| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Moorthi Ponnusamy, Shuai Wang, Melike Yuksel, Mitchell T Hansen, Danielle M Blazier, Joseph D McMillan, Xiaolin Zhang, Eric B Dammer, Lisa Collier, Gopal Thinakara. Loss of forebrain BIN1 attenuates hippocampal pathology and neuroinflammation in a tauopathy model. Brain : a journal of neurology. 2022-09-04. PMID:36059072. |
intriguingly, the loss of bin1 also mitigated tau neuropathology in select regions, including the hippocampus, entorhinal/piriform cortex, and amygdala, thus attenuating hippocampal synapse loss, neuronal death, neuroinflammation, and brain atrophy. |
2022-09-04 |
2023-08-14 |
mouse |
| Moorthi Ponnusamy, Shuai Wang, Melike Yuksel, Mitchell T Hansen, Danielle M Blazier, Joseph D McMillan, Xiaolin Zhang, Eric B Dammer, Lisa Collier, Gopal Thinakara. Loss of forebrain BIN1 attenuates hippocampal pathology and neuroinflammation in a tauopathy model. Brain : a journal of neurology. 2022-09-04. PMID:36059072. |
we conclude that forebrain neuronal bin1 expression promotes hippocampal tau pathogenesis and neuroinflammation. |
2022-09-04 |
2023-08-14 |
mouse |
| Sara R Guerreiro, Marco R Guimarães, Joana M Silva, Chrysoula Dioli, Anastasia Vamvaka-Iakovou, Raquel Sousa, Patrícia Gomes, Anastasia Megalokonomou, Carlos Campos-Marques, Ana Margarida Cunha, Armando Almeida, Nuno Sousa, Hugo Leite-Almeida, Ioannis Sotiropoulo. Chronic pain causes Tau-mediated hippocampal pathology and memory deficits. Molecular psychiatry. 2022-09-02. PMID:36056171. |
using a peripheral (sciatic) neuropathy to model chronic pain in mice-spared nerve injury (sni) for 4 months-in wildtype as well as p301l-tau transgenic mice, we hereby demonstrate that sni triggers ad-related neuropathology characterized by tau hyperphosphorylation, accumulation, and aggregation in hippocampus followed by neuronal atrophy and memory deficits. |
2022-09-02 |
2023-08-14 |
mouse |
| Sara R Guerreiro, Marco R Guimarães, Joana M Silva, Chrysoula Dioli, Anastasia Vamvaka-Iakovou, Raquel Sousa, Patrícia Gomes, Anastasia Megalokonomou, Carlos Campos-Marques, Ana Margarida Cunha, Armando Almeida, Nuno Sousa, Hugo Leite-Almeida, Ioannis Sotiropoulo. Chronic pain causes Tau-mediated hippocampal pathology and memory deficits. Molecular psychiatry. 2022-09-02. PMID:36056171. |
interestingly, genetic ablation of tau blocks the establishment of sni-induced hippocampal morphofunctional deficits supporting the mediating role of tau in sni-evoked hippocampal pathology and memory impairment. |
2022-09-02 |
2023-08-14 |
mouse |
| Ejlal Abu-El-Rub, Ramada R Khasawneh, Fatimah A Almahasneh, Basma Milad Aloud, Hana M Zegalla. The molecular and functional changes of Neural stem cells in Alzheimer's disease: Can they be reinvigorated to conduct Neurogenesis. Current stem cell research & therapy. 2022-09-01. PMID:36045542. |
ad's previously known pathological basis is the deposition of amyloid β (aβ) aggregates and the formation of neurofibrillary tangles by tau hyperphosphorylation in the cell bodies of neurons that are located in the hippocampus, neocortex, and certain other regions of the cerebral hemispheres and limbic system. |
2022-09-01 |
2023-08-14 |
Not clear |
