extraction and laser scanning microscopy. 1998-08-13 2022-01-08 Not clear
C K Combs, P D Coleman, M K O'Banio. Developmental regulation and PKC dependence of Alzheimer's-type tau phosphorylations in cultured fetal rat hippocampal neurons. Brain research. Developmental brain research vol 107 issue 1 1998 9602100 Developmental regulation and PKC dependence of Alzheimer's-type tau phosphorylations in cultured fetal rat hippocampal neurons. 1998-07-27 2022-01-08 Not clear
C K Combs, P D Coleman, M K O'Banio. Developmental regulation and PKC dependence of Alzheimer's-type tau phosphorylations in cultured fetal rat hippocampal neurons. Brain research. Developmental brain research vol 107 issue 1 1998 9602100 Using fetal rat hippocampal cultures, we report a spatial and temporal expression of tau phosphorylation during neuronal differentiation. 1998-07-27 2022-01-08 Not clear
K Imahori, M Hoshi, K Ishiguro, K Sato, M Takahashi, R Shiurba, H Yamaguchi, A Takashima, T Uchid. Possible role of tau protein kinases in pathogenesis of Alzheimer's disease. Neurobiology of aging vol 19 issue 1 Suppl 1998 9562476 Such up-regulation of TPKI and phosphorylatioin of tau were reproduced by treating cultured hippocampal cells with amyloid beta (Abeta) protein. 1998-06-12 2022-01-08 Not clear
B A Bahr, J S Vicent. Age-related phosphorylation and fragmentation events influence the distribution profiles of distinct tau isoforms in mouse brain. Journal of neuropathology and experimental neurology vol 57 issue 2 1998 9600203 When assessing hippocampal tau across age, increasing levels of 69 kDa tau were found to correlate with a gradual reduction in 42-50 kDa isoforms. 1998-06-08 2022-01-08 Not clear
J Collet, L Fehrat, H Pollard, L Ribas de Pouplana, G Charton, A Bernard, J Moreau, Y Ben-Ari, M Khrestchatisk. Developmentally regulated alternative splicing of mRNAs encoding N-terminal tau variants in the rat hippocampus: structural and functional implications. The European journal of neuroscience vol 9 issue 12 1998 9517477 Using the reverse transcriptase-coupled polymerase chain reaction and in situ hybridization, we then focused our developmental study on hippocampal neurons, both in vivo and in vitro, to address the developmental and spatial expression of the alternatively spliced mRNAs encoding N-terminal variants of tau. 1998-04-24 2022-01-08 rat
J Collet, L Fehrat, H Pollard, L Ribas de Pouplana, G Charton, A Bernard, J Moreau, Y Ben-Ari, M Khrestchatisk. Developmentally regulated alternative splicing of mRNAs encoding N-terminal tau variants in the rat hippocampus: structural and functional implications. The European journal of neuroscience vol 9 issue 12 1998 9517477 The timing and pattern of tau alternative splicing were maintained in cultured hippocampal neurons, suggesting that splicing processes are independent of the organized connectivity and of the environmental cues provided in vivo. 1998-04-24 2022-01-08 rat
A Ferreira, Q Lu, L Orecchio, K S Kosi. Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar A beta. Molecular and cellular neurosciences vol 9 issue 3 1997 9245504 Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar A beta. 1997-10-27 2022-01-08 Not clear
A Ferreira, Q Lu, L Orecchio, K S Kosi. Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar A beta. Molecular and cellular neurosciences vol 9 issue 3 1997 9245504 We characterized a hippocampal neuronal culture system in which tau undergoes maturation in vivo; rat neurons maintained in culture for more than 3 weeks replicated the splicing and phosphorylation changes that tau undergoes upon maturation in situ. 1997-10-27 2022-01-08 Not clear
