| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Koping Chang, Alexander Barrett, Khoa Pham, Juan C Troncos. Lateral geniculate body is spared of tau pathology in Pick disease. Journal of neuropathology and experimental neurology. 2024-02-27. PMID:38412343. |
using immunohistochemistry for phospho-tau (at8) and 3r tau isoform, all pid cases demonstrated extensive lesions involving the hippocampus and neocortex. |
2024-02-27 |
2024-03-01 |
Not clear |
| Koping Chang, Alexander Barrett, Khoa Pham, Juan C Troncos. Lateral geniculate body is spared of tau pathology in Pick disease. Journal of neuropathology and experimental neurology. 2024-02-27. PMID:38412343. |
however, the lateral geniculate body (lgb) is spared of significant tau lesions in contrast to the neighboring hippocampus and other thalamic nuclei. |
2024-02-27 |
2024-03-01 |
Not clear |
| Juan Chen, Zhigao Xiang, Zhuo Zhang, Yan Yang, Kai Shu, Ting Le. Acromegalic Rat Model Presented Cognitive Impairments and Tau Hyperphosphorylation in Hippocampus. Neuroendocrinology. 2024-02-18. PMID:38368872. |
acromegalic rat model presented cognitive impairments and tau hyperphosphorylation in hippocampus. |
2024-02-18 |
2024-02-21 |
rat |
| Charles H Wallace, Giovanni Oliveros, Lei Xie, Peter Serrano, Patricia Rockwell, Maria Figueiredo-Pereir. Potential Alzheimer's early biomarkers in a transgenic rat model and benefits of diazoxide/dibenzoylmethane co-treatment on spatial memory and AD-pathology. Scientific reports. vol 14. issue 1. 2024-02-14. PMID:38355687. |
dz/dib-treatment mitigated spatial memory deficits and buildup of hippocampal aβ plaques and tau phf in 11-month tgf344-ad rats but had no effect on wild-type littermates. |
2024-02-14 |
2024-02-17 |
rat |
| Jung-Min Pyun, Young Ho Park, Young Chul Youn, Min Ju Kang, Kyu Hwan Shim, Jae-Won Jang, Jihwan You, Kwangsik Nho, SangYun Ki. Characteristics of discordance between amyloid positron emission tomography and plasma amyloid-β 42/40 positivity. Translational psychiatry. vol 14. issue 1. 2024-02-10. PMID:38341444. |
pet+/plasma+ was significantly associated with higher tau burden assessed by pet in entorhinal, braak iii/iv, and braak v/vi regions, and with decreased volume of hippocampal and precuneus regions compared to pet-/plasma-. |
2024-02-10 |
2024-02-14 |
human |
| Jung-Min Pyun, Young Ho Park, Young Chul Youn, Min Ju Kang, Kyu Hwan Shim, Jae-Won Jang, Jihwan You, Kwangsik Nho, SangYun Ki. Characteristics of discordance between amyloid positron emission tomography and plasma amyloid-β 42/40 positivity. Translational psychiatry. vol 14. issue 1. 2024-02-10. PMID:38341444. |
the pet-/plasma+ showed intermediate changes between pet-/plasma- and pet+/plasma+ in terms of tau burden, hippocampal and precuneus volume, cross-sectional and longitudinal cognition, and prs. |
2024-02-10 |
2024-02-14 |
human |
| Lorenza Guarnieri, Francesca Bosco, Antonio Leo, Rita Citraro, Ernesto Palma, Giovambattista De Sarro, Vincenzo Mollac. Impact of micronutrients and nutraceuticals on cognitive function and performance in Alzheimer's disease. Ageing research reviews. vol 95. 2024-02-09. PMID:38296163. |
another mechanism underlying the pathogenesis of ad is the abnormal phosphorylation of tau protein that accumulates at the level of neurofibrillary aggregates, and the areas most affected by this pathological process are usually the cholinergic neurons in cortical, subcortical, and hippocampal areas. |
2024-02-09 |
2024-02-14 |
Not clear |
| Kaiwu He, Lulin Nie, Chen Yang, Zizhen Liu, Xinfeng Huang, Shupeng Li, Xifei Yan. Exhaustive exercise decreases tau phosphorylation and modifies biological processes associated with the protein translation and electron transport chain in P301L tau transgenic mice. Experimental gerontology. vol 187. 2024-02-09. PMID:38320733. |
