| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Burak Tan, Ercan Babur, Nihal Toy, Buse Günaydın, Nurcan Dursun, Cem Süe. Tau Protein is Differentially Phosphorylated in Young- and Old- Aged Rats with Experimentally Induced Hyperthyroidism. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2022-07-29. PMID:35904470. |
to clarify this issue, ltp and accompanying phosphorylation of tau protein in different residues were investigated in the hippocampus of young and old rats with experimentally induced hyperthyroidism. |
2022-07-29 |
2023-08-14 |
rat |
| Paola C Bello-Medina, Karina Corona-Cervantes, Norma Gabriela Zavala Torres, Antonio González, Marcel Pérez-Morales, Diego A González-Franco, Astrid Gómez, Jaime García-Mena, Sofía Díaz-Cintra, Gustavo Pacheco-Lópe. Chronic-Antibiotics Induced Gut Microbiota Dysbiosis Rescues Memory Impairment and Reduces β-Amyloid Aggregation in a Preclinical Alzheimer's Disease Model. International journal of molecular sciences. vol 23. issue 15. 2022-07-28. PMID:35897785. |
we assessed in offspring (f1) 3xtg, the effect of bgm dysbiosisdysbiosis in mothers (f0) at gestation and f1 from lactation up to the age of 5 months on aβ and tau levels in the hippocampus, as well as on spatial memory at the early symptomatic stage of ad. |
2022-07-28 |
2023-08-14 |
mouse |
| Paola C Bello-Medina, Karina Corona-Cervantes, Norma Gabriela Zavala Torres, Antonio González, Marcel Pérez-Morales, Diego A González-Franco, Astrid Gómez, Jaime García-Mena, Sofía Díaz-Cintra, Gustavo Pacheco-Lópe. Chronic-Antibiotics Induced Gut Microbiota Dysbiosis Rescues Memory Impairment and Reduces β-Amyloid Aggregation in a Preclinical Alzheimer's Disease Model. International journal of molecular sciences. vol 23. issue 15. 2022-07-28. PMID:35897785. |
on pd150, we observed a delay in spatial memory impairment and aβ deposits, but not in tau and ptau protein in the hippocampus at the early symptomatic stage of ad. |
2022-07-28 |
2023-08-14 |
mouse |
| Sanaz Arezoumandan, Sharon X Xie, Katheryn A Q Cousins, Dawn J Mechanic-Hamilton, Claire S Peterson, Camille Y Huang, Daniel T Ohm, Ranjit Ittyerah, Corey T McMillan, David A Wolk, Paul Yushkevich, John Q Trojanowski, Edward B Lee, Murray Grossman, Jeffrey S Phillips, David J Irwi. Regional distribution and maturation of tau pathology among phenotypic variants of Alzheimer's disease. Acta neuropathologica. 2022-07-23. PMID:35871112. |
here, we investigated the distribution and burden of phosphorylated and c-terminally cleaved tau pathologies across hippocampal subfields and cortical regions among phenotypic variants of alzheimer's disease (ad). |
2022-07-23 |
2023-08-14 |
Not clear |
| Alexandria B Marciante, John Howard, Mia N Kelly, Juan Santiago Moreno, Latoya L Allen, Elisa J Gonzalez-Rothi, Gordon S Mitchel. Dose-dependent Phosphorylation of Endogenous Tau by Intermittent Hypoxia in Rat Brain. Journal of applied physiology (Bethesda, Md. : 1985). 2022-07-21. PMID:35861520. |
we hypothesized cih characteristic of moderate sleep apnea would increase dysregulation of phosphorylated tau (phospho-tau) species in sprague-dawley rat hippocampus and pre-frontal cortex. |
2022-07-21 |
2023-08-14 |
human |
| Parul Katiyar, Aaina Singh Rathore, Somesh Banerjee, Sandip Nathani, Walia Zahra, Surya Pratap Singh, Debabrata Sircar, Partha Ro. Wheatgrass extract imparts neuroprotective actions against scopolamine-induced amnesia in mice. Food & function. 2022-07-21. PMID:35861716. |
wheatgrass treatment of mice also regulated the phosphorylation of tau protein and simultaneously prevented its aggregation in the hippocampal region of the brain. |
2022-07-21 |
2023-08-14 |
mouse |
| Diego Sepulveda-Falla, Justin S Sanchez, Maria Camila Almeida, Daniela Boassa, Juliana Acosta-Uribe, Clara Vila-Castelar, Liliana Ramirez-Gomez, Ana Baena, David Aguillon, Nelson David Villalba-Moreno, Jessica Lisa Littau, Andres Villegas, Thomas G Beach, Charles L White, Mark Ellisman, Susanne Krasemann, Markus Glatzel, Keith A Johnson, Reisa A Sperling, Eric M Reiman, Joseph F Arboleda-Velasquez, Kenneth S Kosik, Francisco Lopera, Yakeel T Quiro. Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer's dementia. Acta neuropathologica. 2022-07-15. PMID:35838824. |