M P Mattson, W Fu, G Waeg, K Uchid. 4-Hydroxynonenal, a product of lipid peroxidation, inhibits dephosphorylation of the microtubule-associated protein tau. Neuroreport vol 8 issue 9-10 1997 9243625 We now report that following exposure of cultured rat hippocampal neurons to 4-hydroxynonenal (HNE), an aldehydic product of membrane lipid peroxidation, tau is resistant to dephosphorylation. 1997-10-07 2022-01-08 Not clear
K Sugaya, M Reeves, M McKinne. Topographic associations between DNA fragmentation and Alzheimer's disease neuropathology in the hippocampus. Neurochemistry international vol 31 issue 2 1997 9220460 To identify whether the process of apoptosis bears a topographic relationship to selected aspects of Alzheimer's disease (AD) pathology, we used an in situ nick translation method (TUNEL) to map DNA fragmentation in hippocampal sections immunostained for abnormally phosphorylated tau, which exists in the neurofibrillary tangles (NFTs) and in the dystrophic neurites associated with senile plaques. 1997-09-02 2022-01-08 human
F Malchiodi-Albedi, T C Petrucci, B Picconi, F Iosi, M Falch. Protein phosphatase inhibitors induce modification of synapse structure and tau hyperphosphorylation in cultured rat hippocampal neurons. Journal of neuroscience research vol 48 issue 5 1997 9185666 Protein phosphatase inhibitors induce modification of synapse structure and tau hyperphosphorylation in cultured rat hippocampal neurons. 1997-07-28 2022-01-08 Not clear
C M Kondratick, D D Vandr\\xc3\\xa. Alzheimer's disease neurofibrillary tangles contain mitosis-specific phosphoepitopes. Journal of neurochemistry vol 67 issue 6 1996 8931473 To determine if similar mitosis-associated phosphoepitopes appeared in AD, sections of hippocampal tissue were stained for immunoreactivity with antibodies recognizing both tau and mitotic phosphoepitopes. 1996-12-23 2022-01-07 Not clear
H Geerts, R Nuydens, M De Jong, F Cornelissen, R Nuyens, L Wouter. Sabeluzole stabilizes the neuronal cytoskeleton. Neurobiology of aging vol 17 issue 4 1996 8832632 Previous studies have shown that in human TR14 neuroblastoma cells and in rat hippocampal neurons a hyperstimulating medium of kinase activators leads to induction of aberrant tau phosphorylation followed by neurotoxicity. 1996-12-20 2022-01-07 Not clear
M Kempf, A Clement, A Faissner, G Lee, R Brand. Tau binds to the distal axon early in development of polarity in a microtubule- and microfilament-dependent manner. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 16 issue 18 1996 8795614 Here we report that tau is extracted differentially in cultured hippocampal neurons yielding an axon-specific localization under conditions that keep the integrity of the plasma membrane. 1996-12-11 2022-01-07 Not clear
J W Mandell, G A Banke. A spatial gradient of tau protein phosphorylation in nascent axons. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 16 issue 18 1996 8795628 To test this hypothesis, we mapped relative levels of tau phosphorylation within developing cultured hippocampal neurons. 1996-12-11 2022-01-07 Not clear
K Niizato, K Iked. Long-term antipsychotic medication of schizophrenics does not promote the development of Alzheimer's disease brain pathology. Journal of the neurological sciences vol 138 issue 1-2 1996 8791256 Immunohistological staining of the hippocampal region with anti-human tau antibody was used to examine the degree of AD pathology in seven schizophrenic patients who had received long-term antipsychotic medication and in seven controls. 1996-12-03 2022-01-07 Not clear
E Bednarski, G Lync. Cytosolic proteolysis of tau by cathepsin D in hippocampus following suppression of cathepsins B and L. Journal of neurochemistry vol 67 issue 5 1996 8863489 Cytosolic proteolysis of tau by cathepsin D in hippocampus following suppression of cathepsins B and L. Incubation of cultured hippocampal slices with an inhibitor [N-CBZ-L-phenylalanyl-L-alanine-diazomethyl ketone (ZPAD)] of cathepsins B and L resulted in the degradation of high molecular weight isoforms of tau protein and the production of a 29-kDa tau fragment (tau 29). 1996-12-02 2022-01-07 Not clear
