All Relations between microtubule-associated protein tau and hippocampus

Publication Sentence Publish Date Extraction Date Species
Gabriel Boer Grigoletti-Lima, Marcelo Gustavo Lopes, Ana Tereza Barufi Franco, Aparecida Marcela Damico, Patrìcia Aline Boer, José Antonio Rocha Gontij. Severe Gestational Low-Protein Intake Impacts Hippocampal Cellularity, Tau, and Amyloid-β Levels, and Memory Performance in Male Adult Offspring: An Alzheimer-Simile Disease Model? Journal of Alzheimer's disease reports. vol 6. issue 1. 2022-03-04. PMID:35243209. severe gestational low-protein intake impacts hippocampal cellularity, tau, and amyloid-β levels, and memory performance in male adult offspring: an alzheimer-simile disease model? 2022-03-04 2023-08-13 Not clear
Bin Qiu, Zhaohui Zhong, Shawn Righter, Yuxue Xu, Jun Wang, Ran Deng, Chao Wang, Kent E Williams, Yao-Ying Ma, Gavriil Tsechpenakis, Tiebing Liang, Weidong Yon. FKBP51 modulates hippocampal size and function in post-translational regulation of Parkin. Cellular and molecular life sciences : CMLS. vol 79. issue 3. 2022-03-04. PMID:35244772. ko has more flattened hippocampus using ai-assisted measurement both pyramidal cell layer (pcl) of ca and granular cell layer (gcl) of dg distinguishable as two layers: deep cell layer and superficial layer. distinct map2 expression between deep and superficial layer between ko and wt, higher parkin expression in ko brain mechanism of fkbp51 inhibition resulting in parkin, map2, tau, and tubulin expression differences between ko and wt mice, and resulting neurite outgrowth differences. 2022-03-04 2023-08-13 mouse
Ping Xu, Liang Xu, Shuyun Huang, Danfeng Li, Yanping Liu, Hongmin Guo, Niuniu Dai, Zongyuan Hong, Shuzhi Zhon. Analysis of the Molecular Mechanism of Punicalagin in the Treatment of Alzheimer's Disease by Computer-Aided Drug Research Technology. ACS omega. vol 7. issue 7. 2022-02-28. PMID:35224375. the amyloid β protein (aβ) in the hippocampus was examined by immunohistochemistry, and the phosphorylation of serine at position 404 of the tau protein (tau-ps404) was examined by western blot in the mouse brain. 2022-02-28 2023-08-13 mouse
Li-Fan Lin, Yun-Ting Jhao, Chuang-Hsin Chiu, Lu-Han Sun, Ta-Kai Chou, Chyng-Yann Shiue, Cheng-Yi Cheng, Kuo-Hsing M. Bezafibrate Exerts Neuroprotective Effects in a Rat Model of Sporadic Alzheimer's Disease. Pharmaceuticals (Basel, Switzerland). vol 15. issue 2. 2022-02-26. PMID:35215222. stz-icv administration induced significant cognitive impairment and substantial neuronal loss, tau pathology, glucose hypometabolism, and microgliosis in the cortex and hippocampus, while bezafibrate effectively attenuated these abnormalities. 2022-02-26 2023-08-13 mouse
Tomohiro Umeda, Rumi Uekado, Keiko Shigemori, Hiroshi Eguchi, Takami Tomiyam. Nasal Rifampicin Halts the Progression of Tauopathy by Inhibiting Tau Oligomer Propagation in Alzheimer Brain Extract-Injected Mice. Biomedicines. vol 10. issue 2. 2022-02-25. PMID:35203506. a tau oligomer-rich fraction prepared from the brain of an ad patient was injected into a unilateral hippocampus of tau264 mice that express both 3-repeat and 4-repeat wild-type human tau. 2022-02-25 2023-08-13 mouse
Sang-Seo Park, Hye-Sang Park, Chang-Ju Kim, Seung-Soo Baek, Song-Young Park, Cody Philip Anderson, Myung-Ki Kim, Ik-Ryeul Park, Tae-Woon Ki. Combined effects of Aerobic exercise and 40Hz light flicker exposure on early cognitive impairments in Alzheimer's disease of 3xTg mice. Journal of applied physiology (Bethesda, Md. : 1985). 2022-02-24. PMID:35201933. spatial learning and memory, long-term memory, hippocampal aβ, tau, neuroinflammation, pro-inflammatory cytokine expression, mitochondrial function, and neuroplasticity, were analyzed. 2022-02-24 2023-08-13 mouse