to evaluate this, we examined the levels of total and phosphorylated tau in the hippocampus of pr5 mice, both with and without ee treatment. |
2024-02-09 |
2024-02-14 |
mouse |
| Chan Chen, Ramhari Kumbhar, Hu Wang, Xiuli Yang, Kundlik Gadhave, Cyrus Rastegar, Yasuyoshi Kimura, Adam Behensky, Sumasri Kotha, Grace Kuo, Sruthi Katakam, Deok Jeong, Liang Wang, Anthony Wang, Rong Chen, Shu Zhang, Lingtao Jin, Creg J Workman, Dario A A Vignali, Olga Pletinkova, Hongpeng Jia, Weiyi Peng, David W Nauen, Philip C Wong, Javier Redding-Ochoa, Juan C Troncoso, Mingyao Ying, Valina L Dawson, Ted M Dawson, Xiaobo Ma. Lymphocyte-Activation Gene 3 Facilitates Pathological Tau Neuron-to-Neuron Transmission. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-02-08. PMID:38327094. |
propagation of tau pathology and behavioral deficits induced by injection of tau pff in the hippocampus and overlying cortex are attenuated in mice lacking lag3 selectively in neurons. |
2024-02-08 |
2024-02-10 |
mouse |
| Hyun-Sik Yang, Wai-Ying W Yau, Becky C Carlyle, Bianca A Trombetta, Can Zhang, Zahra Shirzadi, Aaron P Schultz, Jeremy J Pruzin, Colleen D Fitzpatrick, Dylan R Kirn, Jennifer S Rabin, Rachel F Buckley, Timothy J Hohman, Dorene M Rentz, Rudolph E Tanzi, Keith A Johnson, Reisa A Sperling, Steven E Arnold, Jasmeer P Chhatwa. Plasma VEGFA and PGF impact longitudinal tau and cognition in preclinical Alzheimer's disease. Brain : a journal of neurology. 2024-02-05. PMID:38315899. |
we further investigated if effects on cognition were mediated by early neocortical tau accumulation (flortaucipir pet burden in the inferior temporal cortex) or hippocampal atrophy. |
2024-02-05 |
2024-02-09 |
Not clear |
| Dominique Leitner, Geoffrey Pires, Tomas Kavanagh, Evgeny Kanshin, Manor Askenazi, Beatrix Ueberheide, Orrin Devinsky, Thomas Wisniewski, Eleanor Drummon. Similar brain proteomic signatures in Alzheimer's disease and epilepsy. Acta neuropathologica. vol 147. issue 1. 2024-01-30. PMID:38289539. |
immunohistochemistry for aβ and multiple phosphorylated tau species (ptau396/404, ptau217, ptau231) showed a trend for increased intraneuronal ptau217 and ptau231 but no phosphorylated tau aggregates or amyloid plaques in epilepsy hippocampal sections. |
2024-01-30 |
2024-02-01 |
Not clear |
| Zhouquan Jiang, Jing Wang, Yongpeng Qin, Shanggong Liu, Bin Luo, Fan Bai, Huiyi Wei, Shaojuan Zhang, Junjie Wei, Guoyu Ding, Long Ma, Shu He, Rongjie Chen, Ying Sun, Yi Chen, Lu Wang, Hao Xu, Xiangyu Wang, Gong Chen, Wenliang Le. A nonhuman primate model with Alzheimer's disease-like pathology induced by hippocampal overexpression of human tau. Alzheimer's research & therapy. vol 16. issue 1. 2024-01-27. PMID:38281031. |
a nonhuman primate model with alzheimer's disease-like pathology induced by hippocampal overexpression of human tau. |
2024-01-27 |
2024-01-30 |
human |
| Qing Yu, Fang Du, Irla Belli, Patricia A Gomes, Ioannis Sotiropoulos, Clarissa L Waite. Glucocorticoid stress hormones stimulate vesicle-free Tau secretion and spreading in the brain. Cell death & disease. vol 15. issue 1. 2024-01-18. PMID:38238309. |
here, we find that gcs promote secretion of full-length, primarily vesicle-free, phosphorylated tau from murine hippocampal neurons and ex vivo brain slices. |
2024-01-18 |
2024-01-21 |
Not clear |
| Mehrzad Moghadasi, Fatemeh Akbari, Parisa Najaf. Interaction of aerobic exercise and crocin improves memory, learning and hypocampic tau and neurotrophins gene expression in rats treated with trimethytin as a model of Alzheimer's disease. Molecular biology reports. vol 51. issue 1. 2024-01-16. PMID:38227208. |
