| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Samar O El-Ganainy, Omar A Soliman, Aya A Ghazy, Maram Allam, Aya I Elbahnasi, Amira M Mansour, Mennatallah A Gowaye. Intranasal Oxytocin Attenuates Cognitive Impairment, β-Amyloid Burden and Tau Deposition in Female Rats with Alzheimer's Disease: Interplay of ERK1/2/GSK3β/Caspase-3. Neurochemical research. 2022-05-20. PMID:35596040. |
in addition, neuroprotective effects of oxytocin were examined by assessing hippocampal acetylcholinesterase activity, β-amyloid 1-42 protein, and tau levels. |
2022-05-20 |
2023-08-13 |
rat |
| Chaoli Huang, Teng He, Di Wang, Zifeng Wu, Yuanyuan Wang, Hanyu Liu, Jiali Xu, Chun Yang, Guiquan Chen, Cunming Li. PP2A-associated tau hyperphosphorylation was involved in sevoflurane induced neonatal neurotoxicity. Psychopharmacology. 2022-05-17. PMID:35579686. |
however, the exact mechanisms underlying hyperphosphorylation of tau protein in sevoflurane induced abnormalities in central nervous system (cns) development, particularly in the hippocampus, have not been fully determined. |
2022-05-17 |
2023-08-13 |
Not clear |
| Anna Mietelska-Porowska, Justyna Domańska, Andrew Want, Angelika Więckowska-Gacek, Dominik Chutorański, Maciej Koperski, Urszula Wojd. Induction of Brain Insulin Resistance and Alzheimer's Molecular Changes by Western Diet. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35563135. |
ad is the main cause of progressive dementia characterized by the deposition of amyloid-β (aβ) plaques and neurofibrillary tangles consisting of the hyperphosphorylated tau (p-tau) protein in the brain, starting from the entorhinal cortex and the hippocampus. |
2022-05-14 |
2023-08-13 |
mouse |
| Anna Mietelska-Porowska, Justyna Domańska, Andrew Want, Angelika Więckowska-Gacek, Dominik Chutorański, Maciej Koperski, Urszula Wojd. Induction of Brain Insulin Resistance and Alzheimer's Molecular Changes by Western Diet. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35563135. |
in this study, we report that wd-derived impairment in insulin signaling induces tau and aβ brain pathology in wild-type c57bl/6 mice, and that the entorhinal cortex is more sensitive than the hippocampus to the impairment of brain insulin signaling. |
2022-05-14 |
2023-08-13 |
mouse |
| S Tok, H Maurin, C Delay, D Crauwels, N V Manyakov, W Van Der Elst, D Moechars, W H I M Drinkenbur. Neurophysiological effects of human-derived pathological tau conformers in the APPKM670/671NL.PS1/L166P amyloid mouse model of Alzheimer's disease. Scientific reports. vol 12. issue 1. 2022-05-13. PMID:35546164. |
we also report immediate localized hippocampal dysfunction in the electroencephalography (eeg) power spectra associated with tau seeding which returned to comparable levels at 1 month-post-injection. |
2022-05-13 |
2023-08-13 |
mouse |
| Nan-Shan Chan. The strength of WWOX binding with protein partners correlates with cancer suppression and potentially with inhibition of Alzheimer's disease progression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35552574. |
gradual loss of wwox protein in the hippocampus and cortex starting from middle age may slowly induce aggregation of a protein cascade that ultimately causes accumulation of extracellular amyloid beta plaques and intracellular tau tangles, along with reduction in inhibitory gabaergic interneurons, in ad patients over 70 years old. |
2022-05-13 |
2023-08-13 |
mouse |
| Samantha K Baker, Na Wang, Guojun Bu, Chia-Chen Li. Effects of Microglia APOE Expression on Tau Pathology. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35557103. |
apoe3 expressing mice had exacerbated neurodegeneration and tau accumulation in the hippocampus. |
2022-05-13 |
2023-08-13 |
mouse |
| Mike T Lin, Chung-Sik Choi, Meredith Gwin, Sarah Voth, Claire Kolb, Chun Zhou, Amy R Nelson, Althea deWeever, Anna Koloteva, Naga S Annamdevula, James M Murphy, Brant M Wagener, Jean-Francois Pittet, Ssang-Taek S Lim, Ron T Balczon, Troy T Steven. Pulmonary Endothelial Tau Aggregation After Infection. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35557306. |