| Hao Liu, Zhi Yang, Chunyan Yu, Hao Dong, Shiyan Wang, Gang Wang, Denian Wan. Tau aggravates stress-induced anxiety by inhibiting adult ventral hippocampal neurogenesis in mice. Cerebral cortex (New York, N.Y. : 1991). 2022-09-01. PMID:36047921. |
tau aggravates stress-induced anxiety by inhibiting adult ventral hippocampal neurogenesis in mice. |
2022-09-01 |
2023-08-14 |
mouse |
| Hao Liu, Zhi Yang, Chunyan Yu, Hao Dong, Shiyan Wang, Gang Wang, Denian Wan. Tau aggravates stress-induced anxiety by inhibiting adult ventral hippocampal neurogenesis in mice. Cerebral cortex (New York, N.Y. : 1991). 2022-09-01. PMID:36047921. |
furthermore, glycogen synthase kinase-3β and calcium/calmodulin-dependent protein kinase ii-α activity and calcium/calmodulin-dependent protein kinase ii-β upregulation substantially promote tau phosphorylation, which disrupts the dendritic structural plasticity of granule cells in the vdg of the hippocampus, and this action is necessary and sufficient for the stress response. |
2022-09-01 |
2023-08-14 |
mouse |
| Hao Liu, Zhi Yang, Chunyan Yu, Hao Dong, Shiyan Wang, Gang Wang, Denian Wan. Tau aggravates stress-induced anxiety by inhibiting adult ventral hippocampal neurogenesis in mice. Cerebral cortex (New York, N.Y. : 1991). 2022-09-01. PMID:36047921. |
taken together, our findings reveal a novel mechanism by which tau exacerbates stress responses and anxiety-related behavior by inhibiting the proliferation and maturation of hippocampal vdg neurons, providing a potential molecular target for the treatment of anxiety-like behavior induced by stress. |
2022-09-01 |
2023-08-14 |
mouse |
| Yujun Tu, Qi Chen, Wenjia Guo, Pu Xiang, Haifeng Huang, Huizhi Fei, Lin Chen, Yang Yang, Zhe Peng, Chao Gu, Xiaodan Tan, Xia Liu, Yi Lu, Rongchun Chen, Hong Wang, Ying Luo, Junqing Yan. MiR-702-5p ameliorates diabetic encephalopathy in db/db mice by regulating 12/15-LOX. Experimental neurology. 2022-08-27. PMID:36029808. |
in vivo, diabetic mice with cognitive dysfunction and hippocampal neuronal damage had a concomitant increase in amyloid precursor protein (app), amyloid beta(aβ), tau, bax protein expressions; by contrast, bcl-2 protein expression was significantly decreased. |
2022-08-27 |
2023-08-14 |
mouse |
| Yujun Tu, Qi Chen, Wenjia Guo, Pu Xiang, Haifeng Huang, Huizhi Fei, Lin Chen, Yang Yang, Zhe Peng, Chao Gu, Xiaodan Tan, Xia Liu, Yi Lu, Rongchun Chen, Hong Wang, Ying Luo, Junqing Yan. MiR-702-5p ameliorates diabetic encephalopathy in db/db mice by regulating 12/15-LOX. Experimental neurology. 2022-08-27. PMID:36029808. |
overexpression of mir-702-5p significantly reduced the histopathological damage of the hippocampus, improved the learning and memory function of db/db mice, down-regulated 12/15-lox, app, aβ, tau, bax protein expressions significantly and up-regulated the expression of bcl-2. |
2022-08-27 |
2023-08-14 |
mouse |
| Luis A Campero-Garcia, Jose A Cantoral-Ceballos, Alejandra Martinez-Maldonado, Jose Luna-Muñoz, Miguel A Ontiveros-Torres, Andres E Gutierrez-Rodrigue. A Novel Automatic Quantification Protocol for Biomarkers of Tauopathies in the Hippocampus and Entorhinal Cortex of Post-Mortem Samples Using an Extended Semi-Siamese U-Net. Biology. vol 11. issue 8. 2022-08-26. PMID:36009757. |
