| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eduardo R Zimmer, Bruna Bellaver, Wagner Scheeren Brum, Pamela C L Ferreira, Guilherme Povala, Andreia Silva da Rocha, Débora Guerini de Souza, Marco Antônio De Bastian. Tau pathology reshapes GFAP-positive astrocytes phenotype. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109062. |
here, we aimed at evaluating hippocampal astrocyte phenotypes in the presence of tau pathology in a transgenic human tau mouse model. |
2022-02-03 |
2023-08-13 |
mouse |
| Eduardo R Zimmer, Bruna Bellaver, Wagner Scheeren Brum, Pamela C L Ferreira, Guilherme Povala, Andreia Silva da Rocha, Débora Guerini de Souza, Marco Antônio De Bastian. Tau pathology reshapes GFAP-positive astrocytes phenotype. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109062. |
we hypothesize that hippocampal astrocytes will respond to tau pathology by assuming a reactive phenotype. |
2022-02-03 |
2023-08-13 |
mouse |
| Sanaz Arezoumandan, Katheryn A Q Cousins, Jeffrey S Phillips, Daniel T Ohm, Claire Peterson, Ranjit Ittyerah, Corey T McMillan, David A Wolk, Paul A Yushkevich, John Q Trojanowski, Eddie B Lee, Murray Grossman, David J Irwi. Regional distribution of tau pathology in subfields of hippocampus among phenotypic variants of AD and FTLD-tau. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109105. |
regional distribution of tau pathology in subfields of hippocampus among phenotypic variants of ad and ftld-tau. |
2022-02-03 |
2023-08-13 |
Not clear |
| Sanaz Arezoumandan, Katheryn A Q Cousins, Jeffrey S Phillips, Daniel T Ohm, Claire Peterson, Ranjit Ittyerah, Corey T McMillan, David A Wolk, Paul A Yushkevich, John Q Trojanowski, Eddie B Lee, Murray Grossman, David J Irwi. Regional distribution of tau pathology in subfields of hippocampus among phenotypic variants of AD and FTLD-tau. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109105. |
moreover, previous work finds relative sparing of the hippocampal formation compared to typical amnestic ad (aad); however, there is limited data on the regional patterns of tau pathology across subfields of the hippocampus in naad or comparisons with clinically-similar non-amnestic forms of frontotemporal lobar degeneration tauopathies (ftld-tau). |
2022-02-03 |
2023-08-13 |
Not clear |
| Sanaz Arezoumandan, Katheryn A Q Cousins, Jeffrey S Phillips, Daniel T Ohm, Claire Peterson, Ranjit Ittyerah, Corey T McMillan, David A Wolk, Paul A Yushkevich, John Q Trojanowski, Eddie B Lee, Murray Grossman, David J Irwi. Regional distribution of tau pathology in subfields of hippocampus among phenotypic variants of AD and FTLD-tau. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109105. |
here, we perform detailed postmortem comparisons of pathologic burden within the well-established anatomic framework of spreading ad tau pathology within hippocampal subfields to test for divergent microscopic patterns of disease between non-amnestic tauopathies (naad, ftld-tau) and amnestic ad. |
2022-02-03 |
2023-08-13 |
Not clear |
| Marangelie Criado-Marrero, Lindsey B Shelton, Laura J Blai. Reduction in Aha1 chaperone preserves hippocampal neurons and prevents tau-related pathology in rTg4510 tau transgenic mice. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109351. |
reduction in aha1 chaperone preserves hippocampal neurons and prevents tau-related pathology in rtg4510 tau transgenic mice. |
2022-02-03 |
2023-08-13 |
mouse |
| Mohaddeseh Sadat Alavi, Sahar Fanoudi, Mahmoud Hosseini, Hamid R Sadeghni. Beneficial effects of levetiracetam in streptozotocin-induced rat model of Alzheimer's disease. Metabolic brain disease. 2022-01-31. PMID:35098412. |
in addition, lev suppressed stz-induced hippocampal neuronal loss, while restored alterations in the redox status (lipid peroxides and glutathione), ache activity, proinflammatory cytokines (il-1β, il-6, tnf-α), and hyperphosphorylation of tau linked to stz administration. |
