All Relations between microtubule-associated protein tau and hippocampus

Reference Sentence Publish Date Extraction Date Species
Chao He, Ai-Hong Yuan, Jun Yang, Yin-Qiu Fan, Hong-Yu Xi. [Electroacupuncture improves learning-memory ability by down-regulating expression of hippocampal A\\xce\\xb21-42 and Tau and NF-\\xce\\xbaB proteins in diabetic rats with cognitive impairment]. Zhen ci yan jiu = Acupuncture research vol 47 issue 6 2022 35764514 [electroacupuncture improves learning-memory ability by down-regulating expression of hippocampal a\xce\xb21-42 and tau and nf-\xce\xbab proteins in diabetic rats with cognitive impairment]. 2022-06-28 2022-07-04 Not clear
Hai Duc Nguyen, Won Hee Jo, Ngoc Hong Minh Hoang, Byung Pal Yu, Hae Young Chung, Min-Sun Ki. 1,2-Diacetylbenzene impaired hippocampal memory by activating proinflammatory cytokines and upregulating the prolactin pathway: An in vivo and in vitro study. International immunopharmacology vol 108 issue 2022 35729834 qpcr, western blot, morris water maze, and rnaseq analysis were used to identify the association between inflammation and hyperphosphorylated tau in male dab-treated mice (1 or 5\xc2\xa0mg/kg/day), rats (3\xc2\xa0mg/kg/day), in vitro bv2 microglial cells (1 or 5\xc2\xa0\xc2\xb5m), and the hippocampal transcriptome of male dab-treated rats. 2022-06-22 2022-06-27 Not clear
Jiayin Zheng, Yue Wang, Yue Liu, Song Han, Ying Zhang, Yanlin Luo, Yi Yan, Junfa Li, Li Zha. cPKC\\xce\\xb3 Deficiency Exacerbates Autophagy Impairment and Hyperphosphorylated Tau Buildup through the AMPK/mTOR Pathway in Mice with Type 1 Diabetes Mellitus. Neuroscience bulletin vol issue 2022 35596894 in this study, we found that knockout of conventional protein kinase c (cpkc)\xce\xb3 significantly increased the phosphorylation of tau at ser214 and neurofibrillary tangles, but did not affect the activities of gsk-3\xce\xb2 and pp2a in the hippocampal neurons of t1dm mice. 2022-05-21 2022-06-13 Not clear
Samar O El-Ganainy, Omar A Soliman, Aya A Ghazy, Maram Allam, Aya I Elbahnasi, Amira M Mansour, Mennatallah A Gowaye. Intranasal Oxytocin Attenuates Cognitive Impairment, \\xce\\xb2-Amyloid Burden and Tau Deposition in Female Rats with Alzheimer's Disease: Interplay of ERK1/2/GSK3\\xce\\xb2/Caspase-3. Neurochemical research vol issue 2022 35596040 in addition, neuroprotective effects of oxytocin were examined by assessing hippocampal acetylcholinesterase activity, \xce\xb2-amyloid 1-42 protein, and tau levels. 2022-05-20 2022-06-13 Not clear
S Tok, H Maurin, C Delay, D Crauwels, N V Manyakov, W Van Der Elst, D Moechars, W H I M Drinkenbur. Neurophysiological effects of human-derived pathological tau conformers in the APPKM670/671NL.PS1/L166P amyloid mouse model of Alzheimer's disease. Scientific reports vol 12 issue 1 2022 35546164 we also report immediate localized hippocampal dysfunction in the electroencephalography (eeg) power spectra associated with tau seeding which returned to comparable levels at 1\xc2\xa0month-post-injection. 2022-05-13 2022-06-13 Not clear
Elizabeth L Steuer, Lisa J Kemper, Chris J W Hlynialuk, Kailee Leinonen-Wright, Michelle L Montonye, Ian P Lapcinski, Colleen L Forster, Karen H Ashe, Peng Li. Blocking site-specific cleavage of human tau delays progression of disease-related phenotypes in genetically matched tau-transgenic mice modeling frontotemporal dementia. The Journal of neuroscience : the official journal of the Society for Neuroscience vol issue 2022 35508385 importantly, expression of the cleavage-resistant d314e mutant delays transgene-induced tau accumulation in the post-synaptic density, brain atrophy, hippocampal neurodegeneration, and spatial memory impairment, without altering age-related progression of pathological tau conformation and phosphorylation. 2022-05-04 2022-05-07 Not clear
Giovanni Oliveros, Charles H Wallace, Osama Chaudry, Qiao Liu, Yue Qiu, Lei Xie, Patricia Rockwell, Maria E Figueiredo-Pereira, Peter A Serran. Repurposing ibudilast to mitigate Alzheimer's disease by targeting inflammation. Brain : a journal of neurology vol issue 2022 35411386 this transgenic rat model is unique as it exhibits hippocampal-dependent spatial learning and memory deficits, and alzheimer's disease pathology including hippocampal amyloid plaques, tau paired-helical filaments, neuronal loss and microgliosis, in a progressive age-dependent manner that mimics the pathology observed in alzheimer's disease patients. 2022-04-12 2022-04-14 Not clear