K E Roertgen, J E Parisi, H B Clark, D L Barnes, T D O'Brien, K H Johnso. A beta-associated cerebral angiopathy and senile plaques with neurofibrillary tangles and cerebral hemorrhage in an aged wolverine (Gulo gulo). Neurobiology of aging vol 17 issue 2 1996 8744405 Argyrophilic intracellular neurofibrillary tangles containing abnormally phosphorylated (Ser 202) tau protein were present within cortical and hippocampal neurons. 1996-10-24 2022-01-07 Not clear
A Takashima, K Noguchi, G Michel, M Mercken, M Hoshi, K Ishiguro, K Imahor. Exposure of rat hippocampal neurons to amyloid beta peptide (25-35) induces the inactivation of phosphatidyl inositol-3 kinase and the activation of tau protein kinase I/glycogen synthase kinase-3 beta. Neuroscience letters vol 203 issue 1 1996 8742040 Exposure of rat hippocampal neurons to amyloid beta peptide (25-35) induces the inactivation of phosphatidyl inositol-3 kinase and the activation of tau protein kinase I/glycogen synthase kinase-3 beta. 1996-09-26 2022-01-07 Not clear
A Takashima, K Noguchi, G Michel, M Mercken, M Hoshi, K Ishiguro, K Imahor. Exposure of rat hippocampal neurons to amyloid beta peptide (25-35) induces the inactivation of phosphatidyl inositol-3 kinase and the activation of tau protein kinase I/glycogen synthase kinase-3 beta. Neuroscience letters vol 203 issue 1 1996 8742040 Exposure of rat hippocampal neurons to the peptide amyloid beta (A beta) (25-35) as well as A beta (1-40) peptides enhances phosphorylation of tau to a paired helical filament (PHF)-state through activation of tau protein kinase I (TPK I)/glycogen synthase kinase-3 beta (GSK-3 beta) [Busciglio, J., Lorenzo, A., Yeh, J. and Yankner, B.A., Neuron, 14 (1995) 879-888; Takashima, A., Ishiguro, K., Noguchi, K., Michel, G., Hoshi, M., Sato, K., Takahashi, M., Hoshino, T., Uchida, T. and Imahori, K., Neurosci. 1996-09-26 2022-01-07 Not clear
A Takashima, K Noguchi, G Michel, M Mercken, M Hoshi, K Ishiguro, K Imahor. Exposure of rat hippocampal neurons to amyloid beta peptide (25-35) induces the inactivation of phosphatidyl inositol-3 kinase and the activation of tau protein kinase I/glycogen synthase kinase-3 beta. Neuroscience letters vol 203 issue 1 1996 8742040 Wortmannin, an inhibitor of PI-3 kinase, also activated TPK I/GSK-3 beta, leading to an enhancement of tau phosphorylation and neuronal death in hippocampal culture. 1996-09-26 2022-01-07 Not clear
A Takashima, K Noguchi, G Michel, M Mercken, M Hoshi, K Ishiguro, K Imahor. Exposure of rat hippocampal neurons to amyloid beta peptide (25-35) induces the inactivation of phosphatidyl inositol-3 kinase and the activation of tau protein kinase I/glycogen synthase kinase-3 beta. Neuroscience letters vol 203 issue 1 1996 8742040 These results suggest that A beta (25-35) inhibition of PI-3 kinase results in the activation of TPK I/GSK-3 beta, the phosphorylation of tau, and resultant neuronal death in rat hippocampal neurons. 1996-09-26 2022-01-07 Not clear
M L Schmidt, R Huang, J A Martin, J Henley, M Mawal-Dewan, H I Hurtig, V M Lee, J Q Trojanowsk. Neurofibrillary tangles in progressive supranuclear palsy contain the same tau epitopes identified in Alzheimer's disease PHFtau. Journal of neuropathology and experimental neurology vol 55 issue 5 1996 8627344 The immunohistochemical studies showed that all of the tau epitopes detected in brainstem PSP NFTs also were found in hippocampal AD NFTs and vice versa. 1996-06-25 2022-01-07 Not clear
M Hoshi, A Takashima, K Noguchi, M Murayama, M Sato, S Kondo, Y Saitoh, K Ishiguro, T Hoshino, K Imahor. Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3beta in brain. Proceedings of the National Academy of Sciences of the United States of America vol 93 issue 7 1996 8610107 In rat hippocampal culture, betaA exposure activates tau protein kinase I/glycogen synthase kinase 3beta (TPKI/GSK-3beta), which phosphorylates tau protein into Alzheimer disease-like forms, resulting in neuronal death. 1996-05-24 2022-01-07 Not clear