the frontal cortex and the hippocampus, less affected than the occipital cortex by tau pathology, contained related orphan receptor b (rorb) positive neurons, homeostatic astrocytes and higher apoe expression. |
2022-07-15 |
2023-08-14 |
Not clear |
| Ying Han, Le Chen, Jingyun Liu, Jie Chen, Chunyang Wang, Yu Guo, Xuebin Yu, Chenghong Zhang, Haiying Chu, Haiying M. A Class I HDAC Inhibitor Rescues Synaptic Damage and Neuron Loss in APP-Transfected Cells and APP/PS1 Mice through the GRIP1/AMPA Pathway. Molecules (Basel, Switzerland). vol 27. issue 13. 2022-07-09. PMID:35807406. |
in vivo, bg45 alleviated the apoptosis-mediated loss of hippocampal neurons, upregulated synapse-related proteins, reduced aβ deposition and phosphorylation of tau, and increased the levels of the synapse-related genes grik2, scn3b, syp, grm2, and grid2ip. |
2022-07-09 |
2023-08-14 |
mouse |
| Lin Wang, Bi-Qiang Zhou, Ying-Hong Li, Qian-Qian Jiang, Wei-Hong Cong, Ke-Ji Chen, Xiao-Min Wen, Zheng-Zhi W. Lactoferrin modification of berberine nanoliposomes enhances the neuroprotective effects in a mouse model of Alzheimer's disease. Neural regeneration research. vol 18. issue 1. 2022-07-08. PMID:35799547. |
lactoferrin-modified berberine nanoliposomes inhibited acetylcholinesterase activity and apoptosis in the hippocampus, reduced tau over-phosphorylation in the cerebral cortex, and improved mouse behavior. |
2022-07-08 |
2023-08-14 |
mouse |
| Chih-Hsin Lin, Yu-Shao Hsieh, Ying-Chieh Sun, Wun-Han Huang, Shu-Ling Chen, Zheng-Kui Weng, Te-Hsien Lin, Yih-Ru Wu, Kuo-Hsuan Chang, Hei-Jen Huang, Guan-Chiun Lee, Hsiu Mei Hsieh-Li, Guey-Jen Lee-Che. Virtual Screening and Testing of GSK-3 Inhibitors Using Human SH-SY5Y Cells Expressing Tau Folding Reporter and Mouse Hippocampal Primary Culture under Tau Cytotoxicity. Biomolecules & therapeutics. 2022-07-05. PMID:35790892. |
virtual screening and testing of gsk-3 inhibitors using human sh-sy5y cells expressing tau folding reporter and mouse hippocampal primary culture under tau cytotoxicity. |
2022-07-05 |
2023-08-14 |
mouse |
| Meng Yang, Jing Wan. Berberine Ameliorates Cognitive Disorder via GSK3β/PGC-1α Signaling in APP/PS1 Mice. Journal of nutritional science and vitaminology. vol 68. issue 3. 2022-06-29. PMID:35768254. |
additionally, bbr significantly alleviated neuronal damage and reduced the levels of hyperphosphorylated tau at sites of thr205 and thr231 in hippocampus. |
2022-06-29 |
2023-08-14 |
mouse |
| Chao He, Ai-Hong Yuan, Jun Yang, Yin-Qiu Fan, Hong-Yu Xi. [Electroacupuncture improves learning-memory ability by down-regulating expression of hippocampal Aβ1-42 and Tau and NF-κB proteins in diabetic rats with cognitive impairment]. Zhen ci yan jiu = Acupuncture research. vol 47. issue 6. 2022-06-28. PMID:35764514. |
[electroacupuncture improves learning-memory ability by down-regulating expression of hippocampal aβ1-42 and tau and nf-κb proteins in diabetic rats with cognitive impairment]. |
2022-06-28 |
2023-08-14 |
rat |
| Ryszard Pluta, Sławomir Januszewski, Stanisław J Czuczwa. Molecular Hydrogen Neuroprotection in Post-Ischemic Neurodegeneration in the Form of Alzheimer's Disease Proteinopathy: Underlying Mechanisms and Potential for Clinical Implementation-Fantasy or Reality? International journal of molecular sciences. vol 23. issue 12. 2022-06-24. PMID:35743035. |
the death of pyramidal neurons in especially the ca1 area of the hippocampus, increased permeability of the blood-brain barrier, neuroinflammation, amyloid accumulation, tau protein dysfunction, brain atrophy, cognitive deficits and dementia are considered an integral part of the phenomena occurring during brain neurodegeneration after ischemia. |
2022-06-24 |
2023-08-14 |
Not clear |