Giovanni Oliveros, Charles H Wallace, Osama Chaudry, Qiao Liu, Yue Qiu, Lei Xie, Patricia Rockwell, Maria E Figueiredo-Pereira, Peter A Serran. Repurposing ibudilast to mitigate Alzheimer's disease by targeting inflammation. Brain : a journal of neurology vol issue 2022 35411386 we demonstrate that ibudilast-treatment of transgenic rats mitigated hippocampal-dependent spatial memory deficits, as well as hippocampal (hilar subregion) amyloid plaque and tau paired-helical filament load, and microgliosis compared to untreated transgenic rat. 2022-04-12 2022-04-14 Not clear
Sang-Seo Park, Hye-Sang Park, Chang-Ju Kim, Seung-Soo Baek, Song-Young Park, Cody Philip Anderson, Myung-Ki Kim, Ik-Ryeul Park, Tae-Woon Ki. Combined effects of Aerobic exercise and 40Hz light flicker exposure on early cognitive impairments in Alzheimer's disease of 3xTg mice. Journal of applied physiology (Bethesda, Md. : 1985) vol issue 2022 35201933 spatial learning and memory, long-term memory, hippocampal a\xce\xb2, tau, neuroinflammation, pro-inflammatory cytokine expression, mitochondrial function, and neuroplasticity, were analyzed. 2022-04-08 2022-04-14 Not clear
Shihong Li, Qiuzhi Zhou, Enjie Liu, Huiyun Du, Nana Yu, Haitao Yu, Weijin Wang, Mengzhu Li, Ying Weng, Yang Gao, Guilin Pi, Xin Wang, Dan Ke, Jian-Zhi Wan. Alzheimer-like tau accumulation in dentate gyrus mossy cells induces spatial cognitive deficits by disrupting multiple memory-related signaling and inhibiting local neural circuit. Aging cell vol issue 2022 35355405 in the current study, we observed a prominent accumulation of the ad-like hyperphosphorylated and truncated tau (htau n368) proteins in hippocampal dentate gyrus (dg) mossy cells of 3xtg-ad mice. 2022-03-31 2022-04-14 Not clear
Emrah D\\xc3\\xbczel, Gabriel Ziegler, David Berron, Anne Maass, Hartmut Sch\\xc3\\xbctze, Arturo Cardenas-Blanco, Wenzel Glanz, Coraline Metzger, Laura Dobisch, Martin Reuter, Annika Spottke, Frederic Brosseron, Klaus Fliessbach, Michael T Heneka, Christoph Laske, Oliver Peters, Josef Priller, Eike Jakob Spruth, Alfredo Ramirez, Oliver Speck, Anja Schneider, Stefan Teipel, Ingo Kilimann, Wiltfang Jens, Bj\\xc3\\xb6rn-Hendrik Schott, Lukas Preis, Daria Gref, Franziska Maier, Matthias H Munk, Nina Roy, Tomasso Ballarini, Renat Yakupov, John Dylan Haynes, Peter Dechent, Klaus Scheffler, Michael Wagner, Frank Jesse. Amyloid pathology but not APOE \\xce\\xb54 status is permissive for tau-related hippocampal dysfunction. Brain : a journal of neurology vol issue 2022 35352105 apoe status (presence of the e4 allele), a known genetic risk factor for alzheimer's disease, did not mediate the relationship between tau pathology and hippocampal function and memory performance. 2022-03-30 2022-04-14 Not clear
Emrah D\\xc3\\xbczel, Gabriel Ziegler, David Berron, Anne Maass, Hartmut Sch\\xc3\\xbctze, Arturo Cardenas-Blanco, Wenzel Glanz, Coraline Metzger, Laura Dobisch, Martin Reuter, Annika Spottke, Frederic Brosseron, Klaus Fliessbach, Michael T Heneka, Christoph Laske, Oliver Peters, Josef Priller, Eike Jakob Spruth, Alfredo Ramirez, Oliver Speck, Anja Schneider, Stefan Teipel, Ingo Kilimann, Wiltfang Jens, Bj\\xc3\\xb6rn-Hendrik Schott, Lukas Preis, Daria Gref, Franziska Maier, Matthias H Munk, Nina Roy, Tomasso Ballarini, Renat Yakupov, John Dylan Haynes, Peter Dechent, Klaus Scheffler, Michael Wagner, Frank Jesse. Amyloid pathology but not APOE \\xce\\xb54 status is permissive for tau-related hippocampal dysfunction. Brain : a journal of neurology vol issue 2022 35352105 thus, our data show that the presence of amyloid pathology is associated with a linear relationship between tau pathology, hippocampal dysfunction and memory impairment, although the actual severity of amyloid pathology is uncorrelated. 2022-03-30 2022-04-14 Not clear