A Takashima, H Yamaguchi, K Noguchi, G Michel, K Ishiguro, K Sato, T Hoshino, M Hoshi, K Imahor. Amyloid beta peptide induces cytoplasmic accumulation of amyloid protein precursor via tau protein kinase I/glycogen synthase kinase-3 beta in rat hippocampal neurons. Neuroscience letters vol 198 issue 2 1996 8592647 Amyloid beta peptide induces cytoplasmic accumulation of amyloid protein precursor via tau protein kinase I/glycogen synthase kinase-3 beta in rat hippocampal neurons. 1996-04-04 2022-01-07 Not clear
R Brandt, J L\\xc3\\xa9ger, G Le. Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain. The Journal of cell biology vol 131 issue 5 1996 8522593 In hippocampal neurons, tau is differentially extracted by detergent and enriched in the growth cone and the distal axon when membrane is left intact. 1996-01-22 2022-01-07 Not clear
J P Brion, A M Couck, J L Conreu. Calcineurin (phosphatase 2B) is present in neurons containing neurofibrillary tangles and in a subset of senile plaques in Alzheimer's disease. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration vol 4 issue 1 1995 7600182 Calcineurin was present in dystrophic neurites in some senile plaques (SP) located in the hippocampal formation but more rarely in neocortical areas; this calcineurin immunoreactivity did not always overlap with the tau immunoreactivity in SP. 1995-08-10 2022-01-07 human
D Wang, D G Muno. Qualitative and quantitative differences in senile plaque dystrophic neurites of Alzheimer's disease and normal aged brain. Journal of neuropathology and experimental neurology vol 54 issue 4 1995 7602328 Neocortical and hippocampal plaques, the only common type in a group of elderly non-demented subjects (non-AD), incorporated CgA/beta APP, but not tau neurites. 1995-08-10 2022-01-07 human
D Wang, D G Muno. Qualitative and quantitative differences in senile plaque dystrophic neurites of Alzheimer's disease and normal aged brain. Journal of neuropathology and experimental neurology vol 54 issue 4 1995 7602328 In cortical and hippocampal plaques in Alzheimer's disease (AD) beta APP colocalized with CgA in a neuritic population largely distinct from the subset of neurites labeled by tau. 1995-08-10 2022-01-07 human
C R Breese, R Freedman, S S Leonar. Glutamate receptor subtype expression in human postmortem brain tissue from schizophrenics and alcohol abusers. Brain research vol 674 issue 1 1995 7773698 No significant changes were observed in schizophrenic hippocampal GluR1 and GluR5 receptor subtypes or in levels of the structural control proteins, NCAM and tau. 1995-07-11 2022-01-07 human
J Busciglio, A Lorenzo, J Yeh, B A Yankne. beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding. Neuron vol 14 issue 4 1995 7718249 To determine whether amyloid fibril formation affects the phosphorylation state of tau, primary cultures of fetal rat hippocampal and human cortical neurons were treated with beta-amyloid (beta A) in a soluble, amorphous-aggregated, or fibrillar form. 1995-05-23 2022-01-07 Not clear
P Vermersch, Y Robitaille, L Bernier, A Wattez, D Gauvreau, A Delacourt. Biochemical mapping of neurofibrillary degeneration in a case of progressive supranuclear palsy: evidence for general cortical involvement. Acta neuropathologica vol 87 issue 6 1994 8091949 We found that: (i) the abnormal Tau proteins can be detected in all cortical areas, sometimes in larger amounts than in some subcortical areas; (ii) these abnormal Tau proteins consist of a doublet called Tau 64 and 69, except for in the entorhinal cortex where we detected, as for Alzheimer brains, the triplet of Tau proteins called Tau 55, 64 and 69; (iii) the amounts of abnormal Tau proteins were higher in some neocortical regions, especially in the frontal lobe, than in the hippocampal formation. 1994-10-17 2022-01-07 Not clear