| Hai Duc Nguyen, Won Hee Jo, Ngoc Hong Minh Hoang, Byung Pal Yu, Hae Young Chung, Min-Sun Ki. 1,2-Diacetylbenzene impaired hippocampal memory by activating proinflammatory cytokines and upregulating the prolactin pathway: An in vivo and in vitro study. International immunopharmacology. vol 108. 2022-06-22. PMID:35729834. |
qpcr, western blot, morris water maze, and rnaseq analysis were used to identify the association between inflammation and hyperphosphorylated tau in male dab-treated mice (1 or 5 mg/kg/day), rats (3 mg/kg/day), in vitro bv2 microglial cells (1 or 5 µm), and the hippocampal transcriptome of male dab-treated rats. |
2022-06-22 |
2023-08-14 |
mouse |
| Maiko Ono, Masaaki Komatsu, Bin Ji, Yuhei Takado, Masafumi Shimojo, Takeharu Minamihisamatsu, Eiji Warabi, Toru Yanagawa, Gen Matsumoto, Ichio Aoki, Nicholas M Kanaan, Tetsuya Suhara, Naruhiko Sahara, Makoto Higuch. Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy. Aging cell. 2022-06-06. PMID:35662390. |
p301s mutant tau transgenic mice (line ps19) exhibited accumulation of neurofibrillary tangles with localization of p62 mostly in the brainstem, but neuronal loss with few neurofibrillary tangles in the hippocampus. |
2022-06-06 |
2023-08-14 |
mouse |
| Maiko Ono, Masaaki Komatsu, Bin Ji, Yuhei Takado, Masafumi Shimojo, Takeharu Minamihisamatsu, Eiji Warabi, Toru Yanagawa, Gen Matsumoto, Ichio Aoki, Nicholas M Kanaan, Tetsuya Suhara, Naruhiko Sahara, Makoto Higuch. Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy. Aging cell. 2022-06-06. PMID:35662390. |
in the hippocampus of ps19 mice, the p62 level was lower compared to the brainstem, and punctate accumulation of phosphorylated tau unaccompanied by co-localization of p62 was observed. |
2022-06-06 |
2023-08-14 |
mouse |
| Maiko Ono, Masaaki Komatsu, Bin Ji, Yuhei Takado, Masafumi Shimojo, Takeharu Minamihisamatsu, Eiji Warabi, Toru Yanagawa, Gen Matsumoto, Ichio Aoki, Nicholas M Kanaan, Tetsuya Suhara, Naruhiko Sahara, Makoto Higuch. Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy. Aging cell. 2022-06-06. PMID:35662390. |
in ps19 mice deficient in p62 (ps19/p62-ko), increased accumulation of phosphorylated tau, acceleration of neuronal loss, and exacerbation of neuroinflammation were observed in the hippocampus as compared with ps19 mice. |
2022-06-06 |
2023-08-14 |
mouse |
| Kai-Min Hao, Zhen Liu, Hao-Yu Wang, Wen-Xiu Q. [Time dependent expression profiling of PTK2B and its relationship with Aβ, Tau and LRP-1 in hippocampus and blood of APPswe/PS1dE9 double-transgenic mouse]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 38. issue 1. 2022-05-31. PMID:35634664. |
[time dependent expression profiling of ptk2b and its relationship with aβ, tau and lrp-1 in hippocampus and blood of appswe/ps1de9 double-transgenic mouse]. |
2022-05-31 |
2023-08-13 |
mouse |
| Md Ataur Rahman, M D Hasanur Rahman, A N M Mamun-Or-Rashid, Hongik Hwang, Sooyoung Chung, Bonglee Kim, Hyewhon Rhi. Autophagy Modulation in Aggresome Formation: Emerging Implications and Treatments of Alzheimer's Disease. Biomedicines. vol 10. issue 5. 2022-05-28. PMID:35625764. |
alzheimer's disease (ad) is one of the most prevailing neurodegenerative diseases in the world, which is characterized by memory dysfunction and the formation of tau and amyloid β (aβ) aggregates in multiple brain regions, including the hippocampus and cortex. |
2022-05-28 |
2023-08-13 |
Not clear |
| Jiayin Zheng, Yue Wang, Yue Liu, Song Han, Ying Zhang, Yanlin Luo, Yi Yan, Junfa Li, Li Zha. cPKCγ Deficiency Exacerbates Autophagy Impairment and Hyperphosphorylated Tau Buildup through the AMPK/mTOR Pathway in Mice with Type 1 Diabetes Mellitus. Neuroscience bulletin. 2022-05-21. PMID:35596894. |
in this study, we found that knockout of conventional protein kinase c (cpkc)γ significantly increased the phosphorylation of tau at ser214 and neurofibrillary tangles, but did not affect the activities of gsk-3β and pp2a in the hippocampal neurons of t1dm mice. |
2022-05-21 |
2023-08-13 |
mouse |