Lorena Xolalpa-Cueva, Carlos Antonio Garc\\xc3\\xada-Carlos, Roc\\xc3\\xado Villase\\xc3\\xb1or-Zepeda, Erika Orta-Salazar, Sofia D\\xc3\\xadaz-Cintra, Fernando Pe\\xc3\\xb1a-Ortega, George Perry, Siddhartha Mondrag\\xc3\\xb3n-Rodr\\xc3\\xadgue. Hyperphosphorylated Tau Relates to Improved Cognitive Performance and Reduced Hippocampal Excitability in the Young rTg4510 Mouse Model of Tauopathy. Journal of Alzheimer's disease : JAD vol issue 2022 35342085 hyperphosphorylated tau relates to improved cognitive performance and reduced hippocampal excitability in the young rtg4510 mouse model of tauopathy. 2022-03-28 2022-04-14 Not clear
Kurt A Jellinge. Heterogeneity of Multiple System Atrophy: An Update. Biomedicines vol 10 issue 3 2022 35327402 in addition to rare combined or "mixed" msa, there is a broad spectrum of atypical msa variants, such as those with a different age at onset and disease duration, "minimal change" or prodromal forms, msa variants with lewy body disease or severe hippocampal pathology, rare forms with an unusual tau pathology or spinal myoclonus, an increasing number of msa cases with cognitive impairment/dementia, rare familial forms, and questionable conjugal msa. 2022-03-25 2022-04-14 Not clear
Abi Nader Cl\\xc3\\xa9ment, Federica Ribaldi, Giovanni B Frisoni, Valentina Garibotto, Philippe Robert, Nicholas Ayache, Marco Lorenz. SimulAD: a dynamical model for personalized simulation and disease staging in Alzheimer's disease. Neurobiology of aging vol 113 issue 2022 35320737 ds correlated with mmse (\xcf\x81 = -0.55), hippocampal atrophy (\xcf\x81 = -0.62), glucose hypometabolism (\xcf\x81 = -0.67), amyloid burden (\xcf\x81 = 0.31) and tau deposition (\xcf\x81 = 0.62) (p-values < 0.01). 2022-03-23 2022-04-14 Not clear
Wiesje Pelkmans, Ellen M Vromen, Ellen Dicks, Philip Scheltens, Charlotte E Teunissen, Frederik Barkhof, Wiesje M van der Flier, Betty M Tijm. Grey matter network markers identify individuals with prodromal Alzheimer's disease who will show rapid clinical decline. Brain communications vol 4 issue 2 2022 35310828 csf tau phosphorylated at threonine 181 (p-tau181) levels and hippocampal volume]. 2022-03-21 2022-04-14 Not clear
Reza Yekta, Leila Sadeghi, Gholamreza Dehgha. The role of non-enzymatic glycation on Tau-DNA interactions: Kinetic and mechanistic approaches. International journal of biological macromolecules vol issue 2022 35257729 the study of hippocampal cells under hyperglycemic conditions showed that near to 70% of tau proteins glycated in these cells, although the expression of tau remained unaffected. 2022-03-11 2022-03-09 Not clear
Reza Yekta, Leila Sadeghi, Gholamreza Dehgha. The role of non-enzymatic glycation on Tau-DNA interactions: Kinetic and mechanistic approaches. International journal of biological macromolecules vol issue 2022 35257729 the study of hippocampal cells under hyperglycemic conditions showed that near to 70% of tau proteins glycated in these cells, although the expression of tau remained unaffected. 2022-03-08 2022-03-09 Not clear
Gabriel Boer Grigoletti-Lima, Marcelo Gustavo Lopes, Ana Tereza Barufi Franco, Aparecida Marcela Damico, Patr\\xc3\\xaccia Aline Boer, Jos\\xc3\\xa9 Antonio Rocha Gontij. Severe Gestational Low-Protein Intake Impacts Hippocampal Cellularity, Tau, and Amyloid-\\xce\\xb2 Levels, and Memory Performance in Male Adult Offspring: An Alzheimer-Simile Disease Model? Journal of Alzheimer's disease reports vol 6 issue 1 2022 35243209 severe gestational low-protein intake impacts hippocampal cellularity, tau, and amyloid-\xce\xb2 levels, and memory performance in male adult offspring: an alzheimer-simile disease model? 2022-03-04 2022-03-06 Not clear
Sang-Seo Park, Hye-Sang Park, Chang-Ju Kim, Seung-Soo Baek, Song-Young Park, Cody Philip Anderson, Myung-Ki Kim, Ik-Ryeul Park, Tae-Woon Ki. Combined effects of Aerobic exercise and 40Hz light flicker exposure on early cognitive impairments in Alzheimer's disease of 3xTg mice. Journal of applied physiology (Bethesda, Md. : 1985) vol issue 2022 35201933 spatial learning and memory, long-term memory, hippocampal a\xce\xb2, tau, neuroinflammation, pro-inflammatory cytokine expression, mitochondrial function, and neuroplasticity, were analyzed. 2022-02-24 2022-04-14 Not clear
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