Q Lu, R Kanumury, J G Woo. Abnormal phosphorylation of tau proteins associated with bovine brain microtubules: activation by excess ATP and tyrosine dephosphorylation. Journal of neuroscience research vol 37 issue 6 1994 8046776 The profound effect of tyrosine kinase inhibitors on tau phosphorylation was also demonstrated in living cells following microinjection of cultured hippocampal neurons. 1994-08-31 2022-01-07 Not clear
J W Geddes, C Schwab, S Craddock, J L Wilson, L C Pettigre. Alterations in tau immunostaining in the rat hippocampus following transient cerebral ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism vol 14 issue 4 1994 7516935 tau accumulated in neuronal cell bodies throughout the hippocampal formation 30 min to 2 h after the ischemic insult. 1994-07-27 2022-01-07 Not clear
L A Wong, M L Mayer, D E Jane, J C Watkin. Willardiines differentiate agonist binding sites for kainate- versus AMPA-preferring glutamate receptors in DRG and hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 14 issue 6 1994 7515954 Consistent with equilibrium potency measurements, in DRG neurons the kinetics of deactivation for willardiines, recorded following a return to agonist-free solution, were rapid for 5-fluoro (tau off = 43 msec) but slow for 5-iodo (tau off = 4.2 sec), while the opposite sequence was observed for hippocampal neurons, slow for 5-fluoro (tau off = 2.1 sec) and rapid for 5-iodo (tau off = 188 msec). 1994-07-11 2022-01-07 Not clear
Q Lu, J P Soria, J G Woo. p44mpk MAP kinase induces Alzheimer type alterations in tau function and in primary hippocampal neurons. Journal of neuroscience research vol 35 issue 4 1993 7689658 p44mpk MAP kinase induces Alzheimer type alterations in tau function and in primary hippocampal neurons. 1993-09-30 2022-01-07 Not clear
Q Lu, J P Soria, J G Woo. p44mpk MAP kinase induces Alzheimer type alterations in tau function and in primary hippocampal neurons. Journal of neuroscience research vol 35 issue 4 1993 7689658 We show here that tau can be phosphorylated in cultured hippocampal neurons by the MAP kinase p44mpk, and phosphorylation of tau compromises its functional ability to assemble microtubules. 1993-09-30 2022-01-07 Not clear
E M Elliott, M P Mattson, P Vanderklish, G Lynch, I Chang, R M Sapolsk. Corticosterone exacerbates kainate-induced alterations in hippocampal tau immunoreactivity and spectrin proteolysis in vivo. Journal of neurochemistry vol 61 issue 1 1993 8515288 Corticosterone exacerbates kainate-induced alterations in hippocampal tau immunoreactivity and spectrin proteolysis in vivo. 1993-07-22 2022-01-07 rat
M C Schiess, E K Asprodini, D G Rainnie, P Shinnick-Gallaghe. The central nucleus of the rat amygdala: in vitro intracellular recordings. Brain research vol 604 issue 1-2 1993 8457856 The s-AHP was defined by a slow decay time constant with a mean tau AHP = 1.7 s. The s-AHP was similar to the AHP mediated by IAHP, a long duration calcium-dependent, noradrenaline-sensitive current present in hippocampal neurons. 1993-04-26 2022-01-07 Not clear
M P Mattso. Effects of microtubule stabilization and destabilization on tau immunoreactivity in cultured hippocampal neurons. Brain research vol 582 issue 1 1992 1354011 Effects of microtubule stabilization and destabilization on tau immunoreactivity in cultured hippocampal neurons. 1992-09-14 2022-01-07 Not clear
M P Mattso. Effects of microtubule stabilization and destabilization on tau immunoreactivity in cultured hippocampal neurons. Brain research vol 582 issue 1 1992 1354011 Previous data indicated that calcium influx can cause antigenic changes in tau in cultured rat hippocampal and human cortical neurons similar to those seen in NFT. 1992-09-14 2022-01-07 Not clear