we previously hypothesized that the lung endothelium contributes to infection-related neurocognitive dysfunction, since bacteria-exposed endothelial cells release a form(s) of cytotoxic tau that is sufficient to impair long-term potentiation in the hippocampus. |
2022-05-13 |
2023-08-13 |
mouse |
| Elizabeth L Steuer, Lisa J Kemper, Chris J W Hlynialuk, Kailee Leinonen-Wright, Michelle L Montonye, Ian P Lapcinski, Colleen L Forster, Karen H Ashe, Peng Li. Blocking site-specific cleavage of human tau delays progression of disease-related phenotypes in genetically matched tau-transgenic mice modeling frontotemporal dementia. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-05-04. PMID:35508385. |
importantly, expression of the cleavage-resistant d314e mutant delays transgene-induced tau accumulation in the post-synaptic density, brain atrophy, hippocampal neurodegeneration, and spatial memory impairment, without altering age-related progression of pathological tau conformation and phosphorylation. |
2022-05-04 |
2023-08-13 |
mouse |
| Maryam Bazrgar, Pariya Khodabakhsh, Leila Dargahi, Fatemeh Mohagheghi, Abolhassan Ahmadian. MicroRNA modulation is a potential molecular mechanism for neuroprotective effects of intranasal insulin administration in amyloid βeta oligomer induced Alzheimer's like rat model. Experimental gerontology. 2022-04-27. PMID:35476966. |
we observed memory impairment, aβ aggregation, tau hyper-phosphorylation, neuroinflammation, insulin signaling dys-regulation, and down-regulation of mir-26a, mir-124, mir-29a, mir-181b, mir-125b, mir-132, and mir-146a in the hippocampus of aβo-exposed rats 21 days after aβo injection. |
2022-04-27 |
2023-08-13 |
rat |
| Lanxia Meng, Li Zou, Min Xiong, Jiehui Chen, Xingyu Zhang, Ting Yu, Yiming Li, Congcong Liu, Guiqin Chen, Zhihao Wang, Keqiang Ye, Zhentao Zhan. A synapsin Ⅰ cleavage fragment contributes to synaptic dysfunction in Alzheimer's disease. Aging cell. 2022-04-20. PMID:35443102. |
moreover, overexpression of the aep-generated synapsin Ⅰ (83-705) fragment in the hippocampus of tau p301s transgenic mice and wild-type mice promotes synaptic dysfunction and cognitive deficits. |
2022-04-20 |
2023-08-13 |
mouse |
| Giovanni Oliveros, Charles H Wallace, Osama Chaudry, Qiao Liu, Yue Qiu, Lei Xie, Patricia Rockwell, Maria E Figueiredo-Pereira, Peter A Serran. Repurposing ibudilast to mitigate Alzheimer's disease by targeting inflammation. Brain : a journal of neurology. 2022-04-12. PMID:35411386. |
this transgenic rat model is unique as it exhibits hippocampal-dependent spatial learning and memory deficits, and alzheimer's disease pathology including hippocampal amyloid plaques, tau paired-helical filaments, neuronal loss and microgliosis, in a progressive age-dependent manner that mimics the pathology observed in alzheimer's disease patients. |
2022-04-12 |
2023-08-13 |
rat |
| Giovanni Oliveros, Charles H Wallace, Osama Chaudry, Qiao Liu, Yue Qiu, Lei Xie, Patricia Rockwell, Maria E Figueiredo-Pereira, Peter A Serran. Repurposing ibudilast to mitigate Alzheimer's disease by targeting inflammation. Brain : a journal of neurology. 2022-04-12. PMID:35411386. |
we demonstrate that ibudilast-treatment of transgenic rats mitigated hippocampal-dependent spatial memory deficits, as well as hippocampal (hilar subregion) amyloid plaque and tau paired-helical filament load, and microgliosis compared to untreated transgenic rat. |
2022-04-12 |
2023-08-13 |
rat |
| Christian Conze, Marina Rierola, Nataliya I Trushina, Michael Peters, Dennis Janning, Max Holzer, Jürgen J Heinisch, Thomas Arendt, Lidia Bakota, Roland Brand. Caspase-cleaved tau is senescence-associated and induces a toxic gain of function by putting a brake on axonal transport. Molecular psychiatry. 2022-04-08. PMID:35393558. |
here we report that the proportion of tau that is proteolytically cleaved at the caspase-3 site (tauc3) doubles in the hippocampus of senescent mice. |
2022-04-08 |
2023-08-13 |
mouse |