Noorul Hasan, Saima Zameer, Abul Kalam Najmi, Suhel Parvez, Mohd Akhta. Roflumilast Reduces Pathological Symptoms of Sporadic Alzheimer's Disease in Rats Produced by Intracerebroventricular Streptozotocin by Inhibiting NF-κB/BACE-1 Mediated Aβ Production in the Hippocampus and Activating the cAMP/BDNF Signalling Pathway. Neurotoxicity research. 2022-02-22. PMID:35192144. rfm was found to significantly reduce icv-stz-induced neuroinflammation, amyloidogenesis, oxidative stress cholinergic impairments, gsk-3β, and phosphorylated tau levels in the rat hippocampus. 2022-02-22 2023-08-13 rat
Ilie Cosmin Stancu, Chritica Lodder, Pablo Botella Lucena, Sarah Vanherle, Manuel Gutiérrez de Ravé, Dick Terwel, Astrid Bottelbergs, Ilse Dewachte. The NLRP3 inflammasome modulates tau pathology and neurodegeneration in a tauopathy model. Glia. 2022-02-17. PMID:35174546. in this model we studied non-seeded tau pathology and hippocampal atrophy, reminiscent characteristics of tauopathies. 2022-02-17 2023-08-13 mouse
Ilie Cosmin Stancu, Chritica Lodder, Pablo Botella Lucena, Sarah Vanherle, Manuel Gutiérrez de Ravé, Dick Terwel, Astrid Bottelbergs, Ilse Dewachte. The NLRP3 inflammasome modulates tau pathology and neurodegeneration in a tauopathy model. Glia. 2022-02-17. PMID:35174546. tau pathology in hippocampus and cortex was significantly decreased in tau.nlrp3-/- versus tau.nlrp3+/+ mice. 2022-02-17 2023-08-13 mouse
Ilie Cosmin Stancu, Chritica Lodder, Pablo Botella Lucena, Sarah Vanherle, Manuel Gutiérrez de Ravé, Dick Terwel, Astrid Bottelbergs, Ilse Dewachte. The NLRP3 inflammasome modulates tau pathology and neurodegeneration in a tauopathy model. Glia. 2022-02-17. PMID:35174546. we furthermore assessed the effect of nlrp3 deficiency on tau propagation and associated hippocampal atrophy. 2022-02-17 2023-08-13 mouse
Ilie Cosmin Stancu, Chritica Lodder, Pablo Botella Lucena, Sarah Vanherle, Manuel Gutiérrez de Ravé, Dick Terwel, Astrid Bottelbergs, Ilse Dewachte. The NLRP3 inflammasome modulates tau pathology and neurodegeneration in a tauopathy model. Glia. 2022-02-17. PMID:35174546. nlrp3 deficiency significantly decreased prion-like seeding and propagation of tau pathology, reflected in decreased tau pathology in ipsi- and contralateral hippocampus and cortex in tau.nlrp3-/- following tau seeding. 2022-02-17 2023-08-13 mouse
Xiao-Bo Yang, Heng-Bing Zu, Yong-Fei Zhao, Kai Ya. Agomelatine Prevents Amyloid Plaque Deposition, Tau Phosphorylation, and Neuroinflammation in APP/PS1 Mice. Frontiers in aging neuroscience. vol 13. 2022-02-14. PMID:35153715. in this study, we found that agomelatine attenuated spatial memory deficit, amyloid-β (aβ) deposition, tau phosphorylation, and neuroinflammation in the hippocampus of app/ps1 mice. 2022-02-14 2023-08-13 mouse
Marta Scarioni, Priya Gami-Patel, Carel F W Peeters, Florianne de Koning, Harro Seelaar, Merel O Mol, John C van Swieten, Annemieke J M Rozemuller, Jeroen J M Hoozemans, Yolande A L Pijnenburg, Anke A Dijkstr. Psychiatric symptoms of frontotemporal dementia and subcortical (co-)pathology burden: new insights. Brain : a journal of neurology. 2022-02-09. PMID:35136978. in subcortical regions, the presence of psychiatric symptoms showed positive correlations with increased hippocampal pathology burden: hallucinations with tdp-43 in the granular layer (r = 0.33), mania with tdp-43 in ca1 (r = 0.35), depression with tdp-43 in ca3 and with parahippocampal tau (r = 0.30 and r = 0.23), and delusions with ca3 tau (r = 0.26) and subicular amyloid-beta (r = 0.25). 2022-02-09 2023-08-13 Not clear