M P Mattso. Effects of microtubule stabilization and destabilization on tau immunoreactivity in cultured hippocampal neurons. Brain research vol 582 issue 1 1992 1354011 The present study used cultured hippocampal neurons to test the hypothesis that disruption of microtubules is a key event leading to altered antigenic properties of tau that result from calcium influx. 1992-09-14 2022-01-07 Not clear
N Spruston, D Johnsto. Perforated patch-clamp analysis of the passive membrane properties of three classes of hippocampal neurons. Journal of neurophysiology vol 67 issue 3 1992 1578242 Changing the membrane potential by constant current injection resulted in changes in RN and tau 0; subthreshold depolarization produced an increase, and hyperpolarization a decrease, in both RN and tau 0 for all three classes of hippocampal neurons. 1992-06-10 2022-01-07 Not clear
N Spruston, D Johnsto. Perforated patch-clamp analysis of the passive membrane properties of three classes of hippocampal neurons. Journal of neurophysiology vol 67 issue 3 1992 1578242 Extracellular Cs+ effectively blocked the sag in all three classes of hippocampal neurons, but the effect of Cs+ on RN, tau 0, and the voltage dependence of these parameters was unique for each class of neurons. 1992-06-10 2022-01-07 Not clear
A C McKee, K S Kosik, N W Kowal. Neuritic pathology and dementia in Alzheimer's disease. Annals of neurology vol 30 issue 2 1991 1910274 We used antibodies raised against amyloid beta/A4 protein of senile plaque cores and tau protein as well as thioflavine S and the Campbell-Switzer modification of the Hicks silver method to examine the hippocampal formation and five neocortical regions from 22 nondemented elderly control subjects and 34 demented patients with cerebral senile plaques and neurofibrillary tangles, without complicating disease processes. 1991-10-24 2022-01-07 human
C Bancher, I Grundke-Iqbal, K Iqbal, V A Fried, H T Smith, H M Wisniewsk. Abnormal phosphorylation of tau precedes ubiquitination in neurofibrillary pathology of Alzheimer disease. Brain research vol 539 issue 1 1991 1849776 On tissue sections of Alzheimer brain, 4 antibodies to tau immunolabel not only neurofibrillary tangles, neuritic plaques and neuropil threads but also the tangle-free cytoplasm of a subset of hippocampal and cortical neurons we believe to be at a stage of alteration preceding the formation of paired helical filaments (PHF). 1991-05-22 2022-01-07 Not clear
I Mody, D L Tanelian, M B MacIve. Halothane enhances tonic neuronal inhibition by elevating intracellular calcium. Brain research vol 538 issue 2 1991 1901506 Using whole cell patch-clamp recording in hippocampal slices, halothane and pentobarbital were found to prolong the decay time constant (TAU(D)) of GABAA-mediated spontaneous inhibitory postsynaptic currents (sIPSCs). 1991-05-16 2022-01-07 Not clear
A J Barton, P J Harrison, A Najlerahim, J Heffernan, B McDonald, J R Robinson, D C Davies, W J Harrison, P Mitra, J A Hard. Increased tau messenger RNA in Alzheimer's disease hippocampus. The American journal of pathology vol 137 issue 3 1990 2119143 A significant and gene-specific increase in tau mRNA hybridization was found in hippocampal fields CA4 and CA3, with a similar trend in the dentate gyrus. 1990-10-12 2022-01-07 Not clear
A J Barton, P J Harrison, A Najlerahim, J Heffernan, B McDonald, J R Robinson, D C Davies, W J Harrison, P Mitra, J A Hard. Increased tau messenger RNA in Alzheimer's disease hippocampus. The American journal of pathology vol 137 issue 3 1990 2119143 Increased hippocampal expression of tau mRNA also was present in cases of non-Alzheimer's dementia. 1990-10-12 2022-01-07 Not clear