however, the standard approach to exploring the phenomenon of neurodegeneration in tauopathies has not been directed at understanding the molecular mechanism that causes the aberrant polymeric and fibrillar behavior of the tau protein, which forms neurofibrillary tangles that replace neuronal populations in the hippocampal and cortical regions. |
2022-08-26 |
2023-08-14 |
human |
| Kurt Farrell, Megan A Iida, Jonathan D Cherry, Alicia Casella, Thor D Stein, Kevin F Bieniek, Jamie M Walker, Timothy E Richardson, Charles L White, Victor E Alvarez, Bertrand R Huber, Dennis W Dickson, Ricardo Insausti, Kristen Dams-O'Connor, Ann C McKee, John F Crar. Differential Vulnerability of Hippocampal Subfields in Primary Age-Related Tauopathy and Chronic Traumatic Encephalopathy. Journal of neuropathology and experimental neurology. 2022-08-25. PMID:36004533. |
in moderate to advanced cte, nfts accumulate in the hippocampus, potentially overlapping neuroanatomically with primary age-related tauopathy (part), an age-related tauopathy characterized by alzheimer disease-like tau pathology in the hippocampus devoid of amyloid plaques. |
2022-08-25 |
2023-08-14 |
human |
| Keerti Gupta, Jitendra Vishwakarma, Asmita Garg, Rukmani Pandey, Veena Jain, Raksha Gupta, Uttara Das, Somendu Roy, Sanghamitra Bandyopadhya. Arsenic Induces GSK3β-dependent p-tau, neuronal apoptosis and cognitive impairment via an interdependent hippocampal ERα and IL-1/IL-1R1 mechanism in female rats. Toxicological sciences : an official journal of the Society of Toxicology. 2022-08-22. PMID:35993674. |
we observed that environmentally relevant arsenic exposure increased tau phosphorylation and the principal tau kinase, glycogen synthase kinase-3 beta (gsk3β), in the female rat hippocampal neurons. |
2022-08-22 |
2023-08-14 |
rat |
| Caleb Seth Bailey, Julia Elaine Jagielo-Miller, Peggy Sue Keller, Ethan Phares Glaser, Abigail Lowe Wilcox, Mark Alan Prendergas. Ethanol sustains phosphorylated tau protein in the cultured neonatal rat hippocampus: Implications for fetal alcohol spectrum disorders. Alcohol (Fayetteville, N.Y.). 2022-08-14. PMID:35964913. |
ethanol sustains phosphorylated tau protein in the cultured neonatal rat hippocampus: implications for fetal alcohol spectrum disorders. |
2022-08-14 |
2023-08-14 |
rat |
| Caleb Seth Bailey, Julia Elaine Jagielo-Miller, Peggy Sue Keller, Ethan Phares Glaser, Abigail Lowe Wilcox, Mark Alan Prendergas. Ethanol sustains phosphorylated tau protein in the cultured neonatal rat hippocampus: Implications for fetal alcohol spectrum disorders. Alcohol (Fayetteville, N.Y.). 2022-08-14. PMID:35964913. |
the role of the tau protein in the hippocampus is likely to be involved. |
2022-08-14 |
2023-08-14 |
rat |
| Caleb Seth Bailey, Julia Elaine Jagielo-Miller, Peggy Sue Keller, Ethan Phares Glaser, Abigail Lowe Wilcox, Mark Alan Prendergas. Ethanol sustains phosphorylated tau protein in the cultured neonatal rat hippocampus: Implications for fetal alcohol spectrum disorders. Alcohol (Fayetteville, N.Y.). 2022-08-14. PMID:35964913. |
this is the first study to show that etoh exposure sustains tau threonine231 phosphorylation in the perinatal hippocampus regardless of total tau expression. |
2022-08-14 |
2023-08-14 |
rat |
| Tiantian Guo, Xinjia Pan, Guangtong Jiang, Denghong Zhang, Jinghui Qi, Lin Shao, Zhanxiang Wang, Huaxi Xu, Yingjun Zha. Downregulating PTBP1 fails to convert astrocytes into hippocampal neurons and to alleviate symptoms in Alzheimer's mouse models. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-08-09. PMID:35944999. |