| Shihong Li, Qiuzhi Zhou, Enjie Liu, Huiyun Du, Nana Yu, Haitao Yu, Weijin Wang, Mengzhu Li, Ying Weng, Yang Gao, Guilin Pi, Xin Wang, Dan Ke, Jian-Zhi Wan. Alzheimer-like tau accumulation in dentate gyrus mossy cells induces spatial cognitive deficits by disrupting multiple memory-related signaling and inhibiting local neural circuit. Aging cell. 2022-03-31. PMID:35355405. |
in the current study, we observed a prominent accumulation of the ad-like hyperphosphorylated and truncated tau (htau n368) proteins in hippocampal dentate gyrus (dg) mossy cells of 3xtg-ad mice. |
2022-03-31 |
2023-08-13 |
mouse |
| Simon Dujardin, Analiese Fernandes, Riley Bannon, Caitlin Commins, Mark De Los Santos, Tarun V Kamath, Mansuo Hayashi, Bradley T Hyma. Tau propagation is dependent on the genetic background of mouse strains. Brain communications. vol 4. issue 2. 2022-03-30. PMID:35350555. |
we virally expressed human tau locally in the hippocampus and the entorhinal cortex neurons and monitored the cell-to-cell tau protein spread by immunolabelling. |
2022-03-30 |
2023-08-13 |
mouse |
| Emrah Düzel, Gabriel Ziegler, David Berron, Anne Maass, Hartmut Schütze, Arturo Cardenas-Blanco, Wenzel Glanz, Coraline Metzger, Laura Dobisch, Martin Reuter, Annika Spottke, Frederic Brosseron, Klaus Fliessbach, Michael T Heneka, Christoph Laske, Oliver Peters, Josef Priller, Eike Jakob Spruth, Alfredo Ramirez, Oliver Speck, Anja Schneider, Stefan Teipel, Ingo Kilimann, Wiltfang Jens, Björn-Hendrik Schott, Lukas Preis, Daria Gref, Franziska Maier, Matthias H Munk, Nina Roy, Tomasso Ballarini, Renat Yakupov, John Dylan Haynes, Peter Dechent, Klaus Scheffler, Michael Wagner, Frank Jesse. Amyloid pathology but not APOE ε4 status is permissive for tau-related hippocampal dysfunction. Brain : a journal of neurology. 2022-03-30. PMID:35352105. |
apoe status (presence of the e4 allele), a known genetic risk factor for alzheimer's disease, did not mediate the relationship between tau pathology and hippocampal function and memory performance. |
2022-03-30 |
2023-08-13 |
human |
| Emrah Düzel, Gabriel Ziegler, David Berron, Anne Maass, Hartmut Schütze, Arturo Cardenas-Blanco, Wenzel Glanz, Coraline Metzger, Laura Dobisch, Martin Reuter, Annika Spottke, Frederic Brosseron, Klaus Fliessbach, Michael T Heneka, Christoph Laske, Oliver Peters, Josef Priller, Eike Jakob Spruth, Alfredo Ramirez, Oliver Speck, Anja Schneider, Stefan Teipel, Ingo Kilimann, Wiltfang Jens, Björn-Hendrik Schott, Lukas Preis, Daria Gref, Franziska Maier, Matthias H Munk, Nina Roy, Tomasso Ballarini, Renat Yakupov, John Dylan Haynes, Peter Dechent, Klaus Scheffler, Michael Wagner, Frank Jesse. Amyloid pathology but not APOE ε4 status is permissive for tau-related hippocampal dysfunction. Brain : a journal of neurology. 2022-03-30. PMID:35352105. |
thus, our data show that the presence of amyloid pathology is associated with a linear relationship between tau pathology, hippocampal dysfunction and memory impairment, although the actual severity of amyloid pathology is uncorrelated. |
2022-03-30 |
2023-08-13 |
human |
| Lorena Xolalpa-Cueva, Carlos Antonio García-Carlos, Rocío Villaseñor-Zepeda, Erika Orta-Salazar, Sofia Díaz-Cintra, Fernando Peña-Ortega, George Perry, Siddhartha Mondragón-Rodrígue. Hyperphosphorylated Tau Relates to Improved Cognitive Performance and Reduced Hippocampal Excitability in the Young rTg4510 Mouse Model of Tauopathy. Journal of Alzheimer's disease : JAD. 2022-03-28. PMID:35342085. |
hyperphosphorylated tau relates to improved cognitive performance and reduced hippocampal excitability in the young rtg4510 mouse model of tauopathy. |
2022-03-28 |
2023-08-13 |
mouse |
| Kurt A Jellinge. Heterogeneity of Multiple System Atrophy: An Update. Biomedicines. vol 10. issue 3. 2022-03-25. PMID:35327402. |
in addition to rare combined or "mixed" msa, there is a broad spectrum of atypical msa variants, such as those with a different age at onset and disease duration, "minimal change" or prodromal forms, msa variants with lewy body disease or severe hippocampal pathology, rare forms with an unusual tau pathology or spinal myoclonus, an increasing number of msa cases with cognitive impairment/dementia, rare familial forms, and questionable conjugal msa. |
2022-03-25 |
2023-08-13 |
Not clear |