| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David Berron, Jacob W Vogel, Philip S Insel, Joana B Pereira, Long Xie, Laura E M Wisse, Paul A Yushkevich, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Erik Stomrud, Ruben Smith, Olof Strandberg, Oskar Hansso. Early stages of tau pathology and its associations with functional connectivity, atrophy and memory. Brain : a journal of neurology. vol 144. issue 9. 2021-12-09. PMID:33725124. |
second, in cognitively unimpaired individuals, increased tau load was related to local atrophy in the entorhinal cortex, brodmann area 35 and the anterior hippocampus and tau load in several anterior medial temporal lobe subregions was associated with distant atrophy of the posterior hippocampus. |
2021-12-09 |
2023-08-13 |
human |
| David Berron, Jacob W Vogel, Philip S Insel, Joana B Pereira, Long Xie, Laura E M Wisse, Paul A Yushkevich, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Erik Stomrud, Ruben Smith, Olof Strandberg, Oskar Hansso. Early stages of tau pathology and its associations with functional connectivity, atrophy and memory. Brain : a journal of neurology. vol 144. issue 9. 2021-12-09. PMID:33725124. |
finally, in patients with mild cognitive impairment, the association of tau load in the hippocampus with memory performance was partially mediated by posterior hippocampal atrophy. |
2021-12-09 |
2023-08-13 |
human |
| David Berron, Jacob W Vogel, Philip S Insel, Joana B Pereira, Long Xie, Laura E M Wisse, Paul A Yushkevich, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Erik Stomrud, Ruben Smith, Olof Strandberg, Oskar Hansso. Early stages of tau pathology and its associations with functional connectivity, atrophy and memory. Brain : a journal of neurology. vol 144. issue 9. 2021-12-09. PMID:33725124. |
while tau pathology might affect memory performance in cognitively unimpaired individuals via reduced functional connectivity in critical medial temporal lobe-cortical networks, memory impairment in mild cognitively impaired patients is associated with posterior hippocampal atrophy. |
2021-12-09 |
2023-08-13 |
human |
| Fang Yuan, Xiao-Ping Hong, Yan-Jun Duan, Jiao-Rong Chen, Yong-Ming Ha. [Electroacupuncture at "Zusanli"(ST36) ameliorates tau hyperphosphorylation in pancreas and hippocampus of diabetic rats]. Zhen ci yan jiu = Acupuncture research. vol 46. issue 11. 2021-12-08. PMID:34865325. |
[electroacupuncture at "zusanli"(st36) ameliorates tau hyperphosphorylation in pancreas and hippocampus of diabetic rats]. |
2021-12-08 |
2023-08-13 |
rat |
| Fang Yuan, Xiao-Ping Hong, Yan-Jun Duan, Jiao-Rong Chen, Yong-Ming Ha. [Electroacupuncture at "Zusanli"(ST36) ameliorates tau hyperphosphorylation in pancreas and hippocampus of diabetic rats]. Zhen ci yan jiu = Acupuncture research. vol 46. issue 11. 2021-12-08. PMID:34865325. |
to observe the effect of electroacupuncture (ea) at "zusanli"(st36) on the phosphorylated tau levels in pancreas and hippocampus of type 2 diabetes mellitus (t2dm) rats，so as to explore the underlying mechanism of ea in diabetic demention rats. |
2021-12-08 |
2023-08-13 |
rat |
| Katie A Bretland, Li Lin, Kimberly M Bretland, Matthew A Smith, Sheila M Fleming, Christine M Dengler-Cris. Irisin treatment lowers levels of phosphorylated tau in the hippocampus of pre-symptomatic female but not male htau mice. Neuropathology and applied neurobiology. vol 47. issue 7. 2021-12-02. PMID:33768561. |
irisin treatment lowers levels of phosphorylated tau in the hippocampus of pre-symptomatic female but not male htau mice. |
2021-12-02 |
2023-08-13 |
mouse |