here, we demonstrate that ptbp1 downregulation using an astrocyte specific aav-mediated shrna system fails to convert hippocampal astrocytes into neurons in both male and female wt, and β-amyloid (5×fad) and tau (ps19) alzheimer's disease (ad) mouse models, and fails to reverse synaptic/cognitive deficits and ad-associated pathology in male mice. |
2022-08-09 |
2023-08-14 |
mouse |
| Jingqin Luo, Folasade Agboola, Elizabeth Grant, John C Morris, Colin L Masters, Marilyn S Albert, Sterling C Johnson, Eric M McDade, Anne M Fagan, Tammie L S Benzinger, Jason Hassenstab, Randall J Bateman, Richard J Perrin, Guoqiao Wang, Yan Li, Brian Gordon, Carlos Cruchaga, Gregory S Day, Johannes Levin, Jonathan Vöglein, Takeshi Ikeuchi, Kazushi Suzuki, Ricardo F Allegri, Chengjie Xion. Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan. Brain : a journal of neurology. 2022-08-04. PMID:35925685. |
the temporal evolutions and relative orderings of alzheimer disease biomarkers, including csf amyloid-β42 (aβ42), aβ40, total tau (tau) and phosphorylated tau181 (ptau181), standardized uptake value ratio (suvr) from the molecular imaging of cerebral fibrillar amyloid-β with pet using the 11c-pittsburgh compound-b (pib), mri-based hippocampal volume and cortical thickness and cognition have been hypothesized but not yet fully tested with longitudinal data for all major biomarker modalities among cognitively normal individuals across the adult lifespan starting from 18 years. |
2022-08-04 |
2023-08-14 |
human |
| Jingqin Luo, Folasade Agboola, Elizabeth Grant, John C Morris, Colin L Masters, Marilyn S Albert, Sterling C Johnson, Eric M McDade, Anne M Fagan, Tammie L S Benzinger, Jason Hassenstab, Randall J Bateman, Richard J Perrin, Guoqiao Wang, Yan Li, Brian Gordon, Carlos Cruchaga, Gregory S Day, Johannes Levin, Jonathan Vöglein, Takeshi Ikeuchi, Kazushi Suzuki, Ricardo F Allegri, Chengjie Xion. Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan. Brain : a journal of neurology. 2022-08-04. PMID:35925685. |
the earliest acceleration of longitudinal change occurred for csf aβ42 and aβ42/aβ40 ratio (with an increase) and for tau, and ptau181 (with a decrease) at the next baseline age interval of 45-50 years, followed by an accelerated increase for pib suvr at the baseline age of 50-55 years and an accelerated decrease for hippocampal volume at the baseline age of 55-60 years and finally by an accelerated decline for cortical thickness and cognition at the baseline age of 65-70 years. |
2022-08-04 |
2023-08-14 |
human |
| Jingqin Luo, Folasade Agboola, Elizabeth Grant, John C Morris, Colin L Masters, Marilyn S Albert, Sterling C Johnson, Eric M McDade, Anne M Fagan, Tammie L S Benzinger, Jason Hassenstab, Randall J Bateman, Richard J Perrin, Guoqiao Wang, Yan Li, Brian Gordon, Carlos Cruchaga, Gregory S Day, Johannes Levin, Jonathan Vöglein, Takeshi Ikeuchi, Kazushi Suzuki, Ricardo F Allegri, Chengjie Xion. Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan. Brain : a journal of neurology. 2022-08-04. PMID:35925685. |
another acceleration in the rate of change occurred at the baseline age of 65-70 years for aβ42/aβ40 ratio, tau, ptau181, pib suvr and hippocampal volume. |
2022-08-04 |
2023-08-14 |
human |