2022-01-31 |
2023-08-13 |
rat |
| Mohaddeseh Sadat Alavi, Sahar Fanoudi, Mahmoud Hosseini, Hamid R Sadeghni. Beneficial effects of levetiracetam in streptozotocin-induced rat model of Alzheimer's disease. Metabolic brain disease. 2022-01-31. PMID:35098412. |
in conclusion, our study demonstrated that lev alleviated hippocampal cell death and memory deficits in stz-ad rats, through mitigating oxidative damage, suppression of proinflammatory cytokines expression, and inhibition of abnormal tau hyperphosphorylation. |
2022-01-31 |
2023-08-13 |
rat |
| Xiaoqian Peng, Li Chen, Zijuan Wang, Yingying He, John Bosco Ruganzu, Hongsong Guo, Xiao Zhang, Shengfeng Ji, Liming Zheng, Weina Yan. Tanshinone IIA regulates glycogen synthase kinase-3β-related signaling pathway and ameliorates memory impairment in APP/PS1 transgenic mice. European journal of pharmacology. 2022-01-29. PMID:35090935. |
additionally, tan iia markedly attenuated tau hyperphosphorylation and prevented neuronal loss and apoptosis in the parietal cortex and hippocampus. |
2022-01-29 |
2023-08-13 |
mouse |
| Maha A Hegazy, Doaa A Abdelmonsif, Teshreen M Zeitoun, Norhan S El-Sayed, Doaa M Sam. Swimming exercise versus L-carnosine supplementation for Alzheimer's dementia in rats: implication of circulating and hippocampal FNDC5/irisin. Journal of physiology and biochemistry. 2022-01-29. PMID:35091983. |
hippocampal tissues were used to assess expression of fndc5/irisin, bdnf and proteins related to insulin signalling, in addition to β-amyloid peptide and phosphorylated tau protein levels. |
2022-01-29 |
2023-08-13 |
rat |
| Maha A Hegazy, Doaa A Abdelmonsif, Teshreen M Zeitoun, Norhan S El-Sayed, Doaa M Sam. Swimming exercise versus L-carnosine supplementation for Alzheimer's dementia in rats: implication of circulating and hippocampal FNDC5/irisin. Journal of physiology and biochemistry. 2022-01-29. PMID:35091983. |
exercise and carnosine intake almost normalized hippocampal fndc5/irisin expression which was associated with reduced soluble β-amyloid peptide and phosphorylated tau protein, improved bdnf and insulin signalling proteins, with corresponding mitigated cognitive impairments. |
2022-01-29 |
2023-08-13 |
rat |
| Munehisa Maeshiba, Hiroshi Kajiya, Takashi Tsutsumi, Keisuke Migita, Kazuko Goto-T, Yuri Kono, Takashi Tsuzuki, Jun Ohn. Occlusal disharmony transiently decrease cognition via cognitive suppressor molecules and partially restores cognitive ability via clearance molecules. Biochemical and biophysical research communications. vol 594. 2022-01-25. PMID:35078110. |
the expression levels of amyloid-β and phosphorylated tau were significantly upregulated 1 week after hyperocclusal loading in the hippocampus of 2-month-old mice but were constant in 12-month-old mice. |
2022-01-25 |
2023-08-13 |
mouse |
| Anton Meinicke, Wolfgang Härtig, Karsten Winter, Joana Puchta, Bianca Mages, Dominik Michalski, Alexander Emmer, Markus Otto, Karl-Titus Hoffmann, Willi Reimann, Matthias Krause, Stefan Scho. Surfactant Protein-G in Wildtype and 3xTg-AD Mice: Localization in the Forebrain, Age-Dependent Hippocampal Dot-like Deposits and Brain Content. Biomolecules. vol 12. issue 1. 2022-01-21. PMID:35053244. |
exploring whether sp-g might play a role in alzheimer's disease (ad), 3xtg-ad mice were investigated and displayed age-dependent hippocampal deposits of β-amyloid and hyperphosphorylated tau separately from clustered, sp-g-containing dots with additional reelin-ir-which was used as established marker for disease progression in this specific context. |
2022-01-21 |
2023-08-13 |
mouse |