| Hend M Hussien, Doaa A Ghareeb, Hany E A Ahmed, Hani S Hafez, Samar R Sale. Pharmacological implications of ipriflavone against environmental metal-induced neurodegeneration and dementia in rats. Environmental science and pollution research international. vol 28. issue 46. 2021-12-02. PMID:34235690. |
neuropathological biomarkers including oxidative stress (tbars, no, sod, gpx, gst, and gsh), inflammation (tnf- α, il-6, and il-1β), neurotransmission (ache and mao), and insulin resistance (insulin, insulin receptor, and insulin-degrading enzyme) were altered, which consequently elevated the level of amyloid-β42 and tau protein in the hippocampus tissues inducing neuronal injury. |
2021-12-02 |
2023-08-13 |
rat |
| Juan D Rodriguez-Callejas, Eberhard Fuchs, Claudia Perez-Cru. Increased oxidative stress, hyperphosphorylation of tau, and dystrophic microglia in the hippocampus of aged Tupaia belangeri. Glia. vol 68. issue 9. 2021-11-30. PMID:32096580. |
increased oxidative stress, hyperphosphorylation of tau, and dystrophic microglia in the hippocampus of aged tupaia belangeri. |
2021-11-30 |
2023-08-13 |
Not clear |
| Juan D Rodriguez-Callejas, Eberhard Fuchs, Claudia Perez-Cru. Increased oxidative stress, hyperphosphorylation of tau, and dystrophic microglia in the hippocampus of aged Tupaia belangeri. Glia. vol 68. issue 9. 2021-11-30. PMID:32096580. |
adult (mean age 3.8 years), old (mean age 6 years), and aged (mean age 7.5 years) tree shrews were used for histochemical and immunostaining techniques to determine ferritin and iba1 positive microglia, iron tissue content, tau hyperphosphorylation and oxidized-rna in dentate gyrus, subiculum, and ca1-ca3 hippocampal regions. |
2021-11-30 |
2023-08-13 |
Not clear |
| Juan D Rodriguez-Callejas, Eberhard Fuchs, Claudia Perez-Cru. Increased oxidative stress, hyperphosphorylation of tau, and dystrophic microglia in the hippocampus of aged Tupaia belangeri. Glia. vol 68. issue 9. 2021-11-30. PMID:32096580. |
with aging, oxidative damage to rna (8ohg) increased significantly in all hippocampal regions, while tau hyperphosphorylation (at100) was enhanced in dg, ca3, and sub in aged animals. |
2021-11-30 |
2023-08-13 |
Not clear |
| Bora Yoon, Tengfei Guo, Karine Provost, Deniz Korman, Tyler J Ward, Susan M Landau, William J Jagus. Abnormal tau in amyloid PET negative individuals. Neurobiology of aging. vol 109. 2021-11-26. PMID:34715443. |
we compared a-t- (n = 316), a-t+ (n = 63), and a+t+ (n = 182) individuals on demographics, amyloid, tau, hippocampal volumes, and cognition. |
2021-11-26 |
2023-08-13 |
human |
| Bora Yoon, Tengfei Guo, Karine Provost, Deniz Korman, Tyler J Ward, Susan M Landau, William J Jagus. Abnormal tau in amyloid PET negative individuals. Neurobiology of aging. vol 109. 2021-11-26. PMID:34715443. |
the severity of tau deposition, hippocampal atrophy, and cognitive dysfunction in the a-t+ group was intermediate between a-t- and a+t+ (all p < 0.001). |
2021-11-26 |
2023-08-13 |
human |
| Sarah Helena Nies, Hideyuki Takahashi, Charlotte S Herber, Anita Huttner, Alison Chase, Stephen M Strittmatte. Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β. The Journal of biological chemistry. vol 297. issue 4. 2021-11-25. PMID:34480901. |
the density and spreading of tau inclusions triggered by human tau seed were unaltered in the hippocampus and cortex of appswe/psen1Δe9 transgenic and app |
2021-11-25 |
2023-08-13 |
mouse |
| Jorge A Sierra-Fonseca, Minerva Rodriguez, Anapaula Themann, Omar Lira, Francisco J Flores-Ramirez, Javier Vargas-Medrano, Bharathi S Gadad, Sergio D Iñigue. Autophagy Induction and Accumulation of Phosphorylated Tau in the Hippocampus and Prefrontal Cortex of Adult C57BL/6 Mice Subjected to Adolescent Fluoxetine Treatment. Journal of Alzheimer's disease : JAD. vol 83. issue 4. 2021-11-24. PMID:34420960. |