Alexander Neumann, Michelle Vangoidsenhoven, Fahri Küçükali, Stephanie J B Vos, Mara Ten Kate, Frederik Barkhof, Henrik Zetterberg, Lars Bertram, Pieter Jelle Visser, Christine Van Broeckhoven, Kristel Sleeger. Exome-wide rare variant analysis of Alzheimer's disease biomarkers: The EMIF-AD multimodal biomarker discovery study. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108853. we performed an exome-wide rare variant analysis of six biomarkers measured in cerebrospinal fluid (β-amyloid, total tau/phosphorylated tau, nfl, ykl-40, and neurogranin) and hippocampal volume as measured by mri. 2022-02-03 2023-08-13 Not clear
Eduardo R Zimmer, Bruna Bellaver, Wagner Scheeren Brum, Pamela C L Ferreira, Guilherme Povala, Andreia Silva da Rocha, Débora Guerini de Souza, Marco Antônio De Bastian. Tau pathology reshapes GFAP-positive astrocytes phenotype. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109062. here, we aimed at evaluating hippocampal astrocyte phenotypes in the presence of tau pathology in a transgenic human tau mouse model. 2022-02-03 2023-08-13 mouse
Eduardo R Zimmer, Bruna Bellaver, Wagner Scheeren Brum, Pamela C L Ferreira, Guilherme Povala, Andreia Silva da Rocha, Débora Guerini de Souza, Marco Antônio De Bastian. Tau pathology reshapes GFAP-positive astrocytes phenotype. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109062. we hypothesize that hippocampal astrocytes will respond to tau pathology by assuming a reactive phenotype. 2022-02-03 2023-08-13 mouse
Sanaz Arezoumandan, Katheryn A Q Cousins, Jeffrey S Phillips, Daniel T Ohm, Claire Peterson, Ranjit Ittyerah, Corey T McMillan, David A Wolk, Paul A Yushkevich, John Q Trojanowski, Eddie B Lee, Murray Grossman, David J Irwi. Regional distribution of tau pathology in subfields of hippocampus among phenotypic variants of AD and FTLD-tau. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109105. regional distribution of tau pathology in subfields of hippocampus among phenotypic variants of ad and ftld-tau. 2022-02-03 2023-08-13 Not clear
Sanaz Arezoumandan, Katheryn A Q Cousins, Jeffrey S Phillips, Daniel T Ohm, Claire Peterson, Ranjit Ittyerah, Corey T McMillan, David A Wolk, Paul A Yushkevich, John Q Trojanowski, Eddie B Lee, Murray Grossman, David J Irwi. Regional distribution of tau pathology in subfields of hippocampus among phenotypic variants of AD and FTLD-tau. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109105. moreover, previous work finds relative sparing of the hippocampal formation compared to typical amnestic ad (aad); however, there is limited data on the regional patterns of tau pathology across subfields of the hippocampus in naad or comparisons with clinically-similar non-amnestic forms of frontotemporal lobar degeneration tauopathies (ftld-tau). 2022-02-03 2023-08-13 Not clear
Sanaz Arezoumandan, Katheryn A Q Cousins, Jeffrey S Phillips, Daniel T Ohm, Claire Peterson, Ranjit Ittyerah, Corey T McMillan, David A Wolk, Paul A Yushkevich, John Q Trojanowski, Eddie B Lee, Murray Grossman, David J Irwi. Regional distribution of tau pathology in subfields of hippocampus among phenotypic variants of AD and FTLD-tau. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109105. here, we perform detailed postmortem comparisons of pathologic burden within the well-established anatomic framework of spreading ad tau pathology within hippocampal subfields to test for divergent microscopic patterns of disease between non-amnestic tauopathies (naad, ftld-tau) and amnestic ad. 2022-02-03 2023-08-13 Not clear
Marangelie Criado-Marrero, Lindsey B Shelton, Laura J Blai. Reduction in Aha1 chaperone preserves hippocampal neurons and prevents tau-related pathology in rTg4510 tau transgenic mice. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109351. reduction in aha1 chaperone preserves hippocampal neurons and prevents tau-related pathology in rtg4510 tau transgenic mice. 2022-02-03 2023-08-13 mouse