| Pol Andrés-Benito, Margarita Carmona, Mónica Jordán, Joaquín Fernández-Irigoyen, Enrique Santamaría, José Antoni Del Rio, Isidro Ferre. Host Tau Genotype Specifically Designs and Regulates Tau Seeding and Spreading and Host Tau Transformation Following Intrahippocampal Injection of Identical Tau AD Inoculum. International journal of molecular sciences. vol 23. issue 2. 2022-01-21. PMID:35054902. |
the brains of three adult murine genotypes expressing different forms of tau-wt (murine 4rtau), htau (homozygous transgenic mice knock-out for murine tau protein and heterozygous expressing human forms of 3rtau and 4rtau proteins), and mtwt (homozygous transgenic mice knock-out for murine tau protein)-were analyzed following unilateral hippocampal inoculation of sarkosyl-insoluble tau fractions from the same ad and control cases. |
2022-01-21 |
2023-08-13 |
mouse |
| Melanie Alpaugh, Maria Masnata, Aurelie de Rus Jacquet, Eva Lepinay, Hélèna L Denis, Martine Saint-Pierre, Peter Davies, Emmanuel Planel, Francesca Cicchett. Passive immunization against phosphorylated tau improves features of Huntington's disease pathology. Molecular therapy : the journal of the American Society of Gene Therapy. 2022-01-20. PMID:35051614. |
after 12 weeks of treatment, motor impairments, cognitive performance and general health were improved in zq175 mice along with a significant reduction in hippocampal ps202 tau levels. |
2022-01-20 |
2023-08-13 |
mouse |
| Xue Mi, Haiqiao Du, Xinmeng Guo, Yan Wu, Long Shen, Yukun Luo, Dekun Wang, Qiuyue Su, Rong Xiang, Shijing Yue, Songgu Wu, Junbo Gong, Zhuo Yang, Yuying Zhang, Xiaoyue Ta. Asparagine endopeptidase-targeted Ultrasound-responsive Nanobubbles Alleviate Tau Cleavage and Amyloid-β Deposition in an Alzheimer's Disease Model. Acta biomaterialia. 2022-01-19. PMID:35045359. |
as a result, co-administration of nb(11a)-a and nb(11a)-r significantly promoted accumulation of rr-11a in the mouse brain, and substantially alleviated both tau cleavage and amyloid plaques deposition in the hippocampus. |
2022-01-19 |
2023-08-13 |
mouse |
| Xue Mi, Haiqiao Du, Xinmeng Guo, Yan Wu, Long Shen, Yukun Luo, Dekun Wang, Qiuyue Su, Rong Xiang, Shijing Yue, Songgu Wu, Junbo Gong, Zhuo Yang, Yuying Zhang, Xiaoyue Ta. Asparagine endopeptidase-targeted Ultrasound-responsive Nanobubbles Alleviate Tau Cleavage and Amyloid-β Deposition in an Alzheimer's Disease Model. Acta biomaterialia. 2022-01-19. PMID:35045359. |
our results indicated that, co-administration of the nb(11a)-a and nb(11a)-r significantly enhanced accumulation of rr-11a molecules at the ad lesion, alleviated both tau cleavage and amyloid plaques deposition in the hippocampus, and consequently restored cognitive function of the ad model mice. |
2022-01-19 |
2023-08-13 |
mouse |
| Hongxia Yu, Jianhong Shi, Yiyou Lin, Yehui Zhang, Qihang Luo, Suo Huang, Sichen Wang, Jiale Wei, Junhao Huang, Changyu Li, Liting J. Icariin Ameliorates Alzheimer's Disease Pathology by Alleviating Myelin Injury in 3 × Tg-AD Mice. Neurochemical research. 2022-01-17. PMID:35037164. |
tau protein phosphorylation and mbp protein expression in the hippocampus were further analyzed by western blotting. |
2022-01-17 |
2023-08-13 |
mouse |
| Hongxia Yu, Jianhong Shi, Yiyou Lin, Yehui Zhang, Qihang Luo, Suo Huang, Sichen Wang, Jiale Wei, Junhao Huang, Changyu Li, Liting J. Icariin Ameliorates Alzheimer's Disease Pathology by Alleviating Myelin Injury in 3 × Tg-AD Mice. Neurochemical research. 2022-01-17. PMID:35037164. |
we observed that ica treatment improved the learning and memory of 3 × tg-ad mice and reduced aβ deposition and tau protein phosphorylation in the hippocampus. |
2022-01-17 |
2023-08-13 |
mouse |
| Steven G Fagan, Sibylle Bechet, Kumlesh K De. Fingolimod Rescues Memory and Improves Pathological Hallmarks in the 3xTg-AD Model of Alzheimer's Disease. Molecular neurobiology. 2022-01-15. PMID:35031916. |
finally, treatment with fingolimod was shown to reduce phosphorylated tau and app levels in the hippocampus and cortex. |
2022-01-15 |
2023-08-13 |
mouse |