M L Schmidt, V M Lee, J Q Trojanowsk. Relative abundance of tau and neurofilament epitopes in hippocampal neurofibrillary tangles. The American journal of pathology vol 136 issue 5 1990 1693468 Relative abundance of tau and neurofilament epitopes in hippocampal neurofibrillary tangles. 1990-07-09 2022-01-07 Not clear
M G Spillantini, M Goedert, R Jakes, A Klu. Topographical relationship between beta-amyloid and tau protein epitopes in tangle-bearing cells in Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America vol 87 issue 10 1990 1692627 Double-labeling immunohistochemistry was used to investigate the topographical relationship between beta-amyloid and tau protein epitopes present in cells bearing neurofibrillary tangles found in the hippocampal formation of patients with Alzheimer disease. 1990-06-21 2022-01-07 Not clear
M P Mattso. Antigenic changes similar to those seen in neurofibrillary tangles are elicited by glutamate and Ca2+ influx in cultured hippocampal neurons. Neuron vol 4 issue 1 1990 1690014 Antibodies recognizing tau (5E2 and Alz-50) and ubiquitin epitopes in NFTs were used to examine the influence of glutamate and Ca2+ influx on antigen expression in cultured rat hippocampal neurons. 1990-04-19 2022-01-07 Not clear
C G Dotti, G A Banker, L I Binde. The expression and distribution of the microtubule-associated proteins tau and microtubule-associated protein 2 in hippocampal neurons in the rat in situ and in cell culture. Neuroscience vol 23 issue 1 1988 3120034 Using a monoclonal antibody against the microtubule-associated protein tau we compared the distribution and the biochemical maturation of this protein in hippocampal pyramidal neurons in the rat in tau and in culture. 1988-01-11 2022-01-07 Not clear
C G Dotti, G A Banker, L I Binde. The expression and distribution of the microtubule-associated proteins tau and microtubule-associated protein 2 in hippocampal neurons in the rat in situ and in cell culture. Neuroscience vol 23 issue 1 1988 3120034 In hippocampal cultures ranging from 12 h to 4 weeks in vitro tau was present in neurons but not in glial cells, as it is in situ. 1988-01-11 2022-01-07 Not clear
C G Dotti, G A Banker, L I Binde. The expression and distribution of the microtubule-associated proteins tau and microtubule-associated protein 2 in hippocampal neurons in the rat in situ and in cell culture. Neuroscience vol 23 issue 1 1988 3120034 Despite the non-restricted distribution of tau in hippocampal neurons in culture, and despite the presence of only the immature isoform which has a lessened stimulatory effect on microtubule polymerization, axons and dendrites appear to grow normally and to exhibit appropriate functional properties. 1988-01-11 2022-01-07 Not clear
C G Dotti, G A Banker, L I Binde. The expression and distribution of the microtubule-associated proteins tau and microtubule-associated protein 2 in hippocampal neurons in the rat in situ and in cell culture. Neuroscience vol 23 issue 1 1988 3120034 The expression and distribution of the microtubule-associated proteins tau and microtubule-associated protein 2 in hippocampal neurons in the rat in situ and in cell culture. 1988-01-11 2022-01-07 Not clear
J Busciglio, A Ferreira, O Steward, A C\\xc3\\xa1cere. An immunocytochemical and biochemical study of the microtubule-associated protein Tau during post-lesion afferent reorganization in the hippocampus of adult rats. Brain research vol 419 issue 1-2 1988 3119145 The modifications in Tau immunoreactivity in the denervated hippocampus were also accompanied by changes in the polypeptide composition of this heterogeneous group of MAPs, as revealed by immunoblot analysis of hippocampal extracts obtained at different post-lesion intervals; these changes involved a rapid and significant increase in low molecular weight migrating Tau-immunoreactive polypeptides. 1988-01-11 2022-01-07 rat
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