autophagy induction and accumulation of phosphorylated tau in the hippocampus and prefrontal cortex of adult c57bl/6 mice subjected to adolescent fluoxetine treatment. |
2021-11-24 |
2023-08-13 |
mouse |
| Shinobu Kawakatsu, Ryota Kobayashi, Hiroshi Hayashi, Daichi Morioka, Aya Utsunomiya, Takanobu Kabasawa, Rintaro Ohe, Koichi Otan. Clinicopathological heterogeneity of Alzheimer's disease with pure Alzheimer's disease pathology: Cases associated with dementia with Lewy bodies, very early-onset dementia, and primary progressive aphasia. Neuropathology : official journal of the Japanese Society of Neuropathology. 2021-11-24. PMID:34816507. |
tau deposits were also abundant in the cerebral neocortex, hippocampus, basal ganglia, and brain stem. |
2021-11-24 |
2023-08-13 |
Not clear |
| Jacob Raber, Ruby Perez, Eileen Ruth S Torres, Destine Krenik, Sydney Boutros, Esha Patel, Anna C Chlebowski, Estefania Ramos Torres, Zakia Perveen, Arthur Penn, Daniel B Paulsen, Michael G Bartlett, Enze Jia, Sarah Holden, Reed Hall, Jeffrey Morré, Carmen Wong, Emily Ho, Jaewoo Choi, Jan Frederik Stevens, Alexandra Noël, Gerd Bobe, Glen Kisb. Effects of Chronic Secondhand Smoke (SHS) Exposure on Cognitive Performance and Metabolic Pathways in the Hippocampus of Wild-Type and Human Tau Mice. Environmental health perspectives. vol 129. issue 5. 2021-11-23. PMID:34009016. |
effects of chronic secondhand smoke (shs) exposure on cognitive performance and metabolic pathways in the hippocampus of wild-type and human tau mice. |
2021-11-23 |
2023-08-13 |
mouse |
| Jacob Ziontz, Jenna N Adams, Theresa M Harrison, Suzanne L Baker, William J Jagus. Hippocampal Connectivity with Retrosplenial Cortex is Linked to Neocortical Tau Accumulation and Memory Function. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 42. 2021-11-23. PMID:34531286. |
hippocampal connectivity with retrosplenial cortex is linked to neocortical tau accumulation and memory function. |
2021-11-23 |
2023-08-13 |
human |
| Jacob Ziontz, Jenna N Adams, Theresa M Harrison, Suzanne L Baker, William J Jagus. Hippocampal Connectivity with Retrosplenial Cortex is Linked to Neocortical Tau Accumulation and Memory Function. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 42. 2021-11-23. PMID:34531286. |
functional connectivity between hippocampus (hc) and retrosplenial cortex (rsc), a key region of the medial parietal lobe, was associated with tau in medial parietal lobe. |
2021-11-23 |
2023-08-13 |
human |
| Anthoni M Goodman, Bethany M Langner, Nateka Jackson, Capri Alex, Lori L McMaho. Heightened Hippocampal β-Adrenergic Receptor Function Drives Synaptic Potentiation and Supports Learning and Memory in the TgF344-AD Rat Model during Prodromal Alzheimer's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 26. 2021-11-22. PMID:33952633. |
in fact, the locus coeruleus (lc), the sole source of norepinephrine (ne) for >90% of the brain, is the first site of pathologic tau accumulation in human ad with axon loss throughout forebrain, including hippocampus. |
2021-11-22 |
2023-08-13 |
human |
| Hongchun Li, Wei Xu, Denian Wang, Liang Wang, Qiyao Fang, Xuemei Wan, Jiamei Zhang, Yiming Hu, Huifang Li, Jie Zhang, Zhen Yang, Chunqi Liu, Xiaocong Liu, Yonghai Wang, Bin Liu, Zhengtao Hu, Ying Zhao, Qian Bu, Hongbo Wang, Jingwei Tian, Yinglan Zhao, Xiaobo Ce. 4R Tau Modulates Cocaine-Associated Memory through Adult Dorsal Hippocampal Neurogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 31. 2021-11-22. PMID:34099513. |
4r tau modulates cocaine-associated memory through adult dorsal hippocampal neurogenesis. |
2021-11-22 |
2023-08-13 |
mouse |