this study aimed to assess the combined impact of aerobic exercise and crocin on memory, learning, and hippocampal tau and neurotrophins gene expression in ad-like model rats. |
2024-01-16 |
2024-01-18 |
rat |
| Daniel P Chapman, Sarah D Power, Stefano Vicini, Tomás J Ryan, Mark P Burn. Amnesia after repeated head impact is caused by impaired synaptic plasticity in the memory engram. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-01-16. PMID:38228367. |
in sham mice the hippocampal engram neurons exhibited synaptic plasticity, evident in amplified ampa:nmda ratio, enhanced ampa-weighted tau, and increased dendritic spine volume compared to non-engram neurons. |
2024-01-16 |
2024-01-19 |
mouse |
| Tyler R Bell, Carol E Franz, Lisa T Eyler, Christine Fennema-Notestine, Olivia K Puckett, Stephen M Dorros, Matthew S Panizzon, Rahul C Pearce, Donald J Hagler, Michael J Lyons, Asad Beck, Jeremy A Elman, William S Kreme. Probable chronic pain, brain structure, and Alzheimer's plasma biomarkers in older men. The journal of pain. 2024-01-10. PMID:38199594. |
chronic pain leads to tau accumulation and hippocampal atrophy in mice. |
2024-01-10 |
2024-01-13 |
mouse |
| Tyler R Bell, Carol E Franz, Lisa T Eyler, Christine Fennema-Notestine, Olivia K Puckett, Stephen M Dorros, Matthew S Panizzon, Rahul C Pearce, Donald J Hagler, Michael J Lyons, Asad Beck, Jeremy A Elman, William S Kreme. Probable chronic pain, brain structure, and Alzheimer's plasma biomarkers in older men. The journal of pain. 2024-01-10. PMID:38199594. |
in this study, we provide one of the first assessments in humans, examining the associations of probable chronic pain with hippocampal volume, integrity of the locus coeruleus (lc)-an upstream site of tau deposition-and alzheimer's disease (ad)-related plasma biomarkers. |
2024-01-10 |
2024-01-13 |
mouse |
| Yun-Chieh Tsai, Sheng-Min Huang, Hsu-Hsia Peng, Shu-Wha Lin, Shu-Rung Lin, Ting-Yu Chin, Shih-Ming Huan. Imbalance of synaptic and extrasynaptic NMDA receptors induced by the deletion of CRMP1 accelerates age-related cognitive decline in mice. Neurobiology of aging. vol 135. 2024-01-04. PMID:38176125. |
additionally, increasing levels of extrasynaptic nmda receptors and phosphorylation of tau were observed in middle-aged crmp1 ko mice, leading to synaptic and neuronal loss in the ca3 regions of hippocampus. |
2024-01-04 |
2024-01-07 |
mouse |
| Paige E Anton, Lauren N Rutt, Michael L Kaufman, Nicolas Busquet, Elizabeth J Kovacs, Rebecca L McCulloug. Binge ethanol exposure in advanced age elevates neuroinflammation and early indicators of neurodegeneration and cognitive impairment in female mice. Brain, behavior, and immunity. 2023-12-27. PMID:38151165. |
binge ethanol exposure also promoted neuropathology in the hippocampus of aged mice, including tau hyperphosphorylation and neuronal death. |
2023-12-27 |
2023-12-30 |
mouse |
| Yue Zuo, Hui-Ting Liu, Lai-Biao Lin, Rui-Zhu Yue, Huan-Huan Liu, Hong-Wei Wang, Lu Wang, Ruan-Ling Hou, Wei-Zhen Liu, Chang-Zheng Li, Jian-Zhi Wang, Peng Li, Ya-Ling Yi. A new metal ion chelator attenuates human tau accumulation-induced neurodegeneration and memory deficits in mice. Experimental neurology. 2023-12-23. PMID:38141802. |
to explore whether abnormally phosphorylated tau causes metal ion deposition, we overexpressed human full-length tau (htau) in the hippocampal ca3 area of mice and primary cultured hippocampal neurons (cphn) and found that tau accumulation induced iron deposition and activated calcineurin (can), which dephosphorylates glycogen synthase kinase 3 beta (gsk3β), mediating tau hyperphosphorylation. |
2023-12-23 |
2023-12-25